Natural products for the treatment of stress-induced depression: Pharmacology, mechanism and traditional use

The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data

(2021) James M. Brimson et al.   Scientific Reports

From forest to pharmacy: should we be depressed about a sustainable Griffonia simplicifolia (Fabaceae) seed supply chain?

(2021) A.B. Cunningham et al.   JOURNAL OF ETHNOPHARMACOLOGY

Antidepressant‑like effects of Z‑ligustilide on chronic unpredictable mild stress‑induced depression in rats

(2021) Jian-Chun Ma et al.   Experimental and Therapeutic Medicine

Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia

(2021) Alex B. Speers et al.   Current Neuropharmacology

Poria cocos water extract ameliorates the behavioral deficits induced by unpredictable chronic mild stress in rats by down-regulating inflammation

(2020) Yun-Ju Huang et al.   JOURNAL OF ETHNOPHARMACOLOGY

A randomized controlled pilot study of the effectiveness of magnolia tea on alleviating depression in postnatal women

(2020) Lili Xue et al.   Food Science & Nutrition

Xiaoyaosan regulates depression‐related behaviors with physical symptoms by modulating Orexin A/OxR1 in the hypothalamus

(2020) Yajing Hou et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

An Integrated Pharmacology-Based Analysis for Antidepressant Mechanism of Chinese Herbal Formula Xiao-Yao-San

(2020) Naijun Yuan et al.   Frontiers in Pharmacology

Network Pharmacology-based Research of Active Components of Albiziae Flos and Mechanisms of Its Antidepressant Effect

(2020) Wei-chen Xiong et al.   Current Medical Science

Gardenia jasminoides Ellis: Ethnopharmacology, phytochemistry, and pharmacological and industrial applications of an important traditional Chinese medicine

(2020) Liping Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

“Natural” is not synonymous with “Safe”: Toxicity of natural products alone and in combination with pharmaceutical agents

(2020) Tyler E. Gaston et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Glaucacetalin E and galphimidin B from Galphimia glauca and their anxiolytic activity

(2020) María Yolanda Rios et al.   JOURNAL OF ETHNOPHARMACOLOGY

Efficacy and safety of Morinda officinalis oligosaccharide capsules for depressive disorder: a systematic review and meta-analysis

(2020) Yun Du et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Antidepressant activities and regulative effects on serotonin transporter of Nardostachys jatamansi DC

(2020) Ran Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

GABA and 5-HT Systems Are Involved in the Anxiolytic Effect of Gan-Mai-Da-Zao Decoction

(2019) Hong-Shu Chen et al.   Frontiers in Neuroscience

Tetramethylpyrazine ameliorates depression by inhibiting TLR4-NLRP3 inflammasome signal pathway in mice

(2019) Songnian Fu et al.   PSYCHOPHARMACOLOGY

Antidepressant-like effects of paeoniflorin on post-stroke depression in a rat model

(2019) Ming-zhe Hu et al.   NEUROLOGICAL RESEARCH

Effect of saffron (stigma of Crocus sativus L.) aqueous extract on ethanol toxicity in rats: A biochemical, histopathological and molecular study

(2019) Alireza Rezaee-Khorasany et al.   JOURNAL OF ETHNOPHARMACOLOGY

Fighting females: Neural and behavioral consequences of social defeat stress in female mice

(2019) Emily L. Newman et al.   BIOLOGICAL PSYCHIATRY

Diverse Pharmacological Activities and Potential Medicinal Benefits of Geniposide

(2019) Yan-Xi Zhou et al.   Evidence-based Complementary and Alternative Medicine

A review of the phytochemistry and pharmacological activities of Magnoliae officinalis cortex

(2019) Hanyan Luo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model

(2019) Bo Zhang et al.   MOLECULES

Lavender essential oil ameliorates depression-like behavior and increases neurogenesis and dendritic complexity in rats

(2019) Dalinda Isabel Sánchez-Vidaña et al.   NEUROSCIENCE LETTERS

Isorhynchophylline exerts antidepressant-like effects in mice via modulating neuroinflammation and neurotrophins: involvement of the PI3K/Akt/GSK-3β signaling pathway

(2019) Yan-Fang Xian et al.   FASEB JOURNAL

Andrographolide exerts significant antidepressant-like effects involving the hippocampal BDNF system in mice

(2019) Jing-Jing Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Managing Depression with Bupleurum chinense Herbal Formula: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2019) Lingling Yang et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Antidepressant‐like effects of 20( S )‐protopanaxadiol in a mouse model of chronic social defeat stress and the related mechanisms

(2019) Ning Jiang et al.   PHYTOTHERAPY RESEARCH

Cortisol, oxytocin, and quality of life in major depressive disorder

(2019) Ai Ling Tang et al.   QUALITY OF LIFE RESEARCH

The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial

(2019) Alieh Eatemadnia et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Selecting an Appropriate Animal Model of Depression

(2019) Yuanzhen Hao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Grape-Derived Polyphenols Ameliorate Stress-Induced Depression by Regulating Synaptic Plasticity

(2019) Francesca Caracci et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Bioactivities of serotonin transporter mediate antidepressant effects of Acorus tatarinowii Schott

(2019) Feng-Hong Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Bioconversion of essential oil components of Perilla frutescens by Saccharomyces cerevisiae

(2019) Michiru Kimura et al.   Journal of Natural Medicines

Antidepressant‐Like Effect of Ferulic Acid via Promotion of Energy Metabolism Activity

(2019) Kazunori Sasaki et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Revealing Antidepressant Mechanisms of Baicalin in Hypothalamus Through Systems Approaches in Corticosterone- Induced Depressed Mice

(2019) Kuo Zhang et al.   Frontiers in Neuroscience

Rb1, the Primary Active Ingredient in Panax ginseng C.A. Meyer, Exerts Antidepressant-Like Effects via the BDNF–Trkb–CREB Pathway

(2019) Guoli Wang et al.   Frontiers in Pharmacology

Animal models of major depression: drawbacks and challenges

(2019) Barbara Planchez et al.   JOURNAL OF NEURAL TRANSMISSION

Medically Useful Plant Terpenoids: Biosynthesis, Occurrence, and Mechanism of Action

(2019) Matthew E. Bergman et al.   MOLECULES

Toxicity and risk assessment of mercury exposures from cinnabar and Baizi Yangxin Pills based on pharmacokinetic and tissue distribution studies

(2019) Yu-ting Lu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effects of Puerarin on the Ovariectomy-Induced Depressive-Like Behavior in ICR Mice and Its Possible Mechanism of Action

(2019) Ariyawan Tantipongpiradet et al.   MOLECULES

Antidepressant active ingredients from herbs and nutraceuticals used in TCM: pharmacological mechanisms and prospects for drug discovery

(2019) Yan-Shuo Wang et al.   PHARMACOLOGICAL RESEARCH

Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model

(2019) Liandi Chi et al.   PHYTOMEDICINE

Silibinin exerts antidepressant effects by improving neurogenesis through BDNF/TrkB pathway

(2018) Yan-Jiao Li et al.   BEHAVIOURAL BRAIN RESEARCH

SuHeXiang Essential Oil Inhalation Produces Antidepressant- and Anxiolytic-Like Effects in Adult Mice

(2018) Min Liang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Apocynum venetum leaf extract reverses depressive-like behaviors in chronically stressed rats by inhibiting oxidative stress and apoptosis

(2018) Xiangting Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Treatment of depression with Chai Hu Shu Gan San: a systematic review and meta-analysis of 42 randomized controlled trials

(2018) Yan Sun et al.   BMC Complementary and Alternative Medicine

A Review on Possible Therapeutic Effect of Nigella sativa and Thymoquinone in Neurodegenerative Diseases

(2018) Saeed Samarghndian et al.   CNS & Neurological Disorders-Drug Targets

Study on antidepressant activity of chiisanoside in mice

(2018) Xingbo Bian et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Stress management and the role of Rhodiola rosea: a review

(2018) Ion-George Anghelescu et al.   INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE

Morinda officinalis How. – A comprehensive review of traditional uses, phytochemistry and pharmacology

(2018) Jian-hua Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Immunomodulatory effects of Sceletium tortuosum (Trimesemine™) elucidated in vitro : Implications for chronic disease

(2018) Amber C. Bennett et al.   JOURNAL OF ETHNOPHARMACOLOGY

Perilla aldehyde attenuates CUMS-induced depressive-like behaviors via regulating TXNIP/TRX/NLRP3 pathway in rats

(2018) Yichen Song et al.   LIFE SCIENCES

Panax Notoginseng Saponins: A Review of Its Mechanisms of Antidepressant or Anxiolytic Effects and Network Analysis on Phytochemistry and Pharmacology

(2018) Weijie Xie et al.   MOLECULES

What does dopamine mean?

(2018) Joshua D. Berke   NATURE NEUROSCIENCE

Chaihu-Shugan-San exerts an antidepressive effect by downregulating miR-124 and releasing inhibition of the MAPK14 and Gria3 signaling pathways

(2018) Da-Hua Fan et al.   Neural Regeneration Research

High anxiety trait: A vulnerable phenotype for stress-induced depression

(2018) Meltem Weger et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Geniposide improves repeated restraint stress-induced depression-like behavior in mice by ameliorating neuronal apoptosis via regulating GLP-1R/AKT signaling pathway

(2018) Yinghua Zhao et al.   NEUROSCIENCE LETTERS

Saikosaponin A attenuates perimenopausal depression-like symptoms by chronic unpredictable mild stress

(2018) Xue-Qin Chen et al.   NEUROSCIENCE LETTERS

Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance

(2018) K. Simon Yeung et al.   PHYTOTHERAPY RESEARCH

The anxiolytic-like effects of ginsenoside Rg3 on chronic unpredictable stress in rats

(2018) Jia-ning Xu et al.   Scientific Reports

Resveratrol and dimethyl fumarate ameliorate depression-like behaviour in a rat model of chronic unpredictable mild stress

(2018) Amal Ahmed Abd El-Fattah et al.   BRAIN RESEARCH

Antidepressant and immunosuppressive activities of two polysaccharides from Poria cocos (Schw.) Wolf

(2018) Wuxia Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Agarwood Essential Oil Ameliorates Restrain Stress-Induced Anxiety and Depression by Inhibiting HPA Axis Hyperactivity

(2018) Shuai Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Depression

(2018) Gin S Malhi et al.   LANCET

Chronic Unpredictable Mild Stress for Modeling Depression in Rodents:Meta-analysis of Model Reliability

(2018) Svitlana Antoniuk et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Total saponins from the leaves of Panax notoginseng  inhibit depression on mouse chronic unpredictable mild stress model by regulating circRNA expression

(2018) Hualin Zhang et al.   Brain and Behavior

Neuroprotective Effects of Ginsenoside-Rg1 Against Depression-Like Behaviors via Suppressing Glial Activation, Synaptic Deficits, and Neuronal Apoptosis in Rats

(2018) Cuiqin Fan et al.   Frontiers in Immunology

Antidepressant potential of Uncaria rhynchophylla and its active flavanol, catechin, targeting melatonin receptors

(2018) Chang-An Geng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Clinical risks of St John’s Wort (Hypericum perforatum) co-administration

(2017) Samaneh Soleymani et al.   Expert Opinion on Drug Metabolism & Toxicology

Astragalus membranaceus-Polysaccharides Ameliorates Obesity, Hepatic Steatosis, Neuroinflammation and Cognition Impairment without Affecting Amyloid Deposition in Metabolically Stressed APPswe/PS1dE9 Mice

(2017) Yung-Cheng Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Leonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation

(2017) Miaomiao Jia et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis

(2017) Qin Xiang Ng et al.   JOURNAL OF AFFECTIVE DISORDERS

Hypericum perforatum (St John's wort) beyond depression: A therapeutic perspective for pain conditions

(2017) Nicoletta Galeotti   JOURNAL OF ETHNOPHARMACOLOGY

Influence of equol and resveratrol supplementation on health-related quality of life in menopausal women: A randomized, placebo-controlled study

(2017) Sergio Davinelli et al.   MATURITAS

Essential Oils and Their Constituents: An Alternative Source for Novel Antidepressants

(2017) Damião de Sousa et al.   MOLECULES

Oxidative stress, inflammation and treatment response in major depression

(2017) Daniel Lindqvist et al.   PSYCHONEUROENDOCRINOLOGY

Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis

(2017) Hong-Yan Li et al.   PSYCHOPHARMACOLOGY

Antidépresseurs et tolérance : déterminants et prise en charge des principaux effets indésirables

(2016) D.J. David et al.   ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE

GABA-A Receptor Modulation and Anticonvulsant, Anxiolytic, and Antidepressant Activities of Constituents fromArtemisia indicaLinn

(2016) Imran Khan et al.   Evidence-based Complementary and Alternative Medicine

Global Burden Of Disease Studies: Implications For Mental And Substance Use Disorders

(2016) Harvey Whiteford et al.   HEALTH AFFAIRS

New cycloartane glycosides from the rhizomes ofCyperus rotundusand their antidepressant activity

(2016) Zhong-Liu Zhou et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Antidepressant-like effects of albiflorin extracted from Radix paeoniae Alba

(2016) Yu-Lu Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Melissa officinalis L. – A review of its traditional uses, phytochemistry and pharmacology

(2016) Abolfazl Shakeri et al.   JOURNAL OF ETHNOPHARMACOLOGY

Metabonomic identification of the effects of the Zhimu-Baihe saponins on a chronic unpredictable mild stress-induced rat model of depression

(2016) Hongli Du et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Icariin reverses corticosterone-induced depression-like behavior, decrease in hippocampal brain-derived neurotrophic factor (BDNF) and metabolic network disturbances revealed by NMR-based metabonomics in rats

(2016) Meng-juan Gong et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Cellular and molecular basis for stress-induced depression

(2016) J-S Seo et al.   MOLECULAR PSYCHIATRY

Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons

(2016) Elsa Isingrini et al.   NATURE NEUROSCIENCE

Antidepressant-Like Effect of Isorhynchophylline in Mice

(2016) Yan-Fang Xian et al.   NEUROCHEMICAL RESEARCH

Berberine up-regulates the BDNF expression in hippocampus and attenuates corticosterone-induced depressive-like behavior in mice

(2016) Ji-duo Shen et al.   NEUROSCIENCE LETTERS

Cipadesin A, a bioactive ingredient of Xylocarpus granatum, produces antidepressant-like effects in adult mice

(2016) Qiang Gao et al.   NEUROSCIENCE LETTERS

Potential antidepressant constituents of Nigella sativa seeds

(2016) EhabS Elkhayat et al.   Pharmacognosy Magazine

Schisandra chinensis produces the antidepressant-like effects in repeated corticosterone-induced mice via the BDNF/TrkB/CREB signaling pathway

(2016) Tingxu Yan et al.   PSYCHIATRY RESEARCH

Research on the Pathological Mechanism and Drug Treatment Mechanism of Depression

(2015) Guo-jiang Peng et al.   Current Neuropharmacology

Radix Angelica Sinensis Promotes Synaptic Plasticity During Cognitive Recovery in Chronically Stressed Rats

(2015) Min Deng et al.   CURRENT NEUROVASCULAR RESEARCH

The antidepressant-like pharmacological profile of Yuanzhi-1, a novel serotonin, norepinephrine and dopamine reuptake inhibitor

(2015) Zeng-liang Jin et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Tetramethylpyrazine Produces Antidepressant-Like Effects in Mice Through Promotion of BDNF Signaling Pathway

(2015) Bo Jiang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Oxidative Stress and Antioxidant Parameters in Patients With Major Depressive Disorder Compared to Healthy Controls Before and After Antidepressant Treatment

(2015) Sara Jiménez-Fernández et al.   JOURNAL OF CLINICAL PSYCHIATRY

Natural products of relevance in the prevention and supportive treatment of depression

(2015) Bożena Muszyńska et al.   Psychiatria Polska

Is depression associated with increased oxidative stress? A systematic review and meta-analysis

(2015) Catherine N. Black et al.   PSYCHONEUROENDOCRINOLOGY

Plant-derived natural medicines for the management of depression: an overview of mechanisms of action

(2015) Marzieh Sarbandi Farahani et al.   REVIEWS IN THE NEUROSCIENCES

Effect of Korean Red Ginseng as an adjuvant treatment for women with residual symptoms of major depression

(2014) Hyun-Ghang Jeong et al.   Asia-Pacific Psychiatry

Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites

(2014) Hyo Young Jung et al.   BMC Complementary and Alternative Medicine

Piperine Reverses Chronic Unpredictable Mild Stress-Induced Behavioral and Biochemical Alterations in Rats

(2014) Qing-Qiu Mao et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action

(2014) Adrian L. Lopresti et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

The Ups and Downs of Modelling Mood Disorders in Rodents

(2014) D. A. Slattery et al.   ILAR JOURNAL

Herbal medicine (Gan Mai Da Zao decoction) for depression: A systematic review and meta-analysis of randomized controlled trials

(2014) Ji Hee Jun et al.   MATURITAS

Increased left ventricular mass in hypercortisolemic depressed patients: A hypothesis based on a case series

(2014) Maria Gilles et al.   MEDICAL HYPOTHESES

Mental health: A world of depression

(2014) Kerri Smith   NATURE

Antidepressant and Neuroprotective Effect of the Chinese Herb Kaixinsan against Lentiviral shRNA Knockdown Brain-Derived Neurotrophic Factor-Induced Injury in vitro and in vivo

(2014) Yuan Hu et al.   NEUROPSYCHOBIOLOGY

Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management

(2014) Fanny C.F. Ip et al.   NEUROSIGNALS

The discovery of Yuanzhi-1, a triterpenoid saponin derived from the traditional Chinese medicine, has antidepressant-like activity

(2014) Zeng-liang Jin et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Involvement of the central monoaminergic system in the antidepressant-like effect of catalpol in mice

(2014) Junming Wang et al.   BioScience Trends

Antidepressant-Like Effects of Lycii Radicis Cortex and Betaine in the Forced Swimming Test in Rats

(2013) Soo Jeong Kim et al.   Biomolecules & Therapeutics

Citrus aurantium L. essential oil exhibits anxiolytic-like activity mediated by 5-HT1A-receptors and reduces cholesterol after repeated oral treatment

(2013) Celso A R A Costa et al.   BMC Complementary and Alternative Medicine

A case series on the use of lavendula oil capsules in patients suffering from major depressive disorder and symptoms of psychomotor agitation, insomnia and anxiety

(2013) Maria Fißler et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress

(2013) Jin-Fang Ge et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice

(2013) Li-Tao Yi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Passiflora incarnata L.: Ethnopharmacology, clinical application, safety and evaluation of clinical trials

(2013) M. Miroddi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cannabinoid Receptor Activation Prevents the Effects of Chronic Mild Stress on Emotional Learning and LTP in a Rat Model of Depression

(2013) Amir Segev et al.   NEUROPSYCHOPHARMACOLOGY

Accelerated Aging in Major Depression: The Role of Nitro-Oxidative Stress

(2013) Maria Luca et al.   Oxidative Medicine and Cellular Longevity

Antidepressant-like effects of essential oil and asarone, a major essential oil component from the rhizome ofAcorus tatarinowii

(2013) Ping Han et al.   PHARMACEUTICAL BIOLOGY

Inhibitory Effect of Bacopasides on Spontaneous Morphine Withdrawal Induced Depression in Mice

(2013) Khalid Rauf et al.   PHYTOTHERAPY RESEARCH

Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior

(2013) Yann S. Mineur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monoamine neurocircuitry in depression and strategies for new treatments

(2013) Michel Hamon et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Differential levels of brain amino acids in rat models presenting learned helplessness or non-learned helplessness

(2013) Katsumasa Muneoka et al.   PSYCHOPHARMACOLOGY

Isolation, Structural Elucidation, and Neuroprotective Effects of Iridoids fromValeriana jatamansi

(2012) Jing XU et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study

(2012) Ladan Kashani et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Naturally derived anti-inflammatory compounds from Chinese medicinal plants

(2012) Qiuhong Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Antidepressant-like Effect of Fuzi Total Alkaloid on Ovariectomized Mice

(2012) Lei Liu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Potential Antidepressant Activity ofAreca catechuNut via Elevation of Serotonin and Noradrenaline in the Hippocampus of Rats

(2012) Ghulam Abbas et al.   PHYTOTHERAPY RESEARCH

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

(2012) Ronald S. Duman et al.   TRENDS IN NEUROSCIENCES

Antidepressant Effects of a Plant-Derived Flavonoid Baicalein Involving Extracellular Signal-Regulated Kinases Cascade

(2011) Zhe Xiong et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence

(2011) Jerome Sarris et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Involvement of serotonergic system in the antidepressant-like effect of piperine

(2011) Qing-Qiu Mao et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Curcumin inhibits glutamate release in nerve terminals from rat prefrontal cortex: Possible relevance to its antidepressant mechanism

(2011) Tzu Yu Lin et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Potentials of Curcumin as an Antidepressant

(2011) S.K. Kulkarni et al.   TheScientificWorldJOURNAL

The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity

(2010) Eero Castrén et al.   Developmental Neurobiology

Antidepressant-like effects of neferine in the forced swimming test involve the serotonin1A (5-HT1A) receptor in mice

(2010) Yumi Sugimoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antidepressant-like effect of carvacrol (5-Isopropyl-2-methylphenol) in mice: involvement of dopaminergic system

(2010) Francisca Helvira Cavalcante Melo et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Antidepressant-like effects of the active acidic polysaccharide portion of ginseng in mice

(2010) Jia Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression

(2010) N. Farah Idayu et al.   PHYTOMEDICINE

Nuclear factor- B is a critical mediator of stress-impaired neurogenesis and depressive behavior

(2010) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Depression and oxidative damage to lipids

(2010) Sarah Yager et al.   PSYCHONEUROENDOCRINOLOGY

The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?

(2010) Christoph Anacker et al.   PSYCHONEUROENDOCRINOLOGY

Effectiveness, Safety, and Tolerability of Powdered Nigella sativa (Kalonji) Seed in Capsules on Serum Lipid Levels, Blood Sugar, Blood Pressure, and Body Weight in Adults: Results of a Randomized, Double-Blind Controlled Trial

(2009) Waris Qidwai et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

A Review on the Effects of Aromatherapy for Patients with Depressive Symptoms

(2009) V.W.C. Yim et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Fractalkine/CX3CL1 enhances GABA synaptic activity at serotonin neurons in the rat dorsal raphe nucleus

(2009) S. Heinisch et al.   NEUROSCIENCE

Antidepressant effect of the extracts from Fructus Akebiae

(2009) Dan Zhou et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum

(2009) J. Sarris et al.   PSYCHOPHARMACOLOGY

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

(2008) Srijan Sen et al.   BIOLOGICAL PSYCHIATRY

Two New Lignans from the Stem Bark of Magnolia obovata and Their Cytotoxic Activity

(2008) UiJoung Youn et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

On the mechanism of antidepressant-like action of berberine chloride

(2008) Shrinivas K. Kulkarni et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Evolvulus alsinoides (Convolvulaceae): An American herb in the Old World

(2008) Daniel F. Austin   JOURNAL OF ETHNOPHARMACOLOGY

Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice

(2008) Weixing Wang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The link between childhood trauma and depression: Insights from HPA axis studies in humans

(2008) Christine Heim et al.   PSYCHONEUROENDOCRINOLOGY

The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors

(2007) Rui Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents

(2007) Qun Xu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY