Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

The discovery of novel, potent ERR-alpha inverse agonists for the treatment of triple negative breast cancer

(2017) Yongli Du et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial fission facilitates the selective mitophagy of protein aggregates

(2017) Jonathon L. Burman et al.   JOURNAL OF CELL BIOLOGY

Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover

(2017) H-C Chi et al.   ONCOGENE

SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages

(2016) Min-Ji Kim et al.   Autophagy

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects

(2016) Wei Wei et al.   Cell Metabolism

Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice

(2016) Kenji Ohba et al.   ENDOCRINOLOGY

Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle

(2016) Ronny Lesmana et al.   ENDOCRINOLOGY

Mitochondrial biogenesis and clearance: a balancing act

(2016) Christina Ploumi et al.   FEBS Journal

α-MHC MitoTimer mouse: In vivo mitochondrial turnover model reveals remarkable mitochondrial heterogeneity in the heart

(2016) Aleksandr Stotland et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Genomic Context and Corecruitment of SP1 Affect ERRα Coactivation by PGC-1α in Muscle Cells

(2016) Silvia Salatino et al.   MOLECULAR ENDOCRINOLOGY

Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD

(2016) Rohit Anthony Sinha et al.   Cell and Bioscience

Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy

(2015) Jie Li et al.   Autophagy

Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling

(2015) Rohit A Sinha et al.   Autophagy

Regulation of skeletal muscle mitochondrial function by nuclear receptors: implications for health and disease

(2015) Joaquin Perez-Schindler et al.   CLINICAL SCIENCE

Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition

(2015) Brijesh K. Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The orphan estrogen-related receptor alpha and metabolic regulation: new frontiers

(2015) Harmit S. Ranhotra   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC)

(2015) Ivan Casaburi et al.   Oncotarget

The multiple universes of estrogen-related receptor α and γ in metabolic control and related diseases

(2014) Étienne Audet-walsh et al.   ACTA PHARMACOLOGICA SINICA

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

(2014) W. Wu et al.   EMBO REPORTS

A NovelMitoTimerReporter Gene for Mitochondrial Content, Structure, Stress, and Damagein Vivo

(2014) Rhianna C. Laker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigallocatechin-3-Gallate (EGCG), a Green Tea Polyphenol, Stimulates Hepatic Autophagy and Lipid Clearance

(2014) Jin Zhou et al.   PLoS One

β-Adrenergic Agonist and Antagonist Regulation of Autophagy in HepG2 Cells, Primary Mouse Hepatocytes, and Mouse Liver

(2014) Benjamin L. Farah et al.   PLoS One

Novel drugs that target the estrogen-related receptor alpha: their therapeutic potential in breast cancer

(2014) Felicity May   Cancer Management and Research

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

MitoTimer

(2013) Genaro Hernandez et al.   Autophagy

Participation of mitochondrial fission during mitophagy

(2013) Kai Mao et al.   CELL CYCLE

The regulation of mitochondrial DNA copy number in glioblastoma cells

(2013) A Dickinson et al.   CELL DEATH AND DIFFERENTIATION

Molecular and Genetic Crosstalks between mTOR and ERRα Are Key Determinants of Rapamycin-Induced Nonalcoholic Fatty Liver

(2013) Cédric Chaveroux et al.   Cell Metabolism

Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice

(2013) Rohit A. Sinha et al.   HEPATOLOGY

FoxO1 Deacetylation Regulates Thyroid Hormone-induced Transcription of Key Hepatic Gluconeogenic Genes

(2013) Brijesh Kumar Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Mechanism of PositiveversusNegative Regulation by Thyroid Hormone Receptor β1 (TRβ1) Identified by Genome-wide Profiling of Binding Sites in Mouse Liver

(2013) Preeti Ramadoss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thyroid hormones and mitochondria: With a brief look at derivatives and analogues

(2013) Federica Cioffi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

SIRT1 is a Direct Coactivator of Thyroid Hormone Receptor β1 with Gene-Specific Actions

(2013) Ji Ho Suh et al.   PLoS One

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Hepatitis B Virus Disrupts Mitochondrial Dynamics: Induces Fission and Mitophagy to Attenuate Apoptosis

(2013) Seong-Jun Kim et al.   PLoS Pathogens

Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility

(2012) Deborah M. Muoio et al.   Cell Metabolism

Role of Sirtuin 1 in the Regulation of Hepatic Gene Expression by Thyroid Hormone

(2012) Shalini Thakran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy

(2012) E. Itakura et al.   JOURNAL OF CELL SCIENCE

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy

(2012) Rohit Anthony Sinha et al.   JOURNAL OF CLINICAL INVESTIGATION

Methyl donor deficiency impairs fatty acid oxidation through PGC-1α hypomethylation and decreased ER-α, ERR-α, and HNF-4α in the rat liver

(2012) Shabnam Pooya et al.   JOURNAL OF HEPATOLOGY

Transcriptional integration of mitochondrial biogenesis

(2012) Richard C. Scarpulla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation and Function of Uncoordinated-51 Like Kinase Proteins

(2011) Edmond Y. Chan   ANTIOXIDANTS & REDOX SIGNALING

Estrogen related receptors (ERRs): A new dawn in transcriptional control of mitochondrial gene networks

(2011) Lillian J. Eichner et al.   MITOCHONDRION

Coordination of mitochondrial biogenesis by thyroid hormone

(2011) Joachim M. Weitzel et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hsp90-Cdc37 Chaperone Complex Regulates Ulk1- and Atg13-Mediated Mitophagy

(2011) Joung Hyuck Joo et al.   MOLECULAR CELL

Thyroid hormones, mitochondrial bioenergetics and lipid handling

(2011) Federica Cioffi et al.   Current Opinion in Endocrinology Diabetes and Obesity

Evidence of a bigenomic regulation of mitochondrial gene expression by thyroid hormone during rat brain development

(2010) Rohit Anthony Sinha et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oestrogen-related receptor alpha inverse agonist XCT-790 arrests A549 lung cancer cell population growth by inducing mitochondrial reactive oxygen species production

(2010) J. Wang et al.   CELL PROLIFERATION

Imaging type-III secretion reveals dynamics and spatial segregation of Salmonella effectors

(2010) Schuyler B Van Engelenburg et al.   NATURE METHODS

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells

(2009) David Sebastián et al.   JOURNAL OF LIPID RESEARCH

Estrogen-related receptor-  antagonist inhibits both estrogen receptor-positive and estrogen receptor-negative breast tumor growth in mouse xenografts

(2009) M. J. Chisamore et al.   MOLECULAR CANCER THERAPEUTICS

Isoform-Specific Transcriptional Activity of Overlapping Target Genes that Respond to Thyroid Hormone Receptors α1 and β1

(2009) Ivan H. Chan et al.   MOLECULAR ENDOCRINOLOGY

Mitochondrial gene expression is regulated at multiple levels and differentially in the heart and liver by thyroid hormones

(2008) Erika Fernández-Vizarra et al.   CURRENT GENETICS

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors

(2008) Vincent Giguère   ENDOCRINE REVIEWS

Nuclear receptors, mitochondria and lipid metabolism

(2008) William A. Alaynick   MITOCHONDRION

ERRα: a metabolic function for the oldest orphan

(2008) Josep A. Villena et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM