Type VI secretion system: a modular toolkit for bacterial dominance

Delivery of the Pseudomonas aeruginosa Phospholipase Effectors PldA and PldB in a VgrG- and H2-T6SS-Dependent Manner

(2019) Sarah Wettstadt et al.   Frontiers in Microbiology

PAAR proteins act as the ‘sorting hat’ of the type VI secretion system

(2019) Thomas E. Wood et al.   MICROBIOLOGY-SGM

A modular effector with a DNase domain and a marker for T6SS substrates

(2019) Biswanath Jana et al.   Nature Communications

Diverse toxic effectors are harbored by vgrG islands for interbacterial antagonism in type VI secretion system

(2018) Jiale Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Towards a complete structural deciphering of Type VI secretion system

(2018) Van Son Nguyen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Identification of Novel Acinetobacter baumannii Type VI Secretion System Anti-Bacterial Effector and Immunity Pairs

(2018) Timothy C. Fitzsimons et al.   INFECTION AND IMMUNITY

Conditional toxicity and synergy drive diversity among antibacterial effectors

(2018) Kaitlyn D. LaCourse et al.   Nature Microbiology

A type VI secretion system effector delivery mechanism dependent on PAAR and a chaperone–co-chaperone complex

(2018) Brianne J. Burkinshaw et al.   Nature Microbiology

Mechanism of loading and translocation of type VI secretion system effector Tse6

(2018) Dennis Quentin et al.   Nature Microbiology

Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins

(2018) See-Yeun Ting et al.   CELL

The Antibacterial and Anti-Eukaryotic Type VI Secretion System MIX-Effector Repertoire in Vibrionaceae

(2018) Yasmin Dar et al.   Marine Drugs

The Pseudomonas aeruginosa T6SS-VgrG1b spike is topped by a PAAR protein eliciting DNA damage to bacterial competitors

(2018) Panayiota Pissaridou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAAR-Rhs proteins harbor various C-terminal toxins to diversify the antibacterial pathways of type VI secretion systems

(2017) Jiale Ma et al.   ENVIRONMENTAL MICROBIOLOGY

The Pseudomonas putida T6SS is a plant warden against phytopathogens

(2017) Patricia Bernal et al.   ISME Journal

Diverse NADase effector families mediate interbacterial antagonism via the type VI secretion system

(2017) Jenny Y. Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Horizontal Gene Transfer of Functional Type VI Killing Genes by Natural Transformation

(2017) Jacob Thomas et al.   mBio

The Hcp proteins fused with diverse extended-toxin domains represent a novel pattern of antibacterial effectors in type VI secretion systems

(2017) Jiale Ma et al.   Virulence

Subtle variation within conserved effector operon gene products contributes to T6SS-mediated killing and immunity

(2017) Christopher J. Alteri et al.   PLoS Pathogens

A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria

(2017) John C Whitney et al.   eLife

Contact-dependent killing by Caulobacter crescentus via cell surface-associated, glycine zipper proteins

(2017) Leonor García-Bayona et al.   eLife

Cryo-EM structure of the extended type VI secretion system sheath–tube complex

(2017) Jing Wang et al.   Nature Microbiology

Sequential displacement of Type VI Secretion System effector genes leads to evolution of diverse immunity gene arrays in Vibrio cholerae

(2017) Paul C. Kirchberger et al.   Scientific Reports

A phospholipase A1 antibacterial Type VI secretion effector interacts directly with the C-terminal domain of the VgrG spike protein for delivery

(2016) Nicolas Flaugnatti et al.   MOLECULAR MICROBIOLOGY

Spatial structure, cooperation and competition in biofilms

(2016) Carey D. Nadell et al.   NATURE REVIEWS MICROBIOLOGY

VgrG C terminus confers the type VI effector transport specificity and is required for binding with PAAR and adaptor–effector complex

(2016) Devanand D. Bondage et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Pseudomonas aeruginosa Type VI Secretion PGAP1-like Effector Induces Host Autophagy by Activating Endoplasmic Reticulum Stress

(2016) Feng Jiang et al.   Cell Reports

VgrG and PAAR Proteins Define Distinct Versions of a Functional Type VI Secretion System

(2016) Francesca R. Cianfanelli et al.   PLoS Pathogens

The type VII secretion system of Staphylococcus aureus secretes a nuclease toxin that targets competitor bacteria

(2016) Zhenping Cao et al.   Nature Microbiology

An Interbacterial NAD(P)+ Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells

(2015) John C. Whitney et al.   CELL

Chimeric adaptor proteins translocate diverse type VI secretion system effectors in Vibrio cholerae

(2015) D. Unterweger et al.   EMBO JOURNAL

Intraspecies Competition in Serratia marcescens Is Mediated by Type VI-Secreted Rhs Effectors and a Conserved Effector-Associated Accessory Protein

(2015) Juliana Alcoforado Diniz et al.   JOURNAL OF BACTERIOLOGY

Identification of divergent type VI secretion effectors using a conserved chaperone domain

(2015) Xiaoye Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The type VI secretion system of Vibrio cholerae fosters horizontal gene transfer

(2015) S. Borgeaud et al.   SCIENCE

The Tailocin Tale: Peeling off Phage Tails

(2015) Maarten G.K. Ghequire et al.   TRENDS IN MICROBIOLOGY

New Players in the Toxin Field: Polymorphic Toxin Systems in Bacteria

(2015) Anne Jamet et al.   mBio

Bacterial killing via a type IV secretion system

(2015) Diorge P. Souza et al.   Nature Communications

Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria

(2015) Dor Salomon et al.   PLoS Pathogens

A Pseudomonas aeruginosa Type VI Secretion Phospholipase D Effector Targets Both Prokaryotic and Eukaryotic Cells

(2014) Feng Jiang et al.   Cell Host & Microbe

Agrobacterium tumefaciens Deploys a Superfamily of Type VI Secretion DNase Effectors as Weapons for Interbacterial Competition In Planta

(2014) Lay-Sun Ma et al.   Cell Host & Microbe

The VgrG Proteins Are “à la Carte” Delivery Systems for Bacterial Type VI Effectors

(2014) Abderrahman Hachani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Marker for type VI secretion system effectors

(2014) D. Salomon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Vibrio cholerae type VI secretion system employs diverse effector modules for intraspecific competition

(2014) Daniel Unterweger et al.   Nature Communications

Structural basis for type VI secreted peptidoglycanDL-endopeptidase function, specificity and neutralization inSerratia marcescens

(2013) Velupillai Srikannathasan et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Identification, Structure, and Function of a Novel Type VI Secretion Peptidoglycan Glycoside Hydrolase Effector-Immunity Pair

(2013) John C. Whitney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lytic Activity of theVibrio choleraeType VI Secretion Toxin VgrG-3 Is Inhibited by the Antitoxin TsaB

(2013) Teresa M. Brooks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Haemolysin Coregulated Protein Is an Exported Receptor and Chaperone of Type VI Secretion Substrates

(2013) Julie M. Silverman et al.   MOLECULAR CELL

The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device

(2013) Jason N. Busby et al.   NATURE

Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors

(2013) Alistair B. Russell et al.   NATURE

PAAR-repeat proteins sharpen and diversify the type VI secretion system spike

(2013) Mikhail M. Shneider et al.   NATURE

Rhs proteins from diverse bacteria mediate intercellular competition

(2013) S. Koskiniemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual Expression Profile of Type VI Secretion System Immunity Genes Protects Pandemic Vibrio cholerae

(2013) Sarah T. Miyata et al.   PLoS Pathogens

Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics

(2012) Dapeng Zhang et al.   Biology Direct

A Widespread Bacterial Type VI Secretion Effector Superfamily Identified Using a Heuristic Approach

(2012) Alistair B. Russell et al.   Cell Host & Microbe

New secreted toxins and immunity proteins encoded within the Type VI secretion system gene cluster ofSerratia marcescens

(2012) Grant English et al.   MOLECULAR MICROBIOLOGY

Sequence, structure and functional diversity of PD-(D/E)XK phosphodiesterase superfamily

(2012) Kamil Steczkiewicz et al.   NUCLEIC ACIDS RESEARCH

Toxin-Antitoxin Systems in Bacteria and Archaea

(2011) Yoshihiro Yamaguchi et al.   Annual Review of Genetics

Vibrio cholerae Requires the Type VI Secretion System Virulence Factor VasX To Kill Dictyostelium discoideum

(2011) Sarah T. Miyata et al.   INFECTION AND IMMUNITY

Type VI secretion delivers bacteriolytic effectors to target cells

(2011) Alistair B. Russell et al.   NATURE

A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems

(2011) Dapeng Zhang et al.   NUCLEIC ACIDS RESEARCH

Identification of Functional Toxin/Immunity Genes Linked to Contact-Dependent Growth Inhibition (CDI) and Rearrangement Hotspot (Rhs) Systems

(2011) Stephen J. Poole et al.   PLoS Genetics

A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria

(2010) Rachel D. Hood et al.   Cell Host & Microbe

Lysozymes in the animal kingdom

(2010) Lien Callewaert et al.   JOURNAL OF BIOSCIENCES

A widespread family of polymorphic contact-dependent toxin delivery systems in bacteria

(2010) Stephanie K. Aoki et al.   NATURE

Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes

(2009) Carlos J Blondel et al.   BMC GENOMICS

Pore formation: An ancient yet complex form of attack

(2008) Ioan Iacovache et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Type VI secretion: a beginner's guide

(2008) Lewis EH Bingle et al.   CURRENT OPINION IN MICROBIOLOGY