SUMOylation in peripheral tissues under low perfusion‐related pathological states

Heat shock transcription factor 1 is SUMOylated in the activated trimeric state

(2021) Szymon W. Kmiecik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global non-covalent SUMO interaction networks reveal SUMO-dependent stabilization of the non-homologous end joining complex

(2021) Román González-Prieto et al.   Cell Reports

Annexin-A1 SUMOylation regulates microglial polarization after cerebral ischemia by modulating IKKα stability via selective autophagy

(2021) Xing Li et al.   Science Advances

Selective-cerebral-hypothermia-induced neuroprotection against-focal cerebral ischemia/reperfusion injury is associated with an increase in SUMO2/3 conjugation

(2021) Guiliang Sun et al.   BRAIN RESEARCH

SUMOylation modification-mediated cell death

(2021) Zenghua Sheng et al.   Open Biology

Rg3 promotes the SUMOylation of SERCA2a and corrects cardiac dysfunction in heart failure

(2021) Zhihao Liu et al.   PHARMACOLOGICAL RESEARCH

Activated Drp1-mediated mitochondrial ROS influence the gut microbiome and intestinal barrier after hemorrhagic shock

(2020) Chenyang Duan et al.   Aging-US

Suspended in time: Molecular responses to hibernation also promote longevity

(2020) Rasha Al-attar et al.   EXPERIMENTAL GERONTOLOGY

Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels

(2020) Leigh D. Plant et al.   Cell Reports

Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts

(2020) Arda B. Celen et al.   FEBS Journal

Refocusing the Brain: New Approaches in Neuroprotection Against Ischemic Injury

(2020) Cristina Rodriguez et al.   NEUROCHEMICAL RESEARCH

The Hyperoxic-Hypoxic Paradox

(2020) Amir Hadanny et al.   Biomolecules

Drp1-dependent mitochondrial fission in cardiovascular disease

(2020) Jia-yu Jin et al.   ACTA PHARMACOLOGICA SINICA

Hypoxia-inducible factor signaling in pulmonary hypertension

(2020) Soni Savai Pullamsetti et al.   JOURNAL OF CLINICAL INVESTIGATION

SUMO: From Bench to Bedside

(2020) Hui-Ming Chang et al.   PHYSIOLOGICAL REVIEWS

A Chain of Events: Regulating Target Proteins by SUMO Polymers

(2020) Nicolette S. Jansen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ubc9 Attenuates Myocardial Ischemic Injury Through Accelerating Autophagic Flux

(2020) Qing Xiao et al.   Frontiers in Pharmacology

Acute kidney injury pathology and pathophysiology: a retrospective review

(2020) Joseph P Gaut et al.   Clinical Kidney Journal

SUMOylation of the nuclear pore complex basket is involved in sensing cellular stresses

(2019) Hanne Folz et al.   JOURNAL OF CELL SCIENCE

Protective role of the deSUMOylating enzyme SENP3 in myocardial ischemia-reperfusion injury

(2019) Nadiia Rawlings et al.   PLoS One

SUMOylation of Vps34 by SUMO1 promotes phenotypic switching of vascular smooth muscle cells by activating autophagy in pulmonary arterial hypertension

(2019) Yufeng Yao et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Outcomes of traumatic hemorrhagic shock and the epidemiology of preventable death from injury

(2019) Brian J. Eastridge et al.   TRANSFUSION

Zinc-Induced SUMOylation of Dynamin-Related Protein 1 Protects the Heart against Ischemia-Reperfusion Injury

(2019) Xiyun Bian et al.   Oxidative Medicine and Cellular Longevity

Roles and mechanisms of SUMOylation on key proteins in myocardial ischemia/reperfusion injury

(2019) Jingwen Chen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

SUMOylation Landscape of Renal Cortical Collecting Duct Cells

(2019) Qi Wu et al.   JOURNAL OF PROTEOME RESEARCH

Inflammasome-Mediated Inflammation in Liver Ischemia-Reperfusion Injury

(2019) Mónica B. Jiménez-Castro et al.   Cells

Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies

(2019) Ricardo O. S. Soares et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury

(2019) Kuznetsov et al.   Antioxidants

Upregulation of mitochondrial E3 ubiquitin ligase 1 in rat heart contributes to ischemia/reperfusion injury

(2019) Shi-Jing Wang et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The involvement of post-translational modifications in cardiovascular pathologies: Focus on SUMOylation, neddylation, succinylation, and prenylation

(2019) Jinning Gao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary EndotheliumHighlights

(2018) Deepesh Pandey et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Luteolin Modulates SERCA2a Leading to Attenuation of Myocardial Ischemia/ Reperfusion Injury via Sumoylation at Lysine 585 in Mice

(2018) Yinping Du et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Current Mechanistic Concepts in Ischemia and Reperfusion Injury

(2018) Meng-Yu Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Renal ischemia/reperfusion-induced mitophagy protects against renal dysfunction via Drp1-dependent-pathway

(2018) Nan Li et al.   EXPERIMENTAL CELL RESEARCH

SUMO-specific proteases and isopeptidases of the SENP family at a glance

(2018) Kathrin Kunz et al.   JOURNAL OF CELL SCIENCE

The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury

(2018) Lingchen Gao et al.   Journal of Genetics and Genomics

Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion

(2018) Jörn Karhausen et al.   LABORATORY INVESTIGATION

PIAS1 protects against myocardial ischemia-reperfusion injury by stimulating PPARγ SUMOylation

(2018) Bo Xie et al.   BMC CELL BIOLOGY

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

(2018) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

SUMOylation in brain ischemia: Patterns, targets, and translational implications

(2017) Joshua D Bernstock et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Dynamin-related protein-1 as potential therapeutic target in various diseases

(2017) Surinder Singh et al.   INFLAMMOPHARMACOLOGY

SENP-1 enhances hypoxia-induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia-inducible factor-1α

(2016) FANG ZHOU et al.   Molecular Medicine Reports

The SWISS-MODEL Repository—new features and functionality

(2016) Stefan Bienert et al.   NUCLEIC ACIDS RESEARCH

SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons

(2016) Leigh D Plant et al.   eLife

Targeting the SUMO pathway for neuroprotection in brain ischaemia

(2016) Wei Yang et al.   JOURNAL OF INVESTIGATIVE MEDICINE

SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies

(2016) Ya-Chen Liang et al.   Scientific Reports

SUMOylation occurs in acute kidney injury and plays a cytoprotective role

(2015) Chunyuan Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Autophagy in cardiovascular biology

(2015) Sergio Lavandero et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteotoxic stress reprograms the chromatin landscape of SUMO modification

(2015) Anne Seifert et al.   Science Signaling

Global Reprogramming of Host SUMOylation during Influenza Virus Infection

(2015) Patricia Domingues et al.   Cell Reports

Proteotoxic stress reprograms the chromatin landscape of SUMO modification

(2015) Anne Seifert et al.   Science Signaling

Non-nuclear function of sumoylated proteins

(2014) Urszula Wasik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Synthesis of 2′,3′,4′-trihydroxyflavone (2-D08), an inhibitor of protein sumoylation

(2014) Yeong Sang Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development

(2014) L. Wang et al.   EMBO REPORTS

Wrestling with stress: Roles of protein SUMOylation and deSUMOylation in cell stress response

(2014) Chun Guo et al.   IUBMB LIFE

PHD3-SUMO conjugation represses HIF1 transcriptional activity independently of PHD3 catalytic activity

(2014) A. Nunez-O'Mara et al.   JOURNAL OF CELL SCIENCE

Global Consequences of Liver Ischemia/Reperfusion Injury

(2014) Constantinos Nastos et al.   Oxidative Medicine and Cellular Longevity

Small Ubiquitin-Like Modifier 3–Modified Proteome Regulated by Brain Ischemia in Novel Small Ubiquitin-Like Modifier Transgenic Mice

(2014) Wei Yang et al.   STROKE

Disruption of SUMO-Specific Protease 2 Induces Mitochondria Mediated Neurodegeneration

(2014) Jiang Fu et al.   PLoS Genetics

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia

(2013) Chun Guo et al.   EMBO JOURNAL

Molecular targets underlying SUMO-mediated neuroprotection in brain ischemia

(2013) Vasco Silveirinha et al.   JOURNAL OF NEUROCHEMISTRY

Receptor Trafficking and the Regulation of Synaptic Plasticity by SUMO

(2013) Jia Luo et al.   NEUROMOLECULAR MEDICINE

Function and regulation of SUMO proteases

(2012) Christopher M. Hickey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition

(2012) T. Bawa-Khalfe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perspective in Chronic Kidney Disease: Targeting Hypoxia-Inducible Factor (HIF) as Potential Therapeutic Approach

(2012) Aaishwarya B. Deshmukh et al.   RENAL FAILURE

Enhanced SUMOylation and SENP-1 Protein Levels following Oxygen and Glucose Deprivation in Neurones

(2011) Helena Cimarosti et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

SUMO2/3 Conjugation is an Endogenous Neuroprotective Mechanism

(2011) Anna Lena Datwyler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Analysis of Oxygen/Glucose-Deprivation-Induced Changes in SUMO3 Conjugation Using SILAC-Based Quantitative Proteomics

(2011) Wei Yang et al.   JOURNAL OF PROTEOME RESEARCH

SUMO1-dependent modulation of SERCA2a in heart failure

(2011) Changwon Kho et al.   NATURE

Elevated Global SUMOylation in Ubc9 Transgenic Mice Protects Their Brains against Focal Cerebral Ischemic Damage

(2011) Yang-ja Lee et al.   PLoS One

Targets and consequences of protein SUMOylation in neurons

(2010) Kevin A. Wilkinson et al.   BRAIN RESEARCH REVIEWS

SUMO-specific protease 2 in Mdm2-mediated regulation of p53

(2010) M Jiang et al.   CELL DEATH AND DIFFERENTIATION

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia

(2010) X Kang et al.   ONCOGENE

One SUMO is sufficient to silence the dimeric potassium channel K2P1

(2010) L. D. Plant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ligase PIAS1 Restricts Natural Regulatory T Cell Differentiation by Epigenetic Repression

(2010) B. Liu et al.   SCIENCE

SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation

(2009) Chao Huang et al.   EMBO JOURNAL

Translocation of SenP5 from the Nucleoli to the Mitochondria Modulates DRP1-dependent Fission during Mitosis

(2009) Rodolfo Zunino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMOylation and deSUMOylation at a glance

(2009) Y. Wang et al.   JOURNAL OF CELL SCIENCE

Virus Infection Triggers SUMOylation of IRF3 and IRF7, Leading to the Negative Regulation of Type I Interferon Gene Expression

(2008) Toru Kubota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased protein SUMOylation following focal cerebral ischemia

(2007) Helena Cimarosti et al.   NEUROPHARMACOLOGY