Impact of endolysosomal dysfunction upon exosomes in neurodegenerative diseases

Dysfunctional Autophagy and Endolysosomal System in Neurodegenerative Diseases: Relevance and Therapeutic Options

(2021) Silvia Giovedì et al.   Frontiers in Cellular Neuroscience

GBA Mutations Influence the Release and Pathological Effects of Small Extracellular Vesicles from Fibroblasts of Patients with Parkinson’s Disease

(2021) Silvia Cerri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles

(2021) Kathryn A. Jewett et al.   PLoS Genetics

Endosomal‐lysosomal dysfunctions in Alzheimer’s disease: Pathogenesis and therapeutic interventions

(2021) Shereen Shi Min Lai et al.   METABOLIC BRAIN DISEASE

α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology

(2021) Morgan G. Stykel et al.   Cell Reports

Opposing functions for retromer and Rab11 in extracellular vesicle traffic at presynaptic terminals

(2021) Rylie B. Walsh et al.   JOURNAL OF CELL BIOLOGY

Small Neuron-Derived Extracellular Vesicles from Individuals with Down Syndrome Propagate Tau Pathology in the Wildtype Mouse Brain

(2021) Aurélie Ledreux et al.   Journal of Clinical Medicine

Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease

(2020) Min Guo et al.   BRAIN

Brain Derived Exosomes Are a Double-Edged Sword in Alzheimer’s Disease

(2020) Zhiqi Song et al.   Frontiers in Molecular Neuroscience

Extracellular vesicles: where the amyloid precursor protein carboxyl-terminal fragments accumulate and amyloid-β oligomerizes

(2020) Rocío Pérez-González et al.   FASEB JOURNAL

Rab family of small GTPases: an updated view on their regulation and functions

(2020) Yuta Homma et al.   FEBS Journal

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease

(2020) Ruinan Shen et al.   Translational Neurodegeneration

In vivo evidence of exosome-mediated Aβ neurotoxicity

(2020) Ahmed Elsherbini et al.   Acta Neuropathologica Communications

Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation

(2020) Taiji Tsunemi et al.   JOURNAL OF NEUROSCIENCE

LRRK2 and the Endolysosomal System in Parkinson’s Disease

(2020) Madalynn L. Erb et al.   Journal of Parkinsons Disease

Microglia as modulators of exosomal alpha-synuclein transmission

(2019) Yun Xia et al.   Cell Death & Disease

Exosomes from patients with Parkinson’s disease are pathological in mice

(2019) Chao Han et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Role of the endolysosomal system in Parkinson’s disease

(2019) D. J. Vidyadhara et al.   JOURNAL OF NEUROCHEMISTRY

Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors

(2019) Zoë P. Van Acker et al.   Molecular Neurodegeneration

BIN1 favors the spreading of Tau via extracellular vesicles

(2019) Andrea Crotti et al.   Scientific Reports

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Extracellular Vesicles Isolated from Familial Alzheimer’s Disease Neuronal Cultures Induce Aberrant Tau Phosphorylation in the Wild-Type Mouse Brain

(2019) Brent Aulston et al.   JOURNAL OF ALZHEIMERS DISEASE

Exosome/microvesicle content is altered in leucine‐rich repeat kinase 2 mutant induced pluripotent stem cell‐derived neural cells

(2019) Kate M. Candelario et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Endosomal dysfunction impacts extracellular vesicle release: Central role in Aβ pathology

(2019) B.D. Arbo et al.   AGEING RESEARCH REVIEWS

LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease

(2019) Emily M. Rocha et al.   NEUROBIOLOGY OF DISEASE

Aβ42 Protofibrils Interact with and Are Trafficked through Microglial-Derived Microvesicles

(2018) Lisa K. Gouwens et al.   ACS Chemical Neuroscience

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

Impact of late-onset Alzheimer’s genetic risk factors on beta-amyloid endocytic production

(2018) Cláudia Guimas Almeida et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Diagnostic exome sequencing in early-onset Parkinson's disease confirms VPS13C as a rare cause of autosomal-recessive Parkinson's disease

(2018) B. Schormair et al.   CLINICAL GENETICS

The Role of LRRK2 in Neurodegeneration of Parkinson Disease

(2018) Qin Rui et al.   Current Neuropharmacology

Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases

(2018) Chao Wang et al.   CURRENT OPINION IN NEUROBIOLOGY

Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer’s disease

(2018) Edward J. Goetzl et al.   FASEB JOURNAL

An optimized method for enrichment of whole brain-derived extracellular vesicles reveals insight into neurodegenerative processes in a mouse model of Alzheimer’s disease

(2018) Stephanie N. Hurwitz et al.   JOURNAL OF NEUROSCIENCE METHODS

Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures

(2018) André M. Miranda et al.   Nature Communications

The interplay between exosomes and autophagy – partners in crime

(2018) Jing Xu et al.   JOURNAL OF CELL SCIENCE

Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles

(2018) Ruth E. Thomas et al.   PLoS Genetics

Apolipoprotein E4 genotype compromises brain exosome production

(2018) Katherine Y Peng et al.   BRAIN

Neuronal Exosome-Derived Human Tau is Toxic to Recipient Mouse Neurons in vivo

(2018) Charisse N. Winston et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased Release of Apolipoprotein E in Extracellular Vesicles Following Amyloid-β Protofibril Exposure of Neuroglial Co-Cultures

(2017) Elisabeth Nikitidou et al.   JOURNAL OF ALZHEIMERS DISEASE

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

(2017) Diana Chang et al.   NATURE GENETICS

Non-motor features of Parkinson disease

(2017) Anthony H.V. Schapira et al.   NATURE REVIEWS NEUROSCIENCE

Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation

(2017) Patrick Reilly et al.   NEUROBIOLOGY OF DISEASE

VPS35, the Retromer Complex and Parkinson’s Disease

(2017) Erin T. Williams et al.   Journal of Parkinsons Disease

The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

(2017) Tal Nuriel et al.   Frontiers in Neuroscience

The role of exosomes in the pathogenesis of Alzheimer’ disease

(2017) Tingting Xiao et al.   Translational Neurodegeneration

Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities

(2017) Sébastien A. Gauthier et al.   Acta Neuropathologica Communications

Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology

(2017) Jennifer Ngolab et al.   Acta Neuropathologica Communications

Impact of lysosome status on extracellular vesicle content and release

(2016) Erez Eitan et al.   AGEING RESEARCH REVIEWS

D NAJC 6 Mutations Associated With Early-Onset Parkinson's Disease

(2016) Simone Olgiati et al.   ANNALS OF NEUROLOGY

Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress

(2016) Soshi Kanemoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice

(2016) Siân Baker et al.   JOURNAL OF ALZHEIMERS DISEASE

Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

(2016) Juan Carlos Polanco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes in the Pathology of Neurodegenerative Diseases

(2016) Jason Howitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cortactin promotes exosome secretion by controlling branched actin dynamics

(2016) Seema Sinha et al.   JOURNAL OF CELL BIOLOGY

Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway

(2016) Pingping Song et al.   JOURNAL OF NEUROSCIENCE

Endolysosomal dysfunction in Parkinson's disease: Recent developments and future challenges

(2016) Lauren R. Kett et al.   MOVEMENT DISORDERS

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

(2016) Carolina Villarroya-Beltri et al.   Nature Communications

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies

(2015) Anne Stuendl et al.   BRAIN

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson’s disease

(2014) Karen E. Murphy et al.   BRAIN

Prion-like Mechanisms in Alzheimer's Disease

(2014) Rui-Hua Yin et al.   Current Alzheimer Research

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

(2014) Stephanie M.Y. Kong et al.   HUMAN MOLECULAR GENETICS

ATP13A2/PARK9 Regulates Secretion of Exosomes and  -Synuclein

(2014) T. Tsunemi et al.   JOURNAL OF NEUROSCIENCE

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Endosome maturation, transport and functions

(2014) Cameron C. Scott et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein

(2014) Eun-Jin Bae et al.   Nature Communications

Synaptojanin 1 Mutation in Parkinson’s Disease Brings Further Insight into the Neuropathological Mechanisms

(2014) Valérie Drouet et al.   Biomed Research International

DNAJC13 mutations in Parkinson disease

(2013) Carles Vilariño-Güell et al.   HUMAN MOLECULAR GENETICS

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains

(2012) Matthew E. Gegg et al.   ANNALS OF NEUROLOGY

Endocytosis and autophagy: Shared machinery for degradation

(2012) Christopher A. Lamb et al.   BIOESSAYS

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space

(2012) Rocio Perez-Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The link between the GBA gene and parkinsonism

(2012) Ellen Sidransky et al.   LANCET NEUROLOGY

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retromer disruption promotes amyloidogenic APP processing

(2011) Christopher P. Sullivan et al.   NEUROBIOLOGY OF DISEASE

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

(2011) Lydia Alvarez-Erviti et al.   NEUROBIOLOGY OF DISEASE

The recycling endosome and its role in neurological disorders

(2011) Xueyi Li et al.   PROGRESS IN NEUROBIOLOGY

Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains

(2010) Lydia Alvarez-Erviti et al.   ARCHIVES OF NEUROLOGY

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

The role of parkin in familial and sporadic Parkinson's disease

(2010) Ted M. Dawson et al.   MOVEMENT DISORDERS

Phospholipase D in endocytosis and endosomal recycling pathways

(2009) Julie G. Donaldson   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

(2009) Javier Alegre-Abarrategui et al.   HUMAN MOLECULAR GENETICS

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions

(2009) Yaping Chu et al.   NEUROBIOLOGY OF DISEASE

Senescence-Associated Exosome Release from Human Prostate Cancer Cells

(2008) B. D. Lehmann et al.   CANCER RESEARCH

Accelerated release of exosome-associated GM1 ganglioside (GM1) by endocytic pathway abnormality: another putative pathway for GM1-induced amyloid fibril formation

(2008) Kohei Yuyama et al.   JOURNAL OF NEUROCHEMISTRY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE