Benzylisoquinoline Alkaloid Metabolism: A Century of Discovery and a Brave New World

Isolation and characterization of a cDNA encoding (S)-cis-N-methylstylopine 14-hydroxylase from opium poppy, a key enzyme in sanguinarine biosynthesis

(2013) Guillaume A.W. Beaudoin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Spectroscopic, Molecular Modeling, and NMR-Spectroscopic Investigation of the Binding Mode of the Natural Alkaloids Berberine and Sanguinarine to Human Telomeric G-Quadruplex DNA

(2012) Irene Bessi et al.   ACS Chemical Biology

Application of an integrated LC-UV-MS-NMR platform to the identification of secondary metabolites from cell cultures: benzophenanthridine alkaloids from elicited Eschscholzia californica (california poppy) cell cultures

(2012) Rose M. Gathungu et al.   Analytical Methods

Improvement of Benzylisoquinoline Alkaloid Productivity by Overexpression of 3′-Hydroxy-N-methylcoclaurine 4′-O-Methyltransferase in Transgenic Coptis japonica Plants

(2012) Takayuki Inui et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Characterization of a Flavoprotein Oxidase from Opium Poppy Catalyzing the Final Steps in Sanguinarine and Papaverine Biosynthesis

(2012) Jillian M. Hagel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcript and metabolite profiling in cell cultures of 18 plant species that produce benzylisoquinoline alkaloids

(2012) Scott C. Farrow et al.   PHYTOCHEMISTRY

Systematic silencing of benzylisoquinoline alkaloid biosynthetic genes reveals the major route to papaverine in opium poppy

(2012) Isabel Desgagné-Penix et al.   PLANT JOURNAL

Integration of deep transcript and targeted metabolite profiles for eight cultivars of opium poppy

(2012) Isabel Desgagné-Penix et al.   PLANT MOLECULAR BIOLOGY

Characterization of Three O-Methyltransferases Involved in Noscapine Biosynthesis in Opium Poppy

(2012) T.-T. T. Dang et al.   PLANT PHYSIOLOGY

A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine

(2012) T. Winzer et al.   SCIENCE

Mining the Biodiversity of Plants: A Revolution in the Making

(2012) V. De Luca et al.   SCIENCE

Isoquinoline Alkaloid Biosynthesis is Regulated by a Unique bHLH-Type Transcription Factor in Coptis japonica

(2011) Yasuyuki Yamada et al.   PLANT AND CELL PHYSIOLOGY

Systematic knockdown of morphine pathway enzymes in opium poppy using virus-induced gene silencing

(2011) Champa P. Wijekoon et al.   PLANT JOURNAL

Tyrosine Aminotransferase Contributes to Benzylisoquinoline Alkaloid Biosynthesis in Opium Poppy

(2011) E.-J. Lee et al.   PLANT PHYSIOLOGY

Heterologous expression of two FAD-dependent oxidases with (S)-tetrahydroprotoberberine oxidase activity from Arge mone mexicana and Berberis wilsoniae in insect cells

(2011) Andreas Gesell et al.   PLANTA

Biocatalytic production of tetrahydroisoquinolines

(2011) Bettina M. Ruff et al.   TETRAHEDRON LETTERS

Synthetic biosystems for the production of high-value plant metabolites

(2011) Peter J. Facchini et al.   TRENDS IN BIOTECHNOLOGY

A bacterial platform for fermentative production of plant alkaloids

(2011) Akira Nakagawa et al.   Nature Communications

Characterization of two methylenedioxy bridge-forming cytochrome P450-dependent enzymes of alkaloid formation in the Mexican prickly poppy Argemone mexicana

(2010) Maria Luisa Díaz Chávez et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Integration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures

(2010) Isabel Desgagné-Penix et al.   BMC PLANT BIOLOGY

Consumption of Bitter Alkaloids in Drosophila melanogaster in Multiple-Choice Test Conditions

(2010) Marie-Jeanne Sellier et al.   CHEMICAL SENSES

Atomic Structure of Salutaridine Reductase from the Opium Poppy (Papaver somniferum)

(2010) Yasuhiro Higashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Mechanism of Sanguinarine Reductase, an Enzyme of Alkaloid Detoxification

(2010) Matthias Vogel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shotgun Proteomic Analysis of Yeast-Elicited California Poppy (Eschscholzia californica) Suspension Cultures Producing Enhanced Levels of Benzophenanthridine Alkaloids

(2010) John T. Oldham et al.   JOURNAL OF PROTEOME RESEARCH

Overproduction of Alkaloid Phytoalexins in California Poppy Cells Is Associated with the Co-Expression of Biosynthetic and Stress-Protective Enzymes

(2010) Sornitza Angelova et al.   Molecular Plant

Norcoclaurine Synthase: Mechanism of an Enantioselective Pictet-Spengler Catalyzing Enzyme

(2010) Alessandra Bonamore et al.   MOLECULES

Integrating carbon–halogen bond formation into medicinal plant metabolism

(2010) Weerawat Runguphan et al.   NATURE

Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy

(2010) Jillian M Hagel et al.   Nature Chemical Biology

Endovascular Management of Cerebral Vasospasm

(2010) Ben McGuinness et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

The biosynthesis of papaverine proceeds via (S)-reticuline

(2010) Xu Han et al.   PHYTOCHEMISTRY

Manufacturing Molecules Through Metabolic Engineering

(2010) J. D. Keasling   SCIENCE

BIAdb: A curated database of benzylisoquinoline alkaloids

(2010) Deepak Singla et al.   BMC Pharmacology & Toxicology

CYP719B1 Is Salutaridine Synthase, the C-C Phenol-coupling Enzyme of Morphine Biosynthesis in Opium Poppy

(2009) Andreas Gesell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Removal of Substrate Inhibition and Increase in Maximal Velocity in the Short Chain Dehydrogenase/Reductase Salutaridine Reductase Involved in Morphine Biosynthesis

(2009) Jörg Ziegler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Cytochrome P450 Enzymes Catalyze the Phenol-coupling Step in Endogenous Morphine Biosynthesis

(2009) Nadja Grobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNAi suppression of the morphine biosynthetic gene salAT and evidence of association of pathway enzymes

(2009) Katja Kempe et al.   PHYTOCHEMISTRY

Functional characterization of a novel benzylisoquinolineO-methyltransferase suggests its involvement in papaverine biosynthesis in opium poppy (Papaver somniferumL)

(2009) Silke Pienkny et al.   PLANT JOURNAL

Targeted metabolite and transcript profiling for elucidating enzyme function: isolation of novelN-methyltransferases from three benzylisoquinoline alkaloid-producing species

(2009) David K. Liscombe et al.   PLANT JOURNAL

Alkaloid Biosynthesis: Metabolism and Trafficking

(2008) Jörg Ziegler et al.   Annual Review of Plant Biology

The effect of varying alkaloid concentrations on the feeding behavior of gypsy moth larvae, Lymantria dispar (L.) (Lepidoptera: Lymantriidae)

(2008) Vonnie D. C. Shields et al.   Arthropod-Plant Interactions

Conformation, catalytic site, and enzymatic mechanism of the PR10 allergen-related enzyme norcoclaurine synthase

(2008) Hanna Berkner et al.   BIOCHEMICAL JOURNAL

Quantitative 1H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor-treated opium poppy cell cultures

(2008) Katherine G Zulak et al.   BMC PLANT BIOLOGY

Medium- and short-chain dehydrogenase/reductase gene and protein families

(2008) K. L. Kavanagh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Evolutionary and cellular webs in benzylisoquinoline alkaloid biosynthesis

(2008) David K Liscombe et al.   CURRENT OPINION IN BIOTECHNOLOGY

Molecular Cloning and Characterization of CYP80G2, a Cytochrome P450 That Catalyzes an Intramolecular C–C Phenol Coupling of (S)-Reticuline in Magnoflorine Biosynthesis, from CulturedCoptis japonicaCells

(2008) Nobuhiro Ikezawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Enzymatic (S)-Norcoclaurine Biosynthesis

(2008) Andrea Ilari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plant Defense Responses in Opium Poppy Cell Cultures Revealed by Liquid Chromatography-Tandem Mass Spectrometry Proteomics

(2008) Katherine G. Zulak et al.   MOLECULAR & CELLULAR PROTEOMICS

Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae

(2008) Kristy M Hawkins et al.   Nature Chemical Biology

A concerted mechanism for berberine bridge enzyme

(2008) Andreas Winkler et al.   Nature Chemical Biology

Opium poppy and Madagascar periwinkle: model non-model systems to investigate alkaloid biosynthesis in plants

(2008) Peter J. Facchini et al.   PLANT JOURNAL

Quantitative 1H Nuclear Magnetic Resonance Metabolite Profiling as a Functional Genomics Platform to Investigate Alkaloid Biosynthesis in Opium Poppy

(2008) J. M. Hagel et al.   PLANT PHYSIOLOGY

Microbial production of plant benzylisoquinoline alkaloids

(2008) H. Minami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuromuscular block

(2006) W C Bowman   BRITISH JOURNAL OF PHARMACOLOGY