Arsenic is more potent than cadmium or manganese in disrupting the INS-1 beta cell microRNA landscape

Arsenite and its trivalent methylated metabolites inhibit glucose-stimulated calcium influx and insulin secretion in murine pancreatic islets

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Prenatal arsenic exposure and dietary folate and methylcobalamin supplementation alter the metabolic phenotype of C57BL/6J mice in a sex-specific manner

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Circulating miRNAs Associated with Arsenic Exposure

(2018) Rowan Beck et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Impact of in vitro heavy metal exposure on pancreatic β-cell function

(2018) E. Nicole Dover et al.   TOXICOLOGY LETTERS

CaMKII as a pathological mediator of inflammation, oxidative stress, ER stress, autophagy and mitochondrial dysfunction in free fatty acids/hyperlipidemia-induced cardiac remodeling both in vitro and vivo

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miR-146a regulates glucose induced upregulation of inflammatory cytokines extracellular matrix proteins in the retina and kidney in diabetes

(2017) Shali Chen et al.   PLoS One

CaMKII: The molecular villain that aggravates cardiovascular disease

(2017) Peiying Zhang   Experimental and Therapeutic Medicine

Effect of Wnt Signaling on the Differentiation of Islet β-Cells from Adipose-Derived Stem Cells

(2017) Hefei Wang et al.   Biomed Research International

Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure

(2016) Madelyn C. Huang et al.   ARCHIVES OF TOXICOLOGY

Knockout of arsenic (+3 oxidation state) methyltransferase is associated with adverse metabolic phenotype in mice: the role of sex and arsenic exposure

(2016) Christelle Douillet et al.   ARCHIVES OF TOXICOLOGY

U-Shaped Association between Plasma Manganese Levels and Type 2 Diabetes

(2016) Zhilei Shan et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Association of urinary metals levels with type 2 diabetes risk in coke oven workers

(2016) Bing Liu et al.   ENVIRONMENTAL POLLUTION

Environmental Contaminants and Pancreatic Beta-Cells

(2016) Gabriel Fabricio et al.   Journal of Clinical Research in Pediatric Endocrinology

Pancreatic beta cell lines and their applications in diabetes mellitus research

(2016) Masa Skelin   ALTEX-Alternatives to Animal Experimentation

Chronic cadmium exposure in rats produces pancreatic impairment and insulin resistance in multiple peripheral tissues

(2015) Samuel Treviño et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Arsenic Exposure, Arsenic Metabolism, and Incident Diabetes in the Strong Heart Study

(2015) Chin-Chi Kuo et al.   DIABETES CARE

Chronic Exposure to Arsenic and Markers of Cardiometabolic Risk: A Cross-Sectional Study in Chihuahua, Mexico

(2015) Michelle A. Mendez et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

MicroRNAs as Potential Signatures of Environmental Exposure or Effect: A Systematic Review

(2015) Karen Vrijens et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Anti-Inflammatory Role of MicroRNA-146a in the Pathogenesis of Diabetic Nephropathy

(2015) K. Bhatt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes

(2015) Bengt-Frederik Belgardt et al.   NATURE MEDICINE

Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling

(2015) Lishan Fang et al.   Nature Communications

Association between Arsenic Exposure and Diabetes: A Meta-Analysis

(2015) Tzu-Ching Sung et al.   Biomed Research International

Islet-1 Is Essential for Pancreatic  -Cell Function

(2014) B. N. Ediger et al.   DIABETES

Inhibition of Pancreatic β-Cell Ca2+/Calmodulin-dependent Protein Kinase II Reduces Glucose-stimulated Calcium Influx and Insulin Secretion, Impairing Glucose Tolerance

(2014) Prasanna K. Dadi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CaMKII and MEK1/2 inhibition time-dependently modify inflammatory signaling in rat cerebral arteries during organ culture

(2014) Roya Waldsee et al.   Journal of Neuroinflammation

Arsenic induces diabetic effects through beta-cell dysfunction and increased gluconeogenesis in mice

(2014) Su Liu et al.   Scientific Reports

Metabolic memory of ß-cells controls insulin secretion and is mediated by CaMKIIa

(2014) Gustavo Jorge dos Santos et al.   Molecular Metabolism

Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver

(2013) Jonathan Schug et al.   BMC GENOMICS

Metabolome Response to Glucose in the β-Cell Line INS-1 832/13

(2013) Matthew A. Lorenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of inorganic arsenic exposure with type 2 diabetes mellitus: a meta-analysis

(2013) Weijing Wang et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Arsenic Exposure and Prevalence of Diabetes Mellitus in Korean Adults

(2013) Sang Youl Rhee et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Effects of CaMKII-Mediated Phosphorylation of Ryanodine Receptor Type 2 on Islet Calcium Handling, Insulin Secretion, and Glucose Tolerance

(2013) Sayali S. Dixit et al.   PLoS One

Cadmium Induces Apoptosis in Pancreatic β-Cells through a Mitochondria-Dependent Pathway: The Role of Oxidative Stress-Mediated c-Jun N-Terminal Kinase Activation

(2013) Kai-Chih Chang et al.   PLoS One

Accumulation of cadmium in insulin-producing β cells

(2013) Malek El Muayed et al.   Islets

Arsenic Exposure, Diabetes Prevalence, and Diabetes Control in the Strong Heart Study

(2012) M. O. Gribble et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

MicroRNA-29a is up-regulated in beta-cells by glucose and decreases glucose-stimulated insulin secretion

(2012) Annika Bagge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Evaluation of the Association between Arsenic and Diabetes: A National Toxicology Program Workshop Review

(2012) Elizabeth A. Maull et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Methylated trivalent arsenicals are potent inhibitors of glucose stimulated insulin secretion by murine pancreatic islets

(2012) Christelle Douillet et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Expression2Kinases: mRNA profiling linked to multiple upstream regulatory layers

(2011) Edward Y. Chen et al.   BIOINFORMATICS

Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function

(2011) T. L. M. Hectors et al.   DIABETOLOGIA

Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico

(2011) Luz M Del Razo et al.   Environmental Health

Effect of Environmental Contaminants on Beta Cell Function

(2011) Emilija Makaji et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

MicroRNAs 103 and 107 regulate insulin sensitivity

(2011) Mirko Trajkovski et al.   NATURE

Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs

(2011) Anthony K L Leung et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments

(2010) Alexander Lachmann et al.   BIOINFORMATICS

Involvement of MicroRNAs in the Cytotoxic Effects Exerted by Proinflammatory Cytokines on Pancreatic  -Cells

(2010) E. Roggli et al.   DIABETES

Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps

(2009) Sung Wook Chi et al.   NATURE

Activation of Wnt/β-Catenin Signaling Increases Insulin Sensitivity through a Reciprocal Regulation of Wnt10b and SREBP-1c in Skeletal Muscle Cells

(2009) Mounira Abiola et al.   PLoS One

Arsenite reduces insulin secretion in rat pancreatic β-cells by decreasing the calcium-dependent calpain-10 proteolysis of SNAP-25

(2008) A DIAZVILLASENOR et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY