Rab family of small GTPases: an updated view on their regulation and functions

APEX2‐mediated RAB proximity labeling identifies a role for RAB21 in clathrin‐independent cargo sorting

(2019) Tomas Del Olmo et al.   EMBO REPORTS

USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7

(2019) Aysegul Sapmaz et al.   Nature Communications

Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a

(2019) Paolo Sanzà et al.   JOURNAL OF CELL SCIENCE

CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic

(2019) Yuxiao Wang et al.   JOURNAL OF CELL BIOLOGY

Homotypic and heterotypic trans-assembly of human Rab-family small GTPases in reconstituted membrane tethering

(2019) Kazuya Segawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoplasmic control of Rab family small GTPases through BAG6

(2019) Toshiki Takahashi et al.   EMBO REPORTS

Comprehensive knockout analysis of the Rab family GTPases in epithelial cells

(2019) Yuta Homma et al.   JOURNAL OF CELL BIOLOGY

LRRK1 phosphorylation of Rab7 at Ser-72 links trafficking of EGFR-containing endosomes to its effector RILP

(2019) Hiroshi Hanafusa et al.   JOURNAL OF CELL SCIENCE

Loss of Rab25 promotes the development of skin squamous cell carcinoma through the dysregulation of integrin trafficking

(2019) Haengdueng Jeong et al.   JOURNAL OF PATHOLOGY

A germline mutation in Rab43 gene identified from a cancer family predisposes to a hereditary liver-colon cancer syndrome

(2019) Yanting Jiang et al.   BMC CANCER

Specific TBC Domain-Containing Proteins Control the ER-Golgi-Plasma Membrane Trafficking of GPCRs

(2019) Zhe Wei et al.   Cell Reports

In vivo identification of GTPase interactors by mitochondrial relocalization and proximity biotinylation

(2019) Alison K Gillingham et al.   eLife

Transport carrier tethering – how vesicles are captured by organelles

(2019) Alison K Gillingham et al.   CURRENT OPINION IN CELL BIOLOGY

Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen

(2019) Edwin E. Jeng et al.   Cell Host & Microbe

Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex

(2019) Andreas Gerondopoulos et al.   CURRENT BIOLOGY

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

(2019) Kerryn Berndsen et al.   eLife

RAB26-dependent autophagy protects adherens junctional integrity in acute lung injury

(2018) Weijie Dong et al.   Autophagy

Rab GTPases and Membrane Trafficking in Neurodegeneration

(2018) Ferdi Ridvan Kiral et al.   CURRENT BIOLOGY

CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog

(2018) Ganesh V. Pusapati et al.   DEVELOPMENTAL CELL

Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions

(2018) Dijin Xu et al.   JOURNAL OF CELL BIOLOGY

The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution

(2018) Tomoaki Sobajima et al.   JOURNAL OF CELL BIOLOGY

Rab7 knockout unveils regulated autolysosome maturation induced by glutamine starvation

(2018) Yoshihiko Kuchitsu et al.   JOURNAL OF CELL SCIENCE

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

(2018) Jesús Madero-Pérez et al.   Molecular Neurodegeneration

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

(2018) Yvette C. Wong et al.   NATURE

Rab34 regulates adhesion, migration, and invasion of breast cancer cells

(2018) Lixiang Sun et al.   ONCOGENE

Rab38 Mutation and the Lung Phenotype

(2018) Kazuhiro Osanai   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The small GTPase Rab28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium

(2018) Guoxin Ying et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis

(2018) Tomoya Eguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation

(2018) Eun-Jin Bae et al.   Nature Communications

A Steric Gating Mechanism Dictates the Substrate Specificity of a Rab-GEF

(2018) Laura L. Thomas et al.   DEVELOPMENTAL CELL

Rab34 small GTPase is required for Hedgehog signaling and an early step of ciliary vesicle formation in mouse

(2018) Shouying Xu et al.   JOURNAL OF CELL SCIENCE

Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells

(2018) Scott A. Hinger et al.   Cell Reports

Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance

(2018) Jérôme Gilleron et al.   Cell Reports

A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

(2018) Herschel S Dhekne et al.   eLife

RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

(2018) J.-M. Heo et al.   Science Advances

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

(2017) Zhiyong Liu et al.   HUMAN MOLECULAR GENETICS

Ciliary protein trafficking mediated by IFT and BBSome complexes with the aid of kinesin-2 and dynein-2 motors

(2017) Kazuhisa Nakayama et al.   JOURNAL OF BIOCHEMISTRY

Rab7 palmitoylation is required for efficient endosome-to-TGN trafficking

(2017) Graziana Modica et al.   JOURNAL OF CELL SCIENCE

Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy

(2017) Qiang Feng et al.   JOURNAL OF CELL SCIENCE

Rab GTPases: master regulators that establish the secretory and endocytic pathways

(2017) Suzanne R. Pfeffer   MOLECULAR BIOLOGY OF THE CELL

TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi

(2017) John J. H. Shin et al.   NATURE CELL BIOLOGY

RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis

(2017) Daniel R. Gulbranson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action

(2017) Javier R. Jaldin-Fincati et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

(2017) Laura A. Laviolette et al.   Nature Communications

Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease

(2017) Patrick Lüningschrör et al.   Nature Communications

Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37

(2017) Hong-Tai Tzeng et al.   Oncotarget

Site-specific monoubiquitination downregulates Rab5 by disrupting effector binding and guanine nucleotide conversion

(2017) Donghyuk Shin et al.   eLife

Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy

(2017) Naonobu Fujita et al.   eLife

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

(2017) Martin Steger et al.   eLife

TBC1D12 is a novel Rab11-binding protein that modulates neurite outgrowth of PC12 cells

(2017) Mai E. Oguchi et al.   PLoS One

Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination

(2016) Sagar Bhogaraju et al.   CELL

A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP

(2016) Stefania Spanò et al.   Cell Host & Microbe

Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases

(2016) Morié Ishida et al.   CELL STRUCTURE AND FUNCTION

Regulation of Cancer Cell Behavior by the Small GTPase Rab13

(2016) Maria S. Ioannou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes

(2016) Joanne Bruno et al.   JOURNAL OF CELL BIOLOGY

EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells

(2016) Atsuhiro Nakajo et al.   JOURNAL OF CELL BIOLOGY

RAB43 facilitates cross-presentation of cell-associated antigens by CD8α + dendritic cells

(2016) Nicole M. Kretzer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway

(2016) Pingping Song et al.   JOURNAL OF NEUROSCIENCE

High-throughput discovery of novel developmental phenotypes

(2016) Mary E. Dickinson et al.   NATURE

Ubiquitination independent of E1 and E2 enzymes by bacterial effectors

(2016) Jiazhang Qiu et al.   NATURE

An endosomal tether undergoes an entropic collapse to bring vesicles together

(2016) David H. Murray et al.   NATURE

Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking

(2016) Chiara Francavilla et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen

(2016) Rebecca S. Levin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A large Rab GTPase encoded byCRACR2Ais a component of subsynaptic vesicles that transmit T cell activation signals

(2016) Sonal Srikanth et al.   Science Signaling

PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7

(2016) Swapnil Rohidas Shinde et al.   Nature Communications

Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening

(2016) Kerstin Klinkert et al.   Nature Communications

Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking

(2016) Chiara Francavilla et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

(2016) Martin Steger et al.   eLife

A large Rab GTPase encoded byCRACR2Ais a component of subsynaptic vesicles that transmit T cell activation signals

(2016) Sonal Srikanth et al.   Science Signaling

LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts

(2016) Tomoki Kuwahara et al.   Scientific Reports

Phenotypic characterisation ofRAB6Aknockout mouse embryonic fibroblasts

(2015) Sabine Bardin et al.   BIOLOGY OF THE CELL

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

(2015) Y.-C. Lai et al.   EMBO JOURNAL

RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes

(2015) Soujiro Marubashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Persistent cell migration and adhesion rely on retrograde transport of β1 integrin

(2015) Massiullah Shafaq-Zadah et al.   NATURE CELL BIOLOGY

Identification of an oncogenic RAB protein

(2015) D. B. Wheeler et al.   SCIENCE

Targeted disruption of Rab10 causes early embryonic lethality

(2015) Pingping Lv et al.   Protein & Cell

Mutations in RAB39B Cause X-Linked Intellectual Disability and Early-Onset Parkinson Disease with α-Synuclein Pathology

(2014) Gabrielle R. Wilson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Bacterial Pathogen Manipulation of Host Membrane Trafficking

(2014) Seblewongel Asrat et al.   Annual Review of Cell and Developmental Biology

Rab23 regulates Nodal signaling in vertebrate left–right patterning independently of the Hedgehog pathway

(2014) Kimberly Fuller et al.   DEVELOPMENTAL BIOLOGY

Toward a Comprehensive Map of the Effectors of Rab GTPases

(2014) Alison K. Gillingham et al.   DEVELOPMENTAL CELL

A novel mouse model of Warburg Micro syndrome reveals roles for RAB18 in eye development and organisation of the neuronal cytoskeleton

(2014) S. M. Carpanini et al.   Disease Models & Mechanisms

TLR sorting by Rab11 endosomes maintains intestinal epithelial‐microbial homeostasis

(2014) Shiyan Yu et al.   EMBO JOURNAL

Global Ablation of the Mouse Rab11a Gene Impairs Early Embryogenesis and Matrix Metalloproteinase Secretion

(2014) Shiyan Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Rab5a Protein by Protein Kinase Cϵ Is Crucial for T-cell Migration

(2014) Seow Theng Ong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab18 and a Rab18 GEF complex are required for normal ER structure

(2014) Andreas Gerondopoulos et al.   JOURNAL OF CELL BIOLOGY

TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells

(2014) Luciana I. Gallo et al.   MOLECULAR BIOLOGY OF THE CELL

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

(2014) A. Beilina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking

(2014) A. Nishikimi et al.   Science Signaling

Ubiquitin-Dependent Sorting in Endocytosis

(2014) R. C. Piper et al.   Cold Spring Harbor Perspectives in Biology

Canine Hereditary Ataxia in Old English Sheepdogs and Gordon Setters Is Associated with a Defect in the Autophagy Gene Encoding RAB24

(2014) Caryline Agler et al.   PLoS Genetics

Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

(2014) Koji Yamano et al.   eLife

Rab11a is required for apical protein localisation in the intestine

(2014) T. Sobajima et al.   Biology Open

Mutations in RAB28, Encoding a Farnesylated Small GTPase, Are Associated with Autosomal-Recessive Cone-Rod Dystrophy

(2013) Susanne Roosing et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Lysosome-related organelles: unusual compartments become mainstream

(2013) Michael S Marks et al.   CURRENT OPINION IN CELL BIOLOGY

Rab GTPase regulation of membrane identity

(2013) Suzanne R Pfeffer   CURRENT OPINION IN CELL BIOLOGY

RabGEFs are a major determinant for specific Rab membrane targeting

(2013) Julia Blümer et al.   JOURNAL OF CELL BIOLOGY

Ubiquitylation and activation of a Rab GTPase is promoted by a  2AR-HACE1 complex

(2013) V. Lachance et al.   JOURNAL OF CELL SCIENCE

Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis

(2013) T. Sato et al.   JOURNAL OF CELL SCIENCE

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

(2013) David A. MacLeod et al.   NEURON

Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

(2013) H.-W. Rhee et al.   SCIENCE

Rab27 Effectors, Pleiotropic Regulators in Secretory Pathways

(2013) Mitsunori Fukuda   TRAFFIC

Rab7 Is Functionally Required for Selective Cargo Sorting at the Early Endosome

(2013) Emmanuelle Girard et al.   TRAFFIC

Untangling the evolution of Rab G proteins: implications of a comprehensive genomic analysis

(2012) Tobias H Klöpper et al.   BMC BIOLOGY

BLOC-3 Mutated in Hermansky-Pudlak Syndrome Is a Rab32/38 Guanine Nucleotide Exchange Factor

(2012) Andreas Gerondopoulos et al.   CURRENT BIOLOGY

Reversible phosphocholination of Rab proteins byLegionella pneumophilaeffector proteins

(2012) Philip R Goody et al.   EMBO JOURNAL

A NovelRAB33BMutation in Smith-McCort Dysplasia

(2012) Nina Dupuis et al.   HUMAN MUTATION

TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes

(2012) Andrea Longatti et al.   JOURNAL OF CELL BIOLOGY

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology

(2012) Kenta Onoue et al.   JOURNAL OF CELL SCIENCE

Mutation inRAB33B, which encodes a regulator of retrograde Golgi transport, defines a second Dyggve–Melchior–Clausen locus

(2012) Muneera J Alshammari et al.   JOURNAL OF MEDICAL GENETICS

Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor

(2012) L. K. Oesterlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Rab32-Dependent Pathway Contributes to Salmonella Typhi Host Restriction

(2012) S. Spano et al.   SCIENCE

Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos

(2012) Nobuyuki Kawamura et al.   Nature Communications

Loss-of-Function Mutations in RAB18 Cause Warburg Micro Syndrome

(2011) Danai Bem et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rab11 is phosphorylated by classical and novel protein kinase C isoenzymes upon sustained phorbol ester activation

(2011) Martín Pavarotti et al.   BIOLOGY OF THE CELL

TBC proteins: GAPs for mammalian small GTPase Rab?

(2011) Mitsunori Fukuda   BIOSCIENCE REPORTS

DENN Domain Proteins: Regulators of Rab GTPases

(2011) Andrea L. Marat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RUTBC1 Protein, a Rab9A Effector That Activates GTP Hydrolysis by Rab32 and Rab33B Proteins

(2011) Ryan M. Nottingham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation

(2011) Takashi Itoh et al.   JOURNAL OF CELL BIOLOGY

Modulation of Rab GTPase function by a protein phosphocholine transferase

(2011) Shaeri Mukherjee et al.   NATURE

Intrinsic tethering activity of endosomal Rab proteins

(2011) Sheng-Ying Lo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of Rab GTPases in Membrane Traffic and Cell Physiology

(2011) Alex H. Hutagalung et al.   PHYSIOLOGICAL REVIEWS

Rab GTPases Regulating Phagosome Maturation Are Differentially Recruited to Mycobacterial Phagosomes

(2011) Shintaro Seto et al.   TRAFFIC

Thousands of Rab GTPases for the Cell Biologist

(2011) Yoan Diekmann et al.   PLoS Computational Biology

Mutations in the Small GTPase Gene RAB39B Are Responsible for X-linked Mental Retardation Associated with Autism, Epilepsy, and Macrocephaly

(2010) Maila Giannandrea et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rab GEFs and GAPs

(2010) Francis Barr et al.   CURRENT OPINION IN CELL BIOLOGY

Broad-Minded Links Cell Cycle-Related Kinase to Cilia Assembly and Hedgehog Signal Transduction

(2010) Hyuk Wan Ko et al.   DEVELOPMENTAL CELL

Genetic variability at the PARK16 locus

(2010) Arianna Tucci et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas

(2010) Ki Taek Nam et al.   JOURNAL OF CLINICAL INVESTIGATION

A molecular network for de novo generation of the apical surface and lumen

(2010) David M. Bryant et al.   NATURE CELL BIOLOGY

The Legionella Effector Protein DrrA AMPylates the Membrane Traffic Regulator Rab1b

(2010) M. P. Muller et al.   SCIENCE

Comprehensive Screening for Novel Rab-Binding Proteins by GST Pull-Down Assay Using 60 Different Mammalian Rabs‡

(2010) Eiko Kanno et al.   TRAFFIC

Rab7 Regulates Late Endocytic Trafficking Downstream of Multivesicular Body Biogenesis and Cargo Sequestration

(2009) Phillip A. Vanlandingham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intracellular Serotonin Modulates Insulin Secretion from Pancreatic β-Cells by Protein Serotonylation

(2009) Nils Paulmann et al.   PLOS BIOLOGY

Membrane traffic in the secretory pathway

(2008) M. Fukuda   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein

(2008) Miyuki Sato et al.   EMBO JOURNAL

Large Scale Screening for Novel Rab Effectors Reveals Unexpected Broad Rab Binding Specificity

(2008) Mitsunori Fukuda et al.   MOLECULAR & CELLULAR PROTEOMICS

Genome-wide screen reveals APC-associated RNAs enriched in cell protrusions

(2008) Stavroula Mili et al.   NATURE