Neuroprotective Effects of Ginsenoside-Rg1 Against Depression-Like Behaviors via Suppressing Glial Activation, Synaptic Deficits, and Neuronal Apoptosis in Rats

A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization

(2018) Yunjie Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Hepatoprotective effect of ginsenoside Rg1 from Panax ginseng on carbon tetrachloride-induced acute liver injury by activating Nrf2 signaling pathway in mice

(2018) Chenqing Ning et al.   ENVIRONMENTAL TOXICOLOGY

The β2-adrenoceptor agonist clenbuterol reduces the neuroinflammatory response, neutrophil infiltration and apoptosis following intra-striatal IL-1β administration to rats

(2018) Éadaoin W. Griffin et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

MiR-134 modulates chronic stress-induced structural plasticity and depression-like behaviors via downregulation of Limk1/cofilin signaling in rats

(2018) Cuiqin Fan et al.   NEUROPHARMACOLOGY

Curcumin protects against chronic stress-induced dysregulation of neuroplasticity and depression-like behaviors via suppressing IL-1β pathway in rats

(2018) Cuiqin Fan et al.   NEUROSCIENCE

IL-1β Inhibits Connexin 43 and Disrupts Decidualization of Human Endometrial Stromal Cells Through ERK1/2 and p38 MAP Kinase

(2017) Jie Yu et al.   ENDOCRINOLOGY

Neuroprotective Effect of the Ginsenoside Rg1 on Cerebral Ischemic Injury In Vivo and In Vitro Is Mediated by PPARγ-Regulated Antioxidative and Anti-Inflammatory Pathways

(2017) Yang Li et al.   Evidence-based Complementary and Alternative Medicine

Ginsenoside Rg1 inhibits inflammatory responses via modulation of the nuclear factor‑κB pathway and inhibition of inflammasome activation in alcoholic hepatitis

(2017) Jiajun Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

N -methyl- d -aspartate receptor-mediated calcium overload and endoplasmic reticulum stress are involved in interleukin-1beta-induced neuronal apoptosis in rat hippocampus

(2017) Yilong Dong et al.   JOURNAL OF NEUROIMMUNOLOGY

Ginsenoside Rg1 promotes neural differentiation of mouse adipose-derived stem cells via the miRNA-124 signaling pathway

(2017) Juan Dong et al.   Journal of Zhejiang University-SCIENCE B

Protective effect and mechanism of ginsenoside Rg1 on carbon tetrachloride-induced acute liver injury

(2017) Benquan Qi et al.   Molecular Medicine Reports

Ginsenoside Rg1 reverses stress-induced depression-like behaviours and brain-derived neurotrophic factor expression within the prefrontal cortex

(2016) Xiuzhi Zhu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression

(2016) Ren-Hong Du et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization

(2016) An Liu et al.   JOURNAL OF CELL BIOLOGY

Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice

(2016) Q. Zhang et al.   JOURNAL OF NEUROSCIENCE

The effects of ginsenoside Rg1 on chronic stress induced depression-like behaviors, BDNF expression and the phosphorylation of PKA and CREB in rats

(2016) Z. Liu et al.   NEUROSCIENCE

nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology

(2016) Sang-Eun Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compromised MAPK signaling in human diseases: an update

(2015) Eun Kyung Kim et al.   ARCHIVES OF TOXICOLOGY

Fluoxetine Prevents Oligodendrocyte Cell Death by Inhibiting Microglia Activation after Spinal Cord Injury

(2015) Jee Y. Lee et al.   JOURNAL OF NEUROTRAUMA

Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome

(2015) Elísabet Alcocer-Gómez et al.   MOLECULAR NEUROBIOLOGY

Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response

(2015) Paul W. Andrews et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Ginsenoside-Rg1 induces angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a

(2015) Hoi-Hin Kwok et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

Effects of curcumin on chronic, unpredictable, mild, stress-induced depressive-like behaviour and structural plasticity in the lateral amygdala of rats

(2014) Lin Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Microglia of Prefrontal White Matter in Suicide

(2014) Tatiana P. Schnieder et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia/Reperfusion in Mice

(2014) Nan Zhang et al.   MEDIATORS OF INFLAMMATION

Protective effects of ginsenoside Rg1 on chronic restraint stress induced learning and memory impairments in male mice

(2014) Yuchan Wang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

Ginsenoside Rg1 Prevents Cognitive Impairment and Hippocampus Senescence in a Rat Model of D-Galactose-Induced Aging

(2014) Jiahong Zhu et al.   PLoS One

Ginsenoside Rg1 attenuates okadaic acid induced spatial memory impairment by the GSK3β/tau signaling pathway and the Aβ formation prevention in rats

(2013) Xiu-Yun Song et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The NLRP3 Inflammasome in Alzheimer’s Disease

(2013) Meng-Shan Tan et al.   MOLECULAR NEUROBIOLOGY

Expression of the NLRP3 Inflammasome in Cerebral Cortex After Traumatic Brain Injury in a Rat Model

(2013) Huan-Dong Liu et al.   NEUROCHEMICAL RESEARCH

Dysregulated relationship of inflammation and oxidative stress in major depression

(2012) B.J. Rawdin et al.   BRAIN BEHAVIOR AND IMMUNITY

Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus

(2012) Bo Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting IL-1 in depression

(2012) Michael Maes et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Depression as a disease of modernity: Explanations for increasing prevalence

(2012) Brandon H. Hidaka   JOURNAL OF AFFECTIVE DISORDERS

Effects of ginsenoside Rg1 or 17β-estradiol on a cognitively impaired, ovariectomized rat model of Alzheimer’s disease

(2012) X. Zhang et al.   NEUROSCIENCE

Neuropathological abnormalities of astrocytes, GABAergic neurons, and pyramidal neurons in the dorsolateral prefrontal cortices of patients with major depressive disorder

(2011) Dong Hoon Oh et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Chronic stress induces changes in the structure of interneurons and in the expression of molecules related to neuronal structural plasticity and inhibitory neurotransmission in the amygdala of adult mice

(2011) Javier Gilabert-Juan et al.   EXPERIMENTAL NEUROLOGY

Functional Biomarkers of Depression: Diagnosis, Treatment and Pathophysiology

(2011) Heath D Schmidt et al.   NEUROPSYCHOPHARMACOLOGY

The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis

(2011) Jonas Hannestad et al.   NEUROPSYCHOPHARMACOLOGY

The increasing burden of depression

(2011) Mike Briley et al.   Neuropsychiatric Disease and Treatment

Fluoxetine reverts chronic restraint stress-induced depression-like behaviour and increases neuropeptide Y and galanin expression in mice

(2010) S.H. Christiansen et al.   BEHAVIOURAL BRAIN RESEARCH

Inhibitory effect of ginsenoside Rg1 on lipopolysaccharide-induced microglial activation in mice

(2010) Jin-Feng Hu et al.   BRAIN RESEARCH

In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression

(2010) Marta Kubera et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Role of MicroRNA-214 in ginsenoside-Rg1-induced angiogenesis

(2009) Lai-Sheung Chan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Chronic Stress- and Sex-Specific Neuromorphological and Functional Changes in Limbic Structures

(2009) Katie J. McLaughlin et al.   MOLECULAR NEUROBIOLOGY

Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery

(2009) D.S. Goldwater et al.   NEUROSCIENCE

Imbalance between Pro- and Anti-inflammatory Cytokines, and between Th1 and Th2 Cytokines in Depressed Patients: The Effect of Electroacupuncture or Fluoxetine Treatment

(2009) C. Song et al.   PHARMACOPSYCHIATRY

Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: Effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor

(2009) Qing-Qiu Mao et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats

(2008) Zhiyu Zhao et al.   BEHAVIOURAL BRAIN RESEARCH

Stress as a neuroinflammatory condition in brain: Damaging and protective mechanisms

(2008) Borja García-Bueno et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Stress-induced prefrontal reorganization and executive dysfunction in rodents

(2008) Andrew Holmes et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

(2006) Johann Steiner et al.   JOURNAL OF PSYCHIATRIC RESEARCH