A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal

Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes

(2011) Arnout G Schepers et al.   EMBO JOURNAL

A novel mechanism for the transcriptional regulation of Wnt signaling in development

(2011) T. Vacik et al.   GENES & DEVELOPMENT

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

(2011) François Gerbe et al.   JOURNAL OF CELL BIOLOGY

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Single-molecule transcript counting of stem-cell markers in the mouse intestine

(2011) Shalev Itzkovitz et al.   NATURE CELL BIOLOGY

Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion

(2011) Adam J Bass et al.   NATURE GENETICS

T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis

(2011) M. L. Angus-Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal epithelial stem cells do not protect their genome by asymmetric chromosome segregation

(2011) Marion Escobar et al.   Nature Communications

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/β-catenin targets

(2010) Andreas Weise et al.   NUCLEIC ACIDS RESEARCH

Wnt signaling in stem and cancer stem cells

(2010) Peter Wend et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate

(2009) Laurens G. van der Flier et al.   CELL

OLFM4 Is a Robust Marker for Stem Cells in Human Intestine and Marks a Subset of Colorectal Cancer Cells

(2009) Laurens G. van der Flier et al.   GASTROENTEROLOGY

A Wnt Survival Guide: From Flies to Human Disease

(2009) Andy J. Chien et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia

(2009) Hoang Nguyen et al.   NATURE GENETICS

Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk

(2008) Aditi Hazra et al.   CANCER CAUSES & CONTROL

Transcription Factor 7-like 2 Polymorphism and Colon Cancer

(2008) M. L. Slattery et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Bmi1 is expressed in vivo in intestinal stem cells

(2008) Eugenio Sangiorgi et al.   NATURE GENETICS