标题
Methionine cycle in nonalcoholic fatty liver disease and its potential applications
作者
关键词
Methionine Cycle, NAFLD
出版物
BIOCHEMICAL PHARMACOLOGY
Volume 200, Issue -, Pages 115033
出版商
Elsevier BV
发表日期
2022-04-06
DOI
10.1016/j.bcp.2022.115033
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Dysregulation of S-adenosylmethionine Metabolism in Nonalcoholic Steatohepatitis Leads to Polyamine Flux and Oxidative Stress
- (2022) Connor Quinn et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis
- (2022) Diego Sáenz de Urturi et al. Nature Communications
- Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction
- (2022) Ferrol I. Rome et al. Molecular Metabolism
- The Role of the Transsulfuration Pathway in Non-Alcoholic Fatty Liver Disease
- (2021) Mikkel Parsberg Werge et al. Journal of Clinical Medicine
- Dietary Egg White Protein Hydrolysate Improves Orotic Acid-Induced Fatty Liver in Rats by Promoting Hepatic Phospholipid Synthesis and Microsomal Triglyceride Transfer Protein Expression
- (2021) Zhe Jiang et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Betaine Delayed Muscle Loss by Attenuating Samtor Complex Inhibition for mTORC1 Signaling Via Increasing SAM Level
- (2021) Si Chen et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential
- (2020) Hai-Jian Sun et al. Journal of Advanced Research
- Long‐term uninterrupted enzyme replacement therapy prevents liver disease in murine model of severe homocystinuria
- (2020) Insun Park et al. HUMAN MUTATION
- New Perspectives of S-Adenosylmethionine (SAMe) Applications to Attenuate Fatty Acid-Induced Steatosis and Oxidative Stress in Hepatic and Endothelial Cells
- (2020) Laura Vergani et al. MOLECULES
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice
- (2020) Russell R. Fling et al. Scientific Reports
- Impact of the Association Between PNPLA3 Genetic Variation and Dietary Intake on the Risk of Significant Fibrosis in Patients With NAFLD
- (2020) Eduardo Vilar-Gomez et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- EZH2 as a Potential Target for NAFLD Therapy
- (2020) Hyun Jung Lim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A
- (2020) Young-Chae Kim et al. Nature Communications
- TGF-β1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM
- (2019) Kuifeng Wang et al. EBioMedicine
- Gene expression and DNA methylation alterations in the glycine N-methyltransferase gene in diet-induced nonalcoholic fatty liver disease-associated carcinogenesis
- (2019) Barbara Borowa-Mazgaj et al. TOXICOLOGICAL SCIENCES
- Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance
- (2019) Sereana Wan et al. FASEB JOURNAL
- Total liver phosphatidylcholine content associates with non‐alcoholic steatohepatitis and glycine N‐methyltransferase expression
- (2019) Ville Männistö et al. LIVER INTERNATIONAL
- miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease
- (2019) Pablo Fernández-Tussy et al. Molecular Metabolism
- Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma
- (2018) Igor P. Pogribny et al. FASEB JOURNAL
- Homocysteine regulates fatty acid and lipid metabolism in yeast
- (2018) Myriam Visram et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mechanisms of NAFLD development and therapeutic strategies
- (2018) Scott L. Friedman et al. NATURE MEDICINE
- The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity
- (2018) Julien Bricambert et al. Nature Communications
- AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle
- (2018) Young-Chae Kim et al. Nature Communications
- Adiponectin inhibits hepatic stellate cell activation by targeting the PTEN/AKT pathway
- (2018) Pradeep Kumar et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage
- (2018) Cheng-Chieh Fang et al. Scientific Reports
- Knock-down of AHCY and depletion of adenosine induces DNA damage and cell cycle arrest
- (2018) Lucija Belužić et al. Scientific Reports
- ZNF300 stimulates fatty acid oxidation and alleviates hepatosteatosis through regulating PPARα
- (2018) Feng Juan Yan et al. BIOCHEMICAL JOURNAL
- Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice
- (2018) Natalia Presa et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Targeting methionine cycle as a potential therapeutic strategy for immune disorders
- (2017) Heng Li et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci
- (2017) Daniel S. Lupu et al. FASEB JOURNAL
- Role of glutathione in the regulation of epigenetic mechanisms in disease
- (2017) José Luis García-Giménez et al. FREE RADICAL BIOLOGY AND MEDICINE
- Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
- (2017) Zobair Younossi et al. Nature Reviews Gastroenterology & Hepatology
- SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway
- (2017) Xin Gu et al. SCIENCE
- Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis
- (2017) Yuting Wu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Choline, Other Methyl-Donors and Epigenetics
- (2017) Steven Zeisel Nutrients
- Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-deficient mice
- (2016) Jelske N. van der Veen et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Alleviation of hepatic fat accumulation by betaine involves reduction of homocysteine via up-regulation of betaine-homocysteine methyltransferase (BHMT)
- (2016) Chul Won Ahn et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis
- (2016) Imanol Zubiete-Franco et al. JOURNAL OF HEPATOLOGY
- Hepatic stellate cell transdifferentiation involves genome-wide remodeling of the DNA methylation landscape
- (2016) Agata Page et al. JOURNAL OF HEPATOLOGY
- EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
- (2016) JOURNAL OF HEPATOLOGY
- Lack of global epigenetic methylation defects in CBS deficient mice
- (2016) Hyung-Ok Lee et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Nonalcoholic steatohepatitis is associated with a state of betaine-insufficiency
- (2016) Silvia Sookoian et al. LIVER INTERNATIONAL
- Phosphatidylethanolamine N-methyltransferase gene rs7946 polymorphism plays a role in risk of nonalcoholic fatty liver disease
- (2016) Hwa-Li Tan et al. Pharmacogenetics and Genomics
- Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis
- (2016) Atsuko Nakatsuka et al. Scientific Reports
- Exendin-4 regulates redox homeostasis in rats fed with high-fat diet
- (2015) Shiwei Niu et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism
- (2015) Rafael Deminice et al. AMINO ACIDS
- Sulfur amino acid metabolism in Zucker diabetic fatty rats
- (2015) Hui Chan Kwak et al. BIOCHEMICAL PHARMACOLOGY
- High homocysteine induces betaine depletion
- (2015) A. Imbard et al. BIOSCIENCE REPORTS
- The CBS/CSE system: a potential therapeutic target in NAFLD?
- (2015) Lindsei K. Sarna et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice
- (2015) Hiroyuki Tsuchiya et al. GASTROENTEROLOGY
- Role of Methionine Adenosyltransferase α2 and β Phosphorylation and Stabilization in Human Hepatic Stellate Cell Trans-Differentiation
- (2015) Komal Ramani et al. JOURNAL OF CELLULAR PHYSIOLOGY
- S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease
- (2015) Maite Martínez-Uña et al. JOURNAL OF HEPATOLOGY
- Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice
- (2015) Sapna Gupta et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Palm tocotrienol-rich fraction inhibits methionine-induced cystathionine β-synthase in rat liver
- (2015) Yusof Kamisah et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- Tyrosol Attenuates High Fat Diet-Induced Hepatic Oxidative Stress: Potential Involvement of Cystathionine β-Synthase and Cystathionine γ-Lyase
- (2015) Lindsei K. Sarna et al. LIPIDS
- Creatine and the Liver: Metabolism and Possible Interactions
- (2015) R.P. Barcelos et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Differential proteomic and tissue expression analyses identify valuable diagnostic biomarkers of hepatocellular differentiation and hepatoid adenocarcinomas
- (2015) Henning Reis et al. PATHOLOGY
- Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease
- (2015) Tommy Pacana et al. PLoS One
- Downregulation of betaine homocysteine methyltransferase (BHMT) in hepatocellular carcinoma associates with poor prognosis
- (2015) Bin Jin et al. TUMOR BIOLOGY
- Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer
- (2015) Hong-Bin Yang et al. Nature Communications
- 2D DIGE proteomic analysis highlights delayed postnatal repression of α-fetoprotein expression in homocystinuria model mice
- (2015) Shotaro Kamata et al. FEBS Open Bio
- Mallory–Denk Body (MDB) formation modulates ufmylation expression epigenetically in alcoholic hepatitis (AH) and non-alcoholic steatohepatitis (NASH)
- (2014) Hui Liu et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Hydrogen sulfide and the liver
- (2014) Sarathi Mani et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels
- (2014) Christoph Dahlhoff et al. Molecular Metabolism
- Methylenetetrahydrofolate Reductase Gene Polymorphism and Serum Homocysteine Levels in Nonalcoholic Fatty Liver Disease
- (2013) Maria José Franco Brochado et al. ANNALS OF NUTRITION AND METABOLISM
- Acute Liver Injury Induces Nucleocytoplasmic Redistribution of Hepatic Methionine Metabolism Enzymes
- (2013) Miguel Delgado et al. ANTIOXIDANTS & REDOX SIGNALING
- The potential role of homocysteine mediated DNA methylation and associated epigenetic changes in abdominal aortic aneurysm formation
- (2013) Smriti Murali Krishna et al. ATHEROSCLEROSIS
- Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase
- (2013) Jean-Louis Guéant et al. BIOCHIMIE
- Betaine homocysteine methyltransferase (BHMT)-dependent remethylation pathway in human healthy and tumoral liver
- (2013) Hélène Pellanda CLINICAL CHEMISTRY AND LABORATORY MEDICINE
- Blood glutathione redox status and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults
- (2013) Megan M. Niedzwiecki et al. Epigenetics
- Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury
- (2013) Igor P. Pogribny et al. FASEB JOURNAL
- Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis
- (2013) Maite Martínez-Uña et al. HEPATOLOGY
- Choline Supplementation Protects against Liver Damage by Normalizing Cholesterol Metabolism in Pemt/Ldlr Knockout Mice Fed a High-Fat Diet
- (2013) Ala Al Rajabi et al. JOURNAL OF NUTRITION
- Network-based Analysis of Genome Wide Association Data Provides Novel Candidate Genes for Lipid and Lipoprotein Traits
- (2013) Amitabh Sharma et al. MOLECULAR & CELLULAR PROTEOMICS
- Proteomic Differences Between Hepatocellular Carcinoma and Nontumorous Liver Tissue Investigated by a Combined Gel-based and Label-free Quantitative Proteomics Study
- (2013) Dominik A. Megger et al. MOLECULAR & CELLULAR PROTEOMICS
- Correction: Hepatic Methionine Homeostasis Is Conserved in C57BL/6N Mice on High-Fat Diet Despite Major Changes in Hepatic One-Carbon Metabolism
- (2013) Christoph Dahlhoff et al. PLoS One
- Physiological roles of phosphatidylethanolamine N-methyltransferase
- (2012) Dennis E. Vance BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- DNA methylation and hepatic insulin resistance and steatosis
- (2012) Silvia Sookoian et al. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease
- (2012) Carlos Jose Pirola et al. GUT
- Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase
- (2012) Laura Gomez-Santos et al. HEPATOLOGY
- Transcriptional regulation of methionine adenosyltransferase 2A by peroxisome proliferator-activated receptors in rat hepatic stellate cells
- (2012) Komal Ramani et al. HEPATOLOGY
- Wilson's disease: Changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease
- (2012) Valentina Medici et al. HEPATOLOGY
- The Membrane Lipid Phosphatidylcholine Is an Unexpected Source of Triacylglycerol in the Liver
- (2012) Jelske N. van der Veen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis
- (2012) Claudia von Montfort et al. JOURNAL OF HEPATOLOGY
- Proteomic analysis of liver mitochondria of apolipoprotein E knockout mice treated with metformin
- (2012) Aneta Stachowicz et al. Journal of Proteomics
- Proteomics and gene expression analyses of mitochondria from squalene-treated apoE-deficient mice identify short-chain specific acyl-CoA dehydrogenase changes associated with fatty liver amelioration
- (2012) Adela Ramírez-Torres et al. Journal of Proteomics
- Unknown
- (2012) Yi-Jen Liao et al. MOLECULAR MEDICINE
- S-adenosylmethionine in Liver Health, Injury, and Cancer
- (2012) Shelly C. Lu et al. PHYSIOLOGICAL REVIEWS
- Adenosine Kinase Deficiency Disrupts the Methionine Cycle and Causes Hypermethioninemia, Encephalopathy, and Abnormal Liver Function
- (2011) Magnus K. Bjursell et al. AMERICAN JOURNAL OF HUMAN GENETICS
- The metabolic burden of creatine synthesis
- (2011) John T. Brosnan et al. AMINO ACIDS
- Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria
- (2011) Kazutaka Ikeda et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Plasma homocysteine level and hepatic sulfur amino acid metabolism in mice fed a high-fat diet
- (2011) Kang Uk Yun et al. EUROPEAN JOURNAL OF NUTRITION
- Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice
- (2011) Ainara Cano et al. HEPATOLOGY
- Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice
- (2011) Ji Ling et al. HEPATOLOGY
- A splicing variant leads to complete loss of function of betaine–homocysteine methyltransferase (BHMT) gene in hepatocellular carcinoma
- (2011) Hélène Pellanda et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Deletion of Betaine-HomocysteineS-Methyltransferase in Mice Perturbs Choline and 1-Carbon Metabolism, Resulting in Fatty Liver and Hepatocellular Carcinomas
- (2011) Ya-Wen Teng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Corticoadrenal activity regulates in rat betaine-homocysteine S-methyltransferase expression with opposites effects in liver and kidney
- (2011) Osvaldo Fridman et al. JOURNAL OF BIOSCIENCES
- Glycine-N Methyltransferase Expression in HepG2 Cells Is Involved in Methyl Group Homeostasis by Regulating Transmethylation Kinetics and DNA Methylation
- (2011) Yi-Cheng Wang et al. JOURNAL OF NUTRITION
- Methionine Adenosyltransferase II Serves as a Transcriptional Corepressor of Maf Oncoprotein
- (2011) Yasutake Katoh et al. MOLECULAR CELL
- Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity
- (2011) Jana Strakova et al. NUTRITION RESEARCH
- Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice
- (2010) Kristian K. Jensen et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: Impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter
- (2010) Silvia Sookoian et al. HEPATOLOGY
- Impairedde NovoCholine Synthesis Explains Why PhosphatidylethanolamineN-Methyltransferase-deficient Mice Are Protected from Diet-induced Obesity
- (2010) René L. Jacobs et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Steatosis in Mice Is Associated with Gender, Folate Intake, and Expression of Genes of One-Carbon Metabolism
- (2010) Karen E. Christensen et al. JOURNAL OF NUTRITION
- Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment
- (2010) Kenneth N. Maclean et al. MOLECULAR GENETICS AND METABOLISM
- Betaine-homocysteine methyltransferase: Human liver genotype–phenotype correlation
- (2010) Qiping Feng et al. MOLECULAR GENETICS AND METABOLISM
- Deficiency of glycineN-methyltransferase results in deterioration of cellular defense to stress in mouse liver
- (2010) Yi-Jen Liao et al. Proteomics Clinical Applications
- The logic of the hepatic methionine metabolic cycle
- (2009) M.V. Martinov et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- TNF -dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish s-adenosylhomocysteine hydrolase
- (2009) R. P. Matthews et al. DEVELOPMENT
- Conformational signals in the C-terminal domain of methionine adenosyltransferase I/III determine its nucleocytoplasmic distribution
- (2009) Edel Reytor et al. FASEB JOURNAL
- Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
- (2009) Igor P. Pogribny et al. JOURNAL OF HEPATOLOGY
- Methionine-deficient diet induces post-transcriptional downregulation of cystathionine β-synthase
- (2009) Baiqing Tang et al. NUTRITION
- Effect of Transgenic Extrahepatic Expression of Betaine-Homocysteine Methyltransferase on Alcohol or Homocysteine-Induced Fatty Liver
- (2008) Cheng Ji et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Methionine Metabolism and Liver Disease
- (2008) José M. Mato et al. Annual Review of Nutrition
- Early effects of copper accumulation on methionine metabolism
- (2008) M. Delgado et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The Transition from Fatty Liver to NASH Associates with SAMe Depletion in db/db Mice Fed a Methionine Choline-Deficient Diet
- (2008) Matthew Wortham et al. DIGESTIVE DISEASES AND SCIENCES
- Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury
- (2008) Cheng Ji JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Impaired Sulfur-Amino Acid Metabolism and Oxidative Stress in Nonalcoholic Fatty Liver Are Alleviated by Betaine Supplementation in Rats
- (2008) Do Y. Kwon et al. JOURNAL OF NUTRITION
- Expression Pattern, Regulation, and Functions of Methionine Adenosyltransferase 2β Splicing Variants in Hepatoma Cells
- (2007) Heping Yang et al. GASTROENTEROLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started