Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

(2022) Christopher JL Murray et al.   LANCET

MDSC: Markers, development, states, and unaddressed complexity

(2021) Samarth Hegde et al.   IMMUNITY

An acquired acyltransferase promotes Klebsiella pneumoniae ST258 respiratory infection

(2021) Danielle Ahn et al.   Cell Reports

MDSC in Mice and Men: Mechanisms of Immunosuppression in Cancer

(2021) Christophe Vanhaver et al.   Journal of Clinical Medicine

Population genomics of Klebsiella pneumoniae

(2020) Kelly L. Wyres et al.   NATURE REVIEWS MICROBIOLOGY

Linearized Siderophore Products Secreted via MacAB Efflux Pump Protect Salmonella enterica Serovar Typhimurium from Oxidative Stress

(2020) L. M. Bogomolnaya et al.   mBio

Klebsiella pneumoniae type VI secretion system-mediated microbial competition is PhoPQ controlled and reactive oxygen species dependent

(2020) Daniel Storey et al.   PLoS Pathogens

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

(2020) Alexander Hooftman et al.   Cell Metabolism

Klebsiella pneumoniae infections in COVID-19 patients: a 2-month retrospective analysis in an Italian hospital

(2020) Gabriele Arcari et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

(2019) Ilias Angelidis et al.   Nature Communications

Disease Tolerance as an Inherent Component of Immunity

(2019) Rui Martins et al.   Annual Review of Immunology

S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate

(2019) Wei Qin et al.   Nature Chemical Biology

Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor

(2019) Dehong Yan et al.   Frontiers in Immunology

SPARC Is a New Myeloid-Derived Suppressor Cell Marker Licensing Suppressive Activities

(2019) Sabina Sangaletti et al.   Frontiers in Immunology

Emergence of Polymyxin Resistance in Clinical Klebsiella pneumoniae Through Diverse Genetic Adaptations: A Genomic, Retrospective Cohort Study

(2019) Nenad Macesic et al.   CLINICAL INFECTIOUS DISEASES

Type VI secretion system: a modular toolkit for bacterial dominance

(2019) Biswanath Jana et al.   Future Microbiology

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects

(2019) Shan-Ting Liao et al.   Nature Communications

The Campylobacter jejuni Type VI Secretion System Enhances the Oxidative Stress Response and Host Colonization

(2019) Janie Liaw et al.   Frontiers in Microbiology

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis

(2018) Ajit S. Divakaruni et al.   Cell Metabolism

The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations

(2018) Roddy S. O’Connor et al.   Scientific Reports

Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation

(2018) Cong-Hui Yao et al.   PLOS BIOLOGY

Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity

(2018) Josephin N. Rashida Gnanaprakasam et al.   Frontiers in Immunology

metaGraphite–a new layer of pathway annotation to get metabolite networks

(2018) Gabriele Sales et al.   BIOINFORMATICS

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors

(2018) Jonathan M. Weiss et al.   JOURNAL OF CLINICAL INVESTIGATION

Klebsiella pneumoniae type VI secretion system contributes to bacterial competition, cell invasion, type-1 fimbriae expression, and in vivo colonization

(2018) Pei-Fang Hsieh et al.   JOURNAL OF INFECTIOUS DISEASES

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Siderophore-Mediated Iron Acquisition Enhances Resistance to Oxidative and Aromatic Compound Stress in Cupriavidus necator JMP134

(2018) Changfu Li et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression

(2018) Christopher Groth et al.   BRITISH JOURNAL OF CANCER

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Comprehensive Arrayed Transposon Mutant Library of Klebsiella pneumoniae Outbreak Strain KPNIH1

(2017) Beth Ramage et al.   JOURNAL OF BACTERIOLOGY

Towards High-Resolution Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry Coupled to Shear Force Microscopy

(2017) Son N. Nguyen et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Oxidative stress, protein damage and repair in bacteria

(2017) Benjamin Ezraty et al.   NATURE REVIEWS MICROBIOLOGY

Manganese scavenging and oxidative stress response mediated by type VI secretion system inBurkholderia thailandensis

(2017) Meiru Si et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Type VI Secretion System Engages a Redox-Regulated Dual-Functional Heme Transporter for Zinc Acquisition

(2017) Meiru Si et al.   Cell Reports

Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads

(2017) Ryan R. Wick et al.   PLoS Computational Biology

T6SS: The bacterial "fight club" in the host gut

(2017) Thibault G. Sana et al.   PLoS Pathogens

Type VI secretion system contributes to Enterohemorrhagic Escherichia coli virulence by secreting catalase against host reactive oxygen species (ROS)

(2017) Baoshan Wan et al.   PLoS Pathogens

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization

(2016) Guangchuang Yu et al.   Molecular BioSystems

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

Enterobactin as Part of the Oxidative Stress Response Repertoire

(2016) Daiana R. Peralta et al.   PLoS One

Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected

(2015) Douglas Marvel et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies

(2015) F. Hossain et al.   Cancer Immunology Research

DOSE: an R/Bioconductor package for disease ontology semantic and enrichment analysis

(2014) Guangchuang Yu et al.   BIOINFORMATICS

Prokka: rapid prokaryotic genome annotation

(2014) T. Seemann   BIOINFORMATICS

Tit-for-Tat: Type VI Secretion System Counterattack during Bacterial Cell-Cell Interactions

(2013) Marek Basler et al.   CELL

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

(2013) Wenyan Jiang et al.   NATURE BIOTECHNOLOGY

Structural Characterization and Oligomerization of the TssL Protein, a Component Shared by Bacterial Type VI and Type IVb Secretion Systems

(2012) Eric Durand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

imzML — A common data format for the flexible exchange and processing of mass spectrometry imaging data

(2012) Thorsten Schramm et al.   Journal of Proteomics

STAT1-regulated lung MDSC-like cells produce IL-10 and efferocytose apoptotic neutrophils with relevance in resolution of bacterial pneumonia

(2012) S L Poe et al.   Mucosal Immunology

Type VI secretion requires a dynamic contractile phage tail-like structure

(2012) M. Basler et al.   NATURE

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

Carnitine Palmitoyltransferase (CPT) Modulators: A Medicinal Chemistry Perspective on 35 Years of Research

(2011) Simona M. Ceccarelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

phytools: an R package for phylogenetic comparative biology (and other things)

(2011) Liam J. Revell   Methods in Ecology and Evolution

Metabolomic Analysis and Visualization Engine for LC−MS Data

(2010) Eugene Melamud et al.   ANALYTICAL CHEMISTRY

genoPlotR: comparative gene and genome visualization in R

(2010) L. Guy et al.   BIOINFORMATICS

Distribution of the putative type VI secretion system core genes in Klebsiella spp.

(2010) Panagiotis F. Sarris et al.   INFECTION GENETICS AND EVOLUTION

DNAPlotter: circular and linear interactive genome visualization

(2008) T. Carver et al.   BIOINFORMATICS