Assessment of Enzyme Inhibition: A Review with Examples from the Development of Monoamine Oxidase and Cholinesterase Inhibitory Drugs

Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease

(2017) Jacques Joubert et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-inflammatory and protective effects of MT-031, a novel multitarget MAO-A and AChE/BuChE inhibitor in scopolamine mouse model and inflammatory cells

(2017) Wei Liu et al.   NEUROPHARMACOLOGY

Monoaminergic neuropathology in Alzheimer’s disease

(2017) Goran Šimić et al.   PROGRESS IN NEUROBIOLOGY

Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease

(2017) Lhassane Ismaili et al.   PROGRESS IN NEUROBIOLOGY

Serotonergic modulation of the activity of mesencephalic dopaminergic systems: Therapeutic implications

(2017) Philippe De Deurwaerdère et al.   PROGRESS IN NEUROBIOLOGY

Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine

(2016) Philippe De Deurwaerdère et al.   ACS Chemical Neuroscience

Acetylcholinesterase-independent protective effects of huperzine A against iron overload-induced oxidative damage and aberrant iron metabolism signaling in rat cortical neurons

(2016) Ling-xue Tao et al.   ACTA PHARMACOLOGICA SINICA

A spectrophotometric assay for monoamine oxidase activity with 2, 4-dinitrophenylhydrazine as a derivatized reagent

(2016) Guili Huang et al.   ANALYTICAL BIOCHEMISTRY

Design, synthesis and biological evaluation of novel donepezil–coumarin hybrids as multi-target agents for the treatment of Alzheimer’s disease

(2016) Sai-Sai Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY

AChE and the amyloid precursor protein (APP) – Cross-talk in Alzheimer's disease

(2016) Natalia N. Nalivaeva et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Applying the designed multiple ligands approach to inhibit dihydrofolate reductase and thioredoxin reductase for anti-proliferative activity

(2016) Hui-Li Ng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Progress in drug development for Alzheimer's disease: An overview in relation to mitochondrial energy metabolism

(2016) Jana Hroudová et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The safety and efficacy of safinamide mesylate for the treatment of Parkinson’s disease

(2016) Santiago Perez-Lloret et al.   Expert Review of Neurotherapeutics

Design, synthesis and biological activity of 1H-indene-2-carboxamides as multi-targeted anti-Alzheimer agents

(2016) Mehmet Koca et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents

(2016) Leonardo Pisani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif

(2016) Leonardo Pisani et al.   MOLECULES

Tacrine-allyl/propargylcysteine–benzothiazole trihybrids as potential anti-Alzheimer's drug candidates

(2016) Asha Hiremathad et al.   RSC Advances

Disturbed phospholipid homeostasis in endoplasmic reticulum initiates tri-o-cresyl phosphate-induced delayed neurotoxicity

(2016) Li Zhu et al.   Scientific Reports

The safety and efficacy of safinamide mesylate for the treatment of Parkinson’s disease

(2016) Santiago Perez-Lloret et al.   Expert Review of Neurotherapeutics

One for All? Hitting Multiple Alzheimer's Disease Targets with One Drug

(2016) Rebecca E. Hughes et al.   Frontiers in Neuroscience

Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases

(2016) Giuseppe Di Giovanni et al.   Frontiers in Neuroscience

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy

(2016) José Marco-Contelles et al.   Frontiers in Neuroscience

Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease

(2016) Mercedes Unzeta et al.   Frontiers in Neuroscience

Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration

(2016) Rona R. Ramsay et al.   Frontiers in Neuroscience

Drug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening Methodologies

(2016) Katarina Nikolic et al.   Frontiers in Neuroscience

Age-Related Decline in Brain and Hepatic Clearance of Amyloid-Beta is Rectified by the Cholinesterase Inhibitors Donepezil and Rivastigmine in Rats

(2015) Loqman A. Mohamed et al.   ACS Chemical Neuroscience

Sensitive and Selective Ratiometric Fluorescence Probes for Detection of Intracellular Endogenous Monoamine Oxidase A

(2015) Xiaofeng Wu et al.   ANALYTICAL CHEMISTRY

Dose-limiting inhibition of acetylcholinesterase by ladostigil results from the rapid formation and fast hydrolysis of the drug–enzyme complex formed by its major metabolite, R-MCPAI

(2015) Dorit Moradov et al.   BIOCHEMICAL PHARMACOLOGY

Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques

(2015) Rafael J. Rojas et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer’s disease

(2015) Shishun Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Direct Interaction Between Mitochondrial Proteins and Amyloid-β Peptide and its Significance for the Progression and Treatment of Alzheimer’s Disease

(2015) O. Benek et al.   CURRENT MEDICINAL CHEMISTRY

Multi-target tacrine-coumarin hybrids: Cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease

(2015) Sai-Sai Xie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

COX inhibitors: a patent review (2011 – 2014)

(2015) Sara Consalvi et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

cis-cyclopropylamines as mechanism-based inhibitors of monoamine oxidases

(2015) Thomas Malcomson et al.   FEBS Journal

Monoamine Oxidase-A Occupancy by Moclobemide and Phenelzine: Implications for the Development of Monoamine Oxidase Inhibitors

(2015) Lina Chiuccariello et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Monoamine oxidase: radiotracer chemistry and human studies

(2015) Joanna S. Fowler et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases

(2015) Roberta Farina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease

(2015) Matthieu F. Bastide et al.   PROGRESS IN NEUROBIOLOGY

A fluorescence assay for measuring acetylcholinesterase activity in rat blood and a human neuroblastoma cell line (SH-SY5Y)

(2015) Michael F. Santillo et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Butyrylcholinesterase K Variant and Alzheimer’s Disease Risk: A Meta-Analysis

(2015) Jinlian Wang   MEDICAL SCIENCE MONITOR

Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease

(2014) Gerard Esteban et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

(2014) Oscar M. Bautista-Aguilera et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multifunctional compounds: Smart molecules for multifactorial diseases

(2014) Yogita Bansal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel monoamine oxidase inhibitors: a patent review (2012 – 2014)

(2014) Simone Carradori et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Inhibitors of Acetylcholinesterase and Butyrylcholinesterase Meet Immunity

(2014) Miroslav Pohanka   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Predicting targets of compounds against neurological diseases using cheminformatic methodology

(2014) Katarina Nikolic et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Evidence that Formulations of the Selective MAO-B Inhibitor, Selegiline, which Bypass First-Pass Metabolism, also Inhibit MAO-A in the Human Brain

(2014) Joanna S Fowler et al.   NEUROPSYCHOPHARMACOLOGY

Update on the pharmacology of selective inhibitors of MAO-A and MAO-B: Focus on modulation of CNS monoamine neurotransmitter release

(2014) John P.M. Finberg   PHARMACOLOGY & THERAPEUTICS

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

(2013) Mirjana B. Colovic et al.   Current Neuropharmacology

Prospective atom-based 3D-QSAR model prediction, pharmacophore generation, and molecular docking study of carbamate derivatives as dual inhibitors of AChE and MAO-B for Alzheimer’s disease

(2013) Vikas Kumar et al.   MEDICINAL CHEMISTRY RESEARCH

Huperzine A for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

(2013) Guoyan Yang et al.   PLoS One

Free energy landscape for the binding process of Huperzine A to acetylcholinesterase

(2013) Fang Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multi Target Neuroprotective and Neurorestorative Anti-Parkinson and Anti-Alzheimer Drugs Ladostigil and M30 Derived from Rasagiline

(2013) Moussa B.H. Youdim   Experimental Neurobiology

The Novel Multi-Target Iron Chelating-Radical Scavenging Compound M30 Possesses Beneficial Effects on Major Hallmarks of Alzheimer's Disease

(2012) Lana Kupershmidt et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuropathy target esterase (NTE): overview and future

(2012) Rudy J. Richardson et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Ladostigil: A Novel Multimodal Neuroprotective Drug with Cholinesterase and Brain-Selective Monoamine Oxidase Inhibitory Activities for Alzheimers Disease Treatment

(2012) Orly Weinreb et al.   CURRENT DRUG TARGETS

The progress in the cholinesterase quantification methods

(2012) Ondrej Holas et al.   Expert Opinion on Drug Discovery

Restoration of dopamine release deficits during object recognition memory acquisition attenuates cognitive impairment in a triple transgenic mice model of Alzheimer's disease

(2012) K. Guzman-Ramos et al.   LEARNING & MEMORY

Spectrophotometric methods based on 2,6-dichloroindophenol acetate and indoxylacetate for butyrylcholinesterase activity assay in plasma

(2012) Miroslav Pohanka et al.   TALANTA

A review on coumarins as acetylcholinesterase inhibitors for Alzheimer’s disease

(2011) Preet Anand et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Catalytic and inhibitor binding properties of zebrafish monoamine oxidase (zMAO): Comparisons with human MAO A and MAO B

(2011) Milagros Aldeco et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Determination of acetylcholinesterase activity by the Ellman assay: A versatile tool for in vitro research on medical countermeasures against organophosphate poisoning

(2011) Franz Worek et al.   Drug Testing and Analysis

Irreversible Inhibition of Monoamine Oxidase B by the Antiparkinsonian Medicines Rasagiline and Selegiline: A Computational Study

(2011) Rok Borštnar et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Assessment of Acetylcholinesterase Activity Using Indoxylacetate and Comparison with the Standard Ellman’s Method

(2011) Miroslav Pohanka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Monoamine Oxidase A Expression Is Vital for Embryonic Brain Development by Modulating Developmental Apoptosis

(2011) Chi Chiu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil andN-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease

(2011) Irene Bolea et al.   JOURNAL OF MEDICINAL CHEMISTRY

An improved approach to steady-state analysis of monoamine oxidases

(2011) Rona R. Ramsay et al.   JOURNAL OF NEURAL TRANSMISSION

Alzheimer disease-related presenilin-1 variants exert distinct effects on monoamine oxidase-A activity in vitro

(2011) Paul R. Pennington et al.   JOURNAL OF NEURAL TRANSMISSION

A phase II trial of huperzine A in mild to moderate Alzheimer disease

(2011) M. S. Rafii et al.   NEUROLOGY

A direct continuous fluorometric turn-on assay for monoamine oxidase B and its inhibitor-screening based on the abnormal fluorescent behavior of silole

(2010) Lihua Peng et al.   ANALYST

History and New Developments of Assays for Cholinesterase Activity and Inhibition

(2010) Yuqing Miao et al.   CHEMICAL REVIEWS

Monoamine Oxidases Regulate Telencephalic Neural Progenitors in Late Embryonic and Early Postnatal Development

(2010) A. Cheng et al.   JOURNAL OF NEUROSCIENCE

Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2

(2010) Claudia Binda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

R-Deprenyl: Pharmacological Spectrum of its Activity

(2010) K. Magyar et al.   NEUROCHEMICAL RESEARCH

On the formation and nature of the imidazoline I2 binding site on human monoamine oxidase-B

(2010) G. Reid McDonald et al.   PHARMACOLOGICAL RESEARCH

Colorimetric dipstick for assay of organophosphate pesticides and nerve agents represented by paraoxon, sarin and VX

(2010) Miroslav Pohanka et al.   TALANTA

The Butyrylcholinesterase K Variant Confers Structurally Derived Risks for Alzheimer Pathology♦

(2009) Erez Podoly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of a high-throughput screening for nerve agent detoxifying materials using a fully-automated robot-assisted biological assay

(2009) T. Wille et al.   TOXICOLOGY IN VITRO

Structural and Mechanistic Studies of Arylalkylhydrazine Inhibition of Human Monoamine Oxidases A and B†‡

(2008) Claudia Binda et al.   BIOCHEMISTRY

Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans

(2008) I Wessler et al.   BRITISH JOURNAL OF PHARMACOLOGY

Acetylcholinesterase: How is structure related to function?

(2008) Israel Silman et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A novel fluorogenic probe for monoamine oxidase assays

(2008) You You Lu et al.   CHINESE CHEMICAL LETTERS

Amyloid-cholinesterase interactions

(2008) Nibaldo C. Inestrosa et al.   FEBS Journal

The neuroprotective mechanism of action of the multimodal drug ladostigil

(2008) Orly Weinreb   Frontiers in Bioscience-Landmark

Carbamates with Differential Mechanism of Inhibition Toward Acetylcholinesterase and Butyrylcholinesterase

(2008) Sultan Darvesh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Stereochemical Identification, and Selective Inhibitory Activity against Human Monoamine Oxidase-B of 2-Methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones

(2008) Franco Chimenti et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Novel Cholinesterase–Monoamine Oxidase Inhibitor and Antioxidant, Ladostigil, Confers Neuroprotection in Neuroblastoma Cells and Aged Rats

(2008) Orit Bar-Am et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Comparison of the Structural Properties of the Active Site Cavities of Human and Rat Monoamine Oxidase A and B in Their Soluble and Membrane-Bound Forms†

(2007) Anup K. Upadhyay et al.   BIOCHEMISTRY