CD39 is upregulated during activation of mouse and human T cells and attenuates the immune response to Listeria monocytogenes

P2X7 receptor drives Th1 cell differentiation and controls the follicular helper T cell population to protect against Plasmodium chabaudi malaria

(2017) Érika Machado de Salles et al.   PLoS Pathogens

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation

(2016) W. Danquah et al.   Science Translational Medicine

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

(2016) Mausita Karmakar et al.   Nature Communications

CD39 improves survival in microbial sepsis by attenuating systemic inflammation

(2015) Balázs Csóka et al.   FASEB JOURNAL

CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression

(2015) María Rosa Bono et al.   FEBS LETTERS

The expression of CD39 on regulatory T cells is genetically driven and further upregulated at sites of inflammation

(2015) Anne Rissiek et al.   JOURNAL OF AUTOIMMUNITY

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

(2015) Ivan D Mascanfroni et al.   NATURE MEDICINE

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells

(2015) Prakash K. Gupta et al.   PLoS Pathogens

Extracellular Adenosine Protects against Streptococcus pneumoniae Lung Infection by Regulating Pulmonary Neutrophil Recruitment

(2015) Elsa N. Bou Ghanem et al.   PLoS Pathogens

Correlation of Low CD73 Expression on Synovial Lymphocytes With Reduced Adenosine Generation and Higher Disease Severity in Juvenile Idiopathic Arthritis

(2015) Sophie Botta Gordon-Smith et al.   Arthritis & Rheumatology

P2X7 on Mouse T Cells: One Channel, Many Functions

(2015) Björn Rissiek et al.   Frontiers in Immunology

CD39 and CD161 Modulate Th17 Responses in Crohn's Disease

(2014) Aiping Bai et al.   JOURNAL OF IMMUNOLOGY

Intestinal immunopathology is associated with decreased CD73-generated adenosine during lethal infection

(2014) V Francois et al.   Mucosal Immunology

Characterization of Human CD39+ Th17 Cells with Suppressor Activity and Modulation in Inflammatory Bowel Disease

(2014) Maria Serena Longhi et al.   PLoS One

CD73 Is Dispensable for the Regulation of Inflationary CD8+ T-Cells after Murine Cytomegalovirus Infection and Adenovirus Immunisation

(2014) Stuart Sims et al.   PLoS One

Purinergic signalling and immune cells

(2014) Geoffrey Burnstock et al.   Purinergic Signalling

Ecto-5′-Nucleotidase (CD73) Regulates Host Inflammatory Responses and Exacerbates Murine Salmonellosis

(2014) M. Samiul Alam et al.   Scientific Reports

TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses

(2013) H. B. Cohen et al.   BLOOD

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

Decreased frequency of CD73+ CD8+ T cells of HIV-infected patients correlates with immune activation and T cell exhaustion

(2013) Ilona Tóth et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CD39 and CD73 in immunity and inflammation

(2013) Luca Antonioli et al.   TRENDS IN MOLECULAR MEDICINE

ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy

(2013) Yuting Ma et al.   OncoImmunology

Regulation of Lymphocyte Function by Adenosine

(2012) Joel Linden et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host disease

(2012) H. Tsukamoto et al.   BLOOD

CD73 is a phenotypic marker of effector memory Th17 cells in inflammatory bowel disease

(2012) Glen A. Doherty et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Stat3 and Gfi-1 Transcription Factors Control Th17 Cell Immunosuppressive Activity via the Regulation of Ectonucleotidase Expression

(2012) Fanny Chalmin et al.   IMMUNITY

Dendritic cells tolerized with adenosine A2AR agonist attenuate acute kidney injury

(2012) Li Li et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-6 Controls the Innate Immune Response against Listeria monocytogenes via Classical IL-6 Signaling

(2012) J. Hoge et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanism

(2011) M. E. Moreno-Fernandez et al.   BLOOD

Generation of anti-inflammatory adenosine byleukocytes is regulated by TGF-β

(2011) Frederico S. Regateiro et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors

(2011) U. Schenk et al.   Science Signaling

Expression of CD39 by Human Peripheral Blood CD4+CD25+ T Cells Denotes a Regulatory Memory Phenotype

(2010) K. M. Dwyer et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse

(2010) T. Woehrle et al.   BLOOD

NTPDase1 governs P2X7-dependent functions in murine macrophages

(2010) Sébastien A. Lévesque et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Extracellular NAD+shapes the Foxp3+regulatory T cell compartment through the ART2–P2X7 pathway

(2010) Sandra Hubert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ecto-5'-Nucleotidase (CD73) Attenuates Allograft Airway Rejection through Adenosine 2A Receptor Stimulation

(2010) T. Ohtsuka et al.   JOURNAL OF IMMUNOLOGY

Disordered Lymphoid Purine Metabolism Contributes to the Pathogenesis of Persistent Borrelia garinii Infection in Mice

(2010) G. G. Yegutkin et al.   JOURNAL OF IMMUNOLOGY

High Expression of the Ectonucleotidase CD39 on T Cells from the Inflamed Site Identifies Two Distinct Populations, One Regulatory and One Memory T Cell Population

(2010) H. Moncrieffe et al.   JOURNAL OF IMMUNOLOGY

Modulation of pulmonary vascular smooth muscle cell phenotype in hypoxia: role of cGMP-dependent protein kinase and myocardin

(2009) Weilin Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Isolated CD39 Expression on CD4+T Cells Denotes both Regulatory and Memory Populations

(2009) Q. Zhou et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression

(2009) Magis Mandapathil et al.   JOURNAL OF IMMUNOLOGICAL METHODS

The A2B Adenosine Receptor Impairs the Maturation and Immunogenicity of Dendritic Cells

(2009) J. M. Wilson et al.   JOURNAL OF IMMUNOLOGY

CD73 Is Expressed by Human Regulatory T Helper Cells and Suppresses Proinflammatory Cytokine Production andHelicobacter felis–Induced Gastritis in Mice

(2009) Mohammad S. Alam et al.   JOURNAL OF INFECTIOUS DISEASES

CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease

(2009) D. J. Friedman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ecto-5′ Nucleotidase (CD73)-Mediated Adenosine Generation and Signaling in Murine Cardiac Allograft Vasculopathy

(2008) Tomomi Hasegawa et al.   CIRCULATION RESEARCH

Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function

(2008) Balázs Csóka et al.   FASEB JOURNAL

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels

(2008) U. Schenk et al.   Science Signaling