Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases
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Title
Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases
Authors
Keywords
Isoquinoline subclasses, Biosynthesis, Ethnobotany, Pharmacology, Multifactorial diseases, Neurodegenerative disorders, Cancer
Journal
PHARMACOLOGICAL RESEARCH
Volume 177, Issue -, Pages 106126
Publisher
Elsevier BV
Online
2022-02-11
DOI
10.1016/j.phrs.2022.106126
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Note: Only part of the references are listed.- Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impairment in MPTP-Induced Parkinson’s Disease Model
- (2021) Shuxuan Huang et al. Frontiers in Pharmacology
- The Anticancer Effect of Natural Plant Alkaloid Isoquinolines
- (2021) Dahye Yun et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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- (2021) Yew Rong Kong et al. MOLECULES
- Natural products in drug discovery: advances and opportunities
- (2021) Atanas G. Atanasov et al. NATURE REVIEWS DRUG DISCOVERY
- An insight into the medicinal attributes of berberine derivatives: A review
- (2021) Sobhi Gaba et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Cancer statistics for the year 2020: An overview
- (2021) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Recent Progress on Biological Activity of Amaryllidaceae and Further Isoquinoline Alkaloids in Connection with Alzheimer’s Disease
- (2021) Lucie Cahlíková et al. MOLECULES
- Aducanumab: The first targeted Alzheimer's therapy
- (2021) Pan Yang et al. Drug Discoveries and Therapeutics
- Plant isoquinoline alkaloids: Advances in the chemistry and biology of berberine
- (2021) Sneha Singh et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Berberine loaded nanostructured lipid carrier for Alzheimer's disease: Design, statistical optimization and enhanced in vivo performance
- (2021) Marina Raju et al. LIFE SCIENCES
- Narciclasine induces autophagy-mediated apoptosis in gastric cancer cells through the Akt/mTOR signaling pathway
- (2021) Yunfeng Yuan et al. BMC Pharmacology & Toxicology
- Isoquinoline alkaloids from the roots of Zanthoxylum rigidum as multi-target inhibitors of cholinesterase, monoamine oxidase A and Aβ1-42 aggregation
- (2020) Erika Plazas Gonzalez et al. BIOORGANIC CHEMISTRY
- Diagnosis and Treatment of Parkinson Disease
- (2020) Melissa J. Armstrong et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Elucidation the binding mechanism of Nelumbo nucifera-derived isoquinoline alkaloids as Rho-kinase 1 inhibitors by molecular docking and dynamic simulation
- (2020) Jian Liu et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Magnoflorine: A review of its pharmacology, pharmacokinetics and toxicity
- (2020) Tong Xu et al. PHARMACOLOGICAL RESEARCH
- The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
- (2020) Anne-Laure Mahul-Mellier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study
- (2020) Ying-Xuan Chen et al. Lancet Gastroenterology & Hepatology
- Biologic therapy for advanced breast cancer: recent advances and future directions
- (2020) Paolo Tarantino et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- A Paradoxically Significant Medicinal Plant Carapichea ipecacuanha: A Review
- (2020) Sinjini Mondal et al. Indian Journal of Pharmaceutical Education and Research
- A comprehensive review of ethnopharmacological uses, phytochemistry, biological activities, and future prospects of Nigella glandulifera
- (2020) Yunliang Zheng et al. MEDICINAL CHEMISTRY RESEARCH
- Targeting apoptosis in cancer therapy
- (2020) Benedito A. Carneiro et al. Nature Reviews Clinical Oncology
- A Perspective on Multi-target Drugs for Alzheimer’s Disease
- (2020) Ondrej Benek et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Biologically active isoquinoline alkaloids covering 2014–2018
- (2020) Xiao‐Fei Shang et al. MEDICINAL RESEARCH REVIEWS
- Potential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases
- (2020) Xolani H Makhoba et al. Drug Design Development and Therapy
- Targeting cell cycle by β-carboline alkaloids in vitro: Novel therapeutic prospects for the treatment of cancer
- (2020) Imad Ahmad et al. CHEMICO-BIOLOGICAL INTERACTIONS
- World Brain Day 2020: Move together to end Parkinson's disease
- (2020) Tissa Wijeratne et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- The burden of neurological diseases in Europe: an analysis for the Global Burden of Disease Study 2017
- (2020) Günther Deuschl et al. Lancet Public Health
- Direct dating reveals the early history of opium poppy in western Europe
- (2020) Aurélie Salavert et al. Scientific Reports
- Curare alkaloids from Matis Dart Poison: Comparison with d-tubocurarine in interactions with nicotinic, 5-HT3 serotonin and GABAA receptors
- (2019) Ekaterina N. Spirova et al. PLoS One
- A Natural Isoquinoline Alkaloid With Antitumor Activity: Studies of the Biological Activities of Berberine
- (2019) Da Liu et al. Frontiers in Pharmacology
- Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer’s Disease
- (2019) Anna Hostalkova et al. JOURNAL OF NATURAL PRODUCTS
- Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- (2019) Ning-Ning Yuan et al. BMC Complementary and Alternative Medicine
- The molecular machinery of regulated cell death
- (2019) Daolin Tang et al. CELL RESEARCH
- Natural Compounds Targeting Cancer Stem Cells: A Promising Resource for Chemotherapy
- (2019) Plabon K. Das et al. Anti-Cancer Agents in Medicinal Chemistry
- Sanguinarine inhibits the proliferation of BGC-823 gastric cancer cells via regulating miR-96-5p/miR-29c-3p and the MAPK/JNK signaling pathway
- (2019) Xian-Zhe Dong et al. Journal of Natural Medicines
- Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology
- (2019) David K. Simon et al. CLINICS IN GERIATRIC MEDICINE
- Apomorphine for Parkinson’s Disease: Efficacy and Safety of Current and New Formulations
- (2019) Federico Carbone et al. CNS DRUGS
- Sanguinarine inhibits the tumorigenesis of gastric cancer by regulating the TOX/DNA-PKcs/ KU70/80 pathway
- (2019) Hui-Ning Fan et al. PATHOLOGY RESEARCH AND PRACTICE
- Palmatine: A review of pharmacological properties and pharmacokinetics
- (2019) Dominik Tarabasz et al. PHYTOTHERAPY RESEARCH
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- (2019) Huijuan Zhang et al. Cancer Management and Research
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- (2019) Muñoz et al. Cancers
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- (2018) Avinash C. Tripathi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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- (2018) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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- (2018) Vittoria Graziani et al. Scientific Reports
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- (2018) Adam Kostelnik et al. Biomed Research International
- Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
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- (2017) Eun Ji Kang et al. Evidence-based Complementary and Alternative Medicine
- Inhibition of glial hemichannels by boldine treatment reduces neuronal suffering in a murine model of Alzheimer's disease
- (2017) Chenju Yi et al. GLIA
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- Assessment of Enzyme Inhibition: A Review with Examples from the Development of Monoamine Oxidase and Cholinesterase Inhibitory Drugs
- (2017) Rona Ramsay et al. MOLECULES
- APP/Aβ structural diversity and Alzheimer's disease pathogenesis
- (2017) Alex E. Roher et al. NEUROCHEMISTRY INTERNATIONAL
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- (2017) Xinyao Yang et al. PLANTA MEDICA
- Mechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases: Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins?
- (2017) Pekka T. Männistö et al. Frontiers in Aging Neuroscience
- Anticancer and Reversing Multidrug Resistance Activities of Natural Isoquinoline Alkaloids and their Structure-activity Relationship
- (2017) Zhi-Xing Qing et al. CURRENT MEDICINAL CHEMISTRY
- Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry
- (2016) Tarek Mohamed et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets
- (2016) Jakub Chlebek et al. FITOTERAPIA
- Hydrogen peroxide/ceramide/Akt signaling axis play a critical role in the antileukemic potential of sanguinarine
- (2016) Anees Rahman et al. FREE RADICAL BIOLOGY AND MEDICINE
- Narciclasine – an Amaryllidaceae Alkaloid with Potent Antitumor and Anti-Inflammatory Properties
- (2016) Robert Fürst PLANTA MEDICA
- Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration
- (2016) Rona R. Ramsay et al. Frontiers in Neuroscience
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- (2016) Roberta Gaziano World Journal of Gastrointestinal Oncology
- Colchicine: Old and New
- (2015) Anastasia Slobodnick et al. AMERICAN JOURNAL OF MEDICINE
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- (2015) Jing Zhou et al. Autophagy
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- (2015) Michael T Heneka et al. LANCET NEUROLOGY
- The re-emergence of natural products for drug discovery in the genomics era
- (2015) Alan L. Harvey et al. NATURE REVIEWS DRUG DISCOVERY
- Plant alkaloids as drug leads for Alzheimer's disease
- (2015) Yu Pong Ng et al. NEUROCHEMISTRY INTERNATIONAL
- The Relationship Between the Mechanisms of Action and Safety Profiles of Intrathecal Morphine and Ziconotide: A Review of the Literature
- (2015) Lynn R. Webster PAIN MEDICINE
- Berberine and neurodegeneration: A review of literature
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- (2014) David A. Bennett et al. BIOCHEMICAL PHARMACOLOGY
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- (2014) Zhiqing Fang et al. FOOD AND CHEMICAL TOXICOLOGY
- Berberine prevents nigrostriatal dopaminergic neuronal loss and suppresses hippocampal apoptosis in mice with Parkinson’s disease
- (2014) MIA KIM et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Alkaloids from the Tribe Bocconieae (Papaveraceae): A Chemical and Biological Review
- (2014) Xuelong Yu et al. MOLECULES
- Benzylisoquinoline alkaloid biosynthesis in opium poppy
- (2014) Guillaume A. W. Beaudoin et al. PLANTA
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- (2014) Julie A. Meade et al. PSYCHOPHARMACOLOGY
- Biologically active isoquinoline alkaloids with drug-like properties from the genus Corydalis
- (2014) M. Iranshahy et al. RSC Advances
- Shifting from the single to the multitarget paradigm in drug discovery
- (2013) José L. Medina-Franco et al. DRUG DISCOVERY TODAY
- Nitidine chloride inhibits renal cancer cell metastasis via suppressing AKT signaling pathway
- (2013) Zhiqing Fang et al. FOOD AND CHEMICAL TOXICOLOGY
- Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway
- (2013) JUN LIAO et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Physostigmine and Galanthamine Bind in the Presence of Agonist at the Canonical and Noncanonical Subunit Interfaces of a Nicotinic Acetylcholine Receptor
- (2013) A. K. Hamouda et al. JOURNAL OF NEUROSCIENCE
- Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease
- (2013) Eduardo Luis Konrath et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson's disease
- (2013) Ru-Huei Fu et al. NEUROPHARMACOLOGY
- Benzylisoquinoline Alkaloid Metabolism: A Century of Discovery and a Brave New World
- (2013) Jillian M. Hagel et al. PLANT AND CELL PHYSIOLOGY
- Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: Selective inhibitors of dopamine D1 receptor
- (2012) Wangke Qian et al. BIOORGANIC & MEDICINAL CHEMISTRY
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- (2012) Deok-Sung Bae et al. BMB Reports
- Two Hundred Years of Cancer Research
- (2012) Vincent T. DeVita et al. NEW ENGLAND JOURNAL OF MEDICINE
- Molecular Basis of Inhibitory Activities of Berberine against Pathogenic Enzymes in Alzheimer's Disease
- (2012) Hong-Fang Ji et al. TheScientificWorldJOURNAL
- Nitidine Chloride inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway
- (2011) Xinhua Pan et al. CANCER LETTERS
- Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines
- (2011) Chun-Han Chen et al. CANCER LETTERS
- Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease
- (2011) Rafael León et al. MEDICINAL RESEARCH REVIEWS
- Plant Natural Products in Anticancer Drug Discovery
- (2010) Paul G. Grothaus et al. CURRENT ORGANIC CHEMISTRY
- Anti-amnesic activity of neferine with antioxidant and anti-inflammatory capacities, as well as inhibition of ChEs and BACE1
- (2010) Hyun Ah Jung et al. LIFE SCIENCES
- Effects of berberine on 6-hydroxydopamine-induced neurotoxicity in PC12 cells and a rat model of Parkinson's disease
- (2010) Ik Hyun Kwon et al. NEUROSCIENCE LETTERS
- Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids
- (2009) Hyun Ah Jung et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- An Overview on Benzylisoquinoline Derivatives with Dopaminergic and Serotonergic Activities
- (2009) N. Cabedo et al. CURRENT MEDICINAL CHEMISTRY
- The Anti-Cancer Activity of Noscapine: A Review
- (2009) Massoud Mahmoudian et al. Recent Patents on Anti-Cancer Drug Discovery
- Sanguinarine-Induced Apoptosis in Human Leukemia U937 Cells via Bcl-2 Downregulation and Caspase-3 Activation
- (2008) Min Ho Han et al. CHEMOTHERAPY
- Protective effects of protopine on hydrogen peroxide-induced oxidative injury of PC12 cells via Ca2+ antagonism and antioxidant mechanisms
- (2008) Xianghua Xiao et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- l-Stepholidine reduced l-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease
- (2008) Jiao Mo et al. NEUROBIOLOGY OF AGING
- Evaluating the antipsychotic profile of the preferential PDE10A inhibitor, papaverine
- (2008) M. Weber et al. PSYCHOPHARMACOLOGY
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