Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia

Exosomes isolated from the plasma of remote ischemic conditioning rats improved cardiac function and angiogenesis after myocardial infarction through targeting Hsp70

(2020) Qin Chen et al.   Aging-US

Prevention of connexin-43 remodeling protects against Duchenne muscular dystrophy cardiomyopathy

(2020) Eric Himelman et al.   JOURNAL OF CLINICAL INVESTIGATION

Heart-on-a-chip Model with Integrated Extra- and Intra-cellular Bioelectronics for Monitoring Cardiac Electrophysiology under Acute Hypoxia

(2020) Haitao Liu et al.   NANO LETTERS

Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function

(2020) Li Wang et al.   NATURE CELL BIOLOGY

Potential of mesenchymal- and cardiac progenitor cells for therapeutic targeting of B-cells and antibody responses in end-stage heart failure

(2020) Patricia van den Hoogen et al.   PLoS One

Ventricular fibrillation mechanism and global fibrillatory organisation are determined by gap junction coupling and fibrosis pattern

(2020) Balvinder S Handa et al.   CARDIOVASCULAR RESEARCH

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

(2020) Elisa Giacomelli et al.   Cell Stem Cell

EHD1 Modulates Cx43 Gap Junction Remodeling Associated With Cardiac Diseases

(2020) Tania Martins-Marques et al.   CIRCULATION RESEARCH

ATP- and voltage-dependent electro-metabolic signaling regulates blood flow in heart

(2020) Guiling Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis

(2020) Qiang Wu et al.   Cell Death & Disease

Extracellular vesicles derived from microRNA-150-5p-overexpressing mesenchymal stem cells protect rat hearts against ischemia/reperfusion

(2020) Hesheng Ou et al.   Aging-US

Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias

(2020) Shaohua Xiao et al.   JOURNAL OF CLINICAL INVESTIGATION

In vitro controlled release of extracellular vesicles for cardiac repair from poly(glycerol sebacate) acrylate-based polymers

(2020) Thomas Hamada et al.   Acta Biomaterialia

Adrenomedullin Induces Cardiac Lymphangiogenesis After Myocardial Infarction and Regulates Cardiac Edema Via Connexin 43

(2019) Claire E. Trincot et al.   CIRCULATION RESEARCH

Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway

(2019) Richard J. Mills et al.   Cell Stem Cell

Disruption of Ca 2+ i Homeostasis and Cx43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in PKP2-Deficient Mice

(2019) Joon-Chul Kim et al.   CIRCULATION

Biological Functions of Connexin43 Beyond Intercellular Communication

(2019) Tania Martins-Marques et al.   TRENDS IN CELL BIOLOGY

Properties of cardiac conduction in a cell-based computational model

(2019) Karoline Horgmo Jæger et al.   PLoS Computational Biology

Connexin 43 dephosphorylation contributes to arrhythmias and cardiomyocyte apoptosis in ischemia/reperfusion hearts

(2019) Jingyi Xue et al.   BASIC RESEARCH IN CARDIOLOGY

Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial

(2019) Derek J Hausenloy et al.   LANCET

Injectable Supramolecular Ureidopyrimidinone Hydrogels Provide Sustained Release of Extracellular Vesicle Therapeutics

(2019) Emma A. Mol et al.   Advanced Healthcare Materials

Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia‐Reperfusion Injury

(2019) Jingbo Jiang et al.   Journal of the American Heart Association

Endothelial cell nanotube insertions into cardiac and skeletal myocytes during coordinated tissue development

(2019) Yuho Kim et al.   CARDIOVASCULAR RESEARCH

A rule-based method for predicting the electrical activation of the heart with cardiac resynchronization therapy from non-invasive clinical data

(2019) A.W.C. Lee et al.   MEDICAL IMAGE ANALYSIS

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock

(2019) Tinneke Delvaeye et al.   Scientific Reports

RyR2 regulates Cx43 hemichannel intracellular Ca2+-dependent activation in cardiomyocytes

(2019) Alessio Lissoni et al.   CARDIOVASCULAR RESEARCH

Cardioprotection by cardiac progenitor cell-secreted exosomes: role of pregnancy-associated plasma protein-A

(2018) Lucio Barile et al.   CARDIOVASCULAR RESEARCH

Intra-Cardiac Release of Extracellular Vesicles Shapes Inflammation Following Myocardial InfarctionNovelty and Significance

(2018) Xavier Loyer et al.   CIRCULATION RESEARCH

Danegaptide for primary percutaneous coronary intervention in acute myocardial infarction patients: a phase 2 randomised clinical trial

(2018) Thomas Engstrøm et al.   HEART

Role of Non-Myocyte Gap Junctions and Connexin Hemichannels in Cardiovascular Health and Disease: Novel Therapeutic Targets?

(2018) Robert Johnson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Plasma exosomes induced by remote ischaemic preconditioning attenuate myocardial ischaemia/reperfusion injury by transferring miR-24

(2018) Wen Minghua et al.   Cell Death & Disease

Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling

(2018) Wilhelm Roell et al.   Scientific Reports

An Update on in Vivo Imaging of Extracellular Vesicles as Drug Delivery Vehicles

(2018) Prakash Gangadaran et al.   Frontiers in Pharmacology

Exosomes/microvesicles microRNA-423-3p derived from cardiac fibroblasts mediates the cardioprotective effects of ischemic postconditioning

(2018) Hui Luo et al.   CARDIOVASCULAR RESEARCH

Fourth universal definition of myocardial infarction (2018)

(2018) Kristian Thygesen et al.   EUROPEAN HEART JOURNAL

Endothelial cells release cardioprotective exosomes that may contribute to ischaemic preconditioning

(2018) Sean M. Davidson et al.   Scientific Reports

The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation

(2018) Rengasayee Veeraraghavan et al.   eLife

Engineered Exosomes With Ischemic Myocardium‐Targeting Peptide for Targeted Therapy in Myocardial Infarction

(2018) Xu Wang et al.   Journal of the American Heart Association

Circulating blood cells and extracellular vesicles in acute cardioprotection

(2018) Sean M Davidson et al.   CARDIOVASCULAR RESEARCH

Ischaemia alters the effects of cardiomyocyte-derived extracellular vesicles on macrophage activation

(2018) Rafael Almeida Paiva et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Therapeutic Targeting of Connexin Channels: New Views and Challenges

(2018) Tinneke Delvaeye et al.   TRENDS IN MOLECULAR MEDICINE

Cardiac Progenitor Cell–Derived Extracellular Vesicles Reduce Infarct Size and Associate with Increased Cardiovascular Cell Proliferation

(2018) Janita A. Maring et al.   Journal of Cardiovascular Translational Research

Long non-coding RNA CCRR controls cardiac conduction via regulating intercellular coupling

(2018) Yong Zhang et al.   Nature Communications

Role of connexin 43 in different forms of intercellular communication – gap junctions, extracellular vesicles and tunnelling nanotubes

(2017) Teresa M. Ribeiro-Rodrigues et al.   JOURNAL OF CELL SCIENCE

Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by the use of non-diabetic exosomes in vitro

(2017) Sean M. Davidson et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A Multicenter Randomized Controlled Trial Evaluating a Cx43-Mimetic Peptide in Cutaneous Scarring

(2017) Christina L. Grek et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Macrophage-Derived mir-155-Containing Exosomes Suppress Fibroblast Proliferation and Promote Fibroblast Inflammation during Cardiac Injury

(2017) Chunxiao Wang et al.   MOLECULAR THERAPY

Higher functionality of extracellular vesicles isolated using size-exclusion chromatography compared to ultracentrifugation

(2017) Emma A. Mol et al.   Nanomedicine-Nanotechnology Biology and Medicine

High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling

(2017) Robert S. Stephenson et al.   Scientific Reports

Rotigaptide protects the myocardium and arterial vasculature from ischaemia reperfusion injury

(2016) Christian M. Pedersen et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

At the cross-point of connexins, calcium, and ATP: blocking hemichannels inhibits vasoconstriction of rat small mesenteric arteries

(2016) Mélissa Bol et al.   CARDIOVASCULAR RESEARCH

Macrophage-derived exosomes induce inflammatory factors in endothelial cells under hypertensive conditions

(2016) Mayuko Osada-Oka et al.   HYPERTENSION RESEARCH

Exosomal transfer of miR-30a between cardiomyocytes regulates autophagy after hypoxia

(2016) Yan Yang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Electrotonic coupling of excitable and nonexcitable cells in the heart revealed by optogenetics

(2016) T. Alexander Quinn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury

(2016) Janine C. Deddens et al.   Journal of Cardiovascular Translational Research

Connexin43 contributes to electrotonic conduction across scar tissue in the intact heart

(2016) Vanessa M. Mahoney et al.   Scientific Reports

Sustained Release of Cx43 Antisense Oligodeoxynucleotides from Coated Collagen Scaffolds Promotes Wound Healing

(2016) Daniel J. Gilmartin et al.   Advanced Healthcare Materials

Exosomes from Cardiomyocyte Progenitor Cells and Mesenchymal Stem Cells Stimulate Angiogenesis Via EMMPRIN

(2016) Krijn R. Vrijsen et al.   Advanced Healthcare Materials

Macrophage Foam Cell–Derived Extracellular Vesicles Promote Vascular Smooth Muscle Cell Migration and Adhesion

(2016) Chenguang Niu et al.   Journal of the American Heart Association

iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy

(2016) Yuelin Zhang et al.   Stem Cell Reports

Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes

(2015) Tania Martins-Marques et al.   BIOCHEMICAL JOURNAL

To beat or not to beat: degradation of Cx43 imposes the heart rhythm: Figure 1

(2015) Tânia Martins-Marques et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

H9c2 and HL-1 cells demonstrate distinct features of energy metabolism, mitochondrial function and sensitivity to hypoxia-reoxygenation

(2015) Andrey V. Kuznetsov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs

(2015) Tânia Martins-Marques et al.   BIOCHIMIE

Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes

(2015) Nahuel A. Garcia et al.   CARDIOVASCULAR RESEARCH

Revisiting Cardiac Cellular CompositionNovelty and Significance

(2015) Alexander R. Pinto et al.   CIRCULATION RESEARCH

Repeated remote ischemic conditioning attenuates left ventricular remodeling via exosome-mediated intercellular communication on chronic heart failure after myocardial infarction

(2015) Takehiro Yamaguchi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Effect of a Connexin43-Based Peptide on the Healing of Chronic Venous Leg Ulcers: A Multicenter, Randomized Trial

(2015) Gautam S. Ghatnekar et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury

(2015) Jose M. Vicencio et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Glucose Starvation in Cardiomyocytes Enhances Exosome Secretion and Promotes Angiogenesis in Endothelial Cells

(2015) Nahuel A. Garcia et al.   PLoS One

Optogenetic determination of the myocardial requirements for extrasystoles by cell type-specific targeting of ChannelRhodopsin-2

(2015) Tania Zaglia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Topical administration of a connexin43-based peptide augments healing of chronic neuropathic diabetic foot ulcers: A multicenter, randomized trial

(2015) Christina L. Grek et al.   WOUND REPAIR AND REGENERATION

Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

(2015) Ana Rosa Soares et al.   Scientific Reports

Endothelial Cx40 limits myocardial ischaemia/reperfusion injury in mice

(2014) Sandrine Morel et al.   CARDIOVASCULAR RESEARCH

Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc

(2014) Esperanza Agullo-Pascual et al.   CARDIOVASCULAR RESEARCH

Association of circulating endothelial microparticles with cardiometabolic risk factors in the Framingham Heart Study

(2014) Nicolas Amabile et al.   EUROPEAN HEART JOURNAL

Cardiac fibroblast–derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

(2014) Claudia Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles

(2014) Zoltán Giricz et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

c-Src Kinase Inhibition Reduces Arrhythmia Inducibility and Connexin43 Dysregulation After Myocardial Infarction

(2014) Cody A. Rutledge et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Taxol stabilizes gap junctions and reduces ischemic ventricular arrhythmias in rats in vivo

(2014) DEGUO WANG et al.   Molecular Medicine Reports

Computational Model of Erratic Arrhythmias in a Cardiac Cell Network: The Role of Gap Junctions

(2014) Aldo Casaleggio et al.   PLoS One

A 14-3-3 Mode-1 Binding Motif Initiates Gap Junction Internalization During Acute Cardiac Ischemia

(2014) James W. Smyth et al.   TRAFFIC

Circulating p53-Responsive MicroRNAs Are Predictive Indicators of Heart Failure After Acute Myocardial Infarction

(2013) Sen Matsumoto et al.   CIRCULATION RESEARCH

Relationship Between Gap-Junctional Conductance and Conduction Velocity in Mammalian Myocardium

(2013) Paramdeep S. Dhillon et al.   Circulation-Arrhythmia and Electrophysiology

The antiarrhythmic dipeptide ZP1609 (danegaptide) when given at reperfusion reduces myocardial infarct size in pigs

(2013) Andreas Skyschally et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Connexin diversity in the heart: insights from transgenic mouse models

(2013) Sander Verheule et al.   Frontiers in Pharmacology

Vascular Hypoxic Preconditioning Relies on TRPV4-Dependent Calcium Influx and Proper Intercellular Gap Junctions Communication

(2012) Géraldine Rath et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation

(2012) Nan Wang et al.   BASIC RESEARCH IN CARDIOLOGY

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury

(2012) Nan Wang et al.   BASIC RESEARCH IN CARDIOLOGY

Intracoronary microparticles and microvascular obstruction in patients with ST elevation myocardial infarction undergoing primary percutaneous intervention

(2012) I. Porto et al.   EUROPEAN HEART JOURNAL

Connexin 43 Hemichannels Contribute to Cytoplasmic Ca2+Oscillations by Providing a Bimodal Ca2+-dependent Ca2+Entry Pathway

(2012) Marijke De Bock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cx43 Associates with Nav1.5 in the Cardiomyocyte Perinexus

(2012) J. Matthew Rhett et al.   JOURNAL OF MEMBRANE BIOLOGY

Mechanism of TNF-α autocrine effects in hypoxic cardiomyocytes: Initiated by hypoxia inducible factor 1α, presented by exosomes

(2012) Xian Yu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Single intravenous low-dose injections of connexin 43 mimetic peptides protect ischemic heart in vivo against myocardial infarction

(2012) Ghayda Hawat et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

(2012) Eduard Hergenreider et al.   NATURE CELL BIOLOGY

Cardiomyocyte Microvesicles Contain DNA/RNA and Convey Biological Messages to Target Cells

(2012) Anders Waldenström et al.   PLoS One

Vascular Endothelial Growth Factor Secretion by Nonmyocytes Modulates Connexin-43 Levels in Cardiac Organoids

(2012) Rohin K. Iyer et al.   TISSUE ENGINEERING PART A

Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by membrane nanotubes

(2011) Kangmin He et al.   CARDIOVASCULAR RESEARCH

A Peptide Mimetic of the Connexin43 Carboxyl Terminus Reduces Gap Junction Remodeling and Induced Arrhythmia Following Ventricular Injury

(2011) Michael P. O'Quinn et al.   CIRCULATION RESEARCH

Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage

(2011) Yasuhide Kuwabara et al.   Circulation-Cardiovascular Genetics

The Electrophysiological Cardiac Ventricular Substrate in Patients After Myocardial Infarction

(2011) Phillip S. Cuculich et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Human Mesenchymal Stem Cells Reprogram Adult Cardiomyocytes Toward a Progenitor-Like State Through Partial Cell Fusion and Mitochondria Transfer

(2011) Adrien Acquistapace et al.   STEM CELLS

High Throughput Assay of Diffusion through Cx43 Gap Junction Channels with a Microfluidic Chip

(2010) Cédric Bathany et al.   ANALYTICAL CHEMISTRY

Mesenchymal stem cells rescue cardiomyoblasts from cell death in an in vitro ischemia model via direct cell-to-cell connections

(2010) Attila Cselenyák et al.   BMC CELL BIOLOGY

Enhanced Fibroblast–Myocyte Interactions in Response to Cardiac Injury

(2010) Carolina Vasquez et al.   CIRCULATION RESEARCH

Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity

(2010) Raf Ponsaerts et al.   FASEB JOURNAL

Design and characterization of the first peptidomimetic molecule that prevents acidification-induced closure of cardiac gap junctions

(2010) Vandana Verma et al.   HEART RHYTHM

Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium

(2010) James W. Smyth et al.   JOURNAL OF CLINICAL INVESTIGATION

Connexin 43 mimetic peptide Gap26 confers protection to intact heart against myocardial ischemia injury

(2010) Ghayda Hawat et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Structural and Molecular Mechanisms of Gap Junction Remodeling in Epicardial Border Zone Myocytes following Myocardial Infarction

(2009) Fabien Kieken et al.   CIRCULATION RESEARCH

Effects of fibroblast-myocyte coupling on cardiac conduction and vulnerability to reentry: A computational study

(2009) Yuanfang Xie et al.   HEART RHYTHM

Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model

(2008) E Decrock et al.   CELL DEATH AND DIFFERENTIATION