Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease

Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: The case of chelerythrine

(2012) Gerda Brunhofer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae)

(2012) Emmanuel Adekanmi Adewusi et al.   JOURNAL OF ETHNOPHARMACOLOGY

In-vitro evaluation of the P-glycoprotein interactions of a series of potentially CNS-active Amaryllidaceae alkaloids

(2012) André Huss Eriksson et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure–activity relationships

(2012) Zhong-Duo Yang et al.   LIFE SCIENCES

Structural insights into cholinesterases inhibition by harmane β-carbolinium derivatives: A kinetics – molecular modeling approach

(2012) Juliana M. Torres et al.   PHYTOCHEMISTRY

Indole alkaloids of Psychotria as multifunctional cholinesterases and monoamine oxidases inhibitors

(2012) Carolina S. Passos et al.   PHYTOCHEMISTRY

Alkaloids from Galanthus rizehensis

(2012) Buket Bozkurt Sarikaya et al.   Phytochemistry Letters

Structure-fragmentation relationship and rapid dereplication ofBuxussteroidal alkaloids by electrospray ionization-quadrupole time-of-flight mass spectrometry

(2012) Syed Ghulam Musharraf et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Molecular Basis of Inhibitory Activities of Berberine against Pathogenic Enzymes in Alzheimer's Disease

(2012) Hong-Fang Ji et al.   TheScientificWorldJOURNAL

Total synthesis and anti-cholinesterase activity of marine-derived bis-indole alkaloid fascaplysin

(2012) Sandip B. Bharate et al.   MedChemComm

Animal models in the drug discovery pipeline for Alzheimer's disease

(2011) Debby Van Dam et al.   BRITISH JOURNAL OF PHARMACOLOGY

Selective Cholinesterase Inhibitors from Buxus sempervirens L. and their Molecular Docking Studies

(2011) Ilkay E. Orhan et al.   Current Computer-Aided Drug Design

Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species

(2011) Abbas Mollataghi et al.   FITOTERAPIA

New cholinesterase inhibiting bisbenzylisoquinoline alkaloids from Abuta grandifolia

(2011) Maria Francesca Cometa et al.   FITOTERAPIA

Alkaloid profiling and anticholinesterase activity of South AmericanLycopodiaceaespecies

(2011) Eduardo Luis Konrath et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Investigation of the in vitro and ex vivo acetylcholinesterase and antioxidant activities of traditionally used Lycopodium species from South America on alkaloid extracts

(2011) Eduardo Luis Konrath et al.   JOURNAL OF ETHNOPHARMACOLOGY

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Lead Finding for Acetyl Cholinesterase Inhibitors from Natural Origin: Structure Activity Relationship and Scope

(2011) P. K. Mukherjee et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

An Overview on Natural Cholinesterase Inhibitors - A Multi-Targeted Drug Class - and Their Mass Production

(2011) I. Erdogan Orhan et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Acetylcholinesterase-inhibiting Alkaloids from Zephyranthes concolor

(2011) Ricardo Reyes-Chilpa et al.   MOLECULES

Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease

(2011) Hong-Fang Ji et al.   MOLECULES

Perspective: In search of biomarkers

(2011) Neil S. Buckholtz   NATURE

A phase II trial of huperzine A in mild to moderate Alzheimer disease

(2011) M. S. Rafii et al.   NEUROLOGY

Bioactive Isoquinoline Alkaloids fromCorydalis saxicola

(2011) Qiao-Qin Huang et al.   PLANTA MEDICA

Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus

(2010) Torsten Geissler et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anti-Amyloidogenic and Anti-Apoptotic Role of Melatonin in Alzheimer Disease

(2010) Hongwen He et al.   Current Neuropharmacology

Characterization and identification of steroidal alkaloids in Fritillaria species using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry

(2010) Jian-Liang Zhou et al.   JOURNAL OF CHROMATOGRAPHY A

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Triterpenoidal Alkaloids fromBuxus natalensisand Their Acetylcholinesterase Inhibitory Activity

(2010) Wadim L. Matochko et al.   JOURNAL OF NATURAL PRODUCTS

Characterization of Acetylcholinesterase Inhibitory Constituents fromAnnona glabraAssisted by HPLC Microfractionation

(2010) Sheng-Fa Tsai et al.   JOURNAL OF NATURAL PRODUCTS

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease

(2010) Elaine Monteiro Cardoso-Lopes et al.   MOLECULES

Acetylcholinesterase inhibitors fromCorydalis yanhusuo

(2010) Hai-Tao Xiao et al.   NATURAL PRODUCT RESEARCH

Neurochemical basis for symptomatic treatment of Alzheimer's disease

(2010) Paul T. Francis et al.   NEUROPHARMACOLOGY

Triterpenoidal alkaloids from Buxus hyrcana and their enzyme inhibitory, anti-fungal and anti-leishmanial activities

(2010) Athar Ata et al.   PHYTOCHEMISTRY

Alkaloids from Roots ofStephania rotundaand Their Cholinesterase Inhibitory Activity

(2010) Tran Hung et al.   PLANTA MEDICA

Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids

(2009) Hyun Ah Jung et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids

(2009) James McNulty et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Alzheimer disease neuropathology in the oldest old

(2009) Jillian J. Kril   Nature Reviews Neurology

Acetylcholinesterase inhibitory activity of lycopodane-type alkaloids from the Icelandic Lycopodium annotinum ssp. alpestre

(2009) Elsa Steinunn Halldorsdottir et al.   PHYTOCHEMISTRY

Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission

(2009) David M. Pereira et al.   PHYTOMEDICINE

Effect of isoquinoline alkaloids from two Hippeastrum species on in vitro acetylcholinesterase activity

(2009) L.B. Pagliosa et al.   PHYTOMEDICINE

Petrosamine, a potent anticholinesterase pyridoacridine alkaloid from a Thai marine sponge Petrosia n. sp

(2008) Veena S. Nukoolkarn et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Lycoparins A–C, new alkaloids from Lycopodium casuarinoides inhibiting acetylcholinesterase

(2008) Yusuke Hirasawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Natural Products and their Derivatives as Cholinesterase Inhibitors in the Treatment of Neurodegenerative Disorders: An Update

(2008) Monica Loizzo et al.   CURRENT MEDICINAL CHEMISTRY

Acetylcholinesterase Inhibitors as Disease-Modifying Therapies for Alzheimers Disease

(2008) D. Munoz-Torrero   CURRENT MEDICINAL CHEMISTRY

The cyanobacterial alkaloid nostocarboline: an inhibitor of acetylcholinesterase and trypsin

(2008) Paul G. Becher et al.   JOURNAL OF APPLIED PHYCOLOGY

Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii

(2008) Tran Manh Hung et al.   JOURNAL OF ETHNOPHARMACOLOGY

Bioactive 5α-Pregnane-Type Steroidal Alkaloids fromSarcococca hookeriana

(2008) Krishna P. Devkota et al.   JOURNAL OF NATURAL PRODUCTS

Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors

(2008) Raj N Kalaria et al.   LANCET NEUROLOGY

Interactions between the amyloid and cholinergic mechanisms in Alzheimer's disease

(2008) M PAKASKI et al.   NEUROCHEMISTRY INTERNATIONAL