Panax Notoginseng Saponins: A Review of Its Mechanisms of Antidepressant or Anxiolytic Effects and Network Analysis on Phytochemistry and Pharmacology

BDNF Val66Met polymorphism, life stress and depression: A meta-analysis of gene-environment interaction

(2018) Mingzhe Zhao et al.   JOURNAL OF AFFECTIVE DISORDERS

Suppressive Effect of Ginsenoside Rg3 against Lipopolysaccharide-Induced Depression-Like Behavior and Neuroinflammation in Mice

(2017) An Kang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effect of Panax notoginseng saponins on the pharmacokinetics of aspirin in rats

(2017) Zhihao Tian et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Ginsenoside Rg3 exerts anti-depressive effect on an NMDA-treated cell model and a chronic mild stress animal model

(2017) Hualin Zhang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Effect of compatible herbs on the pharmacokinetics of effective components of Panax notoginseng in Fufang Xueshuantong Capsule

(2017) Huan-huan Pang et al.   Journal of Zhejiang University-SCIENCE B

Panax Notoginseng Saponins attenuates sevoflurane-induced nerve cell injury by modulating AKT signaling pathway

(2017) Xu Yang et al.   Molecular Medicine Reports

Antidepressant-like effects of ginsenoside Rg5 in mice: Involving of hippocampus BDNF signaling pathway

(2017) Dawei Xu et al.   NEUROSCIENCE LETTERS

Effects and mechanisms of compound Chinese medicine and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia/reperfusion

(2017) Jing-Yan Han et al.   PHARMACOLOGY & THERAPEUTICS

Epigenetic mechanisms of major depression: Targeting neuronal plasticity

(2017) Shusaku Uchida et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Herb pair Danggui-Honghua: mechanisms underlying blood stasis syndrome by system pharmacology approach

(2017) Shi-Jun Yue et al.   Scientific Reports

Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways

(2017) Chao Zhang et al.   Scientific Reports

Effects of ginseng on stress-related depression, anxiety, and the hypothalamic–pituitary–adrenal axis

(2017) Seungyeop Lee et al.   Journal of Ginseng Research

Protective Effect of Panax notoginseng Root Water Extract against Influenza A Virus Infection by Enhancing Antiviral Interferon-Mediated Immune Responses and Natural Killer Cell Activity

(2017) Jang-Gi Choi et al.   Frontiers in Immunology

Neuronal Surface Autoantibodies in Neuropsychiatric Disorders: Are There Implications for Depression?

(2017) Shenghua Zong et al.   Frontiers in Immunology

Anti-platelet activity of panaxatriol saponins is mediated by suppression of intracellular calcium mobilization and ERK2/p38 activation

(2016) Hongyi Qi et al.   BMC Complementary and Alternative Medicine

The neuroanatomy of depression: A review

(2016) Peter Oakes et al.   CLINICAL ANATOMY

Depression, Serotonin and Tryptophan

(2016) Liliana Dell'Osso et al.   CURRENT PHARMACEUTICAL DESIGN

Gut Permeability and Microbiota in Parkinson’s Disease: Role of Depression, Tryptophan Catabolites, Oxidative and Nitrosative Stress and Melatonergic Pathways

(2016) George Anderson et al.   CURRENT PHARMACEUTICAL DESIGN

Panax notoginseng saponins provide neuroprotection by regulating NgR1/RhoA/ROCK2 pathway expression, in vitro and in vivo

(2016) Xiaowei Shi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk.) F.H. Chen: A review

(2016) Ting Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Antidepressant-like effects of ginsenoside Rg3 in mice via activation of the hippocampal BDNF signaling cascade

(2016) Zhengchen You et al.   Journal of Natural Medicines

Effects of Panax notoginseng saponins on proliferation and differentiation of rat embryonic cortical neural stem cells

(2016) Yinchu Si et al.   Journal of the Chinese Medical Association

The effects of ginsenoside Rg1 on chronic stress induced depression-like behaviors, BDNF expression and the phosphorylation of PKA and CREB in rats

(2016) Z. Liu et al.   NEUROSCIENCE

Targets of polyamine dysregulation in major depression and suicide: Activity-dependent feedback, excitability, and neurotransmission

(2016) Agenor Limon et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Antidepressant-like effects of ginsenosides: A comparison of ginsenoside Rb3 and its four deglycosylated derivatives, Rg3, Rh2, compound K, and 20(S)-protopanaxadiol in mice models of despair

(2016) Hualin Zhang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Endothelium-dependent vasodilation effects of Panax notoginseng and its main components are mediated by nitric oxide and cyclooxygenase pathways

(2016) Yanyan Wang et al.   Experimental and Therapeutic Medicine

Cardioprotective effect of notoginsenoside R1 in a rabbit lung remote ischemic postconditioning model via activation of the TGF-β1/TAK1 signaling pathway

(2016) ZHI-RU GE et al.   Experimental and Therapeutic Medicine

The Immune System and the Role of Inflammation in Perinatal Depression

(2016) Philippe Leff-Gelman et al.   Neuroscience Bulletin

Chemical dampening of Ly6Chi monocytes in the periphery produces anti-depressant effects in mice

(2016) Xiao Zheng et al.   Scientific Reports

Effects of the Combination of the Main Active Components of Astragalus and Panax notoginseng on Inflammation and Apoptosis of Nerve Cell after Cerebral Ischemia-Reperfusion

(2015) Xiao-Ping Huang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Notoginsenoside R1 stimulates osteogenic function in primary osteoblasts via estrogen receptor signaling

(2015) Ting Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-stress Effects of 20(S)-Protopanaxadiol and 20(S)-Protopanaxatriol in Immobilized Mice

(2015) Hyun A Oh et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Qishenyiqi Dropping Pill attenuates myocardial fibrosis in rats by inhibiting RAAS-mediated arachidonic acid inflammation

(2015) Jing Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ginsenoside Rb1 rescues anxiety-like responses in a rat model of post-traumatic stress disorder

(2015) Bombi Lee et al.   Journal of Natural Medicines

Effects of notoginsenoside R1 on CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 activities in rats by cocktail probe drugs

(2015) Shuo Yin et al.   PHARMACEUTICAL BIOLOGY

Effects of the main active components combinations of Astragalus and Panax notoginseng on energy metabolism in brain tissues after cerebral ischemia-reperfusion in mice

(2015) Chang-Qing Deng et al.   Pharmacognosy Magazine

Panax notoginseng saponins suppress radiation-induced osteoporosis by regulating bone formation and resorption

(2015) Du Wenxi et al.   PHYTOMEDICINE

Phytochemical constituents as future antidepressants: a comprehensive review

(2015) Roodabeh Bahramsoltani et al.   REVIEWS IN THE NEUROSCIENCES

Panax Notoginseng Saponins Ameliorates Coxsackievirus B3-Induced Myocarditis by Activating the Cystathionine-γ-Lyase/Hydrogen Sulfide Pathway

(2015) Lulu Pan et al.   Journal of Cardiovascular Translational Research

Systems pharmacology-based dissection of mechanisms of Chinese medicinal formula Bufei Yishen as an effective treatment for chronic obstructive pulmonary disease

(2015) Jiansheng Li et al.   Scientific Reports

Genetic Determinants of Depression

(2015) Erin C. Dunn et al.   HARVARD REVIEW OF PSYCHIATRY

Notoginsenoside R1 Attenuates Hypoxia and Hypercapnia-Induced Vasoconstriction in Isolated Rat Pulmonary Arterial Rings by Reducing the Expression of ERK

(2014) Yixiao Xu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Antidepressant-like effects of aqueous extract from Cecropia pachystachya leaves in a mouse model of chronic unpredictable stress

(2014) Marta Gazal et al.   BRAIN RESEARCH BULLETIN

Effect of panax notoginseng saponins injection on the p38MAPK pathway in lung tissue in a rat model of hypoxic pulmonary hypertension

(2014) Shan Zhao et al.   Chinese Journal of Integrative Medicine

TRYCAT Pathways Link Peripheral Inflammation, Nicotine, Somatization and Depression in the Etiology and Course of Parkinson’s Disease

(2014) George Anderson et al.   CNS & Neurological Disorders-Drug Targets

Transcriptional Dys-regulation in Anxiety and Major Depression: 5-HT1A Gene Promoter Architecture as a Therapeutic Opportunity

(2014) Paul Albert et al.   CURRENT PHARMACEUTICAL DESIGN

The common inflammatory etiology of depression and cognitive impairment: a therapeutic target

(2014) David J Allison et al.   Journal of Neuroinflammation

Rodent Models of Depression: Neurotrophic and Neuroinflammatory Biomarkers

(2014) Mikhail Stepanichev et al.   Biomed Research International

Role of Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways in the Etiology of Depression: Therapeutic Implications

(2013) George Anderson et al.   CNS DRUGS

The Relationship Between Epilepsy and Depression: An Update

(2013) M. Osso et al.   CURRENT MEDICINAL CHEMISTRY

Ginsenoside Rg3 regulates GABAA receptor channel activity: Involvement of interaction with the γ2 subunit

(2013) Byung-Hwan Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Agmatine attenuates chronic unpredictable mild stress induced behavioral alteration in mice

(2013) Brijesh G. Taksande et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neurodegeneration in Parkinson's Disease: Interactions of Oxidative Stress, Tryptophan Catabolites and Depression with Mitochondria and Sirtuins

(2013) George Anderson et al.   MOLECULAR NEUROBIOLOGY

Peripheral immunomodulation with ginsenoside Rg1 ameliorates neuroinflammation-induced behavioral deficits in rats

(2013) X. Zheng et al.   NEUROSCIENCE

Poststroke Depression: A Review Emphasizing the Role of Prophylactic Treatment and Synergy with Treatment for Motor Recovery

(2013) Murray Flaster et al.   Topics in Stroke Rehabilitation

Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus

(2012) Bo Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of Ginsenoside Re on Depression- and Anxiety-Like Behaviors and Cognition Memory Deficit Induced by Repeated Immobilization in Rats

(2012) Bombi Lee   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Schizophrenia is primed for an increased expression of depression through activation of immuno-inflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathways

(2012) George Anderson et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Propofol interacts with stimulus intensities of electroconvulsive shock to regulate behavior and hippocampal BDNF in a rat model of depression

(2012) Jie Luo et al.   PSYCHIATRY RESEARCH

Antidepressant-like Effect of Altered Korean Red Ginseng in Mice

(2011) Na-Hyung Kim et al.   BEHAVIORAL MEDICINE

Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy

(2011) An Kang et al.   Journal of Neuroinflammation

Ginsenoside Rb3 exerts antidepressant-like effects in several animal models

(2011) Jihong Cui et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The antidepressant effects and mechanism of action of total saponins from the caudexes and leaves of Panax notoginseng in animal models of depression

(2011) Hui Xiang et al.   PHYTOMEDICINE

Identification of antidepressant-like ingredients in ginseng root (Panax ginseng C.A. Meyer) using a menopausal depressive-like state in female mice: participation of 5-HT2A receptors

(2011) Noriko Yamada et al.   PSYCHOPHARMACOLOGY

Induction of Differentiation by Panaxydol in Human Hepatocarcinoma SMMC-7721 Cells via cAMP and MAP Kinase Dependent Mechanism

(2011) Ze-Jian WANG et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Dose-dependent effects of caffeine on behavior and thermoregulation in a chronic unpredictable stress model of depression in rats

(2010) D. Pechlivanova et al.   BEHAVIOURAL BRAIN RESEARCH

Inactivation of GABAA receptor reduces ginsenoside Rb3 neuroprotection in mouse hippocampal slices after oxygen–glucose deprivation

(2010) Shan Jiang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Depression Shows Divergent Effects on Evoked and Spontaneous Pain Behaviors in Rats

(2010) Miao Shi et al.   JOURNAL OF PAIN

20(S)-protopanaxadiol, an active ginseng metabolite, exhibits strong antidepressant-like effects in animal tests

(2010) Changjiang Xu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Simultaneous determination of three major bioactive saponins of Panax notoginseng using liquid chromatography-tandem mass spectrometry and a pharmacokinetic study

(2010) Wei Chen et al.   Chinese Medicine

Anxiolytic-like Effects of Ginsenosides Rg3 and Rh2 from Red Ginseng in the Elevated Plus-Maze Model

(2009) Tae Kim et al.   PLANTA MEDICA