Review
Nutrition & Dietetics
Elif Ulug, Reyhan Nergiz-Unal
Summary: The CD36 receptor plays a crucial role in cholesterol homeostasis, with dietary fatty acids influencing its levels and cholesterol metabolism. The effects of saturated fatty acids and trans-fatty acids on CD36-mediated cholesterol homeostasis may be detrimental, while monounsaturated fatty acids could be beneficial. The role of polyunsaturated fatty acids in CD36-mediated cholesterol homeostasis is controversial and depends on the ratio of n-3 to n-6 PUFA.
NUTRITION RESEARCH REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Yunxia Li, Xingguo Huang, Guan Yang, Kang Xu, Yulong Yin, Gabriele Brecchia, Jie Yin
Summary: CD36, located on the cell membrane, plays a critical role in regulating lipid metabolism and is associated with lipid dysmetabolism and obesity. However, the specific mechanisms by which CD36 regulates lipid metabolism and its role in metabolic diseases remain unclear. This review summarizes the latest research on the role of membrane CD36 in fat metabolism, focusing on CD36-mediated fat sensing and transport, and critically discusses the factors affecting CD36-mediated fat dysfunction. Finally, it reviews previous clinical evidence and considers future research directions.
PROGRESS IN LIPID RESEARCH
(2022)
Review
Nutrition & Dietetics
Daniela Alvarez, Yasna Munoz, Macarena Ortiz, Manuel Maliqueo, Raphael Chouinard-Watkins, Rodrigo Valenzuela
Summary: Maternal health is crucial for the supply of essential fatty acids to offspring, and maternal obesity can alter the fatty acid profile, leading to increased risks of obesity and other health issues in the offspring.
Review
Oncology
Chengwei Ruan, Yankai Meng, Hu Song
Summary: CD36 is upregulated in various cancer types and associated with poor clinical outcomes and adverse clinicopathological features. It regulates tumor growth, metastasis, and drug resistance through diverse molecular mechanisms. CD36 plays a crucial role in tumor metabolism and could be a potential therapeutic target.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Food Science & Technology
Jing Duan, Jingkai Pan, Meichen Sun, Yulin Fang
Summary: Ellagic acid (EA), a polyphenol found in fruits and vegetables, can be used as a functional ingredient. This study found that supplementing with EA significantly reduced the body weight of young mice but not adult mice. EA also affected the abundance of certain gut bacteria differently in young and adult mice.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Umar R. Rekhi, Mohamed Omar, Maria Alexiou, Cole Delyea, Linnet Immaraj, Shokrollah Elahi, Maria Febbraio
Summary: Research indicates that endothelial cell CD36 plays a significant role in systemic metabolism and has a sex-specific impact on atherosclerosis and energy substrate use.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Food Science & Technology
Chunxiao Wang, Zhizhou Chen, Margaret A. Brennan, Jie Wang, Jianfeng Sun, Haibin Fang, Min Kang, Charles S. Brennan, Jianlou Mu
Summary: The aim of this study was to investigate the effects of extruded multigrain (Tartary buckwheat, oat and black bean) powder product (MG) fed with a high-fat-diet (HFD) on metabolism and gut microbiota modulation of mice. The results showed that MG reduced the weight gain of HFD-induced mice, improved glucose tolerance, and reduced cholesterol and triglyceride levels. In addition, the intervention of HFMG could promote the release of butyric acid in short chain fatty acids, improve the disorder of intestinal flora, and increase the relative abundance of Bacteroidetes while reducing the relative abundance of Firmicutes.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Chemistry, Analytical
Weiwei Tang, Andrew Gordon, Fang Wang, Yanwen Chen, Bin Li
Summary: HZN matrix, prepared from alkalizing HZN.HCl with ammonia, shows superior imaging performance for a wide range of endogenous compounds in MALDI MSI, providing higher sensitivity and broader molecular coverage in negative and positive-ion modes.
ANALYTICAL CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Zelei Miao, Geng-dong Chen, Shaofeng Huo, Yuanqing Fu, Min-Yu Wu, Fengzhe Xu, Zengliang Jiang, Jun Tang, Wanglong Gou, Congmei Xiao, Yu-ping Liu, Yan-Yan Wu, Ting-yu Sun, Liang Sun, Li-Rong Shen, Xu Lin, Yu-ming Chen, Ju-Sheng Zheng
Summary: This study found that high n-3 PUFAs were associated with improved blood lipids and gut microbial features only among rs1527483-GG carriers.
CLINICAL NUTRITION
(2022)
Article
Toxicology
Stacey Herriage, Guangping Chen, Carey Pope
Summary: Chlorpyrifos oxon inhibits AChE and FAAH, potentially influencing lipid metabolism by blocking the degradation of eCBs or eCB-like metabolites and affecting PPAR receptor activation.
TOXICOLOGY IN VITRO
(2022)
Article
Oncology
Tomonori Yoshida, Takehiko Yokobori, Hideyuki Saito, Kengo Kuriyama, Yuji Kumakura, Hiroaki Honjo, Keigo Hara, Makoto Sakai, Tatsuya Miyazaki, Hideru Obinata, Bilguun Erkhem-Ochir, Navchaa Gombodorj, Makoto Sohda, Hiroshi Saeki, Hiroyuki Kuwano, Ken Shirabe
Summary: High CD36 expression is significantly associated with ESCC progression, and CD36 suppression can reduce proliferation and invasiveness in ESCC cells. ESCC cells under CD36 suppression use specific EAAs as energy sources, while cell viability under CD36 expression depends on FAs.CD36 may serve as a potential biomarker and therapeutic target in ESCC.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Nutrition & Dietetics
Ivan Lopez-Mendez, Karla Mendez-Maldonado, Luis A. Manzo-Francisco, Eva Juarez-Hernandez, Misael Uribe, Varenka J. Barbero-Becerra
Summary: MAFLD is a hepatic disorder linked to active fatty acid metabolism and regulated by GPRs. Obesity, microbiota environment, and dietary characteristics are also associated with MAFLD. The role of active fatty acids in metabolic diseases is a promising area for further research.
NUTRITION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Paula de Albuquerque, Viviani De Marco, Thiago Henrique Annibale Vendramini, Andressa Rodrigues Amaral, Sergio Catanozi, Kelly Gomes Santana, Valeria Sutti Nunes, Edna Regina Nakandakare, Marcio Antonio Brunetto
Summary: The study evaluated the therapeutic efficacy of omega-3 fatty acids associated with different fat content diets in Schnauzer with primary hyperlipidaemia. Both low-fat and moderate-fat diet combined with omega-3 fatty acids effectively reduced triglyceride and cholesterol levels without altering lipoprotein profile in Schnauzer with primary hyperlipidaemia.
Article
Biochemistry & Molecular Biology
Alessandra Ferramosca, Vincenzo Zara
Summary: Diet plays a role in male reproductive potential, but the specific biochemical mechanisms are not well understood. Certain nutrients have effects on sperm quality and are involved in biochemical mechanisms related to sperm bioenergetics. Polyunsaturated fatty acids, especially omega-3 fatty acids, improve sperm quality, while saturated fatty acids have a negative impact. Carbohydrates and proteins also influence sperm mitochondrial function and oxidative stress. Natural polyphenols have varying effects on mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Conny Tanjung, Carla P. Harris, Hans Demmelmair, Sarah Dwitya, Zakiudin Munasir, Herawati Sudoyo, Marie Standl, Damayanti Rusli Sjarif, Berthold Koletzko
Summary: This study found that Indonesian infants with AD have increased rates of endogenous long-chain polyunsaturated fatty acid production and higher levels of C18:1n-9. While GPL-FA measured at birth do not predict later AD incidence, genotype interactions revealed novel effects of myristic acid, which are modified by a FADS3 variant.
Article
Pharmacology & Pharmacy
Antonio Inserra, Giada Giorgini, Sebastien Lacroix, Antonella Bertazzo, Jocelyn Choo, Athanasios Markopolous, Emily Grant, Armita Abolghasemi, Danilo De Gregorio, Nicolas Flamand, Geraint Rogers, Stefano Comai, Cristoforo Silvestri, Gabriella Gobbi, Vincenzo Di Marzo
Summary: This study found that repeated administration of lysergic acid diethylamide (LSD) induces prosocial effects in mice and affects the composition of the hippocampal endocannabinoidome and gut microbiota.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ester Pagano, Barbara Romano, Donatella Cicia, Fabio A. Iannotti, Tommaso Venneri, Giuseppe Lucariello, Maria Francesca Nani, Fabio Cattaneo, Paola De Cicco, Maria D'Armiento, Marcello De Luca, Ruggiero Lionetti, Stefania Lama, Paola Stiuso, Pietro Zoppoli, Geppino Falco, Silvia Marchiano, Stefano Fiorucci, Raffaele Capasso, Vincenzo Di Marzo, Francesca Borrelli, Angelo A. Izzo
Summary: TRPM8 is overexpressed in colorectal cancer and its high expression is associated with lower survival rate of patients and hyperactivation of related signaling pathways. TRPM8 may serve as a prognostic marker and potential drug target for colorectal cancer.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Food Science & Technology
Mariano Mastinu, Melania Melis, Neeta Y. Yousaf, Iole Tomassini Barbarossa, Beverly J. Tepper
Summary: Taste and olfaction elicit conscious feelings and affect physiological responses by connecting directly with the neural circuits of emotions. Sensory attributes determine food liking, but emotional reactions may better predict consumer choices. Understanding emotional reactions is important for product development, marketing, eating psychology, nutrition, and policymaking.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Cell Biology
Francesco Suriano, Claudia Manca, Nicolas Flamand, Matthias Van Hul, Nathalie M. Delzenne, Cristoforo Silvestri, Patrice D. Cani, Vincenzo Di Marzo
Summary: This study characterized the profile of endocannabinoidome and oxylipins in the intestines of obese and diabetic mice, and found correlations between these mediators and intestinal inflammation and gut microbiota composition. The results suggest that the altered eCBome and oxylipin signaling may contribute to obesity and diabetes-induced gut dysbiosis and inflammation.
Article
Biochemistry & Molecular Biology
Lala Chaimae Naciri, Mariano Mastinu, Roberto Crnjar, Iole Tomassini Barbarossa, Melania Melis
Summary: Several studies have used Machine Learning (mL) and Supervised Learning (SL) algorithms to automatically identify the genetic ability to taste PROP and TAS2R38 genotypes. The catBoost algorithm was found to be the most suitable model for this discrimination. The ratings of perceived intensity for PROP solutions and medium taster (MT) category were the most important features in training the model and understanding the difference between genotypes. These findings suggest that SL can be a reliable and objective tool for identifying TAS2R38 variants.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Aniello Schiano Moriello, Fiorentina Roviezzo, Fabio Arturo Iannotti, Giuseppina Rea, Marco Allara, Rosa Camerlingo, Roberta Verde, Vincenzo Di Marzo, Stefania Petrosino
Summary: ARDS is a serious lung disorder caused by SARS-CoV-2 infection. This study evaluated the protective effects of PEA-um and its congener PEA-OXA in acute lung injury models. The results showed that both PEA-OXA and PEA can counteract the inflammatory response and EMT induced by poly-(I:C) or TGF-beta. PEA-OXA was found to be superior to PEA in exerting protective effects, making it a promising candidate in the management of acute lung injury.
Article
Biochemistry & Molecular Biology
Martina Di Bartolomeo, Tibor Stark, Serena Di Martino, Fabio Arturo Iannotti, Jana Ruda-Kucerova, Giovanni Luca Romano, Martin Kuchar, Samuele Laudani, Petr Palivec, Fabiana Piscitelli, Carsten T. Wotjak, Claudio Bucolo, Filippo Drago, Vincenzo Di Marzo, Claudio D'Addario, Vincenzo Micale
Summary: Adolescent exposure to cannabinoids, such as THC, may increase the risk of psychosis in individuals exposed to perinatal insult. In this study, the researchers examined the effects of peripubertal THC exposure on rats that were also exposed to prenatal methylazoxymethanol acetate (MAM) or perinatal THC (pTHC). They found that the rats exposed to MAM or pTHC exhibited adult phenotypes relevant to schizophrenia, including social withdrawal and cognitive impairment. The researchers also observed changes in gene expression and DNA methylation, suggesting potential molecular mechanisms underlying these effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Hayatte-Dounia Mir, Giada Giorgini, Vincenzo Di Marzo
Summary: This review article focuses on the expanded endocannabinoid system (eCBome) and the gut microbiome, which are increasingly attracting attention as sources of chemical signals regulating food intake, energy metabolism, and body weight. The article describes the mechanisms through which these two systems, in interactions with other signaling systems, intervene in eating disorders, based on studies in experimental models or patients. Furthermore, the article discusses the possibility of the involvement of the eCBome-gut microbiome axis in eating disorders, considering the emerging multi-faceted cross-talk mechanisms between these complex systems.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Cell Biology
Hilal Kalkan, Elisabetta Panza, Ester Pagano, Giuseppe Ercolano, Claudia Moriello, Fabiana Piscitelli, Monika Sztretye, Raffaele Capasso, Vincenzo Di Marzo, Fabio Arturo Iannotti
Summary: In this study, the researchers investigated the role of the endocannabinoid system in simvastatin-induced muscle toxicity. They found that the expression of endocannabinoids and specific miRNAs targeting the endocannabinoid CB1 gene increased in myoblasts exposed to simvastatin. Moreover, they discovered that the dysregulation of the CB1 receptor and its downstream signaling pathways contributed to statin-induced myopathy.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Lala Chaimae Naciri, Mariano Mastinu, Melania Melis, Tomer Green, Anne Wolf, Thomas Hummel, Iole Tomassini Barbarossa
Summary: The gustatory, olfactory, and trigeminal systems, although anatomically separated, interact cognitively to form oral perception. A regression model was used to analyze self-ratings of oral sensitivity and found that the trigeminal component was the most significant, with astringency and spiciness providing similar contributions in controls, and astringency being most important in patients. Identifying the significance of oral perception components and differences between groups provides important information for targeted examinations.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Thomas Deschenes, Fred Wilfried Elom Tohoundjona, Pier-Luc Plante, Vincenzo Di Marzo, Frederic Raymond
Summary: This study compared the performance of machine learning approaches according to different types of data representations derived from shotgun metagenomics. Gene-based approaches provided similar or improved classification performances compared to taxonomic and functional profiles. Feature selection based on biological function also improved classification performance for some pathologies. This study proposes new approaches to represent microbiome data for machine learning.
Article
Biochemistry & Molecular Biology
Lala Chaimae Naciri, Mariano Mastinu, Melania Melis, Tomer Green, Anne Wolf, Thomas Hummel, Iole Tomassini Barbarossa
Summary: Taste sensitivity varies widely in healthy humans and can affect food selection and nutritional status. This study used a supervised learning regression method to analyze taste function in healthy controls and patients with chemosensory loss. The findings suggest that specific taste stimuli can be used in routine clinical assessments to predict overall taste statuses.
Article
Biology
Nicola Forte, Charlene Roussel, Brenda Marfella, Anna Lauritano, Rosaria Villano, Elvira De Leonibus, Emanuela Salviati, Tina Khalilzadehsabet, Giada Giorgini, Cristoforo Silvestri, Fabiana Piscitelli, Maria Pina Mollica, Vincenzo Di Marzo, Luigia Cristino
Summary: N-oleoylglycine and N-oleoylalanine reduce the rewarding properties of palatable food, dopamine neuron firing, and the obesogenic effect of a high-fat diet by activating PPAR alpha. Olive oil-rich diets can also decrease weight gain by increasing oleoylglycine levels and enhancing gut microbial diversity.
COMMUNICATIONS BIOLOGY
(2023)
Article
Nutrition & Dietetics
Gianfranca Carta, Elisabetta Murru, Giovanna Trinchese, Gina Cavaliere, Claudia Manca, Maria Pina Mollica, Sebastiano Banni
Summary: This study investigated the effects of varying PUFA/SFA ratios in the diet on insulin resistance, fatty acid metabolism, NAE bioactive metabolite levels, and mitochondrial function. The results showed that reducing the dietary PUFA/SFA ratio positively influenced glucose and lipid metabolism in obese rats, possibly through an increase in OEA biosynthesis, improving metabolic flexibility.
Article
Pharmacology & Pharmacy
Tangui Barre, Vincenzo Di Marzo, Fabienne Marcellin, Patrizia Burra, Patrizia Carrieri
Summary: Obesity and nonalcoholic fatty liver disease (NAFLD) are global epidemics. The endocannabinoid system is seen as a key target for treating NAFLD. Although clinical trials are lacking, research suggests potential benefits of phytocannabinoids in treating liver steatosis. Cannabis plant should be considered a major prospect for NAFLD treatment. Overcoming scientific and non-scientific barriers is necessary for further research.
CANNABIS AND CANNABINOID RESEARCH
(2023)
