Ion Mobility–Mass Spectrometry Reveals the Structures and Stabilities of Biotherapeutic Antibody Aggregates
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Ion Mobility–Mass Spectrometry Reveals the Structures and Stabilities of Biotherapeutic Antibody Aggregates
Authors
Keywords
-
Journal
ANALYTICAL CHEMISTRY
Volume 94, Issue 18, Pages 6745-6753
Publisher
American Chemical Society (ACS)
Online
2022-04-27
DOI
10.1021/acs.analchem.2c00160
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Investigation of Charge-State-Dependent Compaction of Protein Ions with Native Ion Mobility–Mass Spectrometry and Theory
- (2022) Amber D. Rolland et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- An Improved Calibration Approach for Traveling Wave Ion Mobility Spectrometry: Robust, High-Precision Collision Cross Sections
- (2021) K. Richardson et al. ANALYTICAL CHEMISTRY
- Middle level IM-MS and CIU experiments for improved therapeutic immunoglobulin subclass fingerprinting
- (2020) Thomas Botzanowski et al. ANALYTICAL CHEMISTRY
- The impact of standard accelerated stability conditions on antibody higher order structure as assessed by mass spectrometry
- (2019) Richard A. Kerr et al. mAbs
- Antibody-Drug Conjugate-Based Therapeutics: State of the Science
- (2019) Michael J Birrer et al. JNCI-Journal of the National Cancer Institute
- CIUSuite 2: Next-Generation Software for the Analysis of Gas-Phase Protein Unfolding Data
- (2019) Daniel A. Polasky et al. ANALYTICAL CHEMISTRY
- Rapid characterization of structural and functional similarity for a candidate bevacizumab (Avastin) biosimilar using a multipronged mass‐spectrometry‐based approach
- (2019) Kerene A. Brown et al. Drug Testing and Analysis
- Computational insights into compaction of gas-phase protein and protein complex ions in native ion mobility-mass spectrometry
- (2019) Amber D. Rolland et al. TRAC-TRENDS IN ANALYTICAL CHEMISTRY
- A Modified Drift Tube Ion Mobility-Mass Spectrometer for Charge-Multiplexed Collision-Induced Unfolding
- (2019) Daniel D. Vallejo et al. ANALYTICAL CHEMISTRY
- Bispecific antibodies: a mechanistic review of the pipeline
- (2019) Aran F. Labrijn et al. NATURE REVIEWS DRUG DISCOVERY
- Physicochemical Stability of Monoclonal Antibodies: A Review
- (2019) Yoann Le Basle et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Assessment of biosimilarity under native and heat-stressed conditions: rituximab, bevacizumab, and trastuzumab originators and biosimilars
- (2019) Jukyung Kang et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Multifaceted assessment of rituximab biosimilarity: The impact of glycan microheterogeneity on Fc function
- (2019) Jukyung Kang et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Signature of Antibody Domain Exchange by Native Mass Spectrometry and Collision-Induced Unfolding
- (2018) Yasunori Watanabe et al. ANALYTICAL CHEMISTRY
- Native Mass Spectrometry, Ion Mobility, and Collision-Induced Unfolding for Conformational Characterization of IgG4 Monoclonal Antibodies
- (2018) Oscar Hernandez-Alba et al. ANALYTICAL CHEMISTRY
- Collision induced unfolding of isolated proteins in the gas phase: past, present, and future
- (2018) Sugyan M Dixit et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Collision induced unfolding detects subtle differences in intact antibody glycoforms and associated fragments
- (2018) Yuwei Tian et al. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
- Hyphenation of size exclusion chromatography to native ion mobility mass spectrometry for the analytical characterization of therapeutic antibodies and related products
- (2018) Anthony Ehkirch et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- A Novel Online Four-Dimensional SEC×SEC-IM×MS Methodology for Characterization of Monoclonal Antibody Size Variants
- (2018) Anthony Ehkirch et al. ANALYTICAL CHEMISTRY
- A Mass-Spectrometry-Based Modelling Workflow for Accurate Prediction of IgG Antibody Conformations in the Gas Phase
- (2018) Kjetil Hansen et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Quantitative collision-induced unfolding differentiates model antibody-drug conjugates
- (2018) Yuwei Tian et al. PROTEIN SCIENCE
- Collidoscope: An Improved Tool for Computing Collisional Cross-Sections with the Trajectory Method
- (2017) Simon A. Ewing et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Biosimilarity under stress: A forced degradation study of Remicade® and Remsima™
- (2017) Karthik Pisupati et al. mAbs
- The making of bispecific antibodies
- (2017) Ulrich Brinkmann et al. mAbs
- Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates
- (2017) Thomas Botzanowski et al. mAbs
- Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins
- (2017) Liming Liu Protein & Cell
- Study of stability and biophysical characterization of ranibizumab and aflibercept
- (2016) M.R. Moreno et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Antibody-drug conjugate characterization by chromatographic and electrophoretic techniques
- (2016) Tao Chen et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Immunogenicity of Therapeutic Protein Aggregates
- (2016) Ehab M. Moussa et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Review on Ion Mobility Spectrometry. Part 1: current instrumentation
- (2015) R. Cumeras et al. ANALYST
- Collision Induced Unfolding of Intact Antibodies: Rapid Characterization of Disulfide Bonding Patterns, Glycosylation, and Structures
- (2015) Yuwei Tian et al. ANALYTICAL CHEMISTRY
- Ion Mobility-Mass Spectrometry: Time-Dispersive Instrumentation
- (2015) Jody C. May et al. ANALYTICAL CHEMISTRY
- Collision Cross Sections for Structural Proteomics
- (2015) Erik G. Marklund et al. STRUCTURE
- 3D Structural Fluctuation of IgG1 Antibody Revealed by Individual Particle Electron Tomography
- (2015) Xing Zhang et al. Scientific Reports
- Circular Dichroism Spectroscopy as a Tool for Monitoring Aggregation in Monoclonal Antibody Therapeutics
- (2014) Varsha Joshi et al. ANALYTICAL CHEMISTRY
- Dynamics of Intact Immunoglobulin G Explored by Drift-Tube Ion-Mobility Mass Spectrometry and Molecular Modeling
- (2014) Kamila J. Pacholarz et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The therapeutic monoclonal antibody market
- (2014) Dawn M Ecker et al. mAbs
- Therapeutic protein aggregation: mechanisms, design, and control
- (2014) Christopher J. Roberts TRENDS IN BIOTECHNOLOGY
- Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodies
- (2013) Hao Zhang et al. FEBS LETTERS
- Immunogenicity of therapeutic proteins: Influence of aggregation
- (2013) Kirsty D. Ratanji et al. Journal of Immunotoxicology
- Antibody Therapeutics in Cancer
- (2013) M. X. Sliwkowski et al. SCIENCE
- Differential scanning calorimetry as a tool for protein folding and stability
- (2012) Christopher M. Johnson ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- The impact of mass spectrometry on the study of intact antibodies: from post-translational modifications to structural analysis
- (2012) Natalie J. Thompson et al. CHEMICAL COMMUNICATIONS
- Fc-fusion proteins: new developments and future perspectives
- (2012) Daniel M. Czajkowsky et al. EMBO Molecular Medicine
- Structure and Function of Purified Monoclonal Antibody Dimers Induced by Different Stress Conditions
- (2012) Rajsekhar Paul et al. PHARMACEUTICAL RESEARCH
- Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions
- (2012) J. M. Perchiacca et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Combination of Noncovalent Mass Spectrometry and Traveling Wave Ion Mobility Spectrometry Reveals Sugar-Induced Conformational Changes of Central Glycolytic Genes Repressor/DNA Complex
- (2010) Cédric Atmanene et al. ANALYTICAL CHEMISTRY
- Resolving Disulfide Structural Isoforms of IgG2 Monoclonal Antibodies by Ion Mobility Mass Spectrometry
- (2010) Dhanashri Bagal et al. ANALYTICAL CHEMISTRY
- Collision Cross Sections of Proteins and Their Complexes: A Calibration Framework and Database for Gas-Phase Structural Biology
- (2010) Matthew F. Bush et al. ANALYTICAL CHEMISTRY
- Ion mobility–mass spectrometry analysis of large protein complexes
- (2008) Brandon T Ruotolo et al. Nature Protocols
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now