Candidate master microRNA regulator of arsenic-induced pancreatic beta cell impairment revealed by multi-omics analysis

Characterizing RNA stability genome-wide through combined analysis of PRO-seq and RNA-seq data

(2021) Amit Blumberg et al.   BMC BIOLOGY

Origins, fate, and actions of methylated trivalent metabolites of inorganic arsenic: progress and prospects

(2021) Miroslav Stýblo et al.   ARCHIVES OF TOXICOLOGY

ATP1A3-Related Disorders: An Ever-Expanding Clinical Spectrum

(2021) Philippe A. Salles et al.   Frontiers in Neurology

A20 controls expression of beta cell regulatory genes and transcription factors

(2021) Wiktoria Ratajczak et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Free fatty acid receptor 1: a ray of hope in the therapy of type 2 diabetes mellitus

(2021) Arpita Arora et al.   INFLAMMOPHARMACOLOGY

Arsenic Toxicity: Molecular Targets and Therapeutic Agents

(2020) Valeria M. Nurchi et al.   Biomolecules

Role of miRNAs in the pathogenesis of T2DM, insulin secretion, insulin resistance, and β cell dysfunction: the story so far

(2020) Prabhsimran Kaur et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Pathways of arsenic uptake and efflux

(2019) Luis D. Garbinski et al.   ENVIRONMENT INTERNATIONAL

Arsenite and its trivalent methylated metabolites inhibit glucose-stimulated calcium influx and insulin secretion in murine pancreatic islets

(2019) Madelyn Huang et al.   ARCHIVES OF TOXICOLOGY

Arsenic is more potent than cadmium or manganese in disrupting the INS-1 beta cell microRNA landscape

(2019) Rowan Beck et al.   ARCHIVES OF TOXICOLOGY

PACAP stimulates insulin secretion by PAC1 receptor and ion channels in β-cells

(2019) Mengmeng Liu et al.   CELLULAR SIGNALLING

The Beta Cell in Type 2 Diabetes

(2019) Ashley A. Christensen et al.   Current Diabetes Reports

miR-29a Negatively Affects Glucose-Stimulated Insulin Secretion and MIN6 Cell Proliferation via Cdc42/β-Catenin Signaling

(2019) Jing Duan et al.   International Journal of Endocrinology

Metabolic signature of obesity-associated insulin resistance and type 2 diabetes

(2019) Haya Al-Sulaiti et al.   Journal of Translational Medicine

MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling

(2019) Hassan Mziaut et al.   Molecular Metabolism

FFAR1 Agonism Restores Insulin Secretion in Rodents, Human Islets, and Diabetic Monkeys

(2018) JIANYING LIU et al.   DIABETES

Genomic insights into the causes of type 2 diabetes

(2018) Claudia Langenberg et al.   LANCET

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men

(2018) Patrik Rorsman et al.   PHYSIOLOGICAL REVIEWS

miR-149 Negative Regulation of mafA Is Involved in the Arsenite-Induced Dysfunction of Insulin Synthesis and Secretion in Pancreatic Beta Cells

(2018) Qian Sun et al.   TOXICOLOGICAL SCIENCES

Chromatin run-on and sequencing maps the transcriptional regulatory landscape of glioblastoma multiforme

(2018) Tinyi Chu et al.   NATURE GENETICS

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

Friend and foe: β-cell Ca2+ signaling and the development of diabetes

(2018) Paul V. Sabatini et al.   Molecular Metabolism

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Metabolism, toxicity and anticancer activities of arsenic compounds

(2017) Islam Khairul et al.   Oncotarget

MicroRNAs in metabolism

(2016) S. Vienberg et al.   Acta Physiologica

The global menace of arsenic and its conventional remediation - A critical review

(2016) Arpan Sarkar et al.   CHEMOSPHERE

Base-pair-resolution genome-wide mapping of active RNA polymerases using precision nuclear run-on (PRO-seq)

(2016) Dig Bijay Mahat et al.   Nature Protocols

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a

(2015) W. Hu et al.   BLOOD

Identifying a gene expression signature of frequent COPD exacerbations in peripheral blood using network methods

(2015) Jarrett D Morrow et al.   BMC Medical Genomics

β-Cell MicroRNAs: Small but Powerful

(2015) Stephen R. Filios et al.   DIABETES

The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity

(2015) James Dooley et al.   DIABETES

DNA methylation directs functional maturation of pancreatic β cells

(2015) Sangeeta Dhawan et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of transcription factors in the transdifferentiation of pancreatic islet cells

(2015) T. van der Meulen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Growth hormone replacement therapy regulates microRNA-29a and targets involved in insulin resistance

(2015) Artur Galimov et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes

(2015) Bengt-Frederik Belgardt et al.   NATURE MEDICINE

Emerging Role of PACAP as a New Potential Therapeutic Target in Major Diabetes Complications

(2015) Rubina Marzagalli et al.   International Journal of Endocrinology

Role of non-coding RNAs in pancreatic beta-cell development and physiology

(2014) L. Eliasson et al.   Acta Physiologica

Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes

(2014) Patrick Gilon et al.   CELL CALCIUM

GLUT2, glucose sensing and glucose homeostasis

(2014) Bernard Thorens   DIABETOLOGIA

Arsenic induces apoptosis by the lysosomal-mitochondrial pathway in INS-1 cells

(2014) Xiao Pan et al.   ENVIRONMENTAL TOXICOLOGY

MicroRNA-7a regulates pancreatic β cell function

(2014) Mathieu Latreille et al.   JOURNAL OF CLINICAL INVESTIGATION

Rfx6 Maintains the Functional Identity of Adult Pancreatic β Cells

(2014) Julie Piccand et al.   Cell Reports

Influence of miRNA in insulin signaling pathway and insulin resistance: micro-molecules with a major role in type-2 diabetes

(2014) Chiranjib Chakraborty et al.   Wiley Interdisciplinary Reviews-RNA

FFAR1 Is Involved in Both the Acute and Chronic Effects of Palmitate on Insulin Secretion

(2013) Hjalti Kristinsson et al.   ENDOCRINOLOGY

Beta Cell 5′-Shifted isomiRs Are Candidate Regulatory Hubs in Type 2 Diabetes

(2013) Jeanette Baran-Gale et al.   PLoS One

MicroRNA-29a is up-regulated in beta-cells by glucose and decreases glucose-stimulated insulin secretion

(2012) Annika Bagge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Changes in MicroRNA Expression Contribute to Pancreatic  -Cell Dysfunction in Prediabetic NOD Mice

(2012) E. Roggli et al.   DIABETES

Evaluation of the Association between Arsenic and Diabetes: A National Toxicology Program Workshop Review

(2012) Elizabeth A. Maull et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Methylated trivalent arsenicals are potent inhibitors of glucose stimulated insulin secretion by murine pancreatic islets

(2012) Christelle Douillet et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Quality control and preprocessing of metagenomic datasets

(2011) R. Schmieder et al.   BIOINFORMATICS

miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors

(2011) Tal Melkman-Zehavi et al.   EMBO JOURNAL

miR-29a and miR-29b Contribute to Pancreatic  -Cell-Specific Silencing of Monocarboxylate Transporter 1 (Mct1)

(2011) T. J. Pullen et al.   MOLECULAR AND CELLULAR BIOLOGY

cMyc Is a Principal Upstream Driver of β-Cell Proliferation in Rat Insulinoma Cell Lines and Is an Effective Mediator of Human β-Cell Replication

(2011) Esra Karslioglu et al.   MOLECULAR ENDOCRINOLOGY

Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity

(2010) Chunyan Gu et al.   Cell Metabolism

Low-Level Arsenic Impairs Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells: Involvement of Cellular Adaptive Response to Oxidative Stress

(2010) Jingqi Fu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice

(2010) Antonia Sassmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Rfx6 directs islet formation and insulin production in mice and humans

(2010) Stuart B. Smith et al.   NATURE

miR-375 maintains normal pancreatic  - and  -cell mass

(2009) M. N. Poy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines

(2008) I. Cozar-Castellano et al.   DIABETES

Alterations in MicroRNA Expression Contribute to Fatty Acid-Induced Pancreatic  -Cell Dysfunction

(2008) P. Lovis et al.   DIABETES

c-Jun N-terminal kinase 1 is deleterious to the function and survival of murine pancreatic islets

(2008) J. L. Varona-Santos et al.   DIABETOLOGIA

Glucose and leptin induce apoptosis in human β-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases

(2008) Kathrin Maedler et al.   FASEB JOURNAL