Methionine cycle in nonalcoholic fatty liver disease and its potential applications

Dysregulation of S-adenosylmethionine Metabolism in Nonalcoholic Steatohepatitis Leads to Polyamine Flux and Oxidative Stress

(2022) Connor Quinn et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis

(2022) Diego Sáenz de Urturi et al.   Nature Communications

Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction

(2022) Ferrol I. Rome et al.   Molecular Metabolism

The Role of the Transsulfuration Pathway in Non-Alcoholic Fatty Liver Disease

(2021) Mikkel Parsberg Werge et al.   Journal of Clinical Medicine

Dietary Egg White Protein Hydrolysate Improves Orotic Acid-Induced Fatty Liver in Rats by Promoting Hepatic Phospholipid Synthesis and Microsomal Triglyceride Transfer Protein Expression

(2021) Zhe Jiang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Betaine Delayed Muscle Loss by Attenuating Samtor Complex Inhibition for mTORC1 Signaling Via Increasing SAM Level

(2021) Si Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential

(2020) Hai-Jian Sun et al.   Journal of Advanced Research

Long‐term uninterrupted enzyme replacement therapy prevents liver disease in murine model of severe homocystinuria

(2020) Insun Park et al.   HUMAN MUTATION

New Perspectives of S-Adenosylmethionine (SAMe) Applications to Attenuate Fatty Acid-Induced Steatosis and Oxidative Stress in Hepatic and Endothelial Cells

(2020) Laura Vergani et al.   MOLECULES

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice

(2020) Russell R. Fling et al.   Scientific Reports

Impact of the Association Between PNPLA3 Genetic Variation and Dietary Intake on the Risk of Significant Fibrosis in Patients With NAFLD

(2020) Eduardo Vilar-Gomez et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

EZH2 as a Potential Target for NAFLD Therapy

(2020) Hyun Jung Lim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A

(2020) Young-Chae Kim et al.   Nature Communications

TGF-β1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM

(2019) Kuifeng Wang et al.   EBioMedicine

Gene expression and DNA methylation alterations in the glycine N-methyltransferase gene in diet-induced nonalcoholic fatty liver disease-associated carcinogenesis

(2019) Barbara Borowa-Mazgaj et al.   TOXICOLOGICAL SCIENCES

Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance

(2019) Sereana Wan et al.   FASEB JOURNAL

Total liver phosphatidylcholine content associates with non‐alcoholic steatohepatitis and glycine N‐methyltransferase expression

(2019) Ville Männistö et al.   LIVER INTERNATIONAL

miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease

(2019) Pablo Fernández-Tussy et al.   Molecular Metabolism

Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma

(2018) Igor P. Pogribny et al.   FASEB JOURNAL

Homocysteine regulates fatty acid and lipid metabolism in yeast

(2018) Myriam Visram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity

(2018) Julien Bricambert et al.   Nature Communications

AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle

(2018) Young-Chae Kim et al.   Nature Communications

Adiponectin inhibits hepatic stellate cell activation by targeting the PTEN/AKT pathway

(2018) Pradeep Kumar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage

(2018) Cheng-Chieh Fang et al.   Scientific Reports

Knock-down of AHCY and depletion of adenosine induces DNA damage and cell cycle arrest

(2018) Lucija Belužić et al.   Scientific Reports

ZNF300 stimulates fatty acid oxidation and alleviates hepatosteatosis through regulating PPARα

(2018) Feng Juan Yan et al.   BIOCHEMICAL JOURNAL

Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice

(2018) Natalia Presa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeting methionine cycle as a potential therapeutic strategy for immune disorders

(2017) Heng Li et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci

(2017) Daniel S. Lupu et al.   FASEB JOURNAL

Role of glutathione in the regulation of epigenetic mechanisms in disease

(2017) José Luis García-Giménez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway

(2017) Xin Gu et al.   SCIENCE

Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis

(2017) Yuting Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Choline, Other Methyl-Donors and Epigenetics

(2017) Steven Zeisel   Nutrients

Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-deficient mice

(2016) Jelske N. van der Veen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Alleviation of hepatic fat accumulation by betaine involves reduction of homocysteine via up-regulation of betaine-homocysteine methyltransferase (BHMT)

(2016) Chul Won Ahn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis

(2016) Imanol Zubiete-Franco et al.   JOURNAL OF HEPATOLOGY

Hepatic stellate cell transdifferentiation involves genome-wide remodeling of the DNA methylation landscape

(2016) Agata Page et al.   JOURNAL OF HEPATOLOGY

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

(2016)   JOURNAL OF HEPATOLOGY

Lack of global epigenetic methylation defects in CBS deficient mice

(2016) Hyung-Ok Lee et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Nonalcoholic steatohepatitis is associated with a state of betaine-insufficiency

(2016) Silvia Sookoian et al.   LIVER INTERNATIONAL

Phosphatidylethanolamine N-methyltransferase gene rs7946 polymorphism plays a role in risk of nonalcoholic fatty liver disease

(2016) Hwa-Li Tan et al.   Pharmacogenetics and Genomics

Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis

(2016) Atsuko Nakatsuka et al.   Scientific Reports

Exendin-4 regulates redox homeostasis in rats fed with high-fat diet

(2015) Shiwei Niu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism

(2015) Rafael Deminice et al.   AMINO ACIDS

Sulfur amino acid metabolism in Zucker diabetic fatty rats

(2015) Hui Chan Kwak et al.   BIOCHEMICAL PHARMACOLOGY

High homocysteine induces betaine depletion

(2015) A. Imbard et al.   BIOSCIENCE REPORTS

The CBS/CSE system: a potential therapeutic target in NAFLD?

(2015) Lindsei K. Sarna et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice

(2015) Hiroyuki Tsuchiya et al.   GASTROENTEROLOGY

Role of Methionine Adenosyltransferase α2 and β Phosphorylation and Stabilization in Human Hepatic Stellate Cell Trans-Differentiation

(2015) Komal Ramani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease

(2015) Maite Martínez-Uña et al.   JOURNAL OF HEPATOLOGY

Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice

(2015) Sapna Gupta et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Palm tocotrienol-rich fraction inhibits methionine-induced cystathionine β-synthase in rat liver

(2015) Yusof Kamisah et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Tyrosol Attenuates High Fat Diet-Induced Hepatic Oxidative Stress: Potential Involvement of Cystathionine β-Synthase and Cystathionine γ-Lyase

(2015) Lindsei K. Sarna et al.   LIPIDS

Creatine and the Liver: Metabolism and Possible Interactions

(2015) R.P. Barcelos et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Differential proteomic and tissue expression analyses identify valuable diagnostic biomarkers of hepatocellular differentiation and hepatoid adenocarcinomas

(2015) Henning Reis et al.   PATHOLOGY

Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease

(2015) Tommy Pacana et al.   PLoS One

Downregulation of betaine homocysteine methyltransferase (BHMT) in hepatocellular carcinoma associates with poor prognosis

(2015) Bin Jin et al.   TUMOR BIOLOGY

Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer

(2015) Hong-Bin Yang et al.   Nature Communications

2D DIGE proteomic analysis highlights delayed postnatal repression of α-fetoprotein expression in homocystinuria model mice

(2015) Shotaro Kamata et al.   FEBS Open Bio

Mallory–Denk Body (MDB) formation modulates ufmylation expression epigenetically in alcoholic hepatitis (AH) and non-alcoholic steatohepatitis (NASH)

(2014) Hui Liu et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Hydrogen sulfide and the liver

(2014) Sarathi Mani et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels

(2014) Christoph Dahlhoff et al.   Molecular Metabolism

Methylenetetrahydrofolate Reductase Gene Polymorphism and Serum Homocysteine Levels in Nonalcoholic Fatty Liver Disease

(2013) Maria José Franco Brochado et al.   ANNALS OF NUTRITION AND METABOLISM

Acute Liver Injury Induces Nucleocytoplasmic Redistribution of Hepatic Methionine Metabolism Enzymes

(2013) Miguel Delgado et al.   ANTIOXIDANTS & REDOX SIGNALING

The potential role of homocysteine mediated DNA methylation and associated epigenetic changes in abdominal aortic aneurysm formation

(2013) Smriti Murali Krishna et al.   ATHEROSCLEROSIS

Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase

(2013) Jean-Louis Guéant et al.   BIOCHIMIE

Betaine homocysteine methyltransferase (BHMT)-dependent remethylation pathway in human healthy and tumoral liver

(2013) Hélène Pellanda   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Blood glutathione redox status and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults

(2013) Megan M. Niedzwiecki et al.   Epigenetics

Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury

(2013) Igor P. Pogribny et al.   FASEB JOURNAL

Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis

(2013) Maite Martínez-Uña et al.   HEPATOLOGY

Choline Supplementation Protects against Liver Damage by Normalizing Cholesterol Metabolism in Pemt/Ldlr Knockout Mice Fed a High-Fat Diet

(2013) Ala Al Rajabi et al.   JOURNAL OF NUTRITION

Network-based Analysis of Genome Wide Association Data Provides Novel Candidate Genes for Lipid and Lipoprotein Traits

(2013) Amitabh Sharma et al.   MOLECULAR & CELLULAR PROTEOMICS

Proteomic Differences Between Hepatocellular Carcinoma and Nontumorous Liver Tissue Investigated by a Combined Gel-based and Label-free Quantitative Proteomics Study

(2013) Dominik A. Megger et al.   MOLECULAR & CELLULAR PROTEOMICS

Correction: Hepatic Methionine Homeostasis Is Conserved in C57BL/6N Mice on High-Fat Diet Despite Major Changes in Hepatic One-Carbon Metabolism

(2013) Christoph Dahlhoff et al.   PLoS One

Physiological roles of phosphatidylethanolamine N-methyltransferase

(2012) Dennis E. Vance   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

DNA methylation and hepatic insulin resistance and steatosis

(2012) Silvia Sookoian et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease

(2012) Carlos Jose Pirola et al.   GUT

Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase

(2012) Laura Gomez-Santos et al.   HEPATOLOGY

Transcriptional regulation of methionine adenosyltransferase 2A by peroxisome proliferator-activated receptors in rat hepatic stellate cells

(2012) Komal Ramani et al.   HEPATOLOGY

Wilson's disease: Changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease

(2012) Valentina Medici et al.   HEPATOLOGY

The Membrane Lipid Phosphatidylcholine Is an Unexpected Source of Triacylglycerol in the Liver

(2012) Jelske N. van der Veen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis

(2012) Claudia von Montfort et al.   JOURNAL OF HEPATOLOGY

Proteomic analysis of liver mitochondria of apolipoprotein E knockout mice treated with metformin

(2012) Aneta Stachowicz et al.   Journal of Proteomics

Proteomics and gene expression analyses of mitochondria from squalene-treated apoE-deficient mice identify short-chain specific acyl-CoA dehydrogenase changes associated with fatty liver amelioration

(2012) Adela Ramírez-Torres et al.   Journal of Proteomics

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(2012) Yi-Jen Liao et al.   MOLECULAR MEDICINE

S-adenosylmethionine in Liver Health, Injury, and Cancer

(2012) Shelly C. Lu et al.   PHYSIOLOGICAL REVIEWS

Adenosine Kinase Deficiency Disrupts the Methionine Cycle and Causes Hypermethioninemia, Encephalopathy, and Abnormal Liver Function

(2011) Magnus K. Bjursell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The metabolic burden of creatine synthesis

(2011) John T. Brosnan et al.   AMINO ACIDS

Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria

(2011) Kazutaka Ikeda et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Plasma homocysteine level and hepatic sulfur amino acid metabolism in mice fed a high-fat diet

(2011) Kang Uk Yun et al.   EUROPEAN JOURNAL OF NUTRITION

Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice

(2011) Ainara Cano et al.   HEPATOLOGY

Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice

(2011) Ji Ling et al.   HEPATOLOGY

A splicing variant leads to complete loss of function of betaine–homocysteine methyltransferase (BHMT) gene in hepatocellular carcinoma

(2011) Hélène Pellanda et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Deletion of Betaine-HomocysteineS-Methyltransferase in Mice Perturbs Choline and 1-Carbon Metabolism, Resulting in Fatty Liver and Hepatocellular Carcinomas

(2011) Ya-Wen Teng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Corticoadrenal activity regulates in rat betaine-homocysteine S-methyltransferase expression with opposites effects in liver and kidney

(2011) Osvaldo Fridman et al.   JOURNAL OF BIOSCIENCES

Glycine-N Methyltransferase Expression in HepG2 Cells Is Involved in Methyl Group Homeostasis by Regulating Transmethylation Kinetics and DNA Methylation

(2011) Yi-Cheng Wang et al.   JOURNAL OF NUTRITION

Methionine Adenosyltransferase II Serves as a Transcriptional Corepressor of Maf Oncoprotein

(2011) Yasutake Katoh et al.   MOLECULAR CELL

Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity

(2011) Jana Strakova et al.   NUTRITION RESEARCH

Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice

(2010) Kristian K. Jensen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: Impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter

(2010) Silvia Sookoian et al.   HEPATOLOGY

Impairedde NovoCholine Synthesis Explains Why PhosphatidylethanolamineN-Methyltransferase-deficient Mice Are Protected from Diet-induced Obesity

(2010) René L. Jacobs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Steatosis in Mice Is Associated with Gender, Folate Intake, and Expression of Genes of One-Carbon Metabolism

(2010) Karen E. Christensen et al.   JOURNAL OF NUTRITION

Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment

(2010) Kenneth N. Maclean et al.   MOLECULAR GENETICS AND METABOLISM

Betaine-homocysteine methyltransferase: Human liver genotype–phenotype correlation

(2010) Qiping Feng et al.   MOLECULAR GENETICS AND METABOLISM

Deficiency of glycineN-methyltransferase results in deterioration of cellular defense to stress in mouse liver

(2010) Yi-Jen Liao et al.   Proteomics Clinical Applications

The logic of the hepatic methionine metabolic cycle

(2009) M.V. Martinov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

TNF -dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish s-adenosylhomocysteine hydrolase

(2009) R. P. Matthews et al.   DEVELOPMENT

Conformational signals in the C-terminal domain of methionine adenosyltransferase I/III determine its nucleocytoplasmic distribution

(2009) Edel Reytor et al.   FASEB JOURNAL

Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet

(2009) Igor P. Pogribny et al.   JOURNAL OF HEPATOLOGY

Methionine-deficient diet induces post-transcriptional downregulation of cystathionine β-synthase

(2009) Baiqing Tang et al.   NUTRITION

Effect of Transgenic Extrahepatic Expression of Betaine-Homocysteine Methyltransferase on Alcohol or Homocysteine-Induced Fatty Liver

(2008) Cheng Ji et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Methionine Metabolism and Liver Disease

(2008) José M. Mato et al.   Annual Review of Nutrition

Early effects of copper accumulation on methionine metabolism

(2008) M. Delgado et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Transition from Fatty Liver to NASH Associates with SAMe Depletion in db/db Mice Fed a Methionine Choline-Deficient Diet

(2008) Matthew Wortham et al.   DIGESTIVE DISEASES AND SCIENCES

Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury

(2008) Cheng Ji   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Impaired Sulfur-Amino Acid Metabolism and Oxidative Stress in Nonalcoholic Fatty Liver Are Alleviated by Betaine Supplementation in Rats

(2008) Do Y. Kwon et al.   JOURNAL OF NUTRITION

Expression Pattern, Regulation, and Functions of Methionine Adenosyltransferase 2β Splicing Variants in Hepatoma Cells

(2007) Heping Yang et al.   GASTROENTEROLOGY