Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype

(2018) Georgia Minakaki et al.   Autophagy

Extracellular vesicles in neurodegenerative diseases

(2018) Tommaso Croese et al.   MOLECULAR ASPECTS OF MEDICINE

Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures

(2018) André M. Miranda et al.   Nature Communications

Alterations in the properties of the cell membrane due to glycosphingolipid accumulation in a model of Gaucher disease

(2018) Gyula Batta et al.   Scientific Reports

Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside

(2017) Haruhisa Kawasaki et al.   GENE

N370S-GBA1 mutation causes lysosomal cholesterol accumulation in Parkinson's disease

(2017) Patricia García-Sanz et al.   MOVEMENT DISORDERS

The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease

(2017) KerriJ Kinghorn et al.   Neural Regeneration Research

Coenzyme Q10 partially restores pathological alterations in a macrophage model of Gaucher disease

(2017) Mario de la Mata et al.   Orphanet Journal of Rare Diseases

Lipids in exosomes: Current knowledge and the way forward

(2017) Tore Skotland et al.   PROGRESS IN LIPID RESEARCH

Exosomes, an Unmasked Culprit in Neurodegenerative Diseases

(2017) Federico N. Soria et al.   Frontiers in Neuroscience

Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology

(2017) Jennifer Ngolab et al.   Acta Neuropathologica Communications

Impact of lysosome status on extracellular vesicle content and release

(2016) Erez Eitan et al.   AGEING RESEARCH REVIEWS

Total protein or high-abundance protein: Which offers the best loading control for Western blotting?

(2016) Jonathan S. Thacker et al.   ANALYTICAL BIOCHEMISTRY

Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's

(2016) Ganqiang Liu et al.   ANNALS OF NEUROLOGY

Selective endosomal microautophagy is starvation-inducible in Drosophila

(2016) Anindita Mukherjee et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake

(2016) Erik R. Abels et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

LC3/GABARAP family proteins: autophagy-(un)related functions

(2016) Marco B. E. Schaaf et al.   FASEB JOURNAL

Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease

(2016) Joana Magalhaes et al.   HUMAN MOLECULAR GENETICS

Stimulating the Release of Exosomes Increases the Intercellular Transfer of Prions

(2016) Belinda B. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ExoCarta: A Web-Based Compendium of Exosomal Cargo

(2016) Shivakumar Keerthikumar et al.   JOURNAL OF MOLECULAR BIOLOGY

Activation of  -Glucocerebrosidase Reduces Pathological  -Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons

(2016) J. R. Mazzulli et al.   JOURNAL OF NEUROSCIENCE

A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin

(2016) Kerri J. Kinghorn et al.   JOURNAL OF NEUROSCIENCE

Mechanisms ofIn VivoRibosome Maintenance Change in Response to Nutrient Signals

(2016) Andrew D. Mathis et al.   MOLECULAR & CELLULAR PROTEOMICS

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration

(2016) Dominic M. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Variants in GBA , SNCA , and MAPT influence Parkinson disease risk, age at onset, and progression

(2016) Albert A. Davis et al.   NEUROBIOLOGY OF AGING

Mitochondrial dysfunction associated with glucocerebrosidase deficiency

(2016) Matthew E. Gegg et al.   NEUROBIOLOGY OF DISEASE

α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models

(2016) Joseph R. Mazzulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's Diseases

(2016) Heiko Braak et al.   Cold Spring Harbor Perspectives in Biology

Mechanisms and functions of extracellular vesicle release in vivo—What we can learn from flies and worms

(2016) Katharina B. Beer et al.   Cell Adhesion & Migration

Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration

(2016) Marie Y. Davis et al.   PLoS Genetics

Association ofGBAMutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease

(2016) Marie Y. Davis et al.   JAMA Neurology

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

(2016) Hugo J.R. Fernandes et al.   Stem Cell Reports

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

(2015) Marcel Kunadt et al.   ACTA NEUROPATHOLOGICA

Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages

(2015) Elma Aflaki et al.   AGING CELL

Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice

(2015) Emily M. Rocha et al.   ANTIOXIDANTS & REDOX SIGNALING

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies

(2015) Anne Stuendl et al.   BRAIN

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

Altered TFEB-mediated lysosomal biogenesis in Gaucher disease iPSC-derived neuronal cells

(2015) Ola Awad et al.   HUMAN MOLECULAR GENETICS

Glucocerebrosidase 1 deficientDanio reriomirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death

(2015) Marcus Keatinge et al.   HUMAN MOLECULAR GENETICS

Glucocerebrosidase and Parkinson disease: Recent advances

(2015) Anthony H.V. Schapira   MOLECULAR AND CELLULAR NEUROSCIENCE

Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy

(2015) Valerie Uytterhoeven et al.   NEURON

FlyBase: establishing a Gene Group resource forDrosophila melanogaster

(2015) Helen Attrill et al.   NUCLEIC ACIDS RESEARCH

Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level

(2015) Toshihide Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

(2015) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease

(2015) Mario de la Mata et al.   Scientific Reports

An ESCRT module is required for neuron pruning

(2015) Nicolas Loncle et al.   Scientific Reports

Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein

(2015) Norihito Uemura et al.   PLoS Genetics

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments

(2014) Meena Choi et al.   BIOINFORMATICS

GBA-associated Parkinson's disease: Reduced survival and more rapid progression in a prospective longitudinal study

(2014) Kathrin Brockmann et al.   MOVEMENT DISORDERS

Gene: a gene-centered information resource at NCBI

(2014) Garth R. Brown et al.   NUCLEIC ACIDS RESEARCH

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis

(2014) David C. Schöndorf et al.   Nature Communications

Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion

(2014) Ana-Citlali Gradilla et al.   Nature Communications

Glucocerebrosidase mutations influence the natural history of Parkinson’s disease in a community-based incident cohort

(2013) Sophie E. Winder-Rhodes et al.   BRAIN

Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease

(2013) Laura D. Osellame et al.   Cell Metabolism

Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress

(2013) Eleni N. Tsakiri et al.   FASEB JOURNAL

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Lysosomal impairment in Parkinson's disease

(2013) Benjamin Dehay et al.   MOVEMENT DISORDERS

Genetic causes of Parkinson's disease and their links to autophagy regulation

(2013) Ping-Yue Pan et al.   PARKINSONISM & RELATED DISORDERS

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

(2013) A. Rana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

(2013) E. S. Vincow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hrs- and CD63-Dependent Competing Mechanisms Make Different Sized Endosomal Intraluminal Vesicles

(2013) James R. Edgar et al.   TRAFFIC

A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies

(2013) Michael A. Nalls et al.   JAMA Neurology

Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders

(2012) Anja Schneider et al.   CELL AND TISSUE RESEARCH

Topograph, a Software Platform for Precursor Enrichment Corrected Global Protein Turnover Measurements

(2012) Edward J. Hsieh et al.   MOLECULAR & CELLULAR PROTEOMICS

Active Wnt proteins are secreted on exosomes

(2012) Julia Christina Gross et al.   NATURE CELL BIOLOGY

FlyAtlas: database of gene expression in the tissues of Drosophila melanogaster

(2012) S. W. Robinson et al.   NUCLEIC ACIDS RESEARCH

Comet: An open-source MS/MS sequence database search tool

(2012) Jimmy K. Eng et al.   PROTEOMICS

Drosophila S2 Cells Secrete Wingless on Exosome-Like Vesicles but the Wingless Gradient Forms Independently of Exosomes

(2012) Karen Beckett et al.   TRAFFIC

An integrative approach to ortholog prediction for disease-focused and other functional studies

(2011) Yanhui Hu et al.   BMC BIOINFORMATICS

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

(2011) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Accumulation and distribution of α-synuclein and ubiquitin in the CNS of Gaucher disease mouse models

(2011) Y.H. Xu et al.   MOLECULAR GENETICS AND METABOLISM

SignalP 4.0: discriminating signal peptides from transmembrane regions

(2011) Thomas Nordahl Petersen et al.   NATURE METHODS

Proteomics analyses of microvesicles released by Drosophila Kc167 and S2 cells

(2011) Tim Koppen et al.   PROTEOMICS

Reversible Ponceau staining as a loading control alternative to actin in Western blots

(2010) Isabel Romero-Calvo et al.   ANALYTICAL BIOCHEMISTRY

Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains

(2010) Lydia Alvarez-Erviti et al.   ARCHIVES OF NEUROLOGY

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Altered lipid content inhibits autophagic vesicular fusion

(2010) Hiroshi Koga et al.   FASEB JOURNAL

BLAST+: architecture and applications

(2009) Christiam Camacho et al.   BMC BIOINFORMATICS

Characterization of Vesicles Secreted from Insulinoma NIT-1 Cells

(2009) Hyo Sun Lee et al.   JOURNAL OF PROTEOME RESEARCH

The Temporal Program of Chromosome Replication: Genomewide Replication in clb5  Saccharomyces cerevisiae

(2008) H. J. McCune et al.   GENETICS

Ref(2)P, theDrosophila melanogasterhomologue of mammalian p62, is required for the formation of protein aggregates in adult brain

(2008) Ioannis P. Nezis et al.   JOURNAL OF CELL BIOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Membranes: a meeting point for lipids, proteins and therapies

(2008) Pablo V. Escribá et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lipid composition of microdomains is altered in a cell model of Gaucher disease

(2008) Leanne K. Hein et al.   JOURNAL OF LIPID RESEARCH

Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease

(2008) Claudine Kraft et al.   NATURE CELL BIOLOGY