Targeting STAT3 in gastric cancer

A Chemical Biology Approach to Developing STAT Inhibitors: Molecular Strategies for Accelerating Clinical Translation

(2015) Erik A. Nelson et al.   Oncotarget

A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets

(2012) Niantao Deng et al.   GUT

Helicobacter pylori CagA Triggers Expression of the Bactericidal Lectin REG3γ via Gastric STAT3 Activation

(2012) Kai Syin Lee et al.   PLoS One

Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?

(2012) Andrew Jarnicki et al.   Cell Division

Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain

(2011) Brent D.G. Page et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of activated Stat3 reverses drug resistance to chemotherapeutic agents in gastric cancer cells

(2011) Shuling Huang et al.   CANCER LETTERS

Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors

(2011) Arun K Mankan et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The Role of Interleukin-17 in the Helicobacter pylori Induced Infection and Immunity

(2011) Shahjahan Kabir   HELICOBACTER

Helicobacter pylori outer membrane proteins on gastric mucosal interleukin 6 and 11 expression in Mongolian gerbils

(2011) Mitsushige Sugimoto et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

STAT3 Genotypic Variation and Cellular STAT3 Activation and Colon Leukocyte Recruitment in Pediatric Crohn Disease

(2011) Tara A. Willson et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

New generation contraceptives: interleukin 11 family cytokines as non-steroidal contraceptive targets

(2011) E. Dimitriadis et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Inhibition of STAT3 Signaling Pathway by Nitidine Chloride Suppressed the Angiogenesis and Growth of Human Gastric Cancer

(2011) J. Chen et al.   MOLECULAR CANCER THERAPEUTICS

Dovitinib Induces Apoptosis and Overcomes Sorafenib Resistance in Hepatocellular Carcinoma through SHP-1-Mediated Inhibition of STAT3

(2011) W.-T. Tai et al.   MOLECULAR CANCER THERAPEUTICS

Interleukin-10 protects the ischemic heart from reperfusion injury via the STAT3 pathway

(2011) Mariuxi C. Manukyan et al.   SURGERY

(-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 бvia Stat3 in gastric cancer

(2011) Bao-He Zhu   WORLD JOURNAL OF GASTROENTEROLOGY

Eupatilin Inhibits Gastric Cancer Cell Growth by Blocking STAT3-Mediated VEGF Expression

(2011) Jae-Ho Cheong et al.   Journal of Gastric Cancer

Therapeutic Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-11 Ameliorates Cardiac Fibrosis After Myocardial Infarction

(2010) Masanori Obana et al.   CIRCULATION

Helicobacter pylori VacA Reduces the Cellular Expression of STAT3 and Pro-survival Bcl-2 Family Proteins, Bcl-2 and Bcl-XL, Leading to Apoptosis in Gastric Epithelial Cells

(2010) Ayako Matsumoto et al.   DIGESTIVE DISEASES AND SCIENCES

Inhibition of Gastric Carcinogenesis by the Hormone Gastrin Is Mediated by Suppression of TFF1 Epigenetic Silencing

(2010) Hiroyuki Tomita et al.   GASTROENTEROLOGY

STAT3 and cardiac remodeling

(2010) Arash Haghikia et al.   HEART FAILURE REVIEWS

Proinflammatory Cytokine Gene Expression in the Stomach Correlates with Vaccine-Induced Protection againstHelicobacter pyloriInfection in Mice: an Important Role for Interleukin-17 during the Effector Phase

(2010) Carl-Fredrik Flach et al.   INFECTION AND IMMUNITY

Helicobacter pyloriCagA Phosphorylation Status Determines the gp130-activated SHP2/ERK and JAK/STAT Signal Transduction Pathways in Gastric Epithelial Cells

(2010) In Ohk Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

(2010) Yung-Jue Bang et al.   LANCET

Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis

(2010) Okkyung Rho et al.   MOLECULAR CARCINOGENESIS

STAT-3 correlates with lymph node metastasis and cell survival in gastric cancer

(2010) Jing-Yu Deng   WORLD JOURNAL OF GASTROENTEROLOGY

Gastrin Is an Essential Cofactor for Helicobacter- Associated Gastric Corpus Carcinogenesis in C57BL/6 Mice

(2009) Shigeo Takaishi et al.   AMERICAN JOURNAL OF PATHOLOGY

Expression of activated signal transducer and activator of transcription 3 predicts poor clinical outcome in gastric adenocarcinoma

(2009) JEEYUN LEE et al.   APMIS

Novel high-throughput screening system for identifying STAT3–SH2 antagonists

(2009) Yutaka Uehara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cytokine signalling via gp130 in gastric cancer

(2009) M. Howlett et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mouse gastric tumor models with prostaglandin E2 pathway activation show similar gene expression profiles to intestinal-type human gastric cancer

(2009) Hiraku Itadani et al.   BMC GENOMICS

Helicobacter pylori Cytotoxin-Associated Gene A Activates the Signal Transducer and Activator of Transcription 3 Pathway In vitro and In vivo

(2009) D. M. Bronte-Tinkew et al.   CANCER RESEARCH

Helicobacter pylori Stimulates Dendritic Cells To Induce Interleukin-17 Expression from CD4+ T Lymphocytes

(2009) W. Khamri et al.   INFECTION AND IMMUNITY

KCNQ1 is the luminal K+recycling channel during stimulation of gastric acid secretion

(2009) Penghong Song et al.   JOURNAL OF PHYSIOLOGY-LONDON

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Endogenous IL-11 Signaling Is Essential in Th2- and IL-13–Induced Inflammation and Mucus Production

(2008) Chun Geun Lee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice

(2008) Shuiping Tu et al.   CANCER CELL

SagA of CagA in Helicobacter pylori pathogenesis

(2008) Masanori Hatakeyama   CURRENT OPINION IN MICROBIOLOGY

IL-23-mediated regulation of IL-17 production inHelicobacter pylori-infected gastric mucosa

(2008) Roberta Caruso et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeting STAT3 in cancer: how successful are we?

(2008) Peibin Yue et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The Interleukin-6 Family Cytokine Interleukin-11 Regulates Homeostatic Epithelial Cell Turnover and Promotes Gastric Tumor Development

(2008) Meegan Howlett et al.   GASTROENTEROLOGY

STAT3 expression in gastric cancer indicates a poor prognosis

(2008) Dae-Young Kim et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach

(2008) J. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

(2008) N. Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA