The chaperone Clusterin in neurodegeneration−friend or foe?

Chaperoning shape-shifting tau in disease

(2022) Bryan D. Ryder et al.   TRENDS IN BIOCHEMICAL SCIENCES

Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer’s disease neuropathology

(2021) Fading Chen et al.   Molecular Neurodegeneration

The Dual Roles of Clusterin in Extracellular and Intracellular Proteostasis

(2021) Sandeep Satapathy et al.   TRENDS IN BIOCHEMICAL SCIENCES

Reactive microglia enhance the transmission of exosomal alpha-synuclein via toll-like receptor 2

(2021) Yun Xia et al.   BRAIN

Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates

(2021) Jinar Rostami et al.   Journal of Neuroinflammation

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Highly accurate protein structure prediction for the human proteome

(2021) Kathryn Tunyasuvunakool et al.   NATURE

Microglial activation and tau propagate jointly across Braak stages

(2021) Tharick A. Pascoal et al.   NATURE MEDICINE

The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model

(2021) Patricia Yuste-Checa et al.   Nature Communications

Structure-based classification of tauopathies

(2021) Yang Shi et al.   NATURE

Structural basis of soluble membrane attack complex packaging for clearance

(2021) Anaïs Menny et al.   Nature Communications

Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates

(2021) Jack H. Brelstaff et al.   Science Advances

Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease

(2020) Min Guo et al.   BRAIN

LRP1 is a master regulator of tau uptake and spread

(2020) Jennifer N. Rauch et al.   NATURE

Protein transmission in neurodegenerative disease

(2020) Chao Peng et al.   Nature Reviews Neurology

A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease

(2020) Harald Hampel et al.   Frontiers in Immunology

Associations between CLU polymorphisms and memory performance: the role of serum lipids in Alzheimer’s disease

(2020) Lu Hua Chen et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Phosphorylated tau interactome in the human Alzheimer’s disease brain

(2020) Eleanor Drummond et al.   BRAIN

The good, the bad, and the opportunities of the complement system in neurodegenerative disease

(2020) Nicole D. Schartz et al.   Journal of Neuroinflammation

Astrocyte-derived clusterin suppresses amyloid formation in vivo

(2020) Aleksandra M. Wojtas et al.   Molecular Neurodegeneration

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation

(2020) Aleksandra M. Wojtas et al.   Acta Neuropathologica Communications

Clusterin as modulator of carcinogenesis: A potential avenue for targeted cancer therapy

(2020) Prakash Priyadarshi Praharaj et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies

(2019) Evangeline M. Foster et al.   Frontiers in Neuroscience

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Comparative study of cerebrospinal fluid α-synuclein seeding aggregation assays for diagnosis of Parkinson's disease

(2019) Un Jung Kang et al.   MOVEMENT DISORDERS

Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice

(2019) Sofía Fernández de Retana et al.   Alzheimers Research & Therapy

Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

(2019) Tom Scheidt et al.   Science Advances

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression

(2019) Suman De et al.   Acta Neuropathologica Communications

Normal and Pathological Tau Uptake Mediated by M1/M3 Muscarinic Receptors Promotes Opposite Neuronal Changes

(2019) Viktoriya Morozova et al.   Frontiers in Cellular Neuroscience

Mechanisms of secretion and spreading of pathological tau protein

(2019) Cecilia A. Brunello et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation

(2019) John J. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular and secreted forms of clusterin are elevated early in Alzheimer's disease and associate with both Aβ and tau pathology

(2019) Claire E. Shepherd et al.   NEUROBIOLOGY OF AGING

Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer’s Disease

(2019) Yi-Chen Hsieh et al.   Cell Reports

Secreted Clusterin protein inhibits osteoblast differentiation of bone marrow mesenchymal stem cells by suppressing ERK1/2 signaling pathway

(2018) Basem M. Abdallah et al.   BONE

Regulation of Clusterin Gene Expression

(2018) Marilina Garcia-Aranda et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Prions, prionoids and protein misfolding disorders

(2018) Claudia Scheckel et al.   NATURE REVIEWS GENETICS

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

(2018) Sue-Ann Mok et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Associations of plasma clusterin and Alzheimer’s disease-related MRI markers in adults at mid-life: The CARDIA Brain MRI sub-study

(2018) Thaddeus Haight et al.   PLoS One

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

(2018) Sue-Ann Mok et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers

(2018) Daniel R. Whiten et al.   Cell Reports

Blood Clusterin Levels, rs9331888 Polymorphism, and the Risk of Alzheimer's Disease

(2018) Yao-Yao Xing et al.   JOURNAL OF ALZHEIMERS DISEASE

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases

(2018) Mathias Jucker et al.   NATURE NEUROSCIENCE

Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons

(2018) Jacqueline P. Robbins et al.   Frontiers in Neuroscience

Clusterin contributes to early stage of Alzheimer's disease pathogenesis

(2018) Shin-Bi Oh et al.   BRAIN PATHOLOGY

Neurogenetic contributions to amyloid beta and tau spreading in the human cortex

(2018) Jorge Sepulcre et al.   NATURE MEDICINE

Pseudoexfoliation and Alzheimer’s associated CLU risk variant, rs2279590, lies within an enhancer element and regulates CLU, EPHX2 and PTK2B gene expression

(2017) Biswajit Padhy et al.   HUMAN MOLECULAR GENETICS

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

(2017) Aleksandra M. Wojtas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The clinical significance of plasma clusterin and Aβ in the longitudinal follow-up of patients with Alzheimer’s disease

(2017) Jung-Lung Hsu et al.   Alzheimers Research & Therapy

Clusterin protects neurons against intracellular proteotoxicity

(2017) Jenna M. Gregory et al.   Acta Neuropathologica Communications

Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients

(2016) Shuko Takeda et al.   ANNALS OF NEUROLOGY

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Genetically-mediated Grey and White Matter Alteration in Normal Elderly Individuals with the CLU-C Allele Gene

(2016) Lihua Qiu et al.   Current Alzheimer Research

DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative‐associated proteins

(2016) Sarah N Fontaine et al.   EMBO JOURNAL

Identification of plexin A4 as a novel clusterin receptor links two Alzheimer’s disease risk genes

(2016) Silvia S. Kang et al.   HUMAN MOLECULAR GENETICS

Clusterin Binds to Aβ1–42Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation

(2016) Marten Beeg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

(2016) Sofia Söllvander et al.   Molecular Neurodegeneration

A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin

(2016) Yuetiva Deming et al.   NEUROBIOLOGY OF AGING

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding

(2016) Sophia Ungelenk et al.   Nature Communications

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

(2016) Paolo Arosio et al.   Nature Communications

Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts

(2016) Lin Tan et al.   Scientific Reports

Mechanisms of Aβ Clearance and Degradation by Glial Cells

(2016) Miriam Ries et al.   Frontiers in Aging Neuroscience

Alzheimer's disease risk variant in CLU is associated with neural inefficiency in healthy individuals

(2015) Thomas M. Lancaster et al.   Alzheimers & Dementia

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations

(2015) Karolien Bettens et al.   Molecular Neurodegeneration

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

On the lag phase in amyloid fibril formation

(2015) Paolo Arosio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain

(2015) Shuko Takeda et al.   Nature Communications

PLXNA4is associated with Alzheimer disease and modulates tau phosphorylation

(2014) Gyungah Jun et al.   ANNALS OF NEUROLOGY

Cooperative Stabilization of Transthyretin by Clusterin and Diflunisal

(2014) Michael J. Greene et al.   BIOCHEMISTRY

The Chaperone Activity of Clusterin is Dependent on Glycosylation and Redox Environment

(2014) Philipp Rohne et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Deficiency of Clusterin Exacerbates High-Fat Diet-Induced Insulin Resistance in Male Mice

(2014) Min Jung Kwon et al.   ENDOCRINOLOGY

Role of an extracellular chaperone, Clusterin in the pathogenesis of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

(2014) Biswajit Padhy et al.   EXPERIMENTAL EYE RESEARCH

Clusterin Is a Ligand for Apolipoprotein E Receptor 2 (ApoER2) and Very Low Density Lipoprotein Receptor (VLDLR) and Signals via the Reelin-signaling Pathway

(2014) Christian Leeb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglia display modest phagocytic capacity for extracellular tau oligomers

(2014) Petra Majerova et al.   Journal of Neuroinflammation

A combined effect of two Alzheimer's risk genes on medial temporal activity during executive attention in young adults

(2014) Adam E. Green et al.   NEUROPSYCHOLOGIA

Connecting the Dots: Potential of Data Integration to Identify Regulatory SNPs in Late-Onset Alzheimer's Disease GWAS Findings

(2014) Samantha L. Rosenthal et al.   PLoS One

Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease

(2014) Yuan Zhou et al.   PLoS One

Extracellular Chaperones and Proteostasis

(2013) Amy R. Wyatt et al.   Annual Review of Biochemistry

Single Molecule Characterization of the Interactions between Amyloid-β Peptides and the Membranes of Hippocampal Cells

(2013) Priyanka Narayan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway

(2013) So Young Gil et al.   Nature Communications

Quantification of clusterin in paired cerebrospinal fluid and plasma samples

(2013) W. Jongbloed et al.   ANNALS OF CLINICAL BIOCHEMISTRY

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Novel late-onset Alzheimer disease loci variants associate with brain gene expression

(2012) M. Allen et al.   NEUROLOGY

Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains

(2012) Celeste M. Karch et al.   PLoS One

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease

(2011) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

Clusterin facilitates in vivo clearance of extracellular misfolded proteins

(2011) Amy R. Wyatt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Plasma Clusterin and the Risk of Alzheimer Disease

(2011) Elisabeth M. C. Schrijvers   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

CRM1 Protein-mediated Regulation of Nuclear Clusterin (nCLU), an Ionizing Radiation-stimulated, Bax-dependent Pro-death Factor

(2011) Konstantin S. Leskov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide

(2011) Priyanka Narayan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alzheimer's risk variants in the clusterin gene are associated with alternative splicing

(2011) M Szymanski et al.   Translational Psychiatry

CSF markers of neurodegeneration in Parkinson’s disease

(2010) Hana Přikrylová Vranová et al.   JOURNAL OF NEURAL TRANSMISSION

Total and phosphorylated tau protein as biological markers of Alzheimer’s disease

(2009) Harald Hampel et al.   EXPERIMENTAL GERONTOLOGY

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Identification and characterization of glycosylation sites in human serum clusterin

(2009) James T. Kapron et al.   PROTEIN SCIENCE

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

(2008) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY