Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives
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Title
Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives
Authors
Keywords
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Journal
Molecular Cancer
Volume 21, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-05-17
DOI
10.1186/s12943-022-01591-z
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Note: Only part of the references are listed.- Exosomal lncRNA TUG1 from cancer-associated fibroblasts promotes liver cancer cell migration, invasion, and glycolysis by regulating the miR-524-5p/SIX1 axis
- (2022) Le Lu et al. CELLULAR & MOLECULAR BIOLOGY LETTERS
- Circ_0036412 affects the proliferation and cell cycle of hepatocellular carcinoma via hedgehog signaling pathway
- (2022) Liyan Wang et al. Journal of Translational Medicine
- miR-636 inhibits EMT, cell proliferation and cell cycle of ovarian cancer by directly targeting transcription factor Gli2 involved in Hedgehog pathway
- (2021) Jiong Ma et al. Cancer Cell International
- The long noncoding RNA lncCIRBIL disrupts the nuclear translocation of Bclaf1 alleviating cardiac ischemia–reperfusion injury
- (2021) Yang Zhang et al. Nature Communications
- Regulation of Hedgehog Signaling by miRNAs and Nanoformulations: A Possible Therapeutic Solution for Colorectal Cancer
- (2021) Zeeshan Javed et al. Frontiers in Oncology
- Integrated molecular analysis of adult Sonic Hedgehog (SHH)-activated medulloblastomas reveals two clinically relevant tumor subsets with VEGFA as potent prognostic indicator
- (2021) Andrey Korshunov et al. NEURO-ONCOLOGY
- Upregulation of LINC01426 promotes the progression and stemness in lung adenocarcinoma by enhancing the level of SHH protein to activate the hedgehog pathway
- (2021) Xiaoli Liu et al. Cell Death & Disease
- MicroRNA-221 promotes tumor progression by targeting HHIP in human glioblastoma
- (2021) Liang Chang et al. Translational Cancer Research
- Dual activation of Hedgehog and Wnt/β-catenin signaling pathway caused by downregulation of SUFU targeted by miRNA-150 in human gastric cancer
- (2021) Yin Peng et al. Aging-US
- LINC01123 enhances osteosarcoma cell growth by activating the Hedgehog pathway via the miR‐516b‐5p/Gli1 axis
- (2021) Xiaohui Pan et al. CANCER SCIENCE
- MIRLET7BHG promotes hepatocellular carcinoma progression by activating hepatic stellate cells through exosomal SMO to trigger Hedgehog pathway
- (2021) Yunhong Xia et al. Cell Death & Disease
- Novel Long Noncoding RNA miR205HG Functions as an Esophageal Tumor-Suppressive Hedgehog Inhibitor
- (2021) Jee Hoon Song et al. Cancers
- Noncoding RNA therapeutics — challenges and potential solutions
- (2021) Melanie Winkle et al. NATURE REVIEWS DRUG DISCOVERY
- The neurobiology of non-coding RNAs and Alzheimer’s disease pathogenesis: Pathways, mechanisms and translational opportunities
- (2021) Elisabetta Lauretti et al. AGEING RESEARCH REVIEWS
- MiR-144-3p inhibits gastric cancer progression and stemness via directly targeting GLI2 involved in hedgehog pathway
- (2021) Yixun Lu et al. Journal of Translational Medicine
- ciRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma
- (2021) Weipu Mao et al. Molecular Cancer
- Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling
- (2021) Yang Gu et al. Molecular Cancer
- Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer
- (2020) Gaofeng Liang et al. JOURNAL OF NANOBIOTECHNOLOGY
- Protease nexin-1 protects against Alzheimer’s disease by regulating the sonic hedgehog signaling pathway
- (2020) Xiao-Long Li et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- RNA delivery by extracellular vesicles in mammalian cells and its applications
- (2020) Killian O’Brien et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- CircZNF609 enhances hepatocellular carcinoma cell proliferation, metastasis, and stemness by activating the Hedgehog pathway through the regulation of miR-15a-5p/15b-5p and GLI2 expressions
- (2020) Yangke He et al. Cell Death & Disease
- Long Noncoding RNA DIO3OS Hinders Cell Malignant Behaviors of Hepatocellular Carcinoma Cells Through the microRNA-328/Hhip Axis
- (2020) Zhanpeng Wang et al. Cancer Management and Research
- Non-coding RNA in bladder cancer
- (2020) Yi Li et al. CANCER LETTERS
- Transcription activation of circ-STAT3 induced by Gli2 promotes the progression of hepatoblastoma via acting as a sponge for miR-29a/b/c-3p to upregulate STAT3/Gli2
- (2020) Yanfeng Liu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Circ-GLI1 promotes metastasis in melanoma through interacting with p70S6K2 to activate Hedgehog/GLI1 and Wnt/β-catenin pathways and upregulate Cyr61
- (2020) Jun Chen et al. Cell Death & Disease
- Circular RNA DGKB Promotes the Progression of Neuroblastoma by Targeting miR-873/GLI1 Axis
- (2020) Jiale Yang et al. Frontiers in Oncology
- Circ_DCAF6 potentiates cell stemness and growth in breast cancer through GLI1-Hedgehog pathway
- (2020) Guolin Ye et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Non-coding RNAs: The key detectors and regulators in cardiovascular disease
- (2020) Linwen Zhu et al. GENOMICS
- LINC01106 drives colorectal cancer growth and stemness through a positive feedback loop to regulate the Gli family factors
- (2020) Kun Guo et al. Cell Death & Disease
- Downregulation of miR-506-3p Facilitates EGFR-TKI Resistance through Induction of Sonic Hedgehog Signaling in Non-Small-Cell Lung Cancer Cell Lines
- (2020) Inamul Haque et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Silencing of long non‑coding RNA NEAT1 inhibits hepatocellular carcinoma progression by downregulating SMO by sponging microRNA‑503
- (2020) Chuihua Sun et al. Molecular Medicine Reports
- Cholesterol access in cellular membranes controls Hedgehog signaling
- (2020) Arun Radhakrishnan et al. Nature Chemical Biology
- Gene regulation by long non-coding RNAs and its biological functions
- (2020) Luisa Statello et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Micro-RNAs in the regulation of immune response against SARS CoV-2 and other viral infections
- (2020) Tareq Abu-Izneid et al. Journal of Advanced Research
- Long noncoding RNA LINC00657 inhibits cervical cancer development by sponging miR-20a-5p and targeting RUNX3
- (2020) Xiaomin Qin et al. CANCER LETTERS
- HOTAIR and androgen receptor synergistically increase GLI2 transcription to promote tumor angiogenesis and cancer stemness in renal cell carcinoma
- (2020) Ji-Yu Bai et al. CANCER LETTERS
- Targeting Hedgehog signaling pathway: paving the road for cancer therapy
- (2019) Ioana Berindan-Neagoe et al. PHARMACOLOGICAL RESEARCH
- Opposite regulation of Wnt/β-catenin and Shh signaling pathways by Rack1 controls mammalian cerebellar development
- (2019) Haihong Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LIFR-AS1 modulates Sufu to inhibit cell proliferation and migration by miR-197-3p in breast cancer
- (2019) Fangfang Xu et al. BIOSCIENCE REPORTS
- Long noncoding RNA LINC‐PINT regulates laryngeal carcinoma cell stemness and chemoresistance through miR‐425‐5p/PTCH1/SHH axis
- (2019) Zhennan Yuan et al. JOURNAL OF CELLULAR PHYSIOLOGY
- RUNX3 suppresses metastasis and stemness by inhibiting Hedgehog signaling in colorectal cancer
- (2019) Bo Ram Kim et al. CELL DEATH AND DIFFERENTIATION
- MiRNA-204-5p and oxaliplatin-loaded silica nanoparticles for enhanced tumor suppression effect in CD44-overexpressed colon adenocarcinoma
- (2019) Hailing Yang et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Smoothened stimulation by membrane sterols drives Hedgehog pathway activity
- (2019) Ishan Deshpande et al. NATURE
- The how and why of lncRNA function: An innate immune perspective
- (2019) Elektra K. Robinson et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Oncogenic KRAS sensitizes lung adenocarcinoma to GSK-J4-induced metabolic and oxidative stress
- (2019) Beom-Jin Hong et al. CANCER RESEARCH
- DNA‐methylation‐mediated silencing of miR‐7‐5p promotes gastric cancer stem cell invasion via increasing Smo and Hes1
- (2019) Lin Xin et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The biogenesis, biology and characterization of circular RNAs
- (2019) Lasse S. Kristensen et al. NATURE REVIEWS GENETICS
- lncRNA GAS5‐promoted apoptosis in triple‐negative breast cancer by targeting miR‐378a‐5p/SUFU signaling
- (2019) Shipeng Zheng et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma
- (2019) Hiromichi Suzuki et al. NATURE
- Elevated Hedgehog-Interacting Protein Levels in Subjects with Prediabetes and Type 2 Diabetes
- (2019) Lin et al. Journal of Clinical Medicine
- Circular RNA SMO sponges miR-338-3p to promote the growth of glioma by enhancing the expression of SMO
- (2019) Zhiyong Xiong et al. Aging-US
- SOX2-induced upregulation of lncRNA LINC01510 promotes papillary thyroid carcinoma progression by modulating miR-335/SHH and activating Hedgehog pathway
- (2019) Qun Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A novel long noncoding RNA HHIP-AS1 suppresses hepatocellular carcinoma progression through stabilizing HHIP mRNA
- (2019) Changwen Bo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- MicroRNA-182-5p regulates hedgehog signaling pathway and chemosensitivity of cisplatin-resistant lung adenocarcinoma cells via targeting GLI2
- (2019) Carina Seidl et al. CANCER LETTERS
- Down-regulation of microRNA-224 -inhibites growth and epithelial-to-mesenchymal transition phenotype - via modulating SUFU expression in bladder cancer cells
- (2018) Xiaobo Miao et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
- (2018) Aurélie S. Cazet et al. Nature Communications
- miR-7-5p acts as a tumor suppressor in bladder cancer by regulating the hedgehog pathway factor Gli3
- (2018) Jun Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- LOC101930370/MiR-1471 Axis Modulates the Hedgehog Signaling Pathway in Breast Cancer
- (2018) Xin Liu et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Upregulated circular RNA circ-102004 that promotes cell proliferation in prostate cancer
- (2018) Jie Si-Tu et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Hedgehog Signaling in Lung Cancer: From Oncogenesis to Cancer Treatment Resistance
- (2018) Etienne Giroux-Leprieur et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The novel regulatory role of lncRNA-miRNA-mRNA axis in cardiovascular diseases
- (2018) Ying Huang JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Dual delivery nanoscale device for miR-345 and gemcitabine co-delivery to treat pancreatic cancer
- (2018) Metin Uz et al. JOURNAL OF CONTROLLED RELEASE
- The long noncoding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog Signaling
- (2018) Jiayi Wu et al. JOURNAL OF HEPATOLOGY
- A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human
- (2018) Bhairab N. Singh et al. Nature Communications
- Inhibition of the Hedgehog signaling pathway suppresses cell proliferation by regulating the Gli2/miR-124/AURKA axis in human glioma cells
- (2017) Liyao Xu et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- In Vivo Delivery and Therapeutic Effects of a MicroRNA on Colorectal Liver Metastases
- (2017) Go Oshima et al. MOLECULAR THERAPY
- MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
- (2017) Rajesha Rupaimoole et al. NATURE REVIEWS DRUG DISCOVERY
- LncRNA-mediated regulation of cell signaling in cancer
- (2017) W-X Peng et al. ONCOGENE
- The expression of microRNA-324-3p as a tumor suppressor in nasopharyngeal carcinoma and its clinical significance
- (2017) Han-qun Zhang et al. OncoTargets and Therapy
- The long noncoding RNA TUG1 acts as a competing endogenous RNA to regulate the Hedgehog pathway by targeting miR-132 in hepatocellular carcinoma
- (2017) Jingjing Li et al. Oncotarget
- Human CAFs promote lymphangiogenesis in ovarian cancer via the Hh-VEGF-C signaling axis
- (2017) Rui Wei et al. Oncotarget
- Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA
- (2017) Iain M. Dykes et al. GENOMICS PROTEOMICS & BIOINFORMATICS
- Co-delivery of small molecule hedgehog inhibitor and miRNA for treating liver fibrosis
- (2016) Virender Kumar et al. BIOMATERIALS
- HLF/miR-132/TTK axis regulates cell proliferation, metastasis and radiosensitivity of glioma cells
- (2016) Shu Chen et al. BIOMEDICINE & PHARMACOTHERAPY
- Genomic Landscape of Somatic Alterations in Esophageal Squamous Cell Carcinoma and Gastric Cancer
- (2016) Nan Hu et al. CANCER RESEARCH
- Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling
- (2016) Pengxiang Huang et al. CELL
- Autocrine Sonic hedgehog signaling promotes gastric cancer proliferation through induction of phospholipase Cγ1 and the ERK1/2 pathway
- (2016) Zhai Ertao et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Local regulation of gene expression by lncRNA promoters, transcription and splicing
- (2016) Jesse M. Engreitz et al. NATURE
- The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy
- (2016) Zhihua Wang et al. NATURE MEDICINE
- MicroRNA-1271 inhibits proliferation and promotes apoptosis of multiple myeloma cells through inhibiting smoothened-mediated Hedgehog signaling pathway
- (2016) Zhengwei Xu et al. ONCOLOGY REPORTS
- CLL Exosomes Modulate the Transcriptome and Behaviour of Recipient Stromal Cells and Are Selectively Enriched in miR-202-3p
- (2015) Mosavar Farahani et al. PLoS One
- Regulation of circRNA biogenesis
- (2015) Ling-Ling Chen et al. RNA Biology
- Twist1 and Snail Link Hedgehog Signaling to Tumor-Initiating Cell-Like Properties and Acquired Chemoresistance Independently of ABC Transporters
- (2015) Ying Kong et al. STEM CELLS
- LncRNA-Hh Strengthen Cancer Stem Cells Generation in Twist-Positive Breast Cancer via Activation of Hedgehog Signaling Pathway
- (2015) Mingli Zhou et al. STEM CELLS
- Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level
- (2015) Jessian L. Munoz et al. Oncotarget
- microRNA-214 promotes epithelial-mesenchymal transition and metastasis in lung adenocarcinoma by targeting the suppressor-of-fused protein (Sufu)
- (2015) Haixia Long et al. Oncotarget
- Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals
- (2015) Andranik Ivanov et al. Cell Reports
- A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance
- (2014) Z. Liu et al. BLOOD
- lncRNA Directs Cooperative Epigenetic Regulation Downstream of Chemokine Signals
- (2014) Zhen Xing et al. CELL
- miR-204-5p Inhibits Proliferation and Invasion and Enhances Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating RAB22A
- (2014) Y. Yin et al. CLINICAL CANCER RESEARCH
- miR-212 promotes pancreatic cancer cell growth and invasion by targeting the hedgehog signaling pathway receptor patched-1
- (2014) Chenchao Ma et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Detecting and characterizing circular RNAs
- (2014) William R Jeck et al. NATURE BIOTECHNOLOGY
- Targeting the SMO oncogene by miR-326 inhibits glioma biological behaviors and stemness
- (2014) Wenzhong Du et al. NEURO-ONCOLOGY
- miR-506 acts as a tumor suppressor by directly targeting the hedgehog pathway transcription factor Gli3 in human cervical cancer
- (2014) S-Y Wen et al. ONCOGENE
- Targeting of the signal transducer Smo links microRNA-326 to the oncogenic Hedgehog pathway in CD34+CML stem/progenitor cells
- (2013) Sadegh Babashah et al. INTERNATIONAL JOURNAL OF CANCER
- Hedgehog Signaling Pathway in Ovarian Cancer
- (2013) Joanna Szkandera et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs
- (2013) Aamir Ahmad et al. Journal of Hematology & Oncology
- Circular RNAs are a large class of animal RNAs with regulatory potency
- (2013) Sebastian Memczak et al. NATURE
- The mechanisms of Hedgehog signalling and its roles in development and disease
- (2013) James Briscoe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- miRNA-338-3p suppresses cell growth of human colorectal carcinoma by targeting smoothened
- (2013) Kai Sun WORLD JOURNAL OF GASTROENTEROLOGY
- Paracrine Hedgehog Signaling Drives Metabolic Changes in Hepatocellular Carcinoma
- (2012) I. S. Chan et al. CANCER RESEARCH
- Molecular Pathways: The Hedgehog Signaling Pathway in Cancer
- (2012) R. McMillan et al. CLINICAL CANCER RESEARCH
- MicroRNA-212 displays tumor-promoting properties in non-small cell lung cancer cells and targets the hedgehog pathway receptor PTCH1
- (2012) Yuan Li et al. MOLECULAR BIOLOGY OF THE CELL
- Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
- (2012) Aleksandar Sekulic et al. NEW ENGLAND JOURNAL OF MEDICINE
- Circular RNAs are abundant, conserved, and associated with ALU repeats
- (2012) W. R. Jeck et al. RNA
- miR-338-3p suppresses invasion of liver cancer cell by targeting smoothened
- (2011) Xiao-Hui Huang et al. JOURNAL OF PATHOLOGY
- A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes
- (2010) Hanna Tukachinsky et al. JOURNAL OF CELL BIOLOGY
- Indian Hedgehog, a Neglected Member of Hedgehog Pathway, May Offer a Novel Avenue for Colorectal Cancer Therapy
- (2009) Xiangsheng Fu et al. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
- Paracrine Hedgehog Signaling in Cancer
- (2009) J.-W. Theunissen et al. CANCER RESEARCH
- Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
- (2009) Frédéric Varnat et al. EMBO Molecular Medicine
- Hedgehog signalling in colon cancer and stem cells
- (2009) Alberto Gulino et al. EMBO Molecular Medicine
- Long noncoding RNAs: functional surprises from the RNA world
- (2009) J. E. Wilusz et al. GENES & DEVELOPMENT
- Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer
- (2009) J M Bailey et al. ONCOGENE
- Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor-Induced Gliomas
- (2008) O. J. Becher et al. CANCER RESEARCH
- Hedgehog Signaling in Development and Cancer
- (2008) Jin Jiang et al. DEVELOPMENTAL CELL
- Hedgehog: functions and mechanisms
- (2008) M. Varjosalo et al. GENES & DEVELOPMENT
- A paracrine requirement for hedgehog signalling in cancer
- (2008) Robert L. Yauch et al. NATURE
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