Global non-covalent SUMO interaction networks reveal SUMO-dependent stabilization of the non-homologous end joining complex

SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat Shock

(2019) Frauke Liebelt et al.   Cell Reports

Mechanism and chain-specificity of RNF216/TRIAD3, the ubiquitin ligase mutated in Gordon-Holmes Syndrome

(2019) Ramkumar Seenivasan et al.   HUMAN MOLECULAR GENETICS

Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation

(2019) Chi-Hsien Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain

(2019) Annie M. Sriramachandran et al.   Nature Communications

TULIP2: An Improved Method for the Identification of Ubiquitin E3-Specific Targets

(2019) Daniel Salas-Lloret et al.   Frontiers in Chemistry

SUMO targets the APC/C to regulate transition from metaphase to anaphase

(2018) Karolin Eifler et al.   Nature Communications

Site-specific characterization of endogenous SUMOylation across species and organs

(2018) Ivo A. Hendriks et al.   Nature Communications

OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ

(2018) Zhengkui Zhang et al.   MOLECULAR CELL

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Identification of a new small ubiquitin-like modifier (SUMO)-interacting motif in the E3 ligase PIASy

(2017) Kawaljit Kaur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C-terminal motifs in promyelocytic leukemia protein isoforms critically regulate PML nuclear body formation

(2017) Chuang Li et al.   JOURNAL OF CELL SCIENCE

Global Analysis of SUMO-Binding Proteins Identifies SUMOylation as a Key Regulator of the INO80 Chromatin Remodeling Complex

(2017) Eric Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

(2017) Xingyue He et al.   Nature Chemical Biology

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation

(2017) Ivo A Hendriks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ZATT (ZNF451)–mediated resolution of topoisomerase 2 DNA-protein cross-links

(2017) Matthew J. Schellenberg et al.   SCIENCE

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

(2017) Ramesh Kumar et al.   Nature Communications

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation

(2017) Ivo A Hendriks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphorylable tyrosine residue 162 in the double-stranded RNA-dependent kinase PKR modulates its interaction with SUMO

(2017) Carlos F. de la Cruz-Herrera et al.   Scientific Reports

Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining

(2017) Davide Normanno et al.   eLife

Non-homologous end joining: advances and frontiers

(2016) Kai Yang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

SUMO-interacting motifs (SIMs) in Polo-like kinase 1-interacting checkpoint helicase (PICH) ensure proper chromosome segregation during mitosis

(2016) Vinidhra Sridharan et al.   CELL CYCLE

SUMOylation of Rb enhances its binding with CDK2 and phosphorylation at early G1 phase

(2016) Fengxi Meng et al.   CELL CYCLE

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

Nup358 binds to AGO proteins through its SUMO‐interacting motifs and promotes the association of target mRNA with miRISC

(2016) Manas Ranjan Sahoo et al.   EMBO REPORTS

Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylasein Vivo

(2016) Dylan McLaughlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Analysis of a Complex between Small Ubiquitin-like Modifier 1 (SUMO1) and the ZZ Domain of CREB-binding Protein (CBP/p300) Reveals a New Interaction Surface on SUMO

(2016) Carl Diehl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

A comprehensive compilation of SUMO proteomics

(2016) Ivo A. Hendriks et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

USP7 is a SUMO deubiquitinase essential for DNA replication

(2016) Emilio Lecona et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

USP7 is a SUMO deubiquitinase essential for DNA replication

(2016) Emilio Lecona et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mutations in the NHEJ Component XRCC4 Cause Primordial Dwarfism

(2015) Jennie E. Murray et al.   AMERICAN JOURNAL OF HUMAN GENETICS

SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites

(2015) R. Gonzalez-Prieto et al.   EMBO REPORTS

XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency

(2015) Chaowan Guo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Molecular Basis for Phosphorylation-dependent SUMO Recognition by the DNA Repair Protein RAP80

(2015) Anamika et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In cellulophosphorylation of XRCC4 Ser320 by DNA-PK induced by DNA damage

(2015) Mukesh Kumar Sharma et al.   JOURNAL OF RADIATION RESEARCH

The SLX4 Complex Is a SUMO E3 Ligase that Impacts on Replication Stress Outcome and Genome Stability

(2015) Jean-Hugues Guervilly et al.   MOLECULAR CELL

Noncovalent Interactions with SUMO and Ubiquitin Orchestrate Distinct Functions of the SLX4 Complex in Genome Maintenance

(2015) Jian Ouyang et al.   MOLECULAR CELL

A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly

(2015) Nathalie Eisenhardt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase

(2015) Laurent Cappadocia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Screen for multi-SUMO–binding proteins reveals a multi-SIM–binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin

(2015) Elisa Aguilar-Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly

(2015) Nathalie Eisenhardt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase

(2015) Laurent Cappadocia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The spatial organization of non-homologous end joining: From bridging to end joining

(2014) Takashi Ochi et al.   DNA REPAIR

Oxidative stress–induced assembly of PML nuclear bodies controls sumoylation of partner proteins

(2014) Umut Sahin et al.   JOURNAL OF CELL BIOLOGY

The SMN Tudor SIM-like domain is key to SmD1 and coilin interactions and to Cajal body biogenesis

(2014) O. Tapia et al.   JOURNAL OF CELL SCIENCE

Multiple Arkadia/RNF111 Structures Coordinate Its Polycomb Body Association and Transcriptional Control

(2014) Huaiyu Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Uncovering global SUMOylation signaling networks in a site-specific manner

(2014) Ivo A Hendriks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

GPS-SUMO: a tool for the prediction of sumoylation sites and SUMO-interaction motifs

(2014) Qi Zhao et al.   NUCLEIC ACIDS RESEARCH

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Characterization of the SUMO-Binding Activity of the Myeloproliferative and Mental Retardation (MYM)-Type Zinc Fingers in ZNF261 and ZNF198

(2014) Catherine M. Guzzo et al.   PLoS One

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

(2014) F. Impens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteome-Wide Identification of SUMO2 Modification Sites

(2014) T. Tammsalu et al.   Science Signaling

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

Control of Nuclear Activities by Substrate-Selective and Protein-Group SUMOylation

(2013) Stefan Jentsch et al.   Annual Review of Genetics

End-joining inhibition at telomeres requires the translocase and polySUMO-dependent ubiquitin ligase Uls1

(2013) Rachel Lescasse et al.   EMBO JOURNAL

Regulated nuclear entry of over-expressed Setdb1

(2013) Sunwha Cho et al.   GENES TO CELLS

Analysis of SUMOylated proteins using SUMO-traps

(2013) Elisa Da Silva-Ferrada et al.   Scientific Reports

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair

(2012) Ivan Psakhye et al.   CELL

RNF4 is required for DNA double-strand break repair in vivo

(2012) R Vyas et al.   CELL DEATH AND DIFFERENTIATION

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

(2012) Y. Yin et al.   GENES & DEVELOPMENT

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair

(2012) Y. Galanty et al.   GENES & DEVELOPMENT

DNA damage–inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

(2012) Jannie Rendtlew Danielsen et al.   JOURNAL OF CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Function and regulation of SUMO proteases

(2012) Christopher M. Hickey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of two independent SUMO-interacting motifs in Daxx: Evolutionary conservation from Drosophila to humans and their biochemical functions

(2011) Aleixo Santiago et al.   CELL CYCLE

Characterizing the N- and C-terminal Small Ubiquitin-like Modifier (SUMO)-interacting Motifs of the Scaffold Protein DAXX

(2011) Eric Escobar-Cabrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMOylation and SUMO-interacting Motif (SIM) of Metastasis Tumor Antigen 1 (MTA1) Synergistically Regulate Its Transcriptional Repressor Function

(2011) Lin Cong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Proteomics and Dynamic Imaging of the Nucleolus Reveal Distinct Responses to UV and Ionizing Radiation

(2011) Henna M. Moore et al.   MOLECULAR & CELLULAR PROTEOMICS

A public genome-scale lentiviral expression library of human ORFs

(2011) Xiaoping Yang et al.   NATURE METHODS

SUMO-SIM Interactions Regulate the Activity of RGSZ2 Proteins

(2011) Javier Garzón et al.   PLoS One

SUMO-Interacting Motifs of Human TRIM5α are Important for Antiviral Activity

(2011) Gloria Arriagada et al.   PLoS Pathogens

Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53

(2010) Ki Sa Sung et al.   EXPERIMENTAL CELL RESEARCH

A Small Ubiquitin-related Modifier-interacting Motif Functions as the Transcriptional Activation Domain of Krüppel-like Factor 4

(2010) James X. Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-Specific Identification of SUMO-2 Targets in Cells Reveals an Inverted SUMOylation Motif and a Hydrophobic Cluster SUMOylation Motif

(2010) Ivan Matic et al.   MOLECULAR CELL

Post-translational modifications in signal integration

(2010) Yonathan Lissanu Deribe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability

(2010) T Sæther et al.   ONCOGENE

A Role for Non-Covalent SUMO Interaction Motifs in Pc2/CBX4 E3 Activity

(2010) Jacqueline C. Merrill et al.   PLoS One

BIN1 Localizes the L-Type Calcium Channel to Cardiac T-Tubules

(2010) Ting-Ting Hong et al.   PLOS BIOLOGY

SUMO Interaction Motifs in Sizn1 Are Required for Promyelocytic Leukemia Protein Nuclear Body Localization and for Transcriptional Activation

(2009) Ginam Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Binding of CoREST1 to SUMO-2/3 Contributes to Gene-Specific Repression by the LSD1/CoREST1/HDAC Complex

(2009) Jian Ouyang et al.   MOLECULAR CELL

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

(2009) Joanna R. Morris et al.   NATURE

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

(2009) Yaron Galanty et al.   NATURE

Improved visualization of protein consensus sequences by iceLogo

(2009) Niklaas Colaert et al.   NATURE METHODS

System-Wide Changes to SUMO Modifications in Response to Heat Shock

(2009) F. Golebiowski et al.   Science Signaling

Structure of the Small Ubiquitin-like Modifier (SUMO)-interacting Motif of MBD1-containing Chromatin-associated Factor 1 Bound to SUMO-3

(2008) Naotaka Sekiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMO-2/3 Modification and Binding Regulate the Association of CENP-E with Kinetochores and Progression through Mitosis

(2008) Xiang-Dong Zhang et al.   MOLECULAR CELL

Mechanism and Consequences for Paralog-Specific Sumoylation of Ubiquitin-Specific Protease 25

(2008) Erik Meulmeester et al.   MOLECULAR CELL

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY