Targeting methionine cycle as a potential therapeutic strategy for immune disorders
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Title
Targeting methionine cycle as a potential therapeutic strategy for immune disorders
Authors
Keywords
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Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 21, Issue 9, Pages 861-877
Publisher
Informa UK Limited
Online
2017-08-22
DOI
10.1080/14728222.2017.1370454
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Note: Only part of the references are listed.- Homocysteine and disease: Causal associations or epiphenomenons?
- (2017) Luciana Hannibal et al. MOLECULAR ASPECTS OF MEDICINE
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- (2016) Ming Zhao et al. ANNALS OF THE RHEUMATIC DISEASES
- Orofacial manifestations of systemic sclerosis
- (2016) B. J. Veale et al. BRITISH DENTAL JOURNAL
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- (2016) P. Khare et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- The critical role of epigenetics in systemic lupus erythematosus and autoimmunity
- (2016) Hai Long et al. JOURNAL OF AUTOIMMUNITY
- Expression of DNA methylation genes in secondary progressive multiple sclerosis
- (2016) Paolo Fagone et al. JOURNAL OF NEUROIMMUNOLOGY
- Activation of the adenosine A2A receptor exacerbates experimental autoimmune neuritis in Lewis rats in association with enhanced humoral immunity
- (2016) Min Zhang et al. JOURNAL OF NEUROIMMUNOLOGY
- Dual roles of the adenosine A2a receptor in autoimmune neuroinflammation
- (2016) J. Ingwersen et al. Journal of Neuroinflammation
- DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia
- (2016) Christopher C Oakes et al. NATURE GENETICS
- The next generation of therapeutics for chronic kidney disease
- (2016) Matthew D. Breyer et al. NATURE REVIEWS DRUG DISCOVERY
- Mechanism of action of methotrexate in rheumatoid arthritis and the search for biomarkers
- (2016) Philip M. Brown et al. Nature Reviews Rheumatology
- H3K4 tri-methylation breadth at transcription start sites impacts the transcriptome of systemic lupus erythematosus
- (2016) Zhe Zhang et al. Clinical Epigenetics
- Identification of rheumatoid arthritis biomarkers based on single nucleotide polymorphisms and haplotype blocks: A systematic review and meta-analysis
- (2016) Mohamed N. Saad et al. Journal of Advanced Research
- Methionine sulfoxides in serum proteins as potential clinical biomarkers of oxidative stress
- (2016) Satoko Suzuki et al. Scientific Reports
- Elevated homocysteine levels in type 2 diabetes induce constitutive neutrophil extracellular traps
- (2016) Manjunath B Joshi et al. Scientific Reports
- Toll-like receptors: potential targets for lupus treatment
- (2015) Yan-wei Wu et al. ACTA PHARMACOLOGICA SINICA
- Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease
- (2015) Arslan Arinc Kayacelebi et al. AMINO ACIDS
- Adenosine 2A receptor agonism: A single intrathecal administration attenuates motor paralysis in experimental autoimmune encephalopathy in rats
- (2015) Lisa C. Loram et al. BRAIN BEHAVIOR AND IMMUNITY
- s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways
- (2015) Wei Ding et al. Cell Metabolism
- Increased expression of TLR2 in CD4+T cells from SLE patients enhances immune reactivity and promotes IL-17 expression through histone modifications
- (2015) Yu Liu et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Differences in promoter DNA methylation and mRNA expression of individual alleles of the HLA class II DQA1 gene
- (2015) Marta Zajacova et al. IMMUNOLOGY LETTERS
- Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling
- (2015) Irina Tikhanovich et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pathogenesis and targeted treatment of skin injury in SLE
- (2015) Guo-Min Deng et al. Nature Reviews Rheumatology
- Pathological concentrations of homocysteine increases IL-1β production in macrophages in a P2X7, NF-ĸB, and erk-dependent manner
- (2015) Rafael Fernandes Zanin et al. Purinergic Signalling
- DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS
- (2015) John R Glossop et al. Epigenomics
- Correlation of Low CD73 Expression on Synovial Lymphocytes With Reduced Adenosine Generation and Higher Disease Severity in Juvenile Idiopathic Arthritis
- (2015) Sophie Botta Gordon-Smith et al. Arthritis & Rheumatology
- DNA Methylation Profile of Genes Involved in Inflammation and Autoimmunity in Inflammatory Bowel Disease
- (2015) Pantelis S. Karatzas et al. MEDICINE
- Genome-Wide DNA Methylation Profiles Indicate CD8+ T Cell Hypermethylation in Multiple Sclerosis
- (2015) Steffan D. Bos et al. PLoS One
- Serum Homocysteine Concentration Is Significantly Associated with Inflammatory/Immune Factors
- (2015) Tianyu Li et al. PLoS One
- Inhibiting DNA Methylation by 5-Aza-2′-deoxycytidine Ameliorates Atherosclerosis Through Suppressing Macrophage Inflammation
- (2014) Qiang Cao et al. ENDOCRINOLOGY
- A novel upstream enhancer ofFOXP3, sensitive to methylation-induced silencing, exhibits dysregulated methylation in rheumatoid arthritis Treg cells
- (2014) Alan Kennedy et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Hypomethylating Agent 5-Aza-2′-deoxycytidine (DAC) Ameliorates Multiple Sclerosis in Mouse Models
- (2014) Katia Mangano et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Biomarkers of One-Carbon Metabolism Are Associated with Biomarkers of Inflammation in Women
- (2014) Clare Abbenhardt et al. JOURNAL OF NUTRITION
- Unknown
- (2014) Michael Chan et al. MOLECULAR MEDICINE
- Genetic variants of homocysteine metabolism and multiple sclerosis: A case–control study
- (2014) Benjamin V. Ineichen et al. NEUROSCIENCE LETTERS
- The contribution of epigenetics in Sjögren’s Syndrome
- (2014) Orsia D. Konsta et al. Frontiers in Genetics
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- (2013) Shi-jun He et al. ACTA PHARMACOLOGICA SINICA
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- (2013) Clara Dees et al. ANNALS OF THE RHEUMATIC DISEASES
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- (2013) Smriti Murali Krishna et al. ATHEROSCLEROSIS
- Metabolic control of the epigenome in systemic Lupus erythematosus
- (2013) Zachary Oaks et al. AUTOIMMUNITY
- Critical role of transmethylation in TLR signaling and systemic lupus erythematosus
- (2013) Virginie Tardif et al. CLINICAL IMMUNOLOGY
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- (2013) Mehdi Moghaddasi et al. CLINICAL NEUROLOGY AND NEUROSURGERY
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- (2012) Ariane Thielens et al. CURRENT OPINION IN IMMUNOLOGY
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- (2012) Matt Butler et al. EUROPEAN JOURNAL OF IMMUNOLOGY
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- (2012) W. Wei et al. JOURNAL OF IMMUNOLOGY
- Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjects
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- Extracellular adenosine signaling induces CX3CL1 expression in the brain to promote experimental autoimmune encephalomyelitis
- (2012) Jeffrey H Mills et al. Journal of Neuroinflammation
- Arginine methylation regulates antibody responses through modulating cell division and isotype switching in B cells
- (2012) Kikumi Hata et al. MICROBIOLOGY AND IMMUNOLOGY
- Population PK/PD Model of Homocysteine Concentrations after High-Dose Methotrexate Treatment in Patients with Acute Lymphoblastic Leukemia
- (2012) Hauke Rühs et al. PLoS One
- DNA methylation: a promising landscape for immune system-related diseases
- (2012) Beatriz Suarez-Alvarez et al. TRENDS IN GENETICS
- Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells
- (2011) S. Steinfelder et al. BLOOD
- Transmethylation in immunity and autoimmunity
- (2011) Brian R. Lawson et al. CLINICAL IMMUNOLOGY
- Autoimmune Diseases and Polyamines
- (2011) Wesley H. Brooks CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
- DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts
- (2011) E Karouzakis et al. GENES AND IMMUNITY
- Meta-analysis of the relationship between homocysteine, vitamin B12, folate, and multiple sclerosis
- (2011) Ying Zhu et al. JOURNAL OF CLINICAL NEUROSCIENCE
- An Endogenously Anti-Inflammatory Role for Methylation in Mucosal Inflammation Identified through Metabolite Profiling
- (2011) D. J. Kominsky et al. JOURNAL OF IMMUNOLOGY
- Adenosine A2A receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation
- (2011) Gabriela E. Garcia et al. KIDNEY INTERNATIONAL
- Methylation-dependent PAD2 upregulation in multiple sclerosis peripheral blood
- (2011) Roberta Calabrese et al. Multiple Sclerosis Journal
- Epigenetic alterations in autoimmune rheumatic diseases
- (2011) Esteban Ballestar Nature Reviews Rheumatology
- Adenosine Inhibits the Release of Arachidonic Acid in Activated Human Peripheral Mononuclear Cells. A Proposed Model for Physiologic and Pathologic Regulation in Systemic Lupus Erythematosus
- (2011) Sándor Sipka TheScientificWorldJOURNAL
- A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release
- (2011) Katia Varani et al. ARTHRITIS RESEARCH & THERAPY
- Epigenomic deregulation in the immune system
- (2011) Virginia C Rodriguez-Cortez et al. Epigenomics
- Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation
- (2010) Joanna Stanczyk et al. ARTHRITIS AND RHEUMATISM
- Epigenetics in autoimmune disorders: Highlights of the 10th Sjögren's Syndrome Symposium
- (2010) Qianjin Lu et al. AUTOIMMUNITY REVIEWS
- Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: An 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients
- (2010) Jinhyun Kim et al. CLINICAL THERAPEUTICS
- SAMe prevents the up regulation of toll-like receptor signaling in Mallory–Denk body forming hepatocytes
- (2010) Fawzia Bardag-Gorce et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Epigenetics and autoimmunity
- (2010) Wesley H. Brooks et al. JOURNAL OF AUTOIMMUNITY
- Adenosine 2A receptor is protective against renal injury in MRL/lpr mice
- (2010) L Zhang et al. LUPUS
- Preclinical studies of methylthioadenosine for the treatment of multiple sclerosis
- (2010) B. Moreno et al. Multiple Sclerosis Journal
- Plasma total homocysteine level and methylenetetrahydrofolate reductase 677C>T genetic polymorphism in Japanese patients with rheumatoid arthritis
- (2009) Chihiro Fujimaki et al. BIOMARKERS
- Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
- (2009) B. M. Javierre et al. GENOME RESEARCH
- IL-6 Modulates CD5 Expression in B Cells from Patients with Lupus by Regulating DNA Methylation
- (2009) S. Garaud et al. JOURNAL OF IMMUNOLOGY
- The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes
- (2009) R. G. Jenner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synthesis and biological evaluation of immunosuppressive agent DZ2002 and its stereoisomers
- (2008) Yang-Ming Zhang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Exploring the Mechanisms behind S-Adenosylmethionine (SAMe) in the Treatment of Osteoarthritis
- (2008) Heather Joy Hosea Blewett CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
- S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation
- (2008) Ainhoa Iglesias Ara et al. HEPATOLOGY
- Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
- (2008) György Haskó et al. NATURE REVIEWS DRUG DISCOVERY
- Increased plasma homocysteine levels in patients with multiple sclerosis and depression
- (2008) Nikolaos Triantafyllou et al. Annals of General Psychiatry
- The Adenosine A2b Receptor: Its Role in Inflammation
- (2008) J. Ham et al. Endocrine Metabolic & Immune Disorders-Drug Targets
- Ethanol inhibits methionine adenosyltransferase II activity and S-adenosylmethionine biosynthesis and enhances caspase-3-dependent cell death in T lymphocytes: relevance to alcohol-induced immunosuppression
- (2007) Prachi T. Hote et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
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