CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape
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Title
CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape
Authors
Keywords
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Journal
Frontiers in Immunology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-06-17
DOI
10.3389/fimmu.2020.01109
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Note: Only part of the references are listed.- A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target
- (2020) Zachary T. Freeman et al. JOURNAL OF CLINICAL INVESTIGATION
- PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma
- (2020) Masaharu Kawashima et al. LEUKEMIA
- CRISPR-engineered T cells in patients with refractory cancer
- (2020) Edward A. Stadtmauer et al. SCIENCE
- Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist
- (2020) Giulia Parisi et al. Nature Communications
- Improved Antitumor Efficacy of Chimeric Antigen Receptor T Cells that Secrete Single-Domain Antibody Fragments
- (2020) Yushu Joy Xie et al. Cancer Immunology Research
- Human chimeric antigen receptor macrophages for cancer immunotherapy
- (2020) Michael Klichinsky et al. NATURE BIOTECHNOLOGY
- NK cells expressing a chimeric activating receptor eliminate MDSCs and rescue impaired CAR-T cell activity against solid tumors
- (2019) Robin Parihar et al. Cancer Immunology Research
- Collagen density regulates the activity of tumor-infiltrating T cells
- (2019) Dorota E. Kuczek et al. Journal for ImmunoTherapy of Cancer
- Engineering and Design of Chimeric Antigen Receptors
- (2019) Sonia Guedan et al. Molecular Therapy-Methods & Clinical Development
- Evaluating CAR-T Cell Therapy in a Hypoxic 3D Tumor Model
- (2019) Yuta Ando et al. Advanced Healthcare Materials
- Hypoxia induces rapid changes to histone methylation and reprograms chromatin
- (2019) Michael Batie et al. SCIENCE
- Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
- (2019) Abhishek A. Chakraborty et al. SCIENCE
- Regulatory T cells in cancer immunosuppression — implications for anticancer therapy
- (2019) Yosuke Togashi et al. Nature Reviews Clinical Oncology
- CD40 Ligand-Modified Chimeric Antigen Receptor T Cells Enhance Antitumor Function by Eliciting an Endogenous Antitumor Response
- (2019) Nicholas F. Kuhn et al. CANCER CELL
- CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer
- (2019) Laura M. McLane et al. Annual Review of Immunology
- 3D model for CAR‐mediated cytotoxicity using patient‐derived colorectal cancer organoids
- (2019) Theresa E Schnalzger et al. EMBO JOURNAL
- Chimeric antigen receptor T cell persistence and memory cell formation
- (2019) Alexander D McLellan et al. IMMUNOLOGY AND CELL BIOLOGY
- Regional delivery of mesothelin-targeted CAR T cells for pleural cancers: Safety and preliminary efficacy in combination with anti-PD-1 agent.
- (2019) Prasad S. Adusumilli et al. JOURNAL OF CLINICAL ONCOLOGY
- Armored Inducible Expression of IL-12 Enhances Antitumor Activity of Glypican-3–Targeted Chimeric Antigen Receptor–Engineered T Cells in Hepatocellular Carcinoma
- (2019) Ying Liu et al. JOURNAL OF IMMUNOLOGY
- Combined Antitumor Effects of Sorafenib and GPC3-CAR T Cells in Mouse Models of Hepatocellular Carcinoma
- (2019) Xiuqi Wu et al. MOLECULAR THERAPY
- Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice
- (2019) Yushu Joy Xie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia Selectively Impairs CAR-T Cells In Vitro
- (2019) Robert Berahovich et al. Cancers
- Combined Adjuvant of Poly I:C Improves Antitumor Effects of CAR-T Cells
- (2019) Shengmeng Di et al. Frontiers in Oncology
- Remodeling the Tumor Microenvironment Sensitizes Breast Tumors to Anti- Programmed Death-Ligand 1 Immunotherapy
- (2019) Renee Clift et al. CANCER RESEARCH
- Dissecting the Stromal Signaling and Regulation of Myeloid Cells and Memory Effector T Cells in Pancreatic Cancer
- (2019) Alex B. Blair et al. CLINICAL CANCER RESEARCH
- Targeting Hypoxia Downstream Signaling Protein, CAIX, for CAR-T Cell Therapy against Glioblastoma
- (2019) Jing Cui et al. NEURO-ONCOLOGY
- T cells engrafted with a UniCAR 28/z outperform UniCAR BB/z-transduced T cells in the face of regulatory T cell-mediated immunosuppression
- (2019) Alexandra Kegler et al. OncoImmunology
- Chimeric antigen receptor macrophage therapy for breast tumours mediated by targeting the tumour extracellular matrix
- (2019) Wenlong Zhang et al. BRITISH JOURNAL OF CANCER
- CAIX-specific CAR-T Cells and Sunitinib Show Synergistic Effects Against Metastatic Renal Cancer Models
- (2019) Huizhong Li et al. JOURNAL OF IMMUNOTHERAPY
- Clinical lessons learned from the first leg of the CAR T cell journey
- (2019) Robbie G. Majzner et al. NATURE MEDICINE
- PD-1 silencing impairs the anti-tumor function of chimeric antigen receptor modified T cells by inhibiting proliferation activity
- (2019) Jianshu Wei et al. Journal for ImmunoTherapy of Cancer
- MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancers
- (2019) Livingstone Fultang et al. EBioMedicine
- Combination Immunotherapy with CAR T Cells and Checkpoint Blockade for the Treatment of Solid Tumors
- (2019) Rachel Grosser et al. CANCER CELL
- Anti-BCMA CAR T-cell therapy in multiple myeloma: can we do better?
- (2019) Mattia D’Agostino et al. LEUKEMIA
- Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups
- (2019) Lawrence P. Andrews et al. NATURE IMMUNOLOGY
- Enterotoxins can support CAR T cells against solid tumors
- (2019) Bianca von Scheidt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanisms regulating PD-L1 expression on tumor and immune cells
- (2019) Shuming Chen et al. Journal for ImmunoTherapy of Cancer
- c-Jun overexpression in CAR T cells induces exhaustion resistance
- (2019) Rachel C. Lynn et al. NATURE
- Oncolytic Viruses as Antigen-Agnostic Cancer Vaccines
- (2018) Stephen J. Russell et al. CANCER CELL
- CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness
- (2018) Shicheng Su et al. CELL
- Aberrant Lck Signal via CD28 Costimulation Augments Antigen-Specific Functionality and Tumor Control by Redirected T Cells with PD-1 Blockade in Humanized Mice
- (2018) Pratiksha Gulati et al. CLINICAL CANCER RESEARCH
- A peek into cancer-associated fibroblasts: origins, functions and translational impact
- (2018) Valerie S. LeBleu et al. Disease Models & Mechanisms
- Regulation and Function of the PD-L1 Checkpoint
- (2018) Chong Sun et al. IMMUNITY
- HALO 202: Randomized Phase II Study of PEGPH20 Plus Nab-Paclitaxel/Gemcitabine Versus Nab-Paclitaxel/Gemcitabine in Patients With Untreated, Metastatic Pancreatic Ductal Adenocarcinoma
- (2018) Sunil R. Hingorani et al. JOURNAL OF CLINICAL ONCOLOGY
- A new method for tumor imaging by targeting cancer associated fibroblasts
- (2018) Anastasia Loktev et al. JOURNAL OF NUCLEAR MEDICINE
- CD28-ζ CAR T cells resist TGF-β repression through IL-2 signaling which can be mimicked by IL-7 and an engineered IL-7/IL-2Rβ autocrine loop
- (2018) Viktória Golumba-Nagy et al. MOLECULAR THERAPY
- ASGCT 21st Annual Meeting Abstracts
- (2018) MOLECULAR THERAPY
- Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication
- (2018) Christopher C. Kloss et al. MOLECULAR THERAPY
- Rewiring T-cell responses to soluble factors with chimeric antigen receptors
- (2018) ZeNan L Chang et al. Nature Chemical Biology
- The gut microbiota influences anticancer immunosurveillance and general health
- (2018) Bertrand Routy et al. Nature Reviews Clinical Oncology
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- (2018) Carl H. June et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2018) Dinesh K. Ahirwar et al. ONCOGENE
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- (2018) Ellen Puré et al. ONCOGENE
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- (2018) Elisa Peranzoni et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
- (2018) Jonathan T. Sockolosky et al. SCIENCE
- CAR T cell immunotherapy for human cancer
- (2018) Carl H. June et al. SCIENCE
- Cancer immunotherapy using checkpoint blockade
- (2018) Antoni Ribas et al. SCIENCE
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- (2018) Sujita Sukumaran et al. Cancer Discovery
- Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus–Driven Production of a Bispecific T-cell Engager
- (2018) Anna Wing et al. Cancer Immunology Research
- Mitochondrial Morphological and Functional Reprogramming Following CD137 (4-1BB) Costimulation
- (2018) Alvaro Teijeira et al. Cancer Immunology Research
- How to Hit Mesenchymal Stromal Cells and Make the Tumor Microenvironment Immunostimulant Rather Than Immunosuppressive
- (2018) Alessandro Poggi et al. Frontiers in Immunology
- CD19 CAR T Cells Expressing IL-12 Eradicate Lymphoma in Fully Lymphoreplete Mice through Induction of Host Immunity
- (2018) Gray Kueberuwa et al. Molecular Therapy-Oncolytics
- Targeting adenosine for cancer immunotherapy
- (2018) Robert D. Leone et al. Journal for ImmunoTherapy of Cancer
- Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
- (2018) Gang Chen et al. NATURE
- Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo
- (2018) Sarwish Rafiq et al. NATURE BIOTECHNOLOGY
- STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells
- (2018) Prajna Guha et al. ONCOGENE
- Tumor Antigen Escape from CAR T-cell Therapy
- (2018) Robbie G. Majzner et al. Cancer Discovery
- Emerging Cellular Therapies for Cancer
- (2018) Sonia Guedan et al. Annual Review of Immunology
- Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function
- (2018) Sarah L. Buchan et al. IMMUNITY
- Targeting macrophages: therapeutic approaches in cancer
- (2018) Luca Cassetta et al. NATURE REVIEWS DRUG DISCOVERY
- Turning foes to friends: targeting cancer-associated fibroblasts
- (2018) Xueman Chen et al. NATURE REVIEWS DRUG DISCOVERY
- Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology
- (2018) Keisuke Watanabe et al. Frontiers in Immunology
- CAR-T Cells and Oncolytic Viruses: Joining Forces to Overcome the Solid Tumor Challenge
- (2018) Sonia Guedan et al. Frontiers in Immunology
- The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity
- (2018) Valentina Poltavets et al. Frontiers in Oncology
- Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity
- (2017) Anthony T. Phan et al. IMMUNITY
- Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy
- (2017) Paul A. Beavis et al. JOURNAL OF CLINICAL INVESTIGATION
- CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma
- (2017) Andras Heczey et al. MOLECULAR THERAPY
- Tumour-associated macrophages as treatment targets in oncology
- (2017) Alberto Mantovani et al. Nature Reviews Clinical Oncology
- Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors
- (2017) Bertrand Routy et al. SCIENCE
- A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
- (2017) Donald M. O’Rourke et al. Science Translational Medicine
- Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells
- (2017) Marco Ruella et al. Cancer Discovery
- A versatile system for rapid multiplex genome-edited CAR T cell generation
- (2017) Jiangtao Ren et al. Oncotarget
- CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells
- (2017) Levi J. Rupp et al. Scientific Reports
- An oxygen sensitive self-decision making engineered CAR T-cell
- (2017) Alexandre Juillerat et al. Scientific Reports
- Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment
- (2017) Oladapo O. Yeku et al. Scientific Reports
- CAR T Cells Releasing IL-18 Convert to T-Bet high FoxO1 low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors
- (2017) Markus Chmielewski et al. Cell Reports
- CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells
- (2017) Yongping Zhang et al. Frontiers of Medicine
- CEACAM1 as a Multi-Purpose Target for Cancer Immunotherapy
- (2017) Matthew Dankner et al. OncoImmunology
- HER2-Specific Chimeric Antigen Receptor–Modified Virus-Specific T Cells for Progressive Glioblastoma
- (2017) Nabil Ahmed et al. JAMA Oncology
- Galectin 3 as a guardian of the tumor microenvironment
- (2016) Peter P. Ruvolo BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- PD-1 blockade modulates chimeric antigen receptor (CAR)–modified T cells: refueling the CAR
- (2016) Elise A. Chong et al. BLOOD
- Regional CAR-T cell infusions for peritoneal carcinomatosis are superior to systemic delivery
- (2016) S C Katz et al. CANCER GENE THERAPY
- A novel three-dimensional heterotypic spheroid model for the assessment of the activity of cancer immunotherapy agents
- (2016) Sylvia Herter et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors
- (2016) Xiaojun Liu et al. CANCER RESEARCH
- TALEN-Mediated Inactivation of PD-1 in Tumor-Reactive Lymphocytes Promotes Intratumoral T-cell Persistence and Rejection of Established Tumors
- (2016) Laurie Menger et al. CANCER RESEARCH
- A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo
- (2016) Christopher G. Hubert et al. CANCER RESEARCH
- Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche
- (2016) David Clever et al. CELL
- Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease and cancer
- (2016) R B Birge et al. CELL DEATH AND DIFFERENTIATION
- Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer
- (2016) S. R. Hingorani et al. CLINICAL CANCER RESEARCH
- Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition
- (2016) Jiangtao Ren et al. CLINICAL CANCER RESEARCH
- Carcinoma-associated fibroblasts: orchestrating the composition of malignancy
- (2016) Philippe Gascard et al. GENES & DEVELOPMENT
- Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
- (2016) Omkar U. Kawalekar et al. IMMUNITY
- Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition
- (2016) Leonid Cherkassky et al. JOURNAL OF CLINICAL INVESTIGATION
- Tumor Regression and Delayed Onset Toxicity Following B7-H4 CAR T Cell Therapy
- (2016) Jenessa B Smith et al. MOLECULAR THERAPY
- Feasibility and Safety of RNA-transfected CD20-specific Chimeric Antigen Receptor T Cells in Dogs with Spontaneous B Cell Lymphoma
- (2016) M Kazim Panjwani et al. MOLECULAR THERAPY
- S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
- (2016) Petros A. Tyrakis et al. NATURE
- Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy
- (2016) Christine E. Brown et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells
- (2016) Lenka V. Hurton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxic control of metastasis
- (2016) E. B. Rankin et al. SCIENCE
- Depletion of FAP+ cells reduces immunosuppressive cells and improves metabolism and functions CD8+T cells within tumors
- (2016) Ying Zhang et al. Oncotarget
- Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model
- (2016) Eloah Rabello Suarez et al. Oncotarget
- Reduction of MDSCs with All-trans Retinoic Acid Improves CAR Therapy Efficacy for Sarcomas
- (2016) A. H. Long et al. Cancer Immunology Research
- The Role of Myeloid-Derived Suppressor Cells in Patients with Solid Tumors: A Meta-Analysis
- (2016) Shuo Zhang et al. PLoS One
- Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T
- (2015) Rachel A. Burga et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma
- (2015) Elias J. Sayour et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells
- (2015) A. Lo et al. CANCER RESEARCH
- Plasticity beyond Cancer Cells and the “Immunosuppressive Switch”
- (2015) Zvi Granot et al. CANCER RESEARCH
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
- (2015) Chih-Hao Chang et al. CELL
- Targeting the tumor vasculature to enhance T cell activity
- (2015) Evripidis Lanitis et al. CURRENT OPINION IN IMMUNOLOGY
- Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected
- (2015) Douglas Marvel et al. JOURNAL OF CLINICAL INVESTIGATION
- Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer
- (2015) Kevin C. Conlon et al. JOURNAL OF CLINICAL ONCOLOGY
- Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+T cells
- (2015) Pamela M. Odorizzi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A phase I clinical trial of adoptive T cell therapy using IL-12 secreting MUC-16ecto directed chimeric antigen receptors for recurrent ovarian cancer
- (2015) Mythili Koneru et al. Journal of Translational Medicine
- Enhancing Antitumor Efficacy of Chimeric Antigen Receptor T Cells Through Constitutive CD40L Expression
- (2015) Kevin J Curran et al. MOLECULAR THERAPY
- Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
- (2015) Ignazio Caruana et al. NATURE MEDICINE
- 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
- (2015) Adrienne H Long et al. NATURE MEDICINE
- Vaccine-induced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site
- (2015) Maxime Thoreau et al. Oncotarget
- Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells
- (2015) T. Kouo et al. Cancer Immunology Research
- Generation of Potent T-cell Immunotherapy for Cancer Using DAP12-Based, Multichain, Chimeric Immunoreceptors
- (2015) E. Wang et al. Cancer Immunology Research
- IL-12 secreting tumor-targeted chimeric antigen receptor T cells eradicate ovarian tumorsin vivo
- (2015) Mythili Koneru et al. OncoImmunology
- FAP-specific re-directed T cells first in-man study in malignant pleural mesothelioma: experience of the first patient treated
- (2015) Magdalena Pircher et al. Journal for ImmunoTherapy of Cancer
- ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells
- (2014) S. Guedan et al. BLOOD
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
- (2014) Berna C. Özdemir et al. CANCER CELL
- Neutrophil:lymphocyte ratios and serum cytokine changes after hepatic artery chimeric antigen receptor-modified T-cell infusions for liver metastases
- (2014) A Saied et al. CANCER GENE THERAPY
- Safety and Efficacy of VCN-01, an Oncolytic Adenovirus Combining Fiber HSG-Binding Domain Replacement with RGD and Hyaluronidase Expression
- (2014) A. Rodriguez-Garcia et al. CLINICAL CANCER RESEARCH
- Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T cells in Solid Tumors
- (2014) E. K. Moon et al. CLINICAL CANCER RESEARCH
- HIF Transcription Factors, Inflammation, and Immunity
- (2014) Asis Palazon et al. IMMUNITY
- PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
- (2014) Muhammad Zaeem Noman et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Tumor-Associated Hyaluronan Limits Efficacy of Monoclonal Antibody Therapy
- (2014) N. C. Singha et al. MOLECULAR CANCER THERAPEUTICS
- PD-1 blockade induces responses by inhibiting adaptive immune resistance
- (2014) Paul C. Tumeh et al. NATURE
- Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells
- (2014) Debangshu Samanta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- T Cells Bearing a Chimeric Antigen Receptor against Prostate-Specific Membrane Antigen Mediate Vascular Disruption and Result in Tumor Regression
- (2014) S. P. Santoro et al. Cancer Immunology Research
- Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy
- (2013) S. Mok et al. CANCER RESEARCH
- HMGB1 in Cancer: Good, Bad, or Both?
- (2013) R. Kang et al. CLINICAL CANCER RESEARCH
- Interleukin-7 Mediates Selective Expansion of Tumor-redirected Cytotoxic T Lymphocytes (CTLs) without Enhancement of Regulatory T-cell Inhibition
- (2013) S. K. Perna et al. CLINICAL CANCER RESEARCH
- Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells
- (2013) L. B. John et al. CLINICAL CANCER RESEARCH
- Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment
- (2013) Thomas F Gajewski et al. CURRENT OPINION IN IMMUNOLOGY
- Specificity redirection by CAR with human VEGFR-1 affinity endows T lymphocytes with tumor-killing ability and anti-angiogenic potency
- (2013) W Wang et al. GENE THERAPY
- Clinical implications of fibroblast activation protein-α in non-small cell lung cancer after curative resection: a new predictor for prognosis
- (2013) Yida Liao et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia
- (2013) Edward W. Roberts et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia
- (2013) Eric Tran et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Expression of αvβ6 integrin and collagen fibre in oral squamous cell carcinoma: association with clinical outcomes and prognostic implications
- (2013) Hai-Xia Li et al. JOURNAL OF ORAL PATHOLOGY & MEDICINE
- Treatment of malignant pleural mesothelioma by fibroblast activation protein-specific re-directed T cells
- (2013) Petra C Schuberth et al. Journal of Translational Medicine
- Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma
- (2013) Sunitha Kakarla et al. MOLECULAR THERAPY
- Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
- (2013) Andrew L Doedens et al. NATURE IMMUNOLOGY
- Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
- (2013) C. Feig et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fueling Immunity: Insights into Metabolism and Lymphocyte Function
- (2013) E. L. Pearce et al. SCIENCE
- Immunomonitoring and prognostic relevance of neutrophils in clinical trials
- (2013) Frede Donskov SEMINARS IN CANCER BIOLOGY
- Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity
- (2013) L.-C. S. Wang et al. Cancer Immunology Research
- Tumour Hypoxia Affects the Responsiveness of Cancer Cells to Chemotherapy and Promotes Cancer Progression
- (2012) Jean-Philippe Cosse et al. Anti-Cancer Agents in Medicinal Chemistry
- Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
- (2012) H. J. Pegram et al. BLOOD
- Levels of peripheral CD4+FoxP3+ regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer
- (2012) X. Yao et al. BLOOD
- Re-directed T cells for the treatment of fibroblast activation protein (FAP)-positive malignant pleural mesothelioma (FAPME-1)
- (2012) Ulf Petrausch et al. BMC CANCER
- Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
- (2012) Paolo P. Provenzano et al. CANCER CELL
- Local Delivery of lnterleukin-12 Using T Cells Targeting VEGF Receptor-2 Eradicates Multiple Vascularized Tumors in Mice
- (2012) D. Chinnasamy et al. CLINICAL CANCER RESEARCH
- High tissue density of FOXP3+ T cells is associated with clinical outcome in prostate cancer
- (2012) Anna Flammiger et al. EUROPEAN JOURNAL OF CANCER
- IL-2 promotes the function of memory-like autoregulatory CD8+T cells but suppresses their development via FoxP3+Treg cells
- (2012) Afshin Shameli et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
- (2012) Michael A Jacobetz et al. GUT
- Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors
- (2012) Hélène Salmon et al. JOURNAL OF CLINICAL INVESTIGATION
- Chimeric Antigen Receptor T Cells Shape Myeloid Cell Function within the Tumor Microenvironment through IFN- and GM-CSF
- (2012) P. Spear et al. JOURNAL OF IMMUNOLOGY
- Combination of a Bispecific Antibody and Costimulatory Antibody-Ligand Fusion Proteins for Targeted Cancer Immunotherapy
- (2012) Nora Hornig et al. JOURNAL OF IMMUNOTHERAPY
- Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’
- (2012) Aron M. Levin et al. NATURE
- Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature
- (2012) Qiong-wen Zhang et al. PLoS One
- Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma
- (2011) Matthew W. Conklin et al. AMERICAN JOURNAL OF PATHOLOGY
- Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
- (2011) C. U. Louis et al. BLOOD
- Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
- (2011) R. J. Brentjens et al. BLOOD
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
- (2011) Wei Xu et al. CANCER CELL
- IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression
- (2011) M. Chmielewski et al. CANCER RESEARCH
- In vivo Inhibition of Human CD19-Targeted Effector T Cells by Natural T Regulatory Cells in a Xenotransplant Murine Model of B Cell Malignancy
- (2011) J. C. Lee et al. CANCER RESEARCH
- IL-15 and dendritic cells induce proliferation of CD4+CD25+ regulatory T cells from peripheral blood
- (2011) Shuxiong Xu et al. IMMUNOLOGY LETTERS
- CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients
- (2011) Barbara Savoldo et al. JOURNAL OF CLINICAL INVESTIGATION
- CD28 Costimulation Impairs the Efficacy of a Redirected T-cell Antitumor Attack in the Presence of Regulatory T cells Which Can Be Overcome by Preventing Lck Activation
- (2011) David M Kofler et al. MOLECULAR THERAPY
- Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
- (2011) Andrea Facciabene et al. NATURE
- CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans
- (2011) G. L. Beatty et al. SCIENCE
- Immune responses to transgene and retroviral vector in patients treated with ex vivo-engineered T cells
- (2010) C. H. J. Lamers et al. BLOOD
- Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice
- (2010) Dhanalakshmi Chinnasamy et al. JOURNAL OF CLINICAL INVESTIGATION
- T Cell/Transmembrane, Ig, and Mucin-3 Allelic Variants Differentially Recognize Phosphatidylserine and Mediate Phagocytosis of Apoptotic Cells
- (2010) Rosemarie H. DeKruyff et al. JOURNAL OF IMMUNOLOGY
- Hyaluronidase Expression by an Oncolytic Adenovirus Enhances Its Intratumoral Spread and Suppresses Tumor Growth
- (2010) Sonia Guedan et al. MOLECULAR THERAPY
- Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein-
- (2010) M. Kraman et al. SCIENCE
- Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
- (2009) Zvi G. Fridlender et al. CANCER CELL
- VEGFR2 is selectively expressed by FOXP3high CD4+ Treg
- (2009) Hiroyuki Suzuki et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Fibroblast Activation Protein and Its Relationship to Clinical Outcome in Pancreatic Adenocarcinoma
- (2009) Steven J. Cohen et al. PANCREAS
- Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
- (2008) B. G. Till et al. BLOOD
- Hypoxia and Aggressive Tumor Phenotype: Implications for Therapy and Prognosis
- (2008) P. Vaupel ONCOLOGIST
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