Review: RNA-based diagnostic markers discovery and therapeutic targets development in cancer

Biomolecular condensates and cancer

(2021) Ann Boija et al.   CANCER CELL

Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies

(2021) Sumeng Wang et al.   Molecular Cancer

The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

(2021) Arafath K. Najumudeen et al.   NATURE GENETICS

Aberrant phase separation and cancer

(2021) Kenzui Taniue et al.   FEBS Journal

mRNA in cancer immunotherapy: beyond a source of antigen

(2021) Lien Van Hoecke et al.   Molecular Cancer

Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma

(2021) Renjie Dou et al.   Cell Death & Disease

HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A-dependent stabilization of ILF3 mRNA

(2021) Fengjie Jiang et al.   Journal of Hematology & Oncology

mRNA therapeutics in cancer immunotherapy

(2021) Jan D. Beck et al.   Molecular Cancer

CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients

(2021) Mengying Ke et al.   Journal of Hematology & Oncology

CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma

(2021) Chunyan Gu et al.   Molecular Cancer

TTSurv: Exploring the Multi-Gene Prognosis in Thousands of Tumors

(2021) Yue Qi et al.   Frontiers in Oncology

The challenge and prospect of mRNA therapeutics landscape

(2020) Yuhua Weng et al.   BIOTECHNOLOGY ADVANCES

HIF2-Induced Long Noncoding RNA RAB11B-AS1 Promotes Hypoxia-Mediated Angiogenesis and Breast Cancer Metastasis

(2020) Yanling Niu et al.   CANCER RESEARCH

Identification and validation of immune-related lncRNA prognostic signature for breast cancer

(2020) Yong Shen et al.   GENOMICS

Restoration of microRNA function impairs MYC-dependent maintenance of MLL leukemia

(2020) Shouhai Zhu et al.   LEUKEMIA

Long non-coding RNA SOX2OT promotes the stemness phenotype of bladder cancer cells by modulating SOX2

(2020) Yonghao Zhan et al.   Molecular Cancer

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

(2020) Pan Wu et al.   Molecular Cancer

Pan-cancer analysis of whole genomes

(2020)   NATURE

Screening of characteristic biomolecules related to bladder cancer based on construction of ceRNA regulation network

(2020) Yan Sun et al.   WORLD JOURNAL OF UROLOGY

Targeted sequencing in DLBCL, molecular subtypes, and outcomes: a Haematological Malignancy Research Network report

(2020) Stuart E. Lacy et al.   BLOOD

Expression of non-coding RNAs in hematological malignancies

(2020) Soudeh Ghafouri-Fard et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing

(2020) Sha Yu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA-Seq Revealed a Circular RNA-microRNA-mRNA Regulatory Network in Hantaan Virus Infection

(2020) Shuang Lu et al.   Frontiers in Cellular and Infection Microbiology

Nuclear microenvironment in cancer: Control through liquid‐liquid phase separation

(2020) Ryu‐Suke Nozawa et al.   CANCER SCIENCE

Identification of Differential Tumor Subtypes of T1 Bladder Cancer

(2020) A. Gordon Robertson et al.   EUROPEAN UROLOGY

TGFβ biology in cancer progression and immunotherapy

(2020) Rik Derynck et al.   Nature Reviews Clinical Oncology

Factors associated with outcomes after a second CD19-targeted CAR T-cell infusion for refractory B cell malignancies

(2020) Jordan Gauthier et al.   BLOOD

RFWD2 induces cellular proliferation and selective proteasome inhibitor resistance by mediating P27 ubiquitination in multiple myeloma

(2020) Chunyan Gu et al.   LEUKEMIA

CircRNAs in anticancer drug resistance: recent advances and future potential

(2020) Tianwei Xu et al.   Molecular Cancer

Identification of a distinct luminal subgroup diagnosing and stratifying early stage prostate cancer by tissue-based single-cell RNA sequencing

(2020) Xiaoshi Ma et al.   Molecular Cancer

LncRNA SNHG11 promotes gastric cancer progression by activating Wnt/β-catenin pathway and oncogenic autophagy

(2020) Qiong Wu et al.   MOLECULAR THERAPY

Safety and efficacy of quavonlimab, a novel anti-CTLA-4 antibody (MK-1308), in combination with pembrolizumab in first-line advanced non-small-cell lung cancer

(2020) R. Perets et al.   ANNALS OF ONCOLOGY

RNA sequencing: new technologies and applications in cancer research

(2020) Mingye Hong et al.   Journal of Hematology & Oncology

CD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment of metastatic pancreatic adenocarcinoma: an open-label, multicentre, phase 1b study

(2020) Mark H O'Hara et al.   LANCET ONCOLOGY

Targeting Notch in oncology: the path forward

(2020) Samarpan Majumder et al.   NATURE REVIEWS DRUG DISCOVERY

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia

(2020) Haydar Frangoul et al.   NEW ENGLAND JOURNAL OF MEDICINE

LnCeCell: a comprehensive database of predicted lncRNA-associated ceRNA networks at single-cell resolution

(2020) Peng Wang et al.   NUCLEIC ACIDS RESEARCH

Lnc2Cancer 3.0: an updated resource for experimentally supported lncRNA/circRNA cancer associations and web tools based on RNA-seq and scRNA-seq data

(2020) Yue Gao et al.   NUCLEIC ACIDS RESEARCH

LincSNP 3.0: an updated database for linking functional variants to human long non-coding RNAs, circular RNAs and their regulatory elements

(2020) Yue Gao et al.   NUCLEIC ACIDS RESEARCH

The novel roles of circRNAs in human cancer

(2019) Qingfeng Shang et al.   Molecular Cancer

RNA-Seq profiling of circular RNAs in human colorectal Cancer liver metastasis and the potential biomarkers

(2019) Hanchen Xu et al.   Molecular Cancer

MEG3: an Oncogenic Long Non-coding RNA in Different Cancers

(2019) Arwa Al-Rugeebah et al.   PATHOLOGY & ONCOLOGY RESEARCH

The circ RNA ‐micro RNA code: emerging implications for cancer diagnosis and treatment

(2019) Lorena Verduci et al.   Molecular Oncology

MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer

(2019) Lu Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Roles of MicroRNA-34a in Epithelial to Mesenchymal Transition, Competing Endogenous RNA Sponging and Its Therapeutic Potential

(2019) Dongsong Nie et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

miR-101 suppresses the development of MLL-rearranged acute myeloid leukemia

(2019) Estrella Gonzales-Aloy et al.   HAEMATOLOGICA

Extracellular Vesicles Long RNA Sequencing Reveals Abundant mRNA, circRNA, and lncRNA in Human Blood as Potential Biomarkers for Cancer Diagnosis

(2019) Yuchen Li et al.   CLINICAL CHEMISTRY

RNA modifications regulating cell fate in cancer

(2019) Sylvain Delaunay et al.   NATURE CELL BIOLOGY

Analyses of a Panel of Transcripts Identified From a Small Sample Size and Construction of RNA Networks in Hepatocellular Carcinoma

(2019) Zhiyong Sheng et al.   Frontiers in Genetics

circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1

(2019) Zhuoan Cheng et al.   Nature Communications

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

(2019) Lei Miao et al.   NATURE BIOTECHNOLOGY

Targeting mRNA processing as an anticancer strategy

(2019) Joana Desterro et al.   NATURE REVIEWS DRUG DISCOVERY

Intranasal delivery of targeted polyfunctional gold–iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to temozolomide

(2019) Uday K. Sukumar et al.   BIOMATERIALS

Circulating lncRNA SNHG11 as a novel biomarker for early diagnosis and prognosis of colorectal cancer

(2019) Wei Xu et al.   INTERNATIONAL JOURNAL OF CANCER

Circulating miRNA analysis for cancer diagnostics and therapy

(2019) Lukas Valihrach et al.   MOLECULAR ASPECTS OF MEDICINE

pH‐Responsive PEG‐Shedding and Targeting Peptide‐Modified Nanoparticles for Dual‐Delivery of Irinotecan and microRNA to Enhance Tumor‐Specific Therapy

(2019) Vivian Juang et al.   Small

Landscape of Noncoding RNA in Prostate Cancer

(2019) Junjie T. Hua et al.   TRENDS IN GENETICS

Olaparib in patients with metastatic castration-resistant prostate cancer with DNA repair gene aberrations (TOPARP-B): a multicentre, open-label, randomised, phase 2 trial

(2019) Joaquin Mateo et al.   LANCET ONCOLOGY

Unravelling triple-negative breast cancer molecular heterogeneity using an integrative multiomic analysis

(2018) Y Bareche et al.   ANNALS OF ONCOLOGY

The emerging role of circRNAs and their clinical significance in human cancers

(2018) Ling Qian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Circular RNA: An emerging non-coding RNA as a regulator and biomarker in cancer

(2018) Bing Chen et al.   CANCER LETTERS

LncRNA co-expression network analysis reveals novel biomarkers for pancreatic cancer

(2018) Matteo Giulietti et al.   CARCINOGENESIS

Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma

(2018) Si-Yu Zhao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Jun/miR-22/HuR regulatory axis contributes to tumourigenesis in colorectal cancer

(2018) Yanqing Liu et al.   Molecular Cancer

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

‘Liquid biopsy’ for cancer promises early detection

(2018) Jocelyn Kaiser   SCIENCE

Emerging Roles of Non-Coding RNA Transcription

(2018) Minna U. Kaikkonen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Engineering circular RNA for potent and stable translation in eukaryotic cells

(2018) R. Alexander Wesselhoeft et al.   Nature Communications

Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

(2018) Hervé Tiriac et al.   Cancer Discovery

LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway

(2018) Xian-Zi Yang et al.   Molecular Cancer

Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway

(2018) Haiyang Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Competing endogenous RNA (ceRNA) cross talk and language in ceRNA regulatory networks: A new look at hallmarks of breast cancer

(2018) Rasoul Abdollahzadeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mountains and Chasms: Surveying the Oncogenomic Publication Landscape

(2018) Paula Carrio-Cordo et al.   ONCOLOGY

CircRNA: functions and properties of a novel potential biomarker for cancer

(2017) Shujuan Meng et al.   Molecular Cancer

Integrative clinical genomics of metastatic cancer

(2017) Dan R. Robinson et al.   NATURE

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

(2017) Norbert Pardi et al.   NATURE

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs

(2017) Amaresh C. Panda et al.   NUCLEIC ACIDS RESEARCH

CSCD: a database for cancer-specific circular RNAs

(2017) Siyu Xia et al.   NUCLEIC ACIDS RESEARCH

Circular RNAs in cancer: opportunities and challenges in the field

(2017) L S Kristensen et al.   ONCOGENE

CircRNA: a novel type of biomarker for cancer

(2017) He-da Zhang et al.   Breast Cancer

The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency

(2017) Chun-Ying Yu et al.   Nature Communications

Global circular RNA expression profile of human gastric cancer and its clinical significance

(2017) Yongfu Shao et al.   Cancer Medicine

MicroRNAs and breast cancer malignancy: An overview of miRNA-regulated cancer processes leading to metastasis

(2017) Jason Harquail et al.   Cancer Biomarkers

On the Dependency of Cellular Protein Levels on mRNA Abundance

(2016) Yansheng Liu et al.   CELL

Long Noncoding RNAs

(2016) Reinier A. Boon et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

In vitro and ex vivo strategies for intracellular delivery

(2016) Martin P. Stewart et al.   NATURE

Non-coding RNAs as drug targets

(2016) Masayuki Matsui et al.   NATURE REVIEWS DRUG DISCOVERY

A network-biology perspective of microRNA function and dysfunction in cancer

(2016) Cameron P. Bracken et al.   NATURE REVIEWS GENETICS

Distribution of miRNA expression across human tissues

(2016) Nicole Ludwig et al.   NUCLEIC ACIDS RESEARCH

From the RNA world to the clinic

(2016) B. A. Sullenger et al.   SCIENCE

Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs

(2016) Qiupeng Zheng et al.   Nature Communications

The RNA Binding Protein Quaking Regulates Formation of circRNAs

(2015) Simon J. Conn et al.   CELL

The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling

(2015) Yanying Wang et al.   Cell Stem Cell

Design of immunoprobes for electrochemical multiplexed tumor marker detection

(2015) Zhanfang Ma et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Differentiation of mammary tumors and reduction in metastasis uponMalat1lncRNA loss

(2015) Gayatri Arun et al.   GENES & DEVELOPMENT

Sensitivity, Specificity, PPV, and NPV for Predictive Biomarkers

(2015) Richard Simon   JNCI-Journal of the National Cancer Institute

Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma

(2015) Yu-Suo Tong et al.   Molecular Cancer

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

The Landscape of long noncoding RNA classification

(2015) Georges St. Laurent et al.   TRENDS IN GENETICS

MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures

(2015) Tanmoy Mondal et al.   Nature Communications

Prostate-specific RNA aptamer: promising nucleic acid antibody-like cancer detection

(2015) Karina Marangoni et al.   Scientific Reports

Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines

(2015) Gregory Lee Szeto et al.   Scientific Reports

Recombinant messenger RNA technology and its application in cancer immunotherapy, transcript replacement therapies, pluripotent stem cell induction, and beyond

(2015) Britta Vallazza et al.   Wiley Interdisciplinary Reviews-RNA

Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis

(2015) Jiayan Fan et al.   GENOME BIOLOGY

Sensitivity, Specificity, PPV, and NPV for Predictive Biomarkers

(2015) Richard Simon   JNCI-Journal of the National Cancer Institute

Efficacy of gemcitabine conjugated and miRNA-205 complexed micelles for treatment of advanced pancreatic cancer

(2014) Anupama Mittal et al.   BIOMATERIALS

Hyaluronic acid-chitosan nanoparticles for co-delivery of MiR-34a and doxorubicin in therapy against triple negative breast cancer

(2014) Xiongwei Deng et al.   BIOMATERIALS

Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease

(2014) Arunoday Bhan et al.   ChemMedChem

Functions of lncRNA HOTAIR in lung cancer

(2014) Gregory Loewen et al.   Journal of Hematology & Oncology

Towards a therapy for Angelman syndrome by targeting a long non-coding RNA

(2014) Linyan Meng et al.   NATURE

MicroRNA silencing for cancer therapy targeted to the tumour microenvironment

(2014) Christopher J. Cheng et al.   NATURE

The multilayered complexity of ceRNA crosstalk and competition

(2014) Yvonne Tay et al.   NATURE

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Towards efficient cancer immunotherapy: advances in developing artificial antigen-presenting cells

(2014) Loek J. Eggermont et al.   TRENDS IN BIOTECHNOLOGY

Targeting long non-coding RNAs in cancers: Progress and prospects

(2013) Chi Han Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Detection of MicroRNA as Novel Biomarkers of Epithelial Ovarian Cancer From the Serum of Ovarian Cancer Patient

(2013) Ye-Won Chung et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

A colorectal cancer classification system that associates cellular phenotype and responses to therapy

(2013) Anguraj Sadanandam et al.   NATURE MEDICINE

starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data

(2013) Jun-Hao Li et al.   NUCLEIC ACIDS RESEARCH

A novel, disruptive vaccination technology

(2013) Karl-Josef Kallen et al.   Human Vaccines & Immunotherapeutics

miRcode: a map of putative microRNA target sites in the long non-coding transcriptome

(2012) Ashwini Jeggari et al.   BIOINFORMATICS

MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review

(2012) Marilena V. Iorio et al.   EMBO Molecular Medicine

Effect of 5-aza-2′-deoxycytidine on methylation of the putative imprinted control region of H19 during the in vitro development of vitrified bovine two-cell embryos

(2012) Xue-Ming Zhao et al.   FERTILITY AND STERILITY

Elevation of Highly Up-regulated in Liver Cancer (HULC) by Hepatitis B Virus X Protein Promotes Hepatoma Cell Proliferation via Down-regulating p18

(2012) Yumei Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer biomarkers

(2012) N. Lynn Henry et al.   Molecular Oncology

MicroRNA and cancer

(2012) Martin D. Jansson et al.   Molecular Oncology

Whole Transcriptome RNA-Seq Analysis of Breast Cancer Recurrence Risk Using Formalin-Fixed Paraffin-Embedded Tumor Tissue

(2012) Dominick Sinicropi et al.   PLoS One

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

(2012) S. Djuranovic et al.   SCIENCE

Long Noncoding RNA, Polycomb, and the Ghosts Haunting INK4b-ARF-INK4a Expression

(2011) F. Aguilo et al.   CANCER RESEARCH

The Art of MicroRNA Research

(2011) Eva van Rooij   CIRCULATION RESEARCH

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

(2011) H. W. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

MacroRNA underdogs in a microRNA world: Evolutionary, regulatory, and biomedical significance of mammalian long non-protein-coding RNA

(2010) Leonard Lipovich et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Lung Cancer Genomic Signatures

(2010) M. Teresa Agulló-Ortuño et al.   Journal of Thoracic Oncology

CCR4-NOT Deadenylates mRNA Associated with RNA-Induced Silencing Complexes in Human Cells

(2010) X. Piao et al.   MOLECULAR AND CELLULAR BIOLOGY

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

MicroRNA control of signal transduction

(2010) Masafumi Inui et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Locked nucleic acids (LNAs) reveal sequence requirements and kinetics of Xist RNA localization to the X chromosome

(2010) K. Sarma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

(2009) Christine Mayr et al.   CELL

Long non-coding RNAs: insights into functions

(2009) Tim R. Mercer et al.   NATURE REVIEWS GENETICS

A SNP in a let-7 microRNA Complementary Site in the KRAS 3' Untranslated Region Increases Non-Small Cell Lung Cancer Risk

(2008) L. J. Chin et al.   CANCER RESEARCH

Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells

(2008) David J. Wong et al.   Cell Stem Cell

Next-generation DNA sequencing

(2008) Jay Shendure et al.   NATURE BIOTECHNOLOGY

The development and impact of 454 sequencing

(2008) Jonathan M Rothberg et al.   NATURE BIOTECHNOLOGY

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA