Potential of Naturally Derived Alkaloids as Multi-Targeted Therapeutic Agents for Neurodegenerative Diseases

Isoquinoline alkaloids from the roots of Zanthoxylum rigidum as multi-target inhibitors of cholinesterase, monoamine oxidase A and Aβ1-42 aggregation

(2020) Erika Plazas Gonzalez et al.   BIOORGANIC CHEMISTRY

Novel Cinnamoylated Flavoalkaloids Identified in Tea with Acetylcholinesterase Inhibition Effect

(2020) Rashmi Gaur et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Axons Matter: The Promise of Treating Neurodegenerative Disorders by Targeting SARM1-Mediated Axonal Degeneration

(2020) Raul Krauss et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Harmine Ameliorates Cognitive Impairment by Inhibiting NLRP3 Inflammasome Activation and Enhancing the BDNF/TrkB Signaling Pathway in STZ-Induced Diabetic Rats

(2020) Peifang Liu et al.   Frontiers in Pharmacology

Neuroprotective role of polyphenols against oxidative stress-mediated neurodegeneration

(2020) Md Sahab Uddin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification of the first noncompetitive SARM1 inhibitors

(2020) Heather S. Loring et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Natural alkaloid harmine promotes degradation of Alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation

(2019) Cui-Zan Cai et al.   PHYTOMEDICINE

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients

(2019) Matthew K. Tobin et al.   Cell Stem Cell

Natural products and their derivatives as multifunctional ligands against Alzheimer's disease

(2019) Pooja Patil et al.   DRUG DEVELOPMENT RESEARCH

Neuroinflammation as a Common Feature of Neurodegenerative Disorders

(2019) Leonardo Guzman-Martinez et al.   Frontiers in Pharmacology

A new cinnamamide derivative and two new β-carboline alkaloids from the stems of Picrasma quassioides

(2019) Jie Zhang et al.   FITOTERAPIA

BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells

(2019) Mamiko Yano et al.   Journal of Natural Medicines

Ameliorative effect of deoxyvasicine on scopolamine-induced cognitive dysfunction by restoration of cholinergic function in mice

(2019) Gang Deng et al.   PHYTOMEDICINE

Berberine attenuated the cytotoxicity induced by t-BHP via inhibiting oxidative stress and mitochondria dysfunction in PC-12 cells

(2019) Zhengmao Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Berberine alleviates rotenone-induced cytotoxicity by antioxidation and activation of PI3K/Akt signaling pathway in SH-SY5Y cells

(2019) Han Deng et al.   NEUROREPORT

Cholinesterase inhibitory alkaloids from the rhizomes of Coptis chinensis

(2018) Thao Quyen Cao et al.   BIOORGANIC CHEMISTRY

Berberine alleviates amyloid-beta pathology in the brain of APP/PS1 transgenic mice via inhibiting β/γ-secretases activity and enhancing α-secretases

(2018) Zhiyou Cai et al.   Current Alzheimer Research

Neuroprotective effect of berberine against environmental heavy metals-induced neurotoxicity and Alzheimer's-like disease in rats

(2018) Hend M. Hussien et al.   FOOD AND CHEMICAL TOXICOLOGY

Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders

(2018) Ghulam Hussain et al.   International Journal of Biological Sciences

Features and outcomes of drugs for combination therapy as multi-targets strategy to combat Alzheimer's disease

(2018) Atish Kumar Sahoo et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Protective Role of Brain CYP2J in Parkinson’s Disease Models

(2018) Yueran Li et al.   Oxidative Medicine and Cellular Longevity

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease

(2018) Ean-Jeong Seo et al.   PHARMACOLOGICAL RESEARCH

Inhibition of Acetylcholinesterase and Butyrylcholinesterase by a Plant Secondary Metabolite Boldine

(2018) Adam Kostelnik et al.   Biomed Research International

Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their cholinesterase inhibitory activities

(2018) Yang Liu et al.   FITOTERAPIA

Berberine Attenuates Calyculin A-Induced Cytotoxicity and Tau Hyperphosphorylation in HEK293 Cells

(2018) Guang Yu et al.   JOURNAL OF ALZHEIMERS DISEASE

Probing and Trapping a Sensitive Conformation: Amyloid-β Fibrils, Oligomers, and Dimers

(2018) Janelle N. Fawver et al.   JOURNAL OF ALZHEIMERS DISEASE

Three Lycopodium alkaloids from Thai club mosses

(2018) Thanasan Nilsu et al.   PHYTOCHEMISTRY

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Emma Nichols et al.   LANCET NEUROLOGY

Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) E. Ray Dorsey et al.   LANCET NEUROLOGY

Berberine ameliorates lipopolysaccharide-induced learning and memory deficit in the rat: insights into underlying molecular mechanisms

(2018) Sepideh Sadraie et al.   METABOLIC BRAIN DISEASE

Neuroprotective effects of berberine on recognition memory impairment, oxidative stress, and damage to the purinergic system in rats submitted to intracerebroventricular injection of streptozotocin

(2018) Juliana Sorraila de Oliveira et al.   PSYCHOPHARMACOLOGY

The Early Events That Initiate β-Amyloid Aggregation in Alzheimer’s Disease

(2018) Xingyu Zhang et al.   Frontiers in Aging Neuroscience

Isosteroidal alkaloids as potent dual-binding site inhibitors of both acetylcholinesterase and butyrylcholinesterase from the bulbs of Fritillaria walujewii

(2017) Yu-Ming Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors

(2017) Tanja Botić et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of glial hemichannels by boldine treatment reduces neuronal suffering in a murine model of Alzheimer's disease

(2017) Chenju Yi et al.   GLIA

CNS inflammation and neurodegeneration

(2017) Tanuja Chitnis et al.   JOURNAL OF CLINICAL INVESTIGATION

Acetylcholinesterase Inhibitory Alkaloids from the Whole Plants of Zephyranthes carinata

(2017) Guanqun Zhan et al.   JOURNAL OF NATURAL PRODUCTS

Alzheimer’s Disease: Past, Present, and Future

(2017) Mark W. Bondi et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity

(2017) Wan Nurul Nazneem Wan Othman et al.   Phytochemistry Letters

Indole Alkaloids from Plants as Potential Leads for Antidepressant Drugs: A Mini Review

(2017) Hazrulrizawati A. Hamid et al.   Frontiers in Pharmacology

The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro

(2017) Jose A. Morales-García et al.   Scientific Reports

Monoterpene esters and aporphine alkaloids from Illigera aromatica with inhibitory effects against cholinesterase and NO production in LPS-stimulated RAW264.7 macrophages

(2016) Jian-Wei Dong et al.   ARCHIVES OF PHARMACAL RESEARCH

Drug treatments in Alzheimers disease

(2016) R. Briggs et al.   CLINICAL MEDICINE

Alzheimer's disease: Targeting the Cholinergic System

(2016) Talita H. Ferreira-Vieira et al.   Current Neuropharmacology

Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?

(2016) Tarique Hussain et al.   Oxidative Medicine and Cellular Longevity

Squarrosine A and Pyrrolhuperzine A, New Lycopodium Alkaloids from Thai and Philippine Huperzia squarrosa

(2016) Thanasan Nilsu et al.   PLANTA MEDICA

Acetylcholinesterase inhibitory activity and molecular docking study of steroidal alkaloids from Holarrhena pubescens barks

(2016) Sarot Cheenpracha et al.   STEROIDS

New Indole Alkaloids from the Bark of Rauvolfia Reflexa and their Cholinesterase Inhibitory Activity

(2015) Mehran Fadaeinasab et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Oxidant/Antioxidant Imbalance and the Risk of Alzheimer's Disease

(2015) Ahmed Moneim   Current Alzheimer Research

Effects of harmine, an acetylcholinesterase inhibitor, on spatial learning and memory of APP/PS1 transgenic mice and scopolamine-induced memory impairment mice

(2015) Dandan He et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Proaporphine and aporphine alkaloids with acetylcholinesterase inhibitory activity from Stephania epigaea

(2015) Jian-Wei Dong et al.   FITOTERAPIA

Potent AChE and BChE inhibitors isolated from seeds of Peganum harmala Linn by a bioassay-guided fractionation

(2015) Yadi Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases

(2015) Qi-Wei Jiang et al.   MEDICINAL RESEARCH REVIEWS

Natural indole butyrylcholinesterase inhibitors from Nauclea officinalis

(2015) Sook Yee Liew et al.   PHYTOMEDICINE

Adult Neurogenesis in Neurodegenerative Diseases: Figure 1.

(2015) Beate Winner et al.   Cold Spring Harbor Perspectives in Biology

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Alkaloids from the bulbs of Lycoris longituba and their neuroprotective and acetylcholinesterase inhibitory activities

(2014) Yun-Yun Zhu et al.   ARCHIVES OF PHARMACAL RESEARCH

Berberine Attenuates Axonal Transport Impairment and Axonopathy Induced by Calyculin A in N2a Cells

(2014) Xiaofeng Liu et al.   PLoS One

Experimental research Effects of berberine on β-secretase activity in a rabbit model of Alzheimer’s disease

(2013) Negar Panahi et al.   Archives of Medical Science

Complexity of dopamine metabolism

(2013) Johannes Meiser et al.   Cell Communication and Signaling

Amyloidosis in Alzheimer’s Disease: The Toxicity of Amyloid Beta (Aβ), Mechanisms of Its Accumulation and Implications of Medicinal Plants for Therapy

(2013) Anchalee Prasansuklab et al.   Evidence-based Complementary and Alternative Medicine

Amaryllidaceae and Sceletium alkaloids

(2013) Zhong Jin   NATURAL PRODUCT REPORTS

The Clinical Problem of Symptomatic Alzheimer Disease and Mild Cognitive Impairment

(2013) R. Tarawneh et al.   Cold Spring Harbor Perspectives in Medicine

Ectonucleotidases and Nucleotide/Nucleoside Transporters as Pharmacological Targets for Neurological Disorders

(2012) Carla D. Bonan   CNS & Neurological Disorders-Drug Targets

Glial hemichannels and their involvement in aging and neurodegenerative diseases

(2012) Juan A. Orellana et al.   REVIEWS IN THE NEUROSCIENCES

Neuropsychiatric symptoms in Alzheimer’s disease

(2011) Constantine G. Lyketsos et al.   Alzheimers & Dementia

Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species

(2011) Abbas Mollataghi et al.   FITOTERAPIA

The Promise of Neuroprotective Agents in Parkinson?s Disease

(2011) Stacey E. Seidl et al.   Frontiers in Neurology

Beyond the Cholinergic Hypothesis: Do Current Drugs Work in Alzheimer's Disease?

(2010) Alessandro Martorana et al.   CNS Neuroscience & Therapeutics

Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression

(2010) Yun Li et al.   NEUROPHARMACOLOGY