CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate

CD36 and LC3B initiated autophagy in B cells regulates the humoral immune response

(2021) Chenfei He et al.   Autophagy

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

(2021) Xingzhe Ma et al.   Cell Metabolism

Targeting PIM1-Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer

(2021) Gang Xin et al.   Cancer Immunology Research

Circulating CD36 is increased in hyperlipidemic mice: Cellular sources and triggers of release

(2021) Sudipta Biswas et al.   FREE RADICAL BIOLOGY AND MEDICINE

CD36 promotes vasculogenic mimicry in melanoma by mediating adhesion to the extracellular matrix

(2021) Carmela Martini et al.   BMC CANCER

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

(2021) Shihao Xu et al.   IMMUNITY

Downregulation of NK cell activities in Apolipoprotein C-III-induced hyperlipidemia resulting from lipid-induced metabolic reprogramming and crosstalk with lipid-laden dendritic cells

(2021) Xiangyu Hu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A growth factor–expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15

(2021) Andreas Patsalos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enhanced lipid accumulation and metabolism are required for the differentiation and activation of tumor-associated macrophages

(2020) Pan Su et al.   CANCER RESEARCH

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

(2020) Haiping Wang et al.   NATURE IMMUNOLOGY

Lipids in the tumor microenvironment: From cancer progression to treatment

(2020) Kevin C. Corn et al.   PROGRESS IN LIPID RESEARCH

Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function

(2020) Xiaoxiao Luo et al.   EBioMedicine

Nitro-oleic acid, a ligand of CD36, reduces cholesterol accumulation by modulating oxidized-LDL uptake and cholesterol efflux in RAW264.7 macrophages

(2020) Matias M. Vazquez et al.   Redox Biology

A High-Fat Diet Attenuates Amp-Activated Protein Kinase α1 in Adipocytes to Induce Exosome Shedding and Nonalcoholic Fatty Liver Development in Vivo

(2020) Chenghui Yan et al.   DIABETES

Malonylation of GAPDH is an inflammatory signal in macrophages

(2019) Silvia Galván-Peña et al.   Nature Communications

A lipase-independent pathway of lipid release and immune modulation by adipocytes

(2019) Stephen E. Flaherty et al.   SCIENCE

Autophagy protein ATG5 regulates CD36 expression and anti-tumor MHC class II antigen presentation in dendritic cells

(2019) Dong Sun Oh et al.   Autophagy

CD36 gene polymorphism rs1761667 (G > A) is associated with hypertension and coronary artery disease in an Iranian population

(2019) Mohammad Amin Momeni-Moghaddam et al.   BMC Cardiovascular Disorders

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

Thromboelastography characterized CD36 null subjects as slow clot formation and indicative of hypocoagulability

(2019) Bai-Chin Lee et al.   THROMBOSIS RESEARCH

ATP6V0d2 controls Leishmania parasitophorous vacuole biogenesis via cholesterol homeostasis

(2019) Carina Carraro Pessoa et al.   PLoS Pathogens

Innate Immune Control of Adipose Tissue Homeostasis

(2019) Harry Kane et al.   TRENDS IN IMMUNOLOGY

B1 and Marginal Zone B Cells but Not Follicular B2 Cells Require Gpx4 to Prevent Lipid Peroxidation and Ferroptosis

(2019) Jonathan Muri et al.   Cell Reports

Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses

(2019) Yiliang Chen et al.   CIRCULATION RESEARCH

CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies

(2019) William W. Feng et al.   Cell Reports

PKCθ via Activating Transcription Factor 2-Mediated CD36 Expression and Foam Cell Formation of Ly6ChiCells Contributes to Atherosclerosis

(2018) Somasundaram Raghavan et al.   CIRCULATION

Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine AtherosclerosisNovelty and Significance

(2018) Clément Cochain et al.   CIRCULATION RESEARCH

MiR-135a represses oxidative stress and vascular inflammatory events via targeting toll-like receptor 4 in atherogenesis

(2018) Xian-Jin Du et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MiR-181a inhibits vascular inflammation induced by ox-LDL via targeting TLR4 in human macrophages

(2018) Xian-Jin Du et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MiR-182-5p inhibited oxidative stress and apoptosis triggered by oxidized low-density lipoprotein via targeting toll-like receptor 4

(2018) Song-Bai Qin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

STAT3-activated CD36 facilitates fatty acid uptake in chronic lymphocytic leukemia cells

(2018) Uri Rozovski et al.   Oncotarget

Endothelial cell CD36 optimizes tissue fatty acid uptake

(2018) Ni-Huiping Son et al.   JOURNAL OF CLINICAL INVESTIGATION

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

(2018) Spencer C. Wei et al.   Cancer Discovery

Damage-Associated Molecular Patterns in Inflammatory Diseases

(2018) Jong Seong Roh et al.   Immune Network

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

(2018) Shuang Zhang et al.   Cell Metabolism

Polymorphism rs1761667 in the CD36 Gene Is Associated to Changes in Fatty Acid Metabolism and Circulating Endocannabinoid Levels Distinctively in Normal Weight and Obese Subjects

(2017) Melania Melis et al.   Frontiers in Physiology

ROS via BTK-p300-STAT1-PPARγ signaling activation mediates cholesterol crystals-induced CD36 expression and foam cell formation

(2017) Sivareddy Kotla et al.   Redox Biology

Insights into binding of S100 proteins to scavenger receptors: class B scavenger receptor CD36 binds S100A12 with high affinity

(2016) Christoph Tondera et al.   AMINO ACIDS

LPA/PKD-1-FoxO1 Signaling Axis Mediates Endothelial Cell CD36 Transcriptional Repression and Proangiogenic and Proarteriogenic ReprogrammingHighlights

(2016) Bin Ren et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

(2016) Haobin Ye et al.   Cell Stem Cell

Adipose tissue macrophages: going off track during obesity

(2016) Lily Boutens et al.   DIABETOLOGIA

Signal transducer and activator of transcription 5 plays a crucial role in hepatic lipid metabolism through regulation of CD36 expression

(2016) Atsushi Hosui et al.   HEPATOLOGY RESEARCH

miR-34a−/−mice are susceptible to diet-induced obesity

(2016) Christopher A. Lavery et al.   Obesity

The structural basis for CD36 binding by the malaria parasite

(2016) Fu-Lien Hsieh et al.   Nature Communications

Leishmania amazonensis Engages CD36 to Drive Parasitophorous Vacuole Maturation

(2016) Kendi Okuda et al.   PLoS Pathogens

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

CD36 Binds Oxidized Low Density Lipoprotein (LDL) in a Mechanism Dependent upon Fatty Acid Binding

(2015) Anthony G. Jay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidized LDL–bound CD36 recruits an Na+/K+-ATPase–Lyn complex in macrophages that promotes atherosclerosis

(2015) Yiliang Chen et al.   Science Signaling

Oxidized LDL–bound CD36 recruits an Na+/K+-ATPase–Lyn complex in macrophages that promotes atherosclerosis

(2015) Yiliang Chen et al.   Science Signaling

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Regulation of AMPK Activation by CD36 Links Fatty Acid Uptake to β-Oxidation

(2014) Dmitri Samovski et al.   DIABETES

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

Cancer Stem Cell-Specific Scavenger Receptor CD36 Drives Glioblastoma Progression

(2014) James S. Hale et al.   STEM CELLS

Molecular Basis of Antiangiogenic Thrombospondin-1 Type 1 Repeat Domain Interactions With CD36

(2013) Philip A. Klenotic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelets Mediate Oxidized Low-Density Lipoprotein–Induced Monocyte Extravasation and Foam Cell Formation

(2013) Sigrun Badrnya et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells

(2013) L.-Y. Chu et al.   BLOOD

Multimolecular Signaling Complexes Enable Syk-Mediated Signaling of CD36 Internalization

(2013) Bryan Heit et al.   DEVELOPMENTAL CELL

Sulfo-N-succinimidyl Oleate (SSO) Inhibits Fatty Acid Uptake and Signaling for Intracellular Calcium via Binding CD36 Lysine 164

(2013) Ondrej Kuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rosiglitazone-induced CD36 up-regulation resolves inflammation by PPAR  and 5-LO-dependent pathways

(2013) I. Ballesteros et al.   JOURNAL OF LEUKOCYTE BIOLOGY

oxLDL induces inflammatory responses in vascular smooth muscle cells via urokinase receptor association with CD36 and TLR4

(2013) Yulia Kiyan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

The origin of circulating CD36 in type 2 diabetes

(2013) M J Alkhatatbeh et al.   Nutrition & Diabetes

Advanced glycation end products induce a prothrombotic phenotype in mice via interaction with platelet CD36

(2012) W. Zhu et al.   BLOOD

CD36 and Na/K-ATPase-α1 Form a Proinflammatory Signaling Loop in Kidney

(2012) David J. Kennedy et al.   HYPERTENSION

Context Dependent Role of the CD36 - Thrombospondin - Histidine-Rich Glycoprotein Axis in Tumor Angiogenesis and Growth

(2012) James Scott Hale et al.   PLoS One

Platelet CD36 surface expression levels affect functional responses to oxidized LDL and are associated with inheritance of specific genetic polymorphisms

(2011) A. Ghosh et al.   BLOOD

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

CD9 Tetraspanin Interacts with CD36 on the Surface of Macrophages: A Possible Regulatory Influence on Uptake of Oxidized Low Density Lipoprotein

(2011) Wenxin Huang et al.   PLoS One

Soluble CD36− a marker of the (pathophysiological) role of CD36 in the metabolic syndrome?

(2011) Debby P.Y. Koonen et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade

(2010) W. Roberts et al.   BLOOD

A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling

(2010) David J. Kennedy et al.   CARDIOVASCULAR RESEARCH

Soluble CD36 (sCD36) Clusters with Markers of Insulin Resistance, and High sCD36 Is Associated with Increased Type 2 Diabetes Risk

(2010) A. Handberg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

(2010) Aliki Kosteli et al.   JOURNAL OF CLINICAL INVESTIGATION

CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs

(2010) Wei Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Key Role of CD36 in Toll-Like Receptor 2 Signaling in Cerebral Ischemia

(2010) Takato Abe et al.   STROKE

Association of Scavenger Receptors in Adipose Tissue With Insulin Resistance in Nondiabetic Humans

(2009) Neda Rasouli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes

(2009) Andrew E. Fry et al.   HUMAN MOLECULAR GENETICS

The Human Scavenger Receptor CD36

(2009) Sarah J. Hoosdally et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36

(2009) Terry K. Means et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior

(2009) R. L. Silverstein et al.   Science Signaling

Opposite Regulation of CD36 Ubiquitination by Fatty Acids and Insulin

(2008) Jill Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linoleic Acid Induces Calcium Signaling, Src Kinase Phosphorylation, and Neurotransmitter Release in Mouse CD36-positive Gustatory Cells

(2008) Abdelghani El-Yassimi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Regulation of Fatty Acid Translocase/CD36 Expression by CCAAT/Enhancer-binding Protein α

(2008) Liping Qiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima

(2008) Young Mi Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Soluble CD36 in Plasma Is Increased in Patients With Symptomatic Atherosclerotic Carotid Plaques and Is Related to Plaque Instability

(2008) Aase Handberg et al.   STROKE