Journal
JOURNAL OF MOLECULAR ENDOCRINOLOGY
Volume 51, Issue 3, Pages T87-T100Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/JME-13-0258
Keywords
exercise; skeletal muscle; nuclear receptors; molecular endocrinology
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Funding
- US National Institutes of Health [DK057978, DK090962, HL088093, HL105278, CA014195, ES010337]
- Glenn Foundation for Medical Research
- Leona M and Harry B Helmsley Charitable Trust
- Ipsen/Biomeasure
- Ellison Medical Foundation
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Skeletal muscle is the largest organ in the human body and is the major site for energy expenditure. It exhibits remarkable plasticity in response to physiological stimuli such as exercise. Physical exercise remodels skeletal muscle and enhances its capability to burn calories, which has been shown to be beneficial for many clinical conditions including the metabolic syndrome and cancer. Nuclear receptors (NRs) comprise a class of transcription factors found only in metazoans that regulate major biological processes such as reproduction, development, and metabolism. Recent studies have demonstrated crucial roles for NRs and their co-regulators in the regulation of skeletal muscle energy metabolism and exercise-induced muscle remodeling. While nothing can fully replace exercise, development of exercise mimetics that enhance or even substitute for the beneficial effects of physical exercise would be of great benefit. The unique property of NRs that allows modulation by endogenous or synthetic ligands makes them bona fide therapeutic targets. In this review, we present an overview of the current understanding of the role of NRs and their co-regulators in skeletal muscle oxidative metabolism and summarize recent progress in the development of exercise mimetics that target NRs and their co-regulators.
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