Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

(2021) Nicole E. Scharping et al.   NATURE IMMUNOLOGY

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

(2021) McLane J. Watson et al.   NATURE

Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes

(2020) Kevin K. Leung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ZipSeq: barcoding for real-time mapping of single cell transcriptomes

(2020) Kenneth H. Hu et al.   NATURE METHODS

CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape

(2020) Alba Rodriguez-Garcia et al.   Frontiers in Immunology

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

(2019) Yosuke Togashi et al.   Nature Reviews Clinical Oncology

Hypoxia-induced VISTA promotes the suppressive function of myeloid- derived suppressor cells in the tumor microenvironment

(2019) Jie Deng et al.   Cancer Immunology Research

L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling

(2019) Aleksandar Ivetic et al.   Frontiers in Immunology

Hypoxia-induced RelA/p65 derepresses SLC16A3 (MCT4) by downregulating ZBTB7A

(2019) Seo-Hyun Choi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Hypoxia drives glucose transporter 3 expression through HIF-mediated induction of the long non-coding RNA NICI

(2019) Victoria Lauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

(2019) Kathrin Renner et al.   Cell Reports

Activated Leukocyte Cell Adhesion Molecule Stimulates the T-Cell Response in Allergic Asthma

(2018) Mi Na Kim et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

CD39 is upregulated during activation of mouse and human T cells and attenuates the immune response to Listeria monocytogenes

(2018) Friederike Raczkowski et al.   PLoS One

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Equilibrative Nucleoside Transporter 3 Regulates T Cell Homeostasis by Coordinating Lysosomal Function with Nucleoside Availability

(2018) Chin-Wen Wei et al.   Cell Reports

Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

(2018) Alexander J Martinko et al.   eLife

Reprogramming human T cell function and specificity with non-viral genome targeting

(2018) Theodore L. Roth et al.   NATURE

Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression

(2018) Benjamin J. Schmiedel et al.   CELL

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome

(2018) Kevin K. Leung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell–Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses

(2017) Rachel E. O’Neill et al.   JOURNAL OF IMMUNOLOGY

The Skyline ecosystem: Informatics for quantitative mass spectrometry proteomics

(2017) Lindsay K. Pino et al.   MASS SPECTROMETRY REVIEWS

TIGIT: A Key Inhibitor of the Cancer Immunity Cycle

(2017) Nicholas A. Manieri et al.   TRENDS IN IMMUNOLOGY

Culturing CTLs under Hypoxic Conditions Enhances Their Cytolysis and Improves Their Anti-tumor Function

(2017) Yael Gropper et al.   Cell Reports

Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling

(2016) Haitao Wang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Hallmarks of glycosylation in cancer

(2016) Jennifer Munkley et al.   Oncotarget

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Starved and Asphyxiated: How Can CD8+ T Cells within a Tumor Microenvironment Prevent Tumor Progression

(2016) Ying Zhang et al.   Frontiers in Immunology

Hypoxia and antitumor CD8+ T cells: An incompatible alliance?

(2016) Romain Vuillefroy de Silly et al.   OncoImmunology

Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential

(2016) Jamal Qualai et al.   PLoS One

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

(2015) C. D. Madsen et al.   EMBO REPORTS

Phenotypic switch of CD8+T cells reactivated under hypoxia toward IL-10 secreting, poorly proliferative effector cells

(2015) Romain Vuillefroy de Silly et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunological mechanisms of the antitumor effects of supplemental oxygenation

(2015) Stephen M. Hatfield et al.   Science Translational Medicine

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Endothelial hypoxic metabolism in carcinogenesis and dissemination : HIF-A isoforms are a NO metastatic phenomenon

(2015) Cristina Branco-Price et al.   Oncotarget

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection

(2014) Stephen M. Hatfield et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen

(2013) Andrew L Doedens et al.   NATURE IMMUNOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

(2012) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Vasoactive intestinal peptide receptor 1 is downregulated during expansion of antigen-specific CD8 T cells following primary and secondary Listeria monocytogenes infections

(2011) Emilie E. Vomhof-DeKrey et al.   JOURNAL OF NEUROIMMUNOLOGY

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

(2009) M. Ahmadzadeh et al.   BLOOD

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins

(2009) Bernd Wollscheid et al.   NATURE BIOTECHNOLOGY

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE