The good, the bad and the ugly: the impact of extracellular vesicles on the cardiovascular system

Tissue differences in the exosomal/small extracellular vesicle proteome and their potential as indicators of altered tissue metabolism

(2022) Ruben Garcia-Martin et al.   Cell Reports

Donor specific phenotypic variation in hiPSC cardiomyocyte-derived exosomes impacts endothelial cell function

(2021) Amy Turner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardioprotection by remote ischemic conditioning is transferable by plasma and mediated by extracellular vesicles

(2021) Thomas Ravn Lassen et al.   BASIC RESEARCH IN CARDIOLOGY

Pathophysiology of heart failure

(2021) Robert H. G. Schwinger   Cardiovascular Diagnosis and Therapy

Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases

(2021) Susmita Sahoo et al.   CIRCULATION

Extracellular Vesicles from Epicardial Fat Facilitate Atrial Fibrillation

(2021) Olga Shaihov-Teper et al.   CIRCULATION

Myofibroblast-Derived Exosome Induce Cardiac Endothelial Cell Dysfunction

(2021) Prabhat Ranjan et al.   Frontiers in Cardiovascular Medicine

Intracellular and exosomal microRNAome profiling of human vascular smooth muscle cells during replicative senescence

(2021) Diem Duong Ngoc Nguyen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

In Vivo Characterization of Endogenous Cardiovascular Extracellular Vesicles in Larval and Adult Zebrafish

(2021) Aaron Scott et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes

(2021) Clair Crewe et al.   Cell Metabolism

Myocardial hypoxic stress mediates functional cardiac extracellular vesicle release

(2021) Achille Anselmo et al.   EUROPEAN HEART JOURNAL

Downregulation of microRNA-21-5p from macrophages-derived exosomes represses ventricular remodeling after myocardial infarction via inhibiting tissue inhibitors of metalloproteinase 3

(2021) Jing Dong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

M2 macrophage-derived exosomes carry miR-1271-5p to alleviate cardiac injury in acute myocardial infarction through down-regulating SOX6

(2021) Rui Long et al.   MOLECULAR IMMUNOLOGY

Connecting different heart diseases through intercellular communication

(2021) Tania Martins-Marques   Biology Open

Angiotensin II-Treated Cardiac Myocytes Regulate M1 Macrophage Polarization via Transferring Exosomal PVT1

(2021) Feng Cao et al.   Journal of Immunology Research

Perivascular Adipose-Derived Exosomes Reduce Foam Cell Formation by Regulating Expression of Cholesterol Transporters

(2021) Yan Liu et al.   Frontiers in Cardiovascular Medicine

Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury

(2021) Connor G. O’Brien et al.   JACC: CardioOncology

Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured Heart

(2021) Mallikarjun Patil et al.   CIRCULATION RESEARCH

Telocytes in the human ascending aorta: Characterization and exosome‐related KLF‐4/VEGF‐A expression

(2021) Thomas Aschacher et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Subcellular Localization of Connexin 26 in Cardiomyocytes and in Cardiomyocyte-Derived Extracellular Vesicles

(2021) Alessandra Falleni et al.   MOLECULES

Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo

(2021) Victoria James et al.   STEM CELLS AND DEVELOPMENT

CircNPHP4 in monocyte-derived small extracellular vesicles controls heterogeneous adhesion in coronary heart atherosclerotic disease

(2021) Feng Xiong et al.   Cell Death & Disease

Factor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease

(2021) Sarah Irmscher et al.   Scientific Reports

SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart

(2021) Nedyalka Valkov et al.   Life Science Alliance

Exosomes isolated from the plasma of remote ischemic conditioning rats improved cardiac function and angiogenesis after myocardial infarction through targeting Hsp70

(2020) Qin Chen et al.   Aging-US

Donor MSCs release apoptotic bodies to improve myocardial infarction via autophagy regulation in recipient cells

(2020) Huan Liu et al.   Autophagy

M2 macrophage-derived exosomes carry microRNA-148a to alleviate myocardial ischemia/reperfusion injury via inhibiting TXNIP and the TLR4/NF-κB/NLRP3 inflammasome signaling pathway

(2020) Yuxiang Dai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiomyocyte‐derived exosomal microRNA‐92a mediates post‐ischemic myofibroblast activation both in vitro and ex vivo

(2020) Xujun Wang et al.   ESC Heart Failure

Activated CD4+ T cells-derived exosomal miR-142-3p boosts post-ischemic ventricular remodeling by activating myofibroblast

(2020) Lidong Cai et al.   Aging-US

Myofibroblast-Derived Exosomes Contribute to Development of a Susceptible Substrate for Atrial Fibrillation

(2020) Shichao Li et al.   CARDIOLOGY

Extracellular vesicular MicroRNA-27a* contributes to cardiac hypertrophy in chronic heart failure

(2020) Changhai Tian et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sacubitril/Valsartan Improves Cardiac Function and Decreases Myocardial Fibrosis Via Downregulation of Exosomal miR‐181a in a Rodent Chronic Myocardial Infarction Model

(2020) Evgeniya Vaskova et al.   Journal of the American Heart Association

Serum Exosomal MicroRNA-21, MicroRNA-126, and PTEN Are Novel Biomarkers for Diagnosis of Acute Coronary Syndrome

(2020) Hao Ling et al.   Frontiers in Physiology

Expression level and diagnostic value of exosomal NEAT1 / miR ‐204/ MMP ‐9 in acute ST ‐segment elevation myocardial infarction

(2020) Zhenzhen Chen et al.   IUBMB LIFE

Rab27a deletion impairs the therapeutic potential of endothelial progenitor cells for myocardial infarction

(2020) Wenyi Zhou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip

(2020) Moran Yadid et al.   Science Translational Medicine

Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes

(2020) Tania Martins-Marques et al.   Life Science Alliance

Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019

(2020) Gregory A. Roth et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia

(2020) Tania Martins-Marques et al.   TRENDS IN MOLECULAR MEDICINE

Atherosclerotic Conditions Promote the Packaging of Functional MicroRNA-92a-3p into Endothelial Microvesicles

(2019) Yangyang Liu et al.   CIRCULATION RESEARCH

Circulating MiR-17-5p, MiR-126-5p and MiR-145-3p Are Novel Biomarkers for Diagnosis of Acute Myocardial Infarction

(2019) Sheng Xue et al.   Frontiers in Physiology

Exosomal Expression of CXCR4 Targets Cardioprotective Vesicles to Myocardial Infarction and Improves Outcome after Systemic Administration

(2019) Alessandra Ciullo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization

(2019) Jinxuan Zhao et al.   CARDIOVASCULAR RESEARCH

Exosomal MALAT1 derived from ox-LDL-treated endothelial cells induce neutrophil extracellular traps to aggravate atherosclerosis

(2019) Hailai Gao et al.   BIOLOGICAL CHEMISTRY

Circulating exosomes deliver free fatty acids from the bloodstream to cardiac cells: Possible role of CD36

(2019) N. A. Garcia et al.   PLoS One

Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes

(2019) Morayma M Temoche-Diaz et al.   eLife

Long noncoding RNA-enriched vesicles secreted by hypoxic cardiomyocytes drive cardiac fibrosis

(2019) Franziska Kenneweg et al.   Molecular Therapy-Nucleic Acids

LncRNA NRON alleviates atrial fibrosis through suppression of M1 macrophages activated by atrial myocytes

(2019) Fei Sun et al.   BIOSCIENCE REPORTS

The Contrasting Role of Extracellular Vesicles in Vascular Inflammation and Tissue Repair

(2019) Silvia Oggero et al.   Frontiers in Pharmacology

Myocardial infarction-induced microRNA-enriched exosomes contribute to cardiac Nrf2 dysregulation in chronic heart failure

(2018) Changhai Tian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Intra-Cardiac Release of Extracellular Vesicles Shapes Inflammation Following Myocardial InfarctionNovelty and Significance

(2018) Xavier Loyer et al.   CIRCULATION RESEARCH

Acellular therapeutic approach for heart failure: in vitro production of extracellular vesicles from human cardiovascular progenitors

(2018) Nadia El Harane et al.   EUROPEAN HEART JOURNAL

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide

(2018) Adam Vandergriff et al.   Theranostics

miR-217 Promotes Cardiac Hypertrophy and Dysfunction by Targeting PTEN

(2018) Xiang Nie et al.   Molecular Therapy-Nucleic Acids

miR-146a Suppresses SUMO1 Expression and Induces Cardiac Dysfunction in Maladaptive Hypertrophy

(2018) Jae Gyun Oh et al.   CIRCULATION RESEARCH

Selective increase of cardiomyocyte derived extracellular vesicles after experimental myocardial infarction and functional effects on the endothelium

(2018) Jose A. Rodriguez et al.   THROMBOSIS RESEARCH

Endothelial cells release cardioprotective exosomes that may contribute to ischaemic preconditioning

(2018) Sean M. Davidson et al.   Scientific Reports

Engineered Exosomes With Ischemic Myocardium‐Targeting Peptide for Targeted Therapy in Myocardial Infarction

(2018) Xu Wang et al.   Journal of the American Heart Association

Ischaemia alters the effects of cardiomyocyte-derived extracellular vesicles on macrophage activation

(2018) Rafael Almeida Paiva et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure

(2018) Seitaro Nomura et al.   Nature Communications

Macrophage-Derived mir-155-Containing Exosomes Suppress Fibroblast Proliferation and Promote Fibroblast Inflammation during Cardiac Injury

(2017) Chunxiao Wang et al.   MOLECULAR THERAPY

MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression

(2017) Yun Teng et al.   Nature Communications

Extracellular Vesicles Secreted by Atherogenic Macrophages Transfer MicroRNA to Inhibit Cell Migration

(2017) My-Anh Nguyen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Circulating miR-155, miR-145 and let-7c as diagnostic biomarkers of the coronary artery disease

(2017) Julien Faccini et al.   Scientific Reports

Reversible HuR‐microRNA binding controls extracellular export of miR‐122 and augments stress response

(2016) Kamalika Mukherjee et al.   EMBO REPORTS

Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure

(2016) Rosalinda Madonna et al.   EUROPEAN HEART JOURNAL

Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4

(2016) J Xiao et al.   Cell Death & Disease

Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury

(2016) Janine C. Deddens et al.   Journal of Cardiovascular Translational Research

The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting

(2016) Laura Santangelo et al.   Cell Reports

Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs

(2015) M.-S. Njock et al.   BLOOD

Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes

(2015) Nahuel A. Garcia et al.   CARDIOVASCULAR RESEARCH

Revisiting Cardiac Cellular CompositionNovelty and Significance

(2015) Alexander R. Pinto et al.   CIRCULATION RESEARCH

Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury

(2015) Jose M. Vicencio et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

(2015) Ana Rosa Soares et al.   Scientific Reports

Cardiac macrophages and their role in ischaemic heart disease

(2014) Stefan Frantz et al.   CARDIOVASCULAR RESEARCH

Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction

(2014) L. Barile et al.   CARDIOVASCULAR RESEARCH

CD4 + T Cells Promote the Transition From Hypertrophy to Heart Failure During Chronic Pressure Overload

(2014) Fanny Laroumanie et al.   CIRCULATION

Association of circulating endothelial microparticles with cardiometabolic risk factors in the Framingham Heart Study

(2014) Nicolas Amabile et al.   EUROPEAN HEART JOURNAL

Cardiac fibroblast–derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

(2014) Claudia Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA Expression in Circulating Microvesicles Predicts Cardiovascular Events in Patients With Coronary Artery Disease

(2014) Felix Jansen et al.   Journal of the American Heart Association

Circulating p53-Responsive MicroRNAs Are Predictive Indicators of Heart Failure After Acute Myocardial Infarction

(2013) Sen Matsumoto et al.   CIRCULATION RESEARCH

Mutation of SIMPLE in Charcot–Marie–Tooth 1C alters production of exosomes

(2013) Hong Zhu et al.   MOLECULAR BIOLOGY OF THE CELL

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage

(2011) Yasuhide Kuwabara et al.   Circulation-Cardiovascular Genetics

Microautophagy of Cytosolic Proteins by Late Endosomes

(2011) Ranjit Sahu et al.   DEVELOPMENTAL CELL

Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation

(2010) I. Nazarenko et al.   CANCER RESEARCH

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

(2009) A. Zernecke et al.   Science Signaling

MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell-Induced Exosomes Via Distinct Multivesicular Body Pathways

(2009) Sonja I. Buschow et al.   TRAFFIC

Nedd4 Family-interacting Protein 1 (Ndfip1) Is Required for the Exosomal Secretion of Nedd4 Family Proteins

(2008) Ulrich Putz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY