The Beta Cell in Type 2 Diabetes

Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes

(2018) Anoop Arunagiri et al.   Annals of the New York Academy of Sciences

Diabetes pathogenic mechanisms and potential new therapies based upon a novel target called TXNIP

(2018) Lance Thielen et al.   Current Opinion in Endocrinology Diabetes and Obesity

Insulin Acts as a Repressive Factor to Inhibit the Ability of PAR2 to Induce Islet Cell Transdifferentiation

(2018) Seung-Hee Lee et al.   Islets

Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes

(2018) Brandon B. Boland et al.   DIABETES

The impairment of glucose-stimulated insulin secretion in pancreatic β-cells caused by prolonged glucotoxicity and lipotoxicity is associated with elevated adaptive antioxidant response

(2017) Jingqi Fu et al.   FOOD AND CHEMICAL TOXICOLOGY

Metformin prevents glucotoxicity by alleviating oxidative and ER stress–induced CD36 expression in pancreatic beta cells

(2017) Jun Sung Moon et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Opposing effects of prostaglandin E 2 receptors EP3 and EP4 on mouse and human β-cell survival and proliferation

(2017) Bethany A. Carboneau et al.   Molecular Metabolism

Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications

(2017) Susana Rovira-Llopis et al.   Redox Biology

The Role of Inflammation in β-cell Dedifferentiation

(2017) Thierry M. Nordmann et al.   Scientific Reports

Disallowed and Allowed Gene Expression: Two Faces of Mature Islet Beta Cells

(2016) Katleen Lemaire et al.   Annual Review of Nutrition

Alterations of Mitochondrial Function and Insulin Sensitivity in Human Obesity and Diabetes Mellitus

(2016) Chrysi Koliaki et al.   Annual Review of Nutrition

Beta-cell mitochondrial carriers and the diabetogenic stress response

(2016) Thierry Brun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells

(2016) Jing Wang et al.   CELLULAR SIGNALLING

When Less Is Better: ER Stress and Beta Cell Proliferation

(2016) Jing Yong et al.   DEVELOPMENTAL CELL

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

(2016) Ercument Dirice et al.   DIABETES

β-Cell dysfunction in diabetes: a crisis of identity?

(2016) M. F. Brereton et al.   DIABETES OBESITY & METABOLISM

Pancreatic β-cell identity in diabetes

(2016) M. S. Remedi et al.   DIABETES OBESITY & METABOLISM

The PGE2EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice

(2016) Ryan P. Ceddia et al.   ENDOCRINOLOGY

Importance of adipocyte cyclooxygenase-2 and prostaglandin E2–prostaglandin E receptor 3 signaling in the development of obesity-induced adipose tissue inflammation and insulin resistance

(2016) Pei-Chi Chan et al.   FASEB JOURNAL

Increased Frequency of Hormone Negative and Polyhormonal Endocrine Cells in Lean Individuals With Type 2 Diabetes

(2016) Abu Saleh Md Moin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

β-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of β-Cell Dedifferentiation and Degranulation

(2016) Alexandra E. Butler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pancreatic β cell identity requires continual repression of non–β cell programs

(2016) Giselle Domínguez Gutiérrez et al.   JOURNAL OF CLINICAL INVESTIGATION

Pancreatic Inflammation Redirects Acinar to β Cell Reprogramming

(2016) Hannah W. Clayton et al.   Cell Reports

REST is a hypoxia-responsive transcriptional repressor

(2016) Miguel A. S. Cavadas et al.   Scientific Reports

glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis

(2015) L. Ye et al.   DEVELOPMENT

Loss of β-Cell Identity Occurs in Type 2 Diabetes and Is Associated With Islet Amyloid Deposits

(2015) H. Siebe Spijker et al.   DIABETES

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

(2014) Tao Gao et al.   Cell Metabolism

β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

(2014) Philippe A. Halban et al.   DIABETES CARE

High fat programming of beta cell compensation, exhaustion, death and dysfunction

(2014) Marlon E. Cerf   PEDIATRIC DIABETES

Revealing transcription factors during human pancreatic β cell development

(2014) Elizabeth Conrad et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pancreatic β-Cell Proliferation in Obesity

(2014) Amelia K. Linnemann et al.   Advances in Nutrition

Prostaglandin E2 Receptor, EP3, Is Induced in Diabetic Islets and Negatively Regulates Glucose- and Hormone-Stimulated Insulin Secretion

(2013) M. E. Kimple et al.   DIABETES

Conversion of Mature Human  -Cells Into Glucagon-Producing  -Cells

(2013) H. S. Spijker et al.   DIABETES

Inactivation of specific β cell transcription factors in type 2 diabetes

(2013) Shuangli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial function and insulin secretion

(2013) Pierre Maechler   MOLECULAR AND CELLULAR ENDOCRINOLOGY

β-cell dedifferentiation in diabetes is important, but what is it?

(2013) Gordon C Weir et al.   Islets

Regulation of Muscle Pyruvate Dehydrogenase Complex in Insulin Resistance: Effects of Exercise and Dichloroacetate

(2013) Dumitru Constantin-Teodosiu   Diabetes & Metabolism Journal

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

Mitochondrial dynamics and morphology in beta-cells

(2012) Linsey Stiles et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion?

(2012) Frans Schuit et al.   DIABETES

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

Deletion of GαZProtein Protects against Diet-induced Glucose Intolerance via Expansion of β-Cell Mass

(2012) Michelle E. Kimple et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions

(2012) Mohammed Bensellam et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition

(2011) Catherine A. Jurgens et al.   AMERICAN JOURNAL OF PATHOLOGY

REST RegulatesDYRK1ATranscription in a Negative Feedback Loop

(2011) Mei Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PDGF signalling controls age-dependent proliferation in pancreatic β-cells

(2011) Hainan Chen et al.   NATURE

Dual and opposing roles of the unfolded protein response regulated by IRE1  and XBP1 in proinsulin processing and insulin secretion

(2011) A.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ten-year duration of type 2 diabetes as prognostic factor for remission after sleeve gastrectomy

(2011) Giovanni Casella et al.   Surgery for Obesity and Related Diseases

Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass

(2010) G. Fontés et al.   DIABETOLOGIA

Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species

(2010) Charles Affourtit et al.   FREE RADICAL BIOLOGY AND MEDICINE

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Identification of genes selectively disallowed in the pancreatic islet

(2010) Timothy J. Pullen et al.   Islets

p38MAPK Controls Expression of Multiple Cell Cycle Inhibitors and Islet Proliferation with Advancing Age

(2009) Esther Sook Miin Wong et al.   DEVELOPMENTAL CELL

Gestational Diabetes Mellitus Resulting From Impaired  -Cell Compensation in the Absence of FoxM1, a Novel Downstream Effector of Placental Lactogen

(2009) H. Zhang et al.   DIABETES

Adaptive  -Cell Proliferation Is Severely Restricted With Advanced Age

(2009) M. M. Rankin et al.   DIABETES

β-Cell-Specific Overexpression of Glutathione Peroxidase Preserves Intranuclear MafA and Reverses Diabetes indb/dbMice

(2009) Jamie S. Harmon et al.   ENDOCRINOLOGY

Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress

(2009) Mira M. Sachdeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Why expression of some genes is disallowed in β-cells

(2008) Roel Quintens et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion

(2008) C. Leloup et al.   DIABETES

Glucolipotoxicity: Fuel Excess and β-Cell Dysfunction

(2008) Vincent Poitout et al.   ENDOCRINE REVIEWS

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE