Dexmedetomidine ameliorates lipopolysaccharide‐induced acute kidney injury in rats by inhibiting inflammation and oxidative stress via the GSK‐3β/Nrf2 signaling pathway

Role of Nrf2 and Its Activators in Respiratory Diseases

(2019) Qinmei Liu et al.   Oxidative Medicine and Cellular Longevity

Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein–induced Inflammation through a Vagomimetic Action in Mice

(2018) Jun Hu et al.   ANESTHESIOLOGY

RA-XII exerts anti-oxidant and anti-inflammatory activities on lipopolysaccharide-induced acute renal injury by suppressing NF-κB and MAPKs regulated by HO-1/Nrf2 pathway

(2018) Xusheng An et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dexmedetomidine protects against lipopolysaccharide-induced sepsis-associated acute kidney injury via an α7 nAChR-dependent pathway

(2018) Kai Kang et al.   BIOMEDICINE & PHARMACOTHERAPY

Dexmedetomidine restores septic renal function via promoting inflammation resolution in a rat sepsis model

(2018) Rongzong Qiu et al.   LIFE SCIENCES

Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 2: Control of oxidative stress induced damage, increase of antioxidant enzyme activities and attenuation of inflammation

(2018) Massimiliano Gasparrini et al.   FOOD AND CHEMICAL TOXICOLOGY

Activation of Nrf2/HO-1 Pathway by Nardochinoid C Inhibits Inflammation and Oxidative Stress in Lipopolysaccharide-Stimulated Macrophages

(2018) Jin-Fang Luo et al.   Frontiers in Pharmacology

Berberine ameliorates lipopolysaccharide-induced acute lung injury via the PERK-mediated Nrf2/HO-1 signaling axis

(2018) Yuan Liang et al.   PHYTOTHERAPY RESEARCH

Arbutin attenuates LPS-induced lung injury via Sirt1/ Nrf2/ NF-κBp65 pathway

(2018) Jinyan Ye et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Acute kidney injury in sepsis

(2017) Rinaldo Bellomo et al.   INTENSIVE CARE MEDICINE

Oxidative Stress and Acute Kidney Injury in Critical Illness: Pathophysiologic Mechanisms—Biomarkers—Interventions, and Future Perspectives

(2017) Paraskevi Pavlakou et al.   Oxidative Medicine and Cellular Longevity

The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus

(2017) Joshua A. David et al.   Journal of Diabetes Research

Total Coumarins from Hydrangea paniculata Show Renal Protective Effects in Lipopolysaccharide-Induced Acute Kidney Injury via Anti-inflammatory and Antioxidant Activities

(2017) Sen Zhang et al.   Frontiers in Pharmacology

Dexmedetomidine decreases the inflammatory response to myocardial surgery under mini-cardiopulmonary bypass

(2016) N.M.H. Bulow et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Dexmedetomidine attenuates inflammatory reaction in the lung tissues of septic mice by activating cholinergic anti-inflammatory pathway

(2016) Zhaoguo Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Recent knowledge on the pathophysiology of septic acute kidney injury: A narrative review

(2016) Hoi-Ping Shum et al.   JOURNAL OF CRITICAL CARE

Cellular and Molecular Mechanisms of AKI

(2016) A. Agarwal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Perioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery

(2016) Jin Sun Cho et al.   KIDNEY INTERNATIONAL

Dexmedetomidine attenuates repeated propofol exposure-induced hippocampal apoptosis, PI3K/Akt/Gsk-3β signaling disruption, and juvenile cognitive deficits in neonatal rats

(2016) YUJIE WANG et al.   Molecular Medicine Reports

Dexmedetomidine may upregulate the expression of caveolin-1 in lung tissues of rats with sepsis and improve the short-term outcome

(2016) Yun Zhang et al.   Molecular Medicine Reports

Effects of dexmedetomidine postconditioning on myocardial ischemia and the role of the PI3K/Akt-dependent signaling pathway in reperfusion injury

(2016) XIANG YANG CHENG et al.   Molecular Medicine Reports

Dexmedetomidine Pretreatment Attenuates Kidney Injury and Oxidative Stress during Orthotopic Autologous Liver Transplantation in Rats

(2016) Xiaofang Yu et al.   Oxidative Medicine and Cellular Longevity

Dexmedetomidine Protects against Transient Global Cerebral Ischemia/Reperfusion Induced Oxidative Stress and Inflammation in Diabetic Rats

(2016) Xianzhang Zeng et al.   PLoS One

Dexmedetomidine Acts via the JAK2/STAT3 Pathway to Attenuate Isoflurane-Induced Neurocognitive Deficits in Senile Mice

(2016) Yanna Si et al.   PLoS One

Dexmedetomidine Attenuates Bilirubin-Induced Lung Alveolar Epithelial Cell Death In Vitro and In Vivo*

(2015) Jian Cui et al.   CRITICAL CARE MEDICINE

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin D3 pretreatment alleviates renal oxidative stress in lipopolysaccharide-induced acute kidney injury

(2015) Shen Xu et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Dexmedetomidine ameliorates acute lung injury following orthotopic autologous liver transplantation in rats probably by inhibiting Toll-like receptor 4–nuclear factor kappa B signaling

(2015) Xinjin Chi et al.   Journal of Translational Medicine

Sepsis-Associated Acute Kidney Injury

(2015) Rashid Alobaidi et al.   SEMINARS IN NEPHROLOGY

ET-1 increases reactive oxygen species following hypoxia and high-salt diet in the mouse glomerulus

(2014) J. B. Heimlich et al.   Acta Physiologica

Modulation of imidazoline I2binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats

(2014) Marco Lanza et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of Honokiol on Sepsis-Induced Acute Kidney Injury in an Experimental Model of Sepsis in Rats

(2014) Nan Li et al.   INFLAMMATION

Perineural Dexmedetomidine Attenuates Inflammation in Rat Sciatic Nerve via the NF-κB Pathway

(2014) Yan Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes

(2014) Lakhmir S. Chawla et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury: a critical evaluation of current status

(2014) A. Haase-Fielitz et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Reducing damage through Nrf-2

(2013) Jean-Luc Balligand   CARDIOVASCULAR RESEARCH

Magnolol inhibits angiogenesis by regulating ROS-mediated apoptosis and the PI3K/AKT/mTOR signaling pathway in mES/EB-derived endothelial-like cells

(2013) GI DAE KIM et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

(2013) Stacey Ruiz et al.   KIDNEY INTERNATIONAL

TNF-mediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis

(2013) Chang Xu et al.   KIDNEY INTERNATIONAL

Dexmedetomidine Reduced Cytokine Release during Postpartum Bleeding-Induced Multiple Organ Dysfunction Syndrome in Rats

(2013) Liu Xianbao et al.   MEDIATORS OF INFLAMMATION

Biomarkers for incident CKD: a new framework for interpreting the literature

(2013) Michael G. Shlipak et al.   Nature Reviews Nephrology

The Many Facets of Sepsis Pathophysiology and Treatment

(2013) Luciano Cesar Pontes Azevedo   SHOCK

The effects of dexmedetomidine on liver ischemia–reperfusion injury in rats

(2012) Taylan Şahin et al.   JOURNAL OF SURGICAL RESEARCH

Inhibition of glycogen synthase kinase-3β prevents NSAID-induced acute kidney injury

(2012) Hao Bao et al.   KIDNEY INTERNATIONAL

Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice

(2012) Christiana Howard et al.   KIDNEY INTERNATIONAL

Dexmedetomidine protects against oxygen-glucose deprivation-induced injury through the I2 imidazoline receptor-PI3K/AKT pathway in rat C6 glioma cells

(2011) Fengjiang Zhang et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Sepsis and Acute Kidney Injury

(2011) A. Zarjou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury

(2011) Joseph H. Holthoff et al.   KIDNEY INTERNATIONAL

Protein Phosphatase 2A and Glycogen Synthase Kinase 3 Signaling Modulate Prepulse Inhibition of the Acoustic Startle Response by Altering Cortical M-Type Potassium Channel Activity

(2010) D. Kapfhamer et al.   JOURNAL OF NEUROSCIENCE

GSK3  Plays Dirty in Acute Kidney Injury

(2010) P. J. Nelson et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

GSK3  Promotes Apoptosis after Renal Ischemic Injury

(2010) Z. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

GSK3  Mediates Renal Response to Vasopressin by Modulating Adenylate Cyclase Activity

(2010) R. Rao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Conditional ablation of glycogen synthase kinase 3β in postnatal mouse kidney

(2010) Yan Ge et al.   LABORATORY INVESTIGATION

Mitochondria, reactive oxygen species and cadmium toxicity in the kidney

(2010) Glenda Gobe et al.   TOXICOLOGY LETTERS

Dexmedetomidine Increases Hippocampal Phosphorylated Extracellular Signal–regulated Protein Kinase 1 and 2 Content by an α2-Adrenoceptor–independent Mechanism

(2009) Souhayl Dahmani et al.   ANESTHESIOLOGY

Inhibiting glycogen synthase kinase-3 reduces endotoxaemic acute renal failure by down-regulating inflammation and renal cell apoptosis

(2009) Y Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models

(2009) Craig Brooks et al.   JOURNAL OF CLINICAL INVESTIGATION

Animal models of sepsis and sepsis-induced kidney injury

(2009) Kent Doi et al.   JOURNAL OF CLINICAL INVESTIGATION