Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

The Fas Death Signaling Pathway Connecting Reactive Oxygen Species Generation and FLICE Inhibitory Protein Down-Regulation

(2014) L. Wang et al.   JOURNAL OF IMMUNOLOGY

Mangiferin, a Natural Xanthone, Protects Murine Liver in Pb(II) Induced Hepatic Damage and Cell Death via MAP Kinase, NF-κB and Mitochondria Dependent Pathways

(2013) Pabitra Bikash Pal et al.   PLoS One

Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats

(2012) Joydeep Das et al.   AMINO ACIDS

Glutathione and modulation of cell apoptosis

(2012) Magdalena L. Circu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A 43 kD protein from the leaves of the herb Cajanus indicus L. modulates doxorubicin induced nephrotoxicity via MAPKs and both mitochondria dependent and independent pathways

(2012) Sankhadeep Pal et al.   BIOCHIMIE

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Taurine ameliorate alloxan induced oxidative stress and intrinsic apoptotic pathway in the hepatic tissue of diabetic rats

(2012) Kahkashan Rashid et al.   FOOD AND CHEMICAL TOXICOLOGY

Arjunolic acid: beneficial role in type 1 diabetes and its associated organ pathophysiology

(2012) Prasenjit Manna et al.   FREE RADICAL RESEARCH

Iron induces hepatocytes death via MAPK activation and mitochondria-dependent apoptotic pathway: Beneficial role of glycine

(2012) Sudip Bhattacharyya et al.   FREE RADICAL RESEARCH

Protective role of D-saccharic acid-1,4-lactone in alloxan induced oxidative stress in the spleen tissue of diabetic rats is mediated by suppressing mitochondria dependent apoptotic pathway

(2012) Kahkashan Rashid et al.   FREE RADICAL RESEARCH

FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3

(2012) J. Hagenbuchner et al.   JOURNAL OF CELL SCIENCE

Natural Terpenes Prevent Mitochondrial Dysfunction, Oxidative Stress and Release of Apoptotic Proteins during Nimesulide-Hepatotoxicity in Rats

(2012) Brijesh Kumar Singh et al.   PLoS One

Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2–NFκB pathways

(2012) Joydeep Das et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

d-Saccharic acid 1,4-lactone protects diabetic rat kidney by ameliorating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via NF-κB and PKC signaling

(2012) Semantee Bhattacharya et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondrial dysfunction in pancreatic β cells

(2012) Sachin Supale et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mechanism of the protective action of taurine in toxin and drug induced organ pathophysiology and diabetic complications: a review

(2012) Joydeep Das et al.   Food & Function

The prophylactic role ofd-saccharic acid-1,4-lactone against hyperglycemia-induced hepatic apoptosis via inhibition of both extrinsic and intrinsic pathways in diabetic rats

(2012) Semantee Bhattacharya et al.   Food & Function

Oxidative Stress and Programmed Cell Death in Yeast

(2012) Gianluca Farrugia et al.   Frontiers in Oncology

Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis

(2011) Joydeep Das et al.   AMINO ACIDS

Modulation of mercury-induced mitochondria-dependent apoptosis by glycine in hepatocytes

(2011) Pabitra Bikash Pal et al.   AMINO ACIDS

Taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of PI3-K/Akt and inhibition of p53, p38-JNK

(2011) Joydeep Das et al.   BIOCHEMICAL PHARMACOLOGY

Impaired redox signaling and mitochondrial uncoupling contributes vascular inflammation and cardiac dysfunction in type 1 diabetes: Protective role of arjunolic acid

(2011) Prasenjit Manna et al.   BIOCHIMIE

The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis

(2011) Jyotirmoy Ghosh et al.   BIOMATERIALS

Taurine protects the antioxidant defense system in the erythrocytes of cadmium treated mice

(2011) Mahua Sinha et al.   BMB Reports

Protective role of a coumarin-derived schiff base scaffold against tertiary butyl hydroperoxide (TBHP)-induced oxidative impairment and cell death via MAPKs, NF-κB and mitochondria-dependent pathways

(2011) Manoranjan Ghosh et al.   FREE RADICAL RESEARCH

D(+) galactosamine induced oxidative and nitrosative stress-mediated renal damage in rats via NF-κB and inducible nitric oxide synthase (iNOS) pathways is ameliorated by a polyphenol xanthone, mangiferin

(2011) Manoranjan Ghosh et al.   FREE RADICAL RESEARCH

Contribution of nano-copper particles toin vivoliver dysfunction and cellular damage: Role of IκBα/NF-κB, MAPKs and mitochondrial signal

(2011) Prasenjit Manna et al.   Nanotoxicology

Involvement of both intrinsic and extrinsic pathways in hepatoprotection of arjunolic acid against cadmium induced acute damage in vitro

(2011) Sankhadeep Pal et al.   TOXICOLOGY

Nano-copper induces oxidative stress and apoptosis in kidney via both extrinsic and intrinsic pathways

(2011) Abhijit Sarkar et al.   TOXICOLOGY

d-saccharic acid-1,4-lactone ameliorates alloxan-induced diabetes mellitus and oxidative stress in rats through inhibiting pancreatic beta-cells from apoptosis via mitochondrial dependent pathway

(2011) Semantee Bhattacharya et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis

(2011) Joydeep Das et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Protective effect of the fruits of Terminalia arjuna against cadmium-induced oxidant stress and hepatic cell injury via MAPK activation and mitochondria dependent pathway

(2010) Jyotirmoy Ghosh et al.   FOOD CHEMISTRY

Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IκBα/NF-κB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid

(2010) Prasenjit Manna et al.   FREE RADICAL BIOLOGY AND MEDICINE

Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms

(2010) José M. Matés et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatotoxicity of di-(2-ethylhexyl)phthalate is attributed to calcium aggravation, ROS-mediated mitochondrial depolarization, and ERK/NF-κB pathway activation

(2010) Jyotirmoy Ghosh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acetaminophen induced acute liver failure via oxidative stress and JNK activation: Protective role of taurine by the suppression of cytochrome P450 2E1

(2010) Joydeep Das et al.   FREE RADICAL RESEARCH

“Where, O Death, Is Thy Sting?” A Brief Review of Apoptosis Biology

(2010) Andrew H. Wyllie   MOLECULAR NEUROBIOLOGY

Protective Role of Taurine against Arsenic-Induced Mitochondria-Dependent Hepatic Apoptosis via the Inhibition of PKCδ-JNK Pathway

(2010) Joydeep Das et al.   PLoS One

Cell Death Mechanisms and Their Implications in Toxicology

(2010) Sten Orrenius et al.   TOXICOLOGICAL SCIENCES

Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation

(2010) Joydeep Das et al.   TOXICOLOGY

Streptozotocin induced activation of oxidative stress responsive splenic cell signaling pathways: Protective role of arjunolic acid

(2010) Prasenjit Manna et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Prevention of tertiary butyl hydroperoxide induced oxidative impairment and cell death by a novel antioxidant protein molecule isolated from the herb, Phyllanthus niruri

(2010) Mrinal K. Sarkar et al.   TOXICOLOGY IN VITRO

Targeted Activation of Innate Immunity for Therapeutic Induction of Autophagy and Apoptosis in Melanoma Cells

(2009) Damià Tormo et al.   CANCER CELL

Phosphorylation-Dependent Lys63-Linked Polyubiquitination of Daxx Is Essential for Sustained TNF- -Induced ASK1 Activation

(2009) Y. Fukuyo et al.   CANCER RESEARCH

The roles of ASK family proteins in stress responses and diseases

(2009) Kazuki Hattori et al.   Cell Communication and Signaling

Prophylactic role of arjunolic acid in response to streptozotocin mediated diabetic renal injury: Activation of polyol pathway and oxidative stress responsive signaling cascades

(2009) Prasenjit Manna et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Arsenic-induced oxidative cerebral disorders: Protection by taurine

(2009) Joydeep Das et al.   DRUG AND CHEMICAL TOXICOLOGY

Contribution of glutathione status to oxidant-induced mitochondrial DNA damage in colonic epithelial cells

(2009) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP)-induced liver and hepatocyte injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection

(2009) Jyotirmoy Ghosh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prophylactic role of taurine on arsenic mediated oxidative renal dysfunction via MAPKs/ NF-κB and mitochondria dependent pathways

(2009) Anandita Roy et al.   FREE RADICAL RESEARCH

Induction of necrosis in cadmium-induced hepatic oxidative stress and its prevention by the prophylactic properties of taurine

(2009) Mahua Sinha et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Serine 58 of 14-3-3  Is a Molecular Switch Regulating ASK1 and Oxidant Stress-Induced Cell Death

(2009) J. Zhou et al.   MOLECULAR AND CELLULAR BIOLOGY

Ubiquitin-like Sequence in ASK1 Plays Critical Roles in the Recognition and Stabilization by USP9X and Oxidative Stress-Induced Cell Death

(2009) Hiroaki Nagai et al.   MOLECULAR CELL

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acetaminophen induced renal injury via oxidative stress and TNF-α production: Therapeutic potential of arjunolic acid

(2009) Jyotirmoy Ghosh et al.   TOXICOLOGY

Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes

(2009) Lyudmila I. Rachek et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Taurine prevents arsenic-induced cardiac oxidative stress and apoptotic damage: Role of NF-κB, p38 and JNK MAPK pathway

(2009) Jyotirmoy Ghosh et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Taurine protects rat testes against NaAsO2-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways

(2009) Joydeep Das et al.   TOXICOLOGY LETTERS

Taurine plays a beneficial role against cadmium-induced oxidative renal dysfunction

(2008) Prasenjit Manna et al.   AMINO ACIDS

Arsenic-induced oxidative myocardial injury: protective role of arjunolic acid

(2008) Prasenjit Manna et al.   ARCHIVES OF TOXICOLOGY

Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling

(2008) Atsushi Matsuzawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A Protein from Cajanus indicus Spreng Protects Liver and Kidney against Mercuric Chloride-Induced Oxidative Stress

(2008) Ayantika Ghosh et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Amelioration of cadmium-induced cardiac impairment by taurine

(2008) Prasenjit Manna et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Protection of acetaminophen induced mitochondrial dysfunctions and hepatic necrosis via Akt-NF-κB pathway: Role of a novel plant protein

(2008) Ayantika Ghosh et al.   CHEMICO-BIOLOGICAL INTERACTIONS

AIP1 Recruits Phosphatase PP2A to ASK1 in Tumor Necrosis Factor–Induced ASK1-JNK Activation

(2008) Wang Min et al.   CIRCULATION RESEARCH

Distinct signaling pathways of microtubule inhibitors - vinblastine and Taxol induce JNK-dependent cell death but through AP-1-dependent and AP-1-independent mechanisms, respectively

(2008) Sergey N. Kolomeichuk et al.   FEBS Journal

Protective effect of arjunolic acid against arsenic-induced oxidative stress in mouse brain

(2008) Mahua Sinha et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Terminalia arjuna Protects Mouse Hearts Against Sodium Fluoride-Induced Oxidative Stress

(2008) Mahua Sinha et al.   JOURNAL OF MEDICINAL FOOD

Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity

(2008) Maria Cecilia Barone et al.   JOURNAL OF NEUROCHEMISTRY

Patupilone-Induced Apoptosis Is Mediated by Mitochondrial Reactive Oxygen Species through Bim Relocalization to Mitochondria

(2008) N. R. Khawaja et al.   MOLECULAR PHARMACOLOGY

Functional interaction between FOXO3a and ATM regulates DNA damage response

(2008) Wen-Bin Tsai et al.   NATURE CELL BIOLOGY

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE

Protection of arsenic-induced testicular oxidative stress by arjunolic acid

(2008) Prasenjit Manna et al.   REDOX REPORT

Cadmium induced testicular pathophysiology: Prophylactic role of taurine

(2008) Prasenjit Manna et al.   REPRODUCTIVE TOXICOLOGY

Protective role of arjunolic acid in response to streptozotocin-induced type-I diabetes via the mitochondrial dependent and independent pathways

(2008) Prasenjit Manna et al.   TOXICOLOGY

Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis

(2007) Craig Ricci et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Forkhead transcription factor FOXO subfamily is essential for reactive oxygen species-induced apoptosis

(2007) Tomohiro Nakamura et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY