Transcriptional control of energy metabolism by nuclear receptors

A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis

(2022) Anne Loft et al.   Cell Metabolism

The hallmarks of cancer metabolism: Still emerging

(2022) Natalya N. Pavlova et al.   Cell Metabolism

Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

(2022) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Insulin action and resistance are dependent on a GSK3β-FBXW7-ERRα transcriptional axis

(2022) Hui Xia et al.   Nature Communications

A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver

(2021) Yehuda Shabtai et al.   GENES & DEVELOPMENT

PPARα/RXRα downregulates amino acid catabolism in the liver via interaction with HNF4α promoting its proteasomal degradation

(2021) Sandra Tobón-Cornejo et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Regulation and metabolic functions of mTORC1 and mTORC2

(2021) Angelia Szwed et al.   PHYSIOLOGICAL REVIEWS

Transcriptional Regulation of ROS Homeostasis by the ERR Subfamily of Nuclear Receptors

(2021) Charlotte Scholtes et al.   Antioxidants

MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism

(2021) Jin Zhou et al.   Autophagy

Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues

(2021) Keiichi Ito et al.   GENES & DEVELOPMENT

Genome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms

(2021) Thomas A. Johnson et al.   Nature Communications

A structural signature motif enlightens the origin and diversification of nuclear receptors

(2021) Brice Beinsteiner et al.   PLoS Genetics

Individual-specific functional epigenomics reveals genetic determinants of adverse metabolic effects of glucocorticoids

(2021) Wenxiang Hu et al.   Cell Metabolism

Nematode nuclear receptors as integrators of sensory information

(2021) Surojit Sural et al.   CURRENT BIOLOGY

Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes

(2021) Rasmus J. O. Sjögren et al.   DIABETOLOGIA

Thyroid Hormone Receptor α Regulates Autophagy, Mitochondrial Biogenesis, and Fatty Acid Use in Skeletal Muscle

(2021) Jin Zhou et al.   ENDOCRINOLOGY

AMPK phosphorylates PPARδ to mediate its stabilization, inhibit glucose and glutamine uptake and colon tumor growth

(2021) Jiajun Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in metabolic disease and ageing

(2021) Munehiro Kitada et al.   Nature Reviews Endocrinology

Estrogen-related receptor alpha (ERRα) is a key regulator of intestinal homeostasis and protects against colitis

(2021) Allan Tran et al.   Scientific Reports

Adipocyte NR1D1 dictates adipose tissue expansion during obesity

(2021) Ann Louise Hunter et al.   eLife

Transcription Control of Liver Development

(2021) Evangelia C. Tachmatzidi et al.   Cells

A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH

(2021) Sven M. Francque et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα

(2021) Jessica Kain et al.   Molecular Metabolism

Estrogen-related receptors are targetable ROS sensors

(2020) Mathieu Vernier et al.   GENES & DEVELOPMENT

The cell biology of mitochondrial membrane dynamics

(2020) Marta Giacomello et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alterations in promoter interaction landscape and transcriptional network underlying metabolic adaptation to diet

(2020) Yufeng Qin et al.   Nature Communications

Transcriptional Control of Circadian Rhythms and Metabolism: A Matter of Time and Space

(2020) Yong Hoon Kim et al.   ENDOCRINE REVIEWS

Drosophila estrogen-related receptor directs a transcriptional switch that supports adult glycolysis and lipogenesis

(2020) Katherine Beebe et al.   GENES & DEVELOPMENT

Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation

(2020) Karolien De Bosscher et al.   Nature Reviews Endocrinology

Collapse of the hepatic gene regulatory network in the absence of FoxA factors

(2020) Yitzhak Reizel et al.   GENES & DEVELOPMENT

Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes

(2020) Xinzhe Yu et al.   MOLECULAR CELL

The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors

(2020) Kenichi Horisawa et al.   MOLECULAR CELL

Mir214-3p and Hnf4a/Hnf4α reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis

(2020) Da-Hye Lee et al.   Autophagy

Metabolism

(2020) Ayesha Judge et al.   Essays in Biochemistry

Nuclear Receptors as Autophagy-Based Antimicrobial Therapeutics

(2020) Prashanta Silwal et al.   Cells

ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota

(2020) Sup Kim et al.   Autophagy

The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation

(2020) Poonam Dhillon et al.   Cell Metabolism

Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex

(2019) Yuki Murayama et al.   FEBS LETTERS

Crosstalk between metabolism and circadian clocks

(2019) Hans Reinke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and Disease

(2019) Hui Xia et al.   Frontiers in Endocrinology

Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer

(2019) Sunghee Park et al.   Cell Reports

The Nuclear Receptor—Co-repressor Complex in Control of Liver Metabolism and Disease

(2019) Ning Liang et al.   Frontiers in Endocrinology

HNF4 Regulates Fatty Acid Oxidation and is Required for Renewal of Intestinal Stem Cells in Mice

(2019) Lei Chen et al.   GASTROENTEROLOGY

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

(2019) Adrienne Tin et al.   NATURE GENETICS

Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency

(2018) Kenjiro Adachi et al.   Cell Stem Cell

Canonical signaling and nuclear activity of mTOR-a teamwork effort to regulate metabolism and cell growth

(2018) Vincent Giguère   FEBS Journal

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

(2018) Brijesh K. Singh et al.   Science Signaling

ERRγ Promotes Angiogenesis, Mitochondrial Biogenesis, and Oxidative Remodeling in PGC1α/β-Deficient Muscle

(2018) Weiwei Fan et al.   Cell Reports

Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

(2018) Brijesh K. Singh et al.   Science Signaling

The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages

(2018) Viacheslav Mylka et al.   Autophagy

Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism

(2018) Duco Steven Koenis et al.   Cell Reports

Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock

(2018) Kenneth Allen Dyar et al.   PLOS BIOLOGY

Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood

(2018) Gilles Storelli et al.   DEVELOPMENTAL CELL

Indazole-based ligands for estrogen-related receptor α as potential anti-diabetic agents

(2017) Raymond J. Patch et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Liver-specific Prox1 inactivation causes hepatic injury and glucose intolerance in mice

(2017) Toshihiko Goto et al.   FEBS LETTERS

Nuclear mTOR acts as a transcriptional integrator of the androgen signaling pathway in prostate cancer

(2017) Étienne Audet-Walsh et al.   GENES & DEVELOPMENT

Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice

(2017) Kang Ho Kim et al.   HEPATOLOGY

Cardiac nuclear receptors: architects of mitochondrial structure and function

(2017) Rick B. Vega et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation

(2017) Rasmus Siersbæk et al.   MOLECULAR CELL

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells

(2017) Luz E. Tavera-Mendoza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Receptor Function through Genomics: Lessons from the Glucocorticoid Receptor

(2017) Daniel M. Cohen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides

(2017) Sean M. Armour et al.   Nature Communications

Liver-specific deletion of RORα aggravates diet-induced nonalcoholic steatohepatitis by inducing mitochondrial dysfunction

(2017) Hyeon-Ji Kim et al.   Scientific Reports

Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression

(2016) Alicia M. Blessing et al.   Autophagy

Androgen-Dependent Repression of ERRγ Reprograms Metabolism in Prostate Cancer

(2016) Étienne Audet-Walsh et al.   CANCER RESEARCH

Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions

(2016) Erin E. Swinstead et al.   CELL

Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome

(2016) Christopher M. Vockley et al.   CELL

Complementary Roles of Estrogen-Related Receptors in Brown Adipocyte Thermogenic Function

(2016) Marin L. Gantner et al.   ENDOCRINOLOGY

Skeletal muscle PGC-1α modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice

(2016) Kristoffer Svensson et al.   FASEB JOURNAL

Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα

(2016) Ming Yan et al.   GENES & DEVELOPMENT

Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα

(2016) Dariusz Ratman et al.   NUCLEIC ACIDS RESEARCH

DNA binding triggers tetramerization of the glucocorticoid receptor in live cells

(2016) Diego M. Presman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian physiology of metabolism

(2016) Satchidananda Panda   SCIENCE

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer

(2016) Geneviève Deblois et al.   Nature Communications

The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer

(2016) Étienne Audet-Walsh et al.   Cell Reports

ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer

(2016) Sunghee Park et al.   Cell Reports

Role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle

(2015) Anna Vainshtein et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo

(2015) Raymond E. Soccio et al.   CELL

Dependence of Hippocampal Function on ERRγ-Regulated Mitochondrial Metabolism

(2015) Liming Pei et al.   Cell Metabolism

PPARs and ERRs: molecular mediators of mitochondrial metabolism

(2015) Weiwei Fan et al.   CURRENT OPINION IN CELL BIOLOGY

PPARα via HNF4α regulates the expression of genes encoding hepatic amino acid catabolizing enzymes to maintain metabolic homeostasis

(2015) Alejandra V. Contreras et al.   Genes and Nutrition

Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice

(2015) Young Suk Jo et al.   HEPATOLOGY

Rapidly elevated levels of PGC-1α-b protein in human skeletal muscle after exercise: exploring regulatory factors in a randomized controlled trial

(2015) Eva-karin Gidlund et al.   JOURNAL OF APPLIED PHYSIOLOGY

Estrogen-Related Receptor α (ERRα) and ERRγ Are Essential Coordinators of Cardiac Metabolism and Function

(2015) Ting Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Cancer’s Fuel Choice: New Flavors for a Picky Eater

(2015) Gina M. DeNicola et al.   MOLECULAR CELL

Editorial: What's in a Name, or the Impact of Misnomers in Endocrine Research

(2015) Vincent Giguère   MOLECULAR ENDOCRINOLOGY

Discrete functions of nuclear receptor Rev-erb  couple metabolism to the clock

(2015) Y. Zhang et al.   SCIENCE

Transcriptional and Chromatin Regulation during Fasting – The Genomic Era

(2015) Ido Goldstein et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure

(2015) San-Pin Wu et al.   Nature Communications

Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling

(2015) Lars Grøntved et al.   Nature Communications

PPARα via HNF4α regulates the expression of genes encoding hepatic amino acid catabolizing enzymes to maintain metabolic homeostasis

(2015) Alejandra V. Contreras et al.   Genes and Nutrition

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport

(2014) Sokrates Stein et al.   Cell Metabolism

Transcriptional Coregulators: Fine-Tuning Metabolism

(2014) Laurent Mouchiroud et al.   Cell Metabolism

Inhibition of Cancer Cell Proliferation by PPARγ Is Mediated by a Metabolic Switch that Increases Reactive Oxygen Species Levels

(2014) Nishi Srivastava et al.   Cell Metabolism

Nuclear receptors rock around the clock

(2014) X. Zhao et al.   EMBO REPORTS

Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPAR -driven enhancers

(2014) S. E. Step et al.   GENES & DEVELOPMENT

Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk

(2014) Fleur Lien et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional regulation of autophagy by an FXR–CREB axis

(2014) Sunmi Seok et al.   NATURE

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Cooperativity and equilibrium with FOXA1 define the androgen receptor transcriptional program

(2014) Hong-Jian Jin et al.   Nature Communications

Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1

(2014) Takashi Baba et al.   Nature Communications

Molecular Architecture of Transcription Factor Hotspots in Early Adipogenesis

(2014) Rasmus Siersbæk et al.   Cell Reports

SRC-2 Is an Essential Coactivator for Orchestrating Metabolism and Circadian Rhythm

(2014) Erin Stashi et al.   Cell Reports

Folliculin Regulates Ampk-Dependent Autophagy and Metabolic Stress Survival

(2014) Elite Possik et al.   PLoS Genetics

Nuclear Receptor Coactivators: Master Regulators of Human Health and Disease

(2013) Subhamoy Dasgupta et al.   Annual Review of Medicine

The role of retinoic acid in hepatic lipid homeostasis defined by genomic binding and transcriptome profiling

(2013) Yuqi He et al.   BMC GENOMICS

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

Molecular and Genetic Crosstalks between mTOR and ERRα Are Key Determinants of Rapamycin-Induced Nonalcoholic Fatty Liver

(2013) Cédric Chaveroux et al.   Cell Metabolism

A map of the PPARα transcription regulatory network for primary human hepatocytes

(2013) Patrick D. McMullen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements

(2013) Lars Grøntved et al.   EMBO JOURNAL

Peroxisome Proliferator-activated Receptor γ Coactivator 1 (PGC-1)- and Estrogen-related Receptor (ERR)-induced Regulator in Muscle 1 (PERM1) Is a Tissue-specific Regulator of Oxidative Capacity in Skeletal Muscle Cells

(2013) Yoshitake Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Road to exercise mimetics: targeting nuclear receptors in skeletal muscle

(2013) Weiwei Fan et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The orphan nuclear receptors at their 25-year reunion

(2013) Shannon E Mullican et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Peroxisome Proliferator-Activated Receptor   and C/EBP  Synergistically Activate Key Metabolic Adipocyte Genes by Assisted Loading

(2013) M. S. Madsen et al.   MOLECULAR AND CELLULAR BIOLOGY

Multidomain integration in the structure of the HNF-4α nuclear receptor complex

(2013) Vikas Chandra et al.   NATURE

Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

(2013) Estelle Woldt et al.   NATURE MEDICINE

Dynamic regulation of transcriptional states by chromatin and transcription factors

(2013) Ty C. Voss et al.   NATURE REVIEWS GENETICS

Loss of estrogen-related receptor   promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances

(2013) E.-J. Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FoxA1 Specifies Unique Androgen and Glucocorticoid Receptor Binding Events in Prostate Cancer Cells

(2012) B. Sahu et al.   CANCER RESEARCH

Genetic and Molecular Insights Into the Role of PROX1 in Glucose Metabolism

(2012) S. Lecompte et al.   DIABETES

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy

(2012) Rohit Anthony Sinha et al.   JOURNAL OF CLINICAL INVESTIGATION

LRH-1–dependent glucose sensing determines intermediary metabolism in liver

(2012) Maaike H. Oosterveer et al.   JOURNAL OF CLINICAL INVESTIGATION

The Corepressor NCoR1 Antagonizes PGC-1  and Estrogen-Related Receptor   in the Regulation of Skeletal Muscle Function and Oxidative Metabolism

(2012) J. Perez-Schindler et al.   MOLECULAR AND CELLULAR BIOLOGY

The Stat3/GR Interaction Code: Predictive Value of Direct/Indirect DNA Recruitment for Transcription Outcome

(2012) David Langlais et al.   MOLECULAR CELL

Regulation of glucose transport by insulin: traffic control of GLUT4

(2012) Dara Leto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Thiazolidinediones and PPARγ agonists: time for a reassessment

(2012) Bertrand Cariou et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Coordinate Regulation of Lipid Metabolism by Novel Nuclear Receptor Partnerships

(2012) Pranali P. Pathare et al.   PLoS Genetics

A Rapid, Extensive, and Transient Transcriptional Response to Estrogen Signaling in Breast Cancer Cells

(2011) Nasun Hah et al.   CELL

Dynamic Exchange at Regulatory Elements during Chromatin Remodeling Underlies Assisted Loading Mechanism

(2011) Ty C. Voss et al.   CELL

The Drosophila Estrogen-Related Receptor Directs a Metabolic Switch that Supports Developmental Growth

(2011) Jason M. Tennessen et al.   Cell Metabolism

Cellular Energy Depletion Resets Whole-Body Energy by Promoting Coactivator-Mediated Dietary Fuel Absorption

(2011) Atul R. Chopra et al.   Cell Metabolism

Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle

(2011) Noriaki Shimizu et al.   Cell Metabolism

Exercise and PGC-1α-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERRγ

(2011) Vihang A. Narkar et al.   Cell Metabolism

Pioneer transcription factors: establishing competence for gene expression

(2011) K. S. Zaret et al.   GENES & DEVELOPMENT

The nuclear receptor PPAR /  programs muscle glucose metabolism in cooperation with AMPK and MEF2

(2011) Z. Gan et al.   GENES & DEVELOPMENT

S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator-activated receptor alpha activity in the liver

(2011) KyeongJin Kim et al.   HEPATOLOGY

Identification of Diaryl Ether-Based Ligands for Estrogen-Related Receptor α as Potential Antidiabetic Agents

(2011) Raymond J. Patch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Estrogen related receptors (ERRs): A new dawn in transcriptional control of mitochondrial gene networks

(2011) Lillian J. Eichner et al.   MITOCHONDRION

Genome-Wide Profiling of Liver X Receptor, Retinoid X Receptor, and Peroxisome Proliferator-Activated Receptor   in Mouse Liver Reveals Extensive Sharing of Binding Sites

(2011) M. Boergesen et al.   MOLECULAR AND CELLULAR BIOLOGY

Novel Role of Androgens in Mitochondrial Fission and Apoptosis

(2011) V. Choudhary et al.   MOLECULAR CANCER RESEARCH

Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding

(2011) Simon C. Biddie et al.   MOLECULAR CELL

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

(2011) Katja A. Lamia et al.   NATURE

Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA

(2011) Dong Wang et al.   NATURE

Genomic Convergence among ERRα, PROX1, and BMAL1 in the Control of Metabolic Clock Outputs

(2011) Catherine R. Dufour et al.   PLoS Genetics

PER2 Controls Lipid Metabolism by Direct Regulation of PPARγ

(2010) Benedetto Grimaldi et al.   Cell Metabolism

miR-378 ∗ Mediates Metabolic Shift in Breast Cancer Cells via the PGC-1β/ERRγ Transcriptional Pathway

(2010) Lillian J. Eichner et al.   Cell Metabolism

The homeobox protein Prox1 is a negative modulator of ERR /PGC-1  bioenergetic functions

(2010) A. Charest-Marcotte et al.   GENES & DEVELOPMENT

Estrogen-related Receptor γ Is a Key Regulator of Muscle Mitochondrial Activity and Oxidative Capacity

(2010) Shamina M. Rangwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-Specific Determinants of Peroxisome Proliferator-Activated Receptor   Function in Adipocytes and Macrophages

(2010) M. I. Lefterova et al.   MOLECULAR AND CELLULAR BIOLOGY

Origin and evolution of the ligand-binding ability of nuclear receptors

(2010) Gabriel V. Markov et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

An Acetylation Switch Modulates the Transcriptional Activity of Estrogen-Related Receptor α

(2010) Brian J. Wilson et al.   MOLECULAR ENDOCRINOLOGY

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Glucose transporters in the 21st Century

(2009) Bernard Thorens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Nuclear Orphan Receptor COUP-TFII Plays an Essential Role in Adipogenesis, Glucose Homeostasis, and Energy Metabolism

(2009) Luoping Li et al.   Cell Metabolism

Drosophila HNF4 Regulates Lipid Mobilization and β-Oxidation

(2009) Laura Palanker et al.   Cell Metabolism

Peroxisome Proliferator-Activated Receptor-α Control of Lipid and Glucose Metabolism in Human White Adipocytes

(2009) Carole Ribet et al.   ENDOCRINOLOGY

Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications

(2009) Nancy Nader et al.   FASEB JOURNAL

Peroxisome proliferator-activated receptor δ regulates mitofusin 2 expression in the heart

(2009) Yuquan Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin

(2009) Sara Connaughton et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Dynamic Interactions and Cooperative Functions of PGC-1α and MED1 in TRα-Mediated Activation of the Brown-Fat-Specific UCP-1 Gene

(2009) Wei Chen et al.   MOLECULAR CELL

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells

(2008) Xi Chen et al.   CELL

High-Resolution Mapping and Characterization of Open Chromatin across the Genome

(2008) Alan P. Boyle et al.   CELL

Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors

(2008) Vincent Giguère   ENDOCRINE REVIEWS

Genome-wide profiling of PPAR :RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis

(2008) R. Nielsen et al.   GENES & DEVELOPMENT

Suppressing the activity of ERRα in 3T3-L1 adipocytes reduces mitochondrial biogenesis but enhances glycolysis and basal glucose uptake

(2008) Yaohui Nie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

(2008) Vikas Chandra et al.   NATURE

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1 

(2008) A. Coste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters

(2008) Leighton J. Core et al.   SCIENCE

Estradiol Stimulates Transcription of Nuclear Respiratory Factor-1 and Increases Mitochondrial Biogenesis

(2007) Kathleen A. Mattingly et al.   MOLECULAR ENDOCRINOLOGY