LncRNA-mediated regulation of cell signaling in cancer

NOK mediates glycolysis and nuclear PDC associated histone acetylation

(2017) Li Liu   Frontiers in Bioscience-Landmark

The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors

(2017) Aifu Lin et al.   NATURE CELL BIOLOGY

LncRNA AK023948 is a positive regulator of AKT

(2017) Pratirodh Koirala et al.   Nature Communications

LncRNA FER1L4 suppresses cancer cell proliferation and cycle by regulating PTEN expression in endometrial carcinoma

(2016) Qiao Qiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LncRNA-HOTAIR promotes TNF-α production in cardiomyocytes of LPS-induced sepsis mice by activating NF-κB pathway

(2016) Hongwei Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The ins and outs of lncRNA structure: How, why and what comes next?

(2016) Amanda J. Blythe et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Long noncoding RNAs: Re-writing dogmas of RNA processing and stability

(2016) Jeremy E. Wilusz   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The degradation of EZH2 mediated by lncRNA ANCR attenuated the invasion and metastasis of breast cancer

(2016) Zhongwei Li et al.   CELL DEATH AND DIFFERENTIATION

The long noncoding RNA MALAT1 regulates the lipopolysaccharide-induced inflammatory response through its interaction with NF-κB

(2016) Gui Zhao et al.   FEBS LETTERS

LincRNA-Cox2 Promotes Late Inflammatory Gene Transcription in Macrophages through Modulating SWI/SNF-Mediated Chromatin Remodeling

(2016) Guoku Hu et al.   JOURNAL OF IMMUNOLOGY

LncPRESS1 Is a p53-Regulated LncRNA that Safeguards Pluripotency by Disrupting SIRT6-Mediated De-acetylation of Histone H3K56

(2016) Abhinav K. Jain et al.   MOLECULAR CELL

The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

(2016) Aifu Lin et al.   NATURE CELL BIOLOGY

An inducible long noncoding RNA amplifies DNA damage signaling

(2016) Adam M Schmitt et al.   NATURE GENETICS

EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome

(2016) Dejiu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NF-κB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer

(2016) A R Özeş et al.   ONCOGENE

Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer

(2016) Angel Diaz-Lagares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle

(2016) B. R. Nelson et al.   SCIENCE

Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis

(2016) R Singh et al.   Cell Death & Disease

Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment

(2016) Keisuke Katsushima et al.   Nature Communications

EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome

(2016) Dejiu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of androgen receptor splice variant AR3 by PCGEM1

(2016) Ziqiang Zhang et al.   Oncotarget

Long non-coding RNA BC087858 induces non-T790M mutation acquired resistance to EGFR-TKIs by activating PI3K/AKT and MEK/ERK pathways and EMT in non-small-cell lung cancer

(2016) Hui Pan et al.   Oncotarget

MYU, a Target lncRNA for Wnt/c-Myc Signaling, Mediates Induction of CDK6 to Promote Cell Cycle Progression

(2016) Yoshihiro Kawasaki et al.   Cell Reports

Long Intergenic Noncoding RNAs Mediate the Human Chondrocyte Inflammatory Response and Are Differentially Expressed in Osteoarthritis Cartilage

(2016) Mark J. Pearson et al.   Arthritis & Rheumatology

Modulation of Chromatin by Noncoding RNA

(2015) Victoria H. Meller et al.   Annual Review of Genetics

A Cytoplasmic NF-κB Interacting Long Noncoding RNA Blocks IκB Phosphorylation and Suppresses Breast Cancer Metastasis

(2015) Bodu Liu et al.   CANCER CELL

NF-κB: Regulation by Methylation

(2015) Tao Lu et al.   CANCER RESEARCH

Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205

(2015) H. Hirata et al.   CANCER RESEARCH

A Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance

(2015) Douglas M. Anderson et al.   CELL

Discovery and annotation of long noncoding RNAs

(2015) John S Mattick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Linc-RoR promotes c-Myc expression through hnRNP I and AUF1

(2015) Jianguo Huang et al.   NUCLEIC ACIDS RESEARCH

Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA

(2015) Nicolas Léveillé et al.   Nature Communications

Discovery and annotation of long noncoding RNAs

(2015) John S Mattick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute lymphoblastic leukemia

(2015) Yaping Wang et al.   Scientific Reports

Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs in Acute Leukemia

(2014) Thomas Trimarchi et al.   CELL

Intergenic lncRNAs and the evolution of gene expression

(2014) Ana C Marques et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

MicroRNAs in cancer: biomarkers, functions and therapy

(2014) Josie Hayes et al.   TRENDS IN MOLECULAR MEDICINE

MALAT1 promotes the proliferation and metastasis of osteosarcoma cells by activating the PI3K/Akt pathway

(2014) Yongqiang Dong et al.   TUMOR BIOLOGY

Role of the lncRNA-p53 regulatory network in cancer

(2014) A. Zhang et al.   Journal of Molecular Cell Biology

Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1)

(2014) J Huang et al.   Cell Death & Disease

p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes

(2014) Michal Krawczyk et al.   eLife

Direct Competition between hnRNP C and U2AF65 Protects the Transcriptome from the Exonization of Alu Elements

(2013) Kathi Zarnack et al.   CELL

lincRNAs: Genomics, Evolution, and Mechanisms

(2013) Igor Ulitsky et al.   CELL

Negative regulation of lncRNA GAS5 by miR-21

(2013) Z Zhang et al.   CELL DEATH AND DIFFERENTIATION

Acidic pH via NF-κB favours VEGF-C expression in human melanoma cells

(2013) Silvia Peppicelli et al.   CLINICAL & EXPERIMENTAL METASTASIS

Endogenous miRNA Sponge lincRNA-RoR Regulates Oct4, Nanog, and Sox2 in Human Embryonic Stem Cell Self-Renewal

(2013) Yue Wang et al.   DEVELOPMENTAL CELL

Long non-coding RNAs: new players in cell differentiation and development

(2013) Alessandro Fatica et al.   NATURE REVIEWS GENETICS

LncRNA loc285194 is a p53-regulated tumor suppressor

(2013) Qian Liu et al.   NUCLEIC ACIDS RESEARCH

Mammalian ncRNA-disease repository: a global view of ncRNA-mediated disease network

(2013) Y Wang et al.   Cell Death & Disease

A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics

(2013) Nicole A Rapicavoli et al.   eLife

Genome Regulation by Long Noncoding RNAs

(2012) John L. Rinn et al.   Annual Review of Biochemistry

The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage

(2012) Ali Zhang et al.   CELL RESEARCH

Long Non-Coding RNAs and p53 Regulation

(2012) Antonella Baldassarre et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LincRNA-p21 Suppresses Target mRNA Translation

(2012) Je-Hyun Yoon et al.   MOLECULAR CELL

eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription

(2012) Carlos A. Melo et al.   MOLECULAR CELL

Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat

(2012) Claudia Carrieri et al.   NATURE

The functional role of long non-coding RNA in human carcinomas

(2011) Ewan A Gibb et al.   Molecular Cancer

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression

(2011) John R Prensner et al.   NATURE BIOTECHNOLOGY

Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters

(2011) Tiffany Hung et al.   NATURE GENETICS

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

The Phosphoinositide 3-Kinase Regulatory Subunit p85  Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling

(2010) C. M. Taniguchi et al.   CANCER RESEARCH

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

Polypyrimidine tract binding protein regulates IRES-mediated translation of p53 isoforms

(2010) Richa Grover et al.   CELL CYCLE

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation

(2010) Vidisha Tripathi et al.   MOLECULAR CELL

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

(2010) M.-C. Tsai et al.   SCIENCE

Noncoding RNA Gas5 Is a Growth Arrest- and Starvation-Associated Repressor of the Glucocorticoid Receptor

(2010) T. Kino et al.   Science Signaling

Long non-coding RNAs: insights into functions

(2009) Tim R. Mercer et al.   NATURE REVIEWS GENETICS

p53 represses c-Myc through induction of the tumor suppressor miR-145

(2009) M. Sachdeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS