Article
Endocrinology & Metabolism
Olga Horakova, Gabriella Sistilli, Veronika Kalendova, Kristina Bardova, Marko Mitrovic, Tomas Cajka, Ilaria Irodenko, Petra Janovska, Karoline Lackner, Jan Kopecky, Martin Rossmeisl
Summary: This study examined the effect of thermoneutral environment on the progression of non-alcoholic fatty liver disease (NAFLD) in C57BL/6N mice. The results showed that thermoneutrality did not have a significant effect on NAFLD progression in mice fed a high-fat diet. However, in mice fed a standard diet, thermoneutrality increased weight gain, hepatic steatosis, and other NAFLD-associated phenotypes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Food Science & Technology
Juhae Kim, Na-Hyung Kim, Isoo Youn, Eun Kyoung Seo, Choon Young Kim
Summary: The study found that Allium macrostemon Bunge extract can alleviate adipose tissue inflammation and hepatic endoplasmic reticulum stress caused by simultaneous exposure to a high-fat diet and BPA. Further research is needed to determine the specific impact of AM extract supplementation.
Article
Food Science & Technology
Yue Teng, Yu Wang, Wu-yang Guan, Chao Wang, Han-song Yu, Xia Li, Yu-hua Wang
Summary: The beneficial effects of Lactobacillus plantarum LP104 on lipid level and disordered gut microbiota in mice fed a high-fat diet were investigated in this study. The results showed that LP104 supplementation could alleviate body weight gain, liver index increase, colon length reduction, as well as improve TC, TG, LDL, TNF alpha, and LPS levels. High-throughput sequencing analysis revealed that long-term high-fat diet negatively affected microbial abundance and composition in the gut, but LP104 supplementation reduced the ratio of Firmicutes to Bacteroides and positively regulated the gut microbiota community structure. Additionally, the intake of LP104 also increased the abundance of beneficial bacteria Bifidobacterium in the cecum, which improved the intestinal flora disorder induced by a high-fat diet. These findings suggest that LP104 supplementation can improve high-fat diet-induced hyperlipidemia by positively regulating intestinal microorganisms.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Medicine, Research & Experimental
Byungtae Hwang, Min-Gi Kwon, Min Ji Cho, Nam-Kyung Lee, Jangwook Lee, Jeong Woong Lee, Kyoung-Jin Oh, Kwang-Hee Bae, Jung Hwan Hwang, Jeong-Ki Min, Jong-Gil Park
Summary: This study highlights the critical role of PTP4A1 in regulating hepatosteatosis and glucose homeostasis. It demonstrates that PTP4A1 prevents the accumulation of hepatic lipids and regulates glucose uptake by activating the CREBH/FGF21 axis. Modulating PTP4A1 may offer a potential therapeutic strategy against hepatosteatosis-related diseases.
Article
Multidisciplinary Sciences
Shino Nemoto, Tetsuya Kubota, Hiroshi Ohno
Summary: This study investigates the genetic cause of phenotypic differences between B6J and B6N mice, identifying candidate genes with differential expression in metabolic tissues and providing comparative data on body weight, tissue weight, blood components, and energy balance. These findings have important implications for future research in related fields.
Article
Biochemistry & Molecular Biology
Yu Wang, Yuan Tian, Nan Zhang, Xia Li, Xiujuan Wang, Weili Wang, Jun Zhang, Chunhong Piao, Yuhua Wang, Jingsheng Liu
Summary: The study showed that Pediococcus pentococcus PP04 has a significant ameliorative effect on liver injury induced by a high-fat diet, by regulating intestinal permeability and reducing endotoxins and liver enzyme concentrations. Additionally, PP04 improved liver injury by regulating intestinal inflammation and antioxidant expression, and may rebalance intestinal flora disorders by regulating the relative abundance of inflammation and obesity-related bacteria in mice.
Article
Food Science & Technology
Ye -Rang Yun, Ji-Eun Lee
Summary: Active components in kimchi can suppress ER stress and prevent the occurrence of non-alcoholic fatty liver disease (NAFLD).
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Aurora Garcia Tejedor, Claudia Monika Haros, Jose Moises Laparra Llopis
Summary: This study investigated the effects of Chenopodium quinoa's ingredients on the hepatic profile of major lipids and the functional differentiation of monocyte-derived macrophages and innate lymphoid cells in mice on a high-fat diet. The results showed that feeding the mice with a low-molecular-weight protein fraction (LWPF) improved their ability to utilize fatty acids and reduced hepatic lipid accumulation, while feeding them the lipid fraction (qLF) had no effect on lipid accumulation. Therefore, Chenopodium quinoa's ingredients are advantageous for controlling hepatic lipotoxicity and promoting the expansion and functional differentiation of liver macrophages and innate lymphoid cells.
Article
Food Science & Technology
Mengjie Li, Zheng Zhang, Bin Yu, Siqiang Jia, Bo Cui
Summary: This study investigated the potential therapeutic mechanism of Lycium barbarum oligosaccharide (LBO) against hepatic steatosis induced by high-fat diets (HFD) by analyzing the changes in intestinal flora and metabolites in mice. LBO administration significantly reduced serum triglyceride (TG), alanine aminotransferase (ALT), and hepatic TG levels in mice on an HFD, and improved liver lipid accumulation. LBO also modulated the composition of intestinal flora and fecal metabolites related to cholesterol metabolism, bile acid metabolism, and tryptophan metabolic pathways.
Article
Endocrinology & Metabolism
Anne-Francoise Close, Heeyoung Chae, Jean-Christophe Jonas
Summary: The study compared the impact of Nnt(Tr) and other genetic variants between C57BL/6J and C57BL/6N mice on mitochondrial redox state, glucose-stimulated insulin secretion, and glucose tolerance. While NNT was found to play a crucial role in regulating mitochondrial redox state, its effects on GSIS and glucose tolerance were minimized, suggesting that the Nnt(WT) genotype in C57BL/6 mice may not necessarily indicate superior glucose tolerance compared to C57BL/6N mice.
Article
Biochemistry & Molecular Biology
Kristen A. Hagarty-Waite, Melissa S. Totten, Matthew Pierce, Seth M. Armah, Keith M. Erikson
Summary: The purpose of this study was to investigate the influence of sex and strain on the dysregulation of trace element concentration and gene expression in adipose tissue and liver caused by diet induced obesity. The findings showed that there were three-way interactions of diet, sex, and strain on adipose tissue iron concentrations, adipose hepcidin expression, and hepatic iron regulatory protein expression. In addition, high-fat diet increased the Cd11c to Cd163 ratio in adipose tissue, except in B6J females, where tissue iron concentrations were reduced. The expression of liver divalent metal transporter 1 (DMT-1) was increased due to high-fat diet in both B6J males and females, which correlated with the reduction in hepatic iron concentrations. Sex, strain, and diet all had an impact on trace element concentration, gene expression related to trace element homeostasis, and macrophage expression involved in tissue iron-handling in adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Weiqi Xu, Yujie Huang, Wangting Zhou, Yujia Peng, Xuhui Kan, Wei Dong, Guijie Chen, Xiaoxiong Zeng, Zhonghua Liu
Summary: This study found that Theasinensin A (TSA) has hypoglycemic and anti-inflammatory effects in high-fat-diet/streptozotocin-induced diabetic mice, and it improves glucose and lipid metabolism by modulating gut microbiota. High-dose TSA has better beneficial effects on blood biochemical parameters, hepatic function, and gut microbiota.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Biochemistry & Molecular Biology
Mariana Silva Thomaz, Marcela Nascimento Sertorio, Marcos Leoni Gazarini, Daniel Araki Ribeiro, Luciana Pellegrini Pisani, Marcia Regina Nagaoka
Summary: Non-alcoholic fatty liver is the leading cause of liver disease worldwide. This study investigated the role of kinins in experimental non-alcoholic steatohepatitis (NASH) and found that kinins affect the antioxidant system and reduce superoxide dismutase activity in NASH.
Article
Nutrition & Dietetics
Zhitian Lu, Xudong Li, Min Wang, Xiaojun Zhang, Runxuan Zhuang, Fan Wu, Wenxue Li, Wei Zhu, Bo Zhang
Summary: Nobiletin (NOB), a compound found in citrus peels, has potential lipid-lowering and circadian-enhancing properties. This study showed that NOB can reduce liver triglyceride levels and regulate genes involved in lipid and cholesterol metabolism, independently of the core clock component Bmal1.
Article
Biology
Hwa Lee, Seona Cho, Anna Kang, Dong-Ha Shin, Ho-Yong Park, Tae-Sook Jeong
Summary: The combined use of Arazyme and ESLs can reduce HFD-induced body weight gain, hyperglycemia, and hepatic steatosis by regulating liver-gut bile acid circulation, significantly reducing treatment doses and enhancing therapeutic effects, thereby reducing therapeutic healthcare costs.
