Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

Drugging RAS: Know the enemy

(2017) Bjoern Papke et al.   SCIENCE

A proposal for validation of antibodies

(2016) Mathias Uhlen et al.   NATURE METHODS

CDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer

(2016) H J Wright et al.   ONCOGENE

Comparative proteomics of a model MCF10A-KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface

(2016) Xiaoying Ye et al.   Oncotarget

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

(2016) Max A Horlbeck et al.   eLife

Antibody Drug Conjugates: Preclinical Considerations

(2015) Gadi G. Bornstein   AAPS Journal

K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling

(2015) Man-Tzu Wang et al.   CELL

Blinatumomab: a bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia

(2015) Jingjing Wu et al.   Journal of Hematology & Oncology

A High Through-put Platform for Recombinant Antibodies to Folded Proteins

(2015) Michael Hornsby et al.   MOLECULAR & CELLULAR PROTEOMICS

Reproducibility crisis: Blame it on the antibodies

(2015) Monya Baker   NATURE

Cancer: The Ras renaissance

(2015) Heidi Ledford   NATURE

CUB-domain-containing protein 1 overexpression in solid cancers promotes cancer cell growth by activating Src family kinases

(2015) C Leroy et al.   ONCOGENE

Comparative analysis of KRAS codon 12, 13, 18, 61 and 117 mutations using human MCF10A isogenic cell lines

(2015) Britta Stolze et al.   Scientific Reports

Oncogenic KRAS signalling in pancreatic cancer

(2014) S Eser et al.   BRITISH JOURNAL OF CANCER

Dragging Ras Back in the Ring

(2014) Andrew G. Stephen et al.   CANCER CELL

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

(2014) Luke A. Gilbert et al.   CELL

Oncogenic Ras/ERK Signaling Activates CDCP1 to Promote Tumor Invasion and Metastasis

(2014) Takamasa Uekita et al.   MOLECULAR CANCER RESEARCH

Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map

(2014) Maria M. Martins et al.   Cancer Discovery

Prognostic significance of aberrantly silenced ANPEP expression in prostate cancer

(2013) K D Sørensen et al.   BRITISH JOURNAL OF CANCER

Targeting AKT with the allosteric AKT inhibitor MK-2206 in non-small cell lung cancer cells with acquired resistance to cetuximab

(2013) Mari Iida et al.   CANCER BIOLOGY & THERAPY

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

(2013) Luke A. Gilbert et al.   CELL

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells

(2013) M. Kampmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global cellular response to chemotherapy-induced apoptosis

(2013) Arun P Wiita et al.   eLife

Fc-fusion proteins: new developments and future perspectives

(2012) Daniel M. Czajkowsky et al.   EMBO Molecular Medicine

CDR-H3 Diversity Is Not Required for Antigen Recognition by Synthetic Antibodies

(2012) Helena Persson et al.   JOURNAL OF MOLECULAR BIOLOGY

In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated β1 integrin and induction of FAK/PI3K/Akt motility signaling

(2012) B Casar et al.   ONCOGENE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

Integrins in Cell Migration

(2011) A. Huttenlocher et al.   Cold Spring Harbor Perspectives in Biology

MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo

(2010) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

Defining the transcriptome and proteome in three functionally different human cell lines

(2010) Emma Lundberg et al.   Molecular Systems Biology

A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival

(2009) Anurag Singh et al.   CANCER CELL

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins

(2009) Bernd Wollscheid et al.   NATURE BIOTECHNOLOGY

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

(2008) Stephen D. Barrett et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Expression of CUB domain containing protein (CDCP1) is correlated with prognosis and survival of patients with adenocarcinoma of lung

(2008) Jun-ichiro Ikeda et al.   CANCER SCIENCE

Analysis of Cell Surface Proteome Changes via Label-free, Quantitative Mass Spectrometry

(2008) Ralph Schiess et al.   MOLECULAR & CELLULAR PROTEOMICS