Targeting the SUMO pathway for neuroprotection in brain ischaemia

Evaluation of the activity and substrate specificity of the human SENP family of SUMO proteases

(2016) Andreia V. Mendes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Ubiquitin-Like SUMO System and Heart Function

(2016) Luca Mendler et al.   CIRCULATION RESEARCH

Global SUMOylation facilitates the multimodal neuroprotection afforded by quercetin against the deleterious effects of oxygen/glucose deprivation and the restoration of oxygen/glucose

(2016) Yang-ja Lee et al.   JOURNAL OF NEUROCHEMISTRY

Sumoylation of LYS590 of NCX3 f-Loop by SUMO1 Participates in Brain Neuroprotection Induced by Ischemic Preconditioning

(2016) Ornella Cuomo et al.   STROKE

Hand in hand with the world to conquer stroke

(2016) Yongjun Wang et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Heart Disease and Stroke Statistics—2016 Update

(2015) Dariush Mozaffarian et al.   CIRCULATION

Neuroprotection for ischaemic stroke: Current status and challenges

(2015) Antonio Moretti et al.   PHARMACOLOGY & THERAPEUTICS

SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer

(2015) Karolin Eifler et al.   TRENDS IN BIOCHEMICAL SCIENCES

Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure

(2015) Changwon Kho et al.   Nature Communications

Emerging Potential of Therapeutic Targeting of Ubiquitin-Specific Proteases in the Treatment of Cancer

(2014) A. Pal et al.   CANCER RESEARCH

SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development

(2014) L. Wang et al.   EMBO REPORTS

SUMO2/3 is Associated with Ubiquitinated Protein Aggregates in the Mouse Neocortex after Middle Cerebral Artery Occlusion

(2014) Karin Hochrainer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Identification of 1,2,5-Oxadiazoles as a New Class of SENP2 Inhibitors Using Structure Based Virtual Screening

(2014) Ashutosh Kumar et al.   Journal of Chemical Information and Modeling

Important Role of SUMOylation of Spliceosome Factors in Prostate Cancer Cells

(2014) Donghua Wen et al.   JOURNAL OF PROTEOME RESEARCH

SUMO proteomics to decipher the SUMO-modified proteome regulated by various diseases

(2014) Wei Yang et al.   PROTEOMICS

Small Ubiquitin-Like Modifier 3–Modified Proteome Regulated by Brain Ischemia in Novel Small Ubiquitin-Like Modifier Transgenic Mice

(2014) Wei Yang et al.   STROKE

Global SUMOylation is a molecular mechanism underlying hypothermia-induced ischemic tolerance

(2014) Yang-ja Lee et al.   Frontiers in Cellular Neuroscience

The ROS/SUMO Axis Contributes to the Response of Acute Myeloid Leukemia Cells to Chemotherapeutic Drugs

(2014) Guillaume Bossis et al.   Cell Reports

Identification and Characterization of a New Chemotype of Noncovalent SENP Inhibitors

(2013) Ikenna G. Madu et al.   ACS Chemical Biology

SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia

(2013) Chun Guo et al.   EMBO JOURNAL

Molecular targets underlying SUMO-mediated neuroprotection in brain ischemia

(2013) Vasco Silveirinha et al.   JOURNAL OF NEUROCHEMISTRY

SUMO-1 Gene Transfer Improves Cardiac Function in a Large-Animal Model of Heart Failure

(2013) L. Tilemann et al.   Science Translational Medicine

Senp1 Is Essential for Desumoylating Sumo1-Modified Proteins but Dispensable for Sumo2 and Sumo3 Deconjugation in the Mouse Embryo

(2013) Prashant Sharma et al.   Cell Reports

Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors

(2012) Masaharu Uno et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small ubiquitin-like modifier 1-3 is activated in human astrocytic brain tumors and is required for glioblastoma cell survival

(2012) Wei Yang et al.   CANCER SCIENCE

Discovery of Specific Inhibitors of Human USP7/HAUSP Deubiquitinating Enzyme

(2012) Céline Reverdy et al.   CHEMISTRY & BIOLOGY

DeSUMOylating isopeptidase: a second class of SUMO protease

(2012) Eun Ju Shin et al.   EMBO REPORTS

Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions

(2012) Sarah Schulz et al.   EMBO REPORTS

Moderate hypothermia induces marked increase in levels and nuclear accumulation of SUMO2/3-conjugated proteins in neurons

(2012) Liangli Wang et al.   JOURNAL OF NEUROCHEMISTRY

Function and regulation of SUMO proteases

(2012) Christopher M. Hickey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global Protein Conjugation by Ubiquitin-Like-Modifiers during Ischemic Stress Is Regulated by MicroRNAs and Confers Robust Tolerance to Ischemia

(2012) Yang-ja Lee et al.   PLoS One

Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors

(2011) Zhitao Qiao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Functional Characterization of a SUMO Deconjugating Protease of Plasmodium falciparum Using Newly Identified Small Molecule Inhibitors

(2011) Elizabeth L. Ponder et al.   CHEMISTRY & BIOLOGY

Development of Small Molecule Inhibitors and Probes of Human SUMO Deconjugating Proteases

(2011) Victoria E. Albrow et al.   CHEMISTRY & BIOLOGY

Enhanced SUMOylation and SENP-1 Protein Levels following Oxygen and Glucose Deprivation in Neurones

(2011) Helena Cimarosti et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

SUMO2/3 Conjugation is an Endogenous Neuroprotective Mechanism

(2011) Anna Lena Datwyler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

SUMO1-dependent modulation of SERCA2a in heart failure

(2011) Changwon Kho et al.   NATURE

Elevated Global SUMOylation in Ubc9 Transgenic Mice Protects Their Brains against Focal Cerebral Ischemic Damage

(2011) Yang-ja Lee et al.   PLoS One

Comparative Proteomic Analysis Identifies a Role for SUMO in Protein Quality Control

(2011) M. H. Tatham et al.   Science Signaling

Distribution and paralogue specificity of mammalian deSUMOylating enzymes

(2010) Nagamalleswari Kolli et al.   BIOCHEMICAL JOURNAL

SUMO-Specific Protease 2 Is Essential for Suppression of Polycomb Group Protein-Mediated Gene Silencing during Embryonic Development

(2010) Xunlei Kang et al.   MOLECULAR CELL

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

Deep Hypothermia Markedly Activates the Small Ubiquitin-Like Modifier Conjugation Pathway; Implications for the Fate of Cells Exposed to Transient Deep Hypothermic Cardiopulmonary Bypass

(2009) Wei Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

SUMOylation participates in induction of ischemic tolerance

(2009) Yang ja Lee et al.   JOURNAL OF NEUROCHEMISTRY

Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3

(2008) E. Evdokimov et al.   JOURNAL OF CELL SCIENCE

Transient Focal Cerebral Ischemia Induces a Dramatic Activation of Small Ubiquitin-Like Modifier Conjugation

(2008) Wei Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral ischemiastroke and small ubiquitin-like modifier (SUMO) conjugation a new target for therapeutic intervention?

(2008) Wei Yang et al.   JOURNAL OF NEUROCHEMISTRY

Increased protein SUMOylation following focal cerebral ischemia

(2007) Helena Cimarosti et al.   NEUROPHARMACOLOGY