Origins, fate, and actions of methylated trivalent metabolites of inorganic arsenic: progress and prospects

Comparative Cytotoxicity of Inorganic Arsenite and Methylarsenite in Human Brain Cells

(2020) Kunie Yoshinaga-Sakurai et al.   ACS Chemical Neuroscience

Analytical Methodologies for the Determination of Organoarsenicals in Edible Marine Species: A Review

(2020) Caleb Luvonga et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Great Oxidation Event expanded the genetic repertoire of arsenic metabolism and cycling

(2020) Song-Can Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro model insights into the role of human gut microbiota on arsenic bioaccessibility and its speciation in soils

(2020) Haifeng Chi et al.   ENVIRONMENTAL POLLUTION

Organoarsenicals inhibit bacterial peptidoglycan biosynthesis by targeting the essential enzyme MurA

(2020) Luis D. Garbinski et al.   CHEMOSPHERE

Arsenic-induced changes in miRNA expression in cancer and other diseases

(2020) Ana P. Ferragut Cardoso et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inorganic arsenic and its methylated metabolites as endocrine disruptors in the placenta: Mechanisms underpinning glucocorticoid receptor (GR) pathway perturbations

(2020) Cassandra J. Meakin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pathways of arsenic uptake and efflux

(2019) Luis D. Garbinski et al.   ENVIRONMENT INTERNATIONAL

Arsenite and its trivalent methylated metabolites inhibit glucose-stimulated calcium influx and insulin secretion in murine pancreatic islets

(2019) Madelyn Huang et al.   ARCHIVES OF TOXICOLOGY

A global survey of arsenic-related genes in soil microbiomes

(2019) Taylor K. Dunivin et al.   BMC BIOLOGY

Review of arsenic toxicity, speciation and polyadenylation of canonical histones

(2019) Max Costa   TOXICOLOGY AND APPLIED PHARMACOLOGY

Arsenic is more potent than cadmium or manganese in disrupting the INS-1 beta cell microRNA landscape

(2019) Rowan Beck et al.   ARCHIVES OF TOXICOLOGY

Metabolism and disposition of arsenic species from controlled dosing with dimethylarsinic acid (DMAV) in adult female CD-1 mice. V. Toxicokinetic studies following oral and intravenous administration

(2019) Nathan C. Twaddle et al.   FOOD AND CHEMICAL TOXICOLOGY

Arsenic speciation analysis: A review with an emphasis on chromatographic separations

(2019) Michael S. Reid et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Investigation of hydride generation from arsenosugars - Is it feasible for speciation analysis?

(2018) Karel Marschner et al.   ANALYTICA CHIMICA ACTA

A unique arsenic speciation profile in Elaphomyces spp. (“deer truffles”)—trimethylarsine oxide and methylarsonous acid as significant arsenic compounds

(2018) Simone Braeuer et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The Structure of an As(III) S-Adenosylmethionine Methyltransferase with 3-Coordinately Bound As(III) Depicts the First Step in Catalysis

(2018) Charles Packianathan et al.   BIOCHEMISTRY

Metabolism and disposition of arsenic species after repeated oral dosing with sodium arsenite in drinking water. II. Measurements in pregnant and fetal CD-1 mice

(2018) Nathan C. Twaddle et al.   FOOD AND CHEMICAL TOXICOLOGY

Arsenic speciation in hair and nails of acute promyelocytic leukemia (APL) patients undergoing arsenic trioxide treatment

(2018) Baowei Chen et al.   TALANTA

Arsenic-Induced Carcinogenesis: The Impact of miRNA Dysregulation

(2018) Ana P Ferragut Cardoso et al.   TOXICOLOGICAL SCIENCES

Metabolism and disposition of arsenic species from controlled dosing with sodium arsenite in adult female CD-1 mice. III. Toxicokinetic studies following oral and intravenous administration

(2018) Nathan C. Twaddle et al.   FOOD AND CHEMICAL TOXICOLOGY

Metabolic Phenotype of Wild-Type and As3mt -Knockout C57BL/6J Mice Exposed to Inorganic Arsenic: The Role of Dietary Fat and Folate Intake

(2018) Madelyn C. Huang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Circulating miRNAs Associated with Arsenic Exposure

(2018) Rowan Beck et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The antibiotic action of methylarsenite is an emergent property of microbial communities

(2018) Jian Chen et al.   MOLECULAR MICROBIOLOGY

The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence

(2017) Chin-Chi Kuo et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Arsenic metabolism and cancer risk: A meta-analysis

(2017) Brenda Gamboa-Loira et al.   ENVIRONMENTAL RESEARCH

Conserved cysteine residues determine substrate specificity in a novel As(III) S-adenosylmethionine methyltransferase fromAspergillus fumigatus

(2017) Jian Chen et al.   MOLECULAR MICROBIOLOGY

Arsenic methylation by a novel ArsM As(III) S -adenosylmethionine methyltransferase that requires only two conserved cysteine residues

(2017) Ke Huang et al.   MOLECULAR MICROBIOLOGY

Down-regulation of cytochrome P450 1A1 by monomethylarsonous acid in human HepG2 cells

(2017) Osama H. Elshenawy et al.   TOXICOLOGY LETTERS

The tumor suppressor phosphatase and tensin homolog protein (PTEN) is negatively regulated by NF-κb p50 homodimers and involves histone 3 methylation/deacetylation in UROtsa cells chronically exposed to monomethylarsonous acid

(2017) C. Oliva-González et al.   TOXICOLOGY LETTERS

Genetic and epigenetic mechanisms underlying arsenic-associated diabetes mellitus: a perspective of the current evidence

(2017) Elizabeth M. Martin et al.   Epigenomics

Co-expression of Cyanobacterial Genes for Arsenic Methylation and Demethylation in Escherichia coli Offers Insights into Arsenic Resistance

(2017) Yu Yan et al.   Frontiers in Microbiology

Epigenomic reprogramming in inorganic arsenic-mediated gene expression patterns during carcinogenesis

(2017) Meredith Eckstein et al.   REVIEWS ON ENVIRONMENTAL HEALTH

AS3MT-mediated tolerance to arsenic evolved by multiple independent horizontal gene transfers from bacteria to eukaryotes

(2017) Michael Palmgren et al.   PLoS One

Recurrent horizontal transfer of arsenite methyltransferase genes facilitated adaptation of life to arsenic

(2017) Song-Can Chen et al.   Scientific Reports

p-Azidophenylarsenoxide: An Arsenical “Bait” for the In Situ Capture and Identification of Cellular Arsenic-Binding Proteins

(2016) Xiaowen Yan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Knockout of arsenic (+3 oxidation state) methyltransferase is associated with adverse metabolic phenotype in mice: the role of sex and arsenic exposure

(2016) Christelle Douillet et al.   ARCHIVES OF TOXICOLOGY

The global menace of arsenic and its conventional remediation - A critical review

(2016) Arpan Sarkar et al.   CHEMOSPHERE

Efficient Arsenic Methylation and Volatilization Mediated by a Novel Bacterium from an Arsenic-Contaminated Paddy Soil

(2016) Ke Huang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Determination of multiple human arsenic metabolites employing high performance liquid chromatography inductively coupled plasma mass spectrometry

(2016) Szabina Stice et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Oxidation state specific analysis of arsenic species in tissues of wild-type and arsenic (+ 3 oxidation state) methyltransferase-knockout mice

(2016) Jenna M. Currier et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Cellular arsenic transport pathways in mammals

(2016) Barbara A. Roggenbeck et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

The organoarsenical biocycle and the primordial antibiotic methylarsenite

(2016) Jiaojiao Li et al.   Metallomics

Environmental contaminants and microRNA regulation: Transcription factors as regulators of toxicant-altered microRNA expression

(2016) James Sollome et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Monomethylarsonous acid, but not inorganic arsenic, is a mitochondria-specific toxicant in vascular smooth muscle cells

(2016) Clare Pace et al.   TOXICOLOGY IN VITRO

Inorganic Arsenic-induced cellular transformation is coupled with genome wide changes in chromatin structure, transcriptome and splicing patterns

(2015) Caitlyn Riedmann et al.   BMC GENOMICS

Arsenic Demethylation by a C·As Lyase in Cyanobacterium Nostoc sp. PCC 7120

(2015) Yu Yan et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic

(2015) Hai-nan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monomethylarsonous acid (MMA+3) Inhibits IL-7 Signaling in Mouse Pre-B Cells

(2015) Peace C. Ezeh et al.   TOXICOLOGICAL SCIENCES

A disulfide-bond cascade mechanism for arsenic(III)S-adenosylmethionine methyltransferase

(2015) Kavitha Marapakala et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Monomethylarsonous Acid (MMAIII) Has an Adverse Effect on the Innate Immune Response of Human Bronchial Epithelial Cells to Pseudomonas aeruginosa

(2015) Emily G. Notch et al.   PLoS One

Speciation Analysis of Arsenic by Selective Hydride Generation-Cryotrapping-Atomic Fluorescence Spectrometry with Flame-in-Gas-Shield Atomizer: Achieving Extremely Low Detection Limits with Inexpensive Instrumentation

(2014) Stanislav Musil et al.   ANALYTICAL CHEMISTRY

Earth Abides Arsenic Biotransformations

(2014) Yong-Guan Zhu et al.   Annual Review of Earth and Planetary Sciences

Proinflammatory effect of trivalent arsenical species in a co-culture of Caco-2 cells and peripheral blood mononuclear cells

(2014) Marta Calatayud et al.   ARCHIVES OF TOXICOLOGY

Pathway of Human AS3MT Arsenic Methylation

(2014) Dharmendra S. Dheeman et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Chemical Mechanism of Arsenic Biomethylation

(2014) William R. Cullen   CHEMICAL RESEARCH IN TOXICOLOGY

Associations between Arsenic Species in Exfoliated Urothelial Cells and Prevalence of Diabetes among Residents of Chihuahua, Mexico

(2014) Jenna M. Currier et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Volatilization of Arsenic from Polluted Soil by Pseudomonas putida Engineered for Expression of the arsM Arsenic(III) S-Adenosine Methyltransferase Gene

(2014) Jian Chen et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Identification of the Third Binding Site of Arsenic in Human Arsenic (III) Methyltransferase

(2014) Xiangli Li et al.   PLoS One

The Functions of Crucial Cysteine Residues in the Arsenite Methylation Catalyzed by Recombinant Human Arsenic (III) Methyltransferase

(2014) Shuping Wang et al.   PLoS One

Arsenic speciation in saliva of acute promyelocytic leukemia patients undergoing arsenic trioxide treatment

(2013) Baowei Chen et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Arsenic Binding to Proteins

(2013) Shengwen Shen et al.   CHEMICAL REVIEWS

Selective hydride generation-cryotrapping-ICP-MS for arsenic speciation analysis at picogram levels: analysis of river and sea water reference materials and human bladder epithelial cells

(2013) Tomáš Matoušek et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Arsenic and the Epigenome: Interindividual Differences in Arsenic Metabolism Related to Distinct Patterns of DNA Methylation

(2013) Kathryn A. Bailey et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Residues in Human Arsenic (+3 Oxidation State) Methyltransferase Forming Potential Hydrogen Bond Network around S-adenosylmethionine

(2013) Xiangli Li et al.   PLoS One

Effect of dietary treatment with dimethylarsinous acid (DMAIII) on the urinary bladder epithelium of arsenic (+3 oxidation state) methyltransferase (As3mt) knockout and C57BL/6 wild type female mice

(2013) Puttappa R. Dodmane et al.   TOXICOLOGY

Trivalent arsenic species induce changes in expression and levels of proinflammatory cytokines in intestinal epithelial cells

(2013) M. Calatayud et al.   TOXICOLOGY LETTERS

Tumors and proliferative lesions in adult offspring after maternal exposure to methylarsonous acid during gestation in CD1 mice

(2012) Erik J. Tokar et al.   ARCHIVES OF TOXICOLOGY

Structure of an As(III) S-Adenosylmethionine Methyltransferase: Insights into the Mechanism of Arsenic Biotransformation

(2012) A. Abdul Ajees et al.   BIOCHEMISTRY

Identification of Catalytic Residues in the As(III) S-Adenosylmethionine Methyltransferase

(2012) Kavitha Marapakala et al.   BIOCHEMISTRY

Transport routes of metalloids into and out of the cell: A review of the current knowledge

(2012) Ronen Zangi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Evaluation of the Association between Arsenic and Diabetes: A National Toxicology Program Workshop Review

(2012) Elizabeth A. Maull et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Arsenic and Antimony Transporters in Eukaryotes

(2012) Ewa Maciaszczyk-Dziubinska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rapid Equilibrium Kinetic Analysis of Arsenite Methylation Catalyzed by Recombinant Human Arsenic (+3 Oxidation State) Methyltransferase (hAS3MT)

(2012) Shuping Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Environmental exposure to arsenic, AS3MT polymorphism and prevalence of diabetes in Mexico

(2012) Zuzana Drobná et al.   Journal of Exposure Science and Environmental Epidemiology

Arsenic undergoes significant speciation changes upon incubation of contaminated rice with human colon micro biota

(2012) Pradeep Alava et al.   JOURNAL OF HAZARDOUS MATERIALS

Prenatal Arsenic Exposure Alters Gene Expression in the Adult Liver to a Proinflammatory State Contributing to Accelerated Atherosclerosis

(2012) J. Christopher States et al.   PLoS One

Methylation of arsenic by recombinant human wild-type arsenic (+3 oxidation state) methyltransferase and its methionine 287 threonine (M287T) polymorph: Role of glutathione

(2012) Lan Ding et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Methylated trivalent arsenicals are potent inhibitors of glucose stimulated insulin secretion by murine pancreatic islets

(2012) Christelle Douillet et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

HPLC-ICP-MS method development to monitor arsenic speciation changes by human gut microbiota

(2011) Pradeep Alava et al.   BIOMEDICAL CHROMATOGRAPHY

Direct Analysis of Methylated Trivalent Arsenicals in Mouse Liver by Hydride Generation-Cryotrapping-Atomic Absorption Spectrometry

(2011) Jenna M. Currier et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Epigenetic Changes in Individuals with Arsenicosis

(2011) Lisa Smeester et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico

(2011) Luz M Del Razo et al.   Environmental Health

Intracellular, time-resolved speciation and quantification of arsenic compounds in human urothelial and hepatoma cells

(2011) Joerg Hippler et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Arsenic–glutathione conjugate transport by the human multidrug resistance proteins (MRPs/ABCCs)

(2011) Elaine M. Leslie   JOURNAL OF INORGANIC BIOCHEMISTRY

Arsenic speciation in biomedical sciences: Recent advances and applications

(2011) Keng-Chang Hsu et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Direct analysis and stability of methylated trivalent arsenic metabolites in cells and tissues

(2011) Jenna M. Currier et al.   Metallomics

Generation of thioarsenicals is dependent on the enterohepatic circulation in rats

(2011) Na Bu et al.   Metallomics

Mouse Arsenic (+3 Oxidation State) Methyltransferase Genotype Affects Metabolism and Tissue Dosimetry of Arsenicals after Arsenite Administration in Drinking Water

(2011) Baowei Chen et al.   TOXICOLOGICAL SCIENCES

Effect of Sodium Arsenite Dose Administered in the Drinking Water on the Urinary Bladder Epithelium of Female Arsenic (+3 Oxidation State) Methyltransferase Knockout Mice

(2011) Masanao Yokohira et al.   TOXICOLOGICAL SCIENCES

Dose-dependent urinary phenotype of inorganic arsenic methylation in mice with a focus on trivalent methylated metabolites

(2011) Eliud A. García-Montalvo et al.   TOXICOLOGY MECHANISMS AND METHODS

Functional and structural evaluation of cysteine residues in the human arsenic (+3 oxidation state) methyltransferase (hAS3MT)

(2010) Xiaoli Song et al.   BIOCHIMIE

Monomethylarsonous Acid Produces Irreversible Events Resulting in Malignant Transformation of a Human Bladder Cell Line Following 12 Weeks of Low-Level Exposure

(2010) Shawn M. Wnek et al.   TOXICOLOGICAL SCIENCES

Severe systemic toxicity and urinary bladder cytotoxicity and regenerative hyperplasia induced by arsenite in arsenic (+3 oxidation state) methyltransferase knockout mice. A preliminary report

(2010) Masanao Yokohira et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Arsenic (+3 oxidation state) methyltransferase genotype affects steady-state distribution and clearance of arsenic in arsenate-treated mice

(2010) Michael F. Hughes et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Identification of Arsenic-Binding Proteins in Human Cells by Affinity Chromatography and Mass Spectrometry

(2009) Huiming Yan et al.   ANALYTICAL CHEMISTRY

Metabolism of arsenic in human liver: the role of membrane transporters

(2009) Zuzana Drobná et al.   ARCHIVES OF TOXICOLOGY

Disruption of the Arsenic (+3 Oxidation State) Methyltransferase Gene in the Mouse Alters the Phenotype for Methylation of Arsenic and Affects Distribution and Retention of Orally Administered Arsenate

(2009) Zuzana Drobna et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Structure–function roles of four cysteine residues in the human arsenic (+3 oxidation state) methyltransferase (hAS3MT) by site-directed mutagenesis

(2009) Xiaoli Song et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cellular uptake, subcellular distribution and toxicity of arsenic compounds in methylating and non-methylating cells

(2009) E. Dopp et al.   ENVIRONMENTAL RESEARCH

Oncogene expression profiles in K6/ODC mouse skin and papillomas following a chronic exposure to monomethylarsonous acid

(2009) Don A. Delker et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Impact of arsenic on nucleotide excision repair: XPC function, protein level, and gene expression

(2009) Maike Nollen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Disruption of Histone Modification and CARM1 Recruitment by Arsenic Represses Transcription at Glucocorticoid Receptor-Regulated Promoters

(2009) Fiona D. Barr et al.   PLoS One

Association of AS3MT polymorphisms and the risk of premalignant arsenic skin lesions

(2009) Olga L. Valenzuela et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Subcellular Distribution of Inorganic and Methylated Arsenic Compounds in Human Urothelial Cells and Human Hepatocytes

(2008) E. Dopp et al.   DRUG METABOLISM AND DISPOSITION

Transport pathways for arsenic and selenium: A minireview

(2008) Barry P. Rosen et al.   ENVIRONMENT INTERNATIONAL

Determination of arsenic species in human urine using high performance liquid chromatography (HPLC) coupled with inductively coupled plasma mass spectrometry (ICP-MS)

(2008) Sasan Rabieh et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Speciation analysis of arsenic in biological matrices by automated hydride generation-cryotrapping-atomic absorption spectrometry with multiple microflame quartz tube atomizer (multiatomizer)

(2008) Araceli Hernández-Zavala et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Inhibition by methylated organoarsenicals of the respiratory 2-oxo-acid dehydrogenases

(2008) Erik R. Bergquist et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Monomethylarsenite Competes with Zn2+for Binding Sites in the Glucocorticoid Receptor

(2008) Anne M. Spuches et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity

(2007) Kirk T. Kitchin et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Oxidation state specific generation of arsines from methylated arsenicals based on l-cysteine treatment in buffered media for speciation analysis by hydride generation-automated cryotrapping-gas chromatography-atomic absorption spectrometry with the multiatomizer

(2007) Tomáš Matoušek et al.   SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY

Tissue dosimetry, metabolism and excretion of pentavalent and trivalent dimethylated arsenic in mice after oral administration

(2007) Michael F. Hughes et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY