Role of miRNAs in the pathogenesis of T2DM, insulin secretion, insulin resistance, and β cell dysfunction: the story so far

In Vivo Silencing of MicroRNA-132 Reduces Blood Glucose and Improves Insulin Secretion

(2019) Roel Bijkerk et al.   Nucleic Acid Therapeutics

Adipose tissue macrophage-derived exosomal miR-29a regulates obesity-associated insulin resistance

(2019) Ting Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-223 is essential for maintaining functional β-cell mass during diabetes through inhibiting both FOXO1 and SOX6 pathways

(2019) Yutian Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-125b-5p improves pancreatic β-cell function through inhibiting JNK signaling pathway by targeting DACT1 in mice with type 2 diabetes mellitus

(2019) Cheng-Yong Yu et al.   LIFE SCIENCES

Down-regulation of MicroRNA-592 in obesity contributes to hyperglycemia and insulin resistance

(2019) Yuping Song et al.   EBioMedicine

515-P: Mitochondrial AKT1 in Renal Tubules Is a Novel Modulator for the Development of Glomerulosclerosis and Subsequent Renal Failure

(2019) HUGO YOU-HSIEN LIN et al.   DIABETES

Acute suppression of insulin resistance-associated hepatic miR-29 in vivo improves glycemic control in adult mice

(2019) Yu-Han Hung et al.   PHYSIOLOGICAL GENOMICS

MiRNA-92a protects pancreatic B-cell function by targeting KLF2 in diabetes mellitus

(2018) Wenyi Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MiR-29 family members interact with SPARC to regulate glucose metabolism

(2018) Haiyan Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of a Panel of MiRNAs as Positive Regulators of Insulin Release in Pancreatic Β-Cells

(2018) Hongmei Lang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Identification of miR-9 as a negative factor of insulin secretion from beta cells

(2018) Dongzhi Hu et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

miR-330-5p/Tim-3 axis regulates macrophage M2 polarization and insulin resistance in diabetes mice

(2018) Jiling Sun et al.   MOLECULAR IMMUNOLOGY

Adipocyte-Derived Exosomal MiR-27a Induces Insulin Resistance in Skeletal Muscle Through Repression of PPARγ

(2018) Yang Yu et al.   Theranostics

Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

(2018) Melanie J. Davies et al.   DIABETOLOGIA

Network of three specific microRNAs influence type 2 diabetes through inducing insulin resistance in muscle cell lines

(2018) Maryam Honardoost et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MicroRNA-21 regulates hepatic glucose metabolism by targeting FOXO1

(2017) Ailing Luo et al.   GENE

A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus

(2017) Yuqing He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice

(2016) Audrey Jalabert et al.   DIABETOLOGIA

HNF-4α regulated miR-122 contributes to development of gluconeogenesis and lipid metabolism disorders in Type 2 diabetic mice and in palmitate-treated HepG2 cells

(2016) Shengnan Wei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

microRNA-16 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion

(2016) David E. Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

miR-182 Regulates Metabolic Homeostasis by Modulating Glucose Utilization in Muscle

(2016) Duo Zhang et al.   Cell Reports

MicroRNA-194 Modulates Glucose Metabolism and Its Skeletal Muscle Expression Is Reduced in Diabetes

(2016) Celine Latouche et al.   PLoS One

Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1

(2015) Xiaojing Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-16 modulates macrophage polarization leading to improved insulin sensitivity in myoblasts

(2015) Malathi Talari et al.   BIOCHIMIE

Differentially Expressed MicroRNA-483 Confers Distinct Functions in Pancreatic β- and α-Cells

(2015) Ramkumar Mohan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Upregulation of miR-497 induces hepatic insulin resistance in E3 rats with HFD-MetS by targeting insulin receptor

(2015) Xuan Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Contribution of Intronic miR-338–3p and Its Hosting Gene AATK to Compensatory β-Cell Mass Expansion

(2015) Cécile Jacovetti et al.   MOLECULAR ENDOCRINOLOGY

Obesity-induced miR-15b is linked causally to the development of insulin resistance through the repression of the insulin receptor in hepatocytes

(2015) Won-Mo Yang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

MicroRNA-185 Targets SOCS3 to Inhibit Beta-Cell Dysfunction in Diabetes

(2015) Lidao Bao et al.   PLoS One

MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion

(2014) Guido Sebastiani et al.   ACTA DIABETOLOGICA

MiRNA-145 is involved in the development of resistin-induced insulin resistance in HepG2 cells

(2014) Fengyun Wen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Novel Function of MicroRNA 130a-3p in Hepatic Insulin Sensitivity and Liver Steatosis

(2014) F. Xiao et al.   DIABETES

Downregulation of Carnitine Acyl-Carnitine Translocase by miRNAs 132 and 212 Amplifies Glucose-Stimulated Insulin Secretion

(2014) Mufaddal S. Soni et al.   DIABETES

MicroRNA-29 Fine-tunes the Expression of Key FOXA2-Activated Lipid Metabolism Genes and Is Dysregulated in Animal Models of Insulin Resistance and Diabetes

(2014) C. L. Kurtz et al.   DIABETES

Saturated fatty acid-induced miR-195 impairs insulin signaling and glycogen metabolism in HepG2 cells

(2014) Won-Mo Yang et al.   FEBS LETTERS

MicroRNA-7a regulates pancreatic β cell function

(2014) Mathieu Latreille et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-492 reverses high glucose-induced insulin resistance in HUVEC cells through targeting resistin

(2014) Cai Ying et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

miRNA-375 promotes beta pancreatic differentiation in human induced pluripotent stem (hiPS) cells

(2014) Reyhaneh Lahmy et al.   MOLECULAR BIOLOGY REPORTS

miR-135a targets IRS2 and regulates insulin signaling and glucose uptake in the diabetic gastrocnemius skeletal muscle

(2013) Priyanka Agarwal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MicroRNA-24/MODY Gene Regulatory Pathway Mediates Pancreatic β-Cell Dysfunction

(2013) Yunxia Zhu et al.   DIABETES

miRNA-30a-5p-mediated silencing of Beta2/NeuroD expression is an important initial event of glucotoxicity-induced beta cell dysfunction in rodent models

(2013) J.-W. Kim et al.   DIABETOLOGIA

Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion

(2013) J. M. Locke et al.   DIABETOLOGIA

Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes

(2013) Valeria Nesca et al.   DIABETOLOGIA

Dynamic expression of microRNAs during the differentiation of human embryonic stem cells into insulin-producing cells

(2013) Rui Wei et al.   GENE

miR-375, a microRNA related to diabetes

(2013) Xueling Li   GENE

miR-200s Contribute to Interleukin-6 (IL-6)-induced Insulin Resistance in Hepatocytes

(2013) Lin Dou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-106b induces mitochondrial dysfunction and insulin resistance in C2C12 myotubes by targeting mitofusin-2

(2013) Ying Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The miRNA Profile of Human Pancreatic Islets and Beta-Cells and Relationship to Type 2 Diabetes Pathogenesis

(2013) Martijn van de Bunt et al.   PLoS One

MicroRNA Expression in Alpha and Beta Cells of Human Pancreatic Islets

(2013) Dagmar Klein et al.   PLoS One

MiR-184 regulates insulin secretion through repression of Slc25a22

(2013) Sumiyo Morita et al.   PeerJ

MicroRNA-29a is up-regulated in beta-cells by glucose and decreases glucose-stimulated insulin secretion

(2012) Annika Bagge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-7 Regulates the mTOR Pathway and Proliferation in Adult Pancreatic  -Cells

(2012) Y. Wang et al.   DIABETES

Emerging roles of non-coding RNAs in pancreatic β-cell function and dysfunction

(2012) C. Guay et al.   DIABETES OBESITY & METABOLISM

Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity

(2012) B. Zhou et al.   DIABETOLOGIA

MiRNA-21 Reverses High Glucose and High Insulin Induced Insulin Resistance in 3T3-L1 Adipocytes through Targeting Phosphatase and Tensin Homologue

(2012) H.-y. Ling et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

MicroRNAs in Insulin Resistance and Obesity

(2012) Michael D. Williams et al.   Experimental Diabetes Research

MicroRNA-30d Induces Insulin Transcription Factor MafA and Insulin Production by Targeting Mitogen-activated Protein 4 Kinase 4 (MAP4K4) in Pancreatic β-Cells

(2012) Xiaomin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity

(2012) Cécile Jacovetti et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-107: a Toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes

(2012) N. H. Foley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

MicroRNAs in  -Cell Biology, Insulin Resistance, Diabetes and Its Complications

(2011) S. L. Fernandez-Valverde et al.   DIABETES

miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors

(2011) Tal Melkman-Zehavi et al.   EMBO JOURNAL

Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets

(2011) Deepti Ramachandran et al.   FEBS Journal

MicroRNAs 103 and 107 regulate insulin sensitivity

(2011) Mirko Trajkovski et al.   NATURE

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism

(2011) Sabine D. Jordan et al.   NATURE CELL BIOLOGY

MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus

(2011) Dwi Setyowati Karolina et al.   PLoS One

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling

(2011) A. Davalos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetes mellitus, a microRNA-related disease?

(2011) Claudiane Guay et al.   Translational Research

Identification of microRNAs with a role in glucose stimulated insulin secretion by expression profiling of MIN6 cells

(2010) Erica Hennessy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-15a positively regulates insulin synthesis by inhibiting uncoupling protein-2 expression

(2010) Liang-Liang Sun et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes

(2010) B. M. Herrera et al.   DIABETOLOGIA

MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes

(2009) Blanca M Herrera et al.   BMC Medical Genomics

CHANGES IN microRNA (miR) PROFILE AND EFFECTS OF miR-320 IN INSULIN-RESISTANT 3T3-L1 ADIPOCYTES

(2009) Hong-Yan Ling et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

miR-375 maintains normal pancreatic  - and  -cell mass

(2009) M. N. Poy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs

(2008) Pascal Lovis et al.   BIOLOGICAL CHEMISTRY

Expression of islet-specific microRNAs during human pancreatic development

(2008) Mugdha V. Joglekar et al.   GENE EXPRESSION PATTERNS

Identification of glucose-regulated miRNAs from pancreatic   cells reveals a role for miR-30d in insulin transcription

(2008) X. Tang et al.   RNA