Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma

Changes in the Prevalence of Hepatitis C Virus Infection, Nonalcoholic Steatohepatitis, and Alcoholic Liver Disease Among Patients With Cirrhosis or Liver Failure on the Waitlist for Liver Transplantation

(2017) David Goldberg et al.   GASTROENTEROLOGY

Nonalcoholic fatty liver disease in adolescents and young adults: The next frontier in the epidemic

(2017) Iliana Doycheva et al.   HEPATOLOGY

Proteome Characteristics of Non-Alcoholic Steatohepatitis Liver Tissue and Associated Hepatocellular Carcinomas

(2017) Anna Kakehashi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The epidemiology of non-alcoholic fatty liver disease

(2017) Stefano Bellentani   LIVER INTERNATIONAL

Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation

(2017) Aline de Conti et al.   MOLECULAR CANCER RESEARCH

Liver Cancer: Connections with Obesity, Fatty Liver, and Cirrhosis

(2016) Andrea Marengo et al.   Annual Review of Medicine

S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation

(2016) Madalena Barroso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Association between homocysteine and non-alcoholic fatty liver disease in Chinese adults: a cross-sectional study

(2016) Haijiang Dai et al.   Nutrition Journal

Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism

(2015) Rafael Deminice et al.   AMINO ACIDS

Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States

(2015) Robert J. Wong et al.   GASTROENTEROLOGY

Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009

(2015) Zobair M. Younossi et al.   HEPATOLOGY

Current efforts and trends in the treatment of NASH

(2015) Vlad Ratziu et al.   JOURNAL OF HEPATOLOGY

Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice

(2015) Sapna Gupta et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Adult-onset liver disease and hepatocellular carcinoma in S-adenosylhomocysteine hydrolase deficiency

(2015) Stefan Stender et al.   MOLECULAR GENETICS AND METABOLISM

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease

(2015) Tommy Pacana et al.   PLoS One

Epidemiology and Natural History of Nonalcoholic Fatty Liver Disease

(2015) Sanjaya Satapathy et al.   SEMINARS IN LIVER DISEASE

Characterization of hepatic lipid profiles in a mouse model with nonalcoholic steatohepatitis and subsequent fibrosis

(2015) Kosuke Saito et al.   Scientific Reports

Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease

(2015) Mariana Verdelho Machado et al.   PLoS One

Serum homocysteine levels, oxidative stress and cardiovascular risk in non-alcoholic steatohepatitis

(2014) Nicoleta V. Leach et al.   European Journal of Internal Medicine

Plasma Levels of Homocysteine and Cysteine Increased in Pediatric NAFLD and Strongly Correlated with Severity of Liver Damage

(2014) Anna Pastore et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of methionine-deficient and methionine-supplemented diets on the hepatic one-carbon and lipid metabolism in mice

(2014) Alexandre Ferro Aissa et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury

(2013) Igor P. Pogribny et al.   FASEB JOURNAL

Relationship Between Methylome and Transcriptome in Patients With Nonalcoholic Fatty Liver Disease

(2013) Susan K. Murphy et al.   GASTROENTEROLOGY

Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis

(2013) Maddalena Frau et al.   JOURNAL OF HEPATOLOGY

A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma

(2013) Masato Fujii et al.   Medical Molecular Morphology

Molecular Mechanisms of Fibrosis-Associated Promotion of Liver Carcinogenesis

(2013) Takeki Uehara et al.   TOXICOLOGICAL SCIENCES

Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism

(2012) Volodymyr Tryndyak et al.   FASEB JOURNAL

Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice

(2012) Masato Tsuchiya et al.   HEPATOLOGY

Homocysteinemia in Mice with Genetic Betaine Homocysteine S-Methyltransferase Deficiency Is Independent of Dietary Folate Intake

(2012) Ya-Wen Teng et al.   JOURNAL OF NUTRITION

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Alterations in hepatic one-carbon metabolism and related pathways following a high-fat dietary intervention

(2011) Isabel Rubio-Aliaga et al.   PHYSIOLOGICAL GENOMICS

New Insights from Rodent Models of Fatty Liver Disease

(2010) Jacquelyn J. Maher   ANTIOXIDANTS & REDOX SIGNALING

Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease

(2010) Valentina Medici et al.   JOURNAL OF HEPATOLOGY

Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet

(2010) Volodymyr P. Tryndyak et al.   MOLECULAR NUTRITION & FOOD RESEARCH

TNF -dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish s-adenosylhomocysteine hydrolase

(2009) R. P. Matthews et al.   DEVELOPMENT

Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet

(2009) Igor P. Pogribny et al.   JOURNAL OF HEPATOLOGY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Abnormalities of Lipid Metabolism in Nonalcoholic Fatty Liver Disease

(2008) Onpan Cheung et al.   SEMINARS IN LIVER DISEASE