A Mass-Spectrometry-Based Modelling Workflow for Accurate Prediction of IgG Antibody Conformations in the Gas Phase

Signature of Antibody Domain Exchange by Native Mass Spectrometry and Collision-Induced Unfolding

(2018) Yasunori Watanabe et al.   ANALYTICAL CHEMISTRY

Influence of disulfide bond isoforms on drug conjugation sites in cysteine-linked IgG2 antibody-drug conjugates

(2018) Lily Liu-Shin et al.   mAbs

Antibodies to watch in 2018

(2018) Hélène Kaplon et al.   mAbs

Bispecific antibodies for cancer therapy: A review

(2018) Anuradha Krishnamurthy et al.   PHARMACOLOGY & THERAPEUTICS

A Structural Model of the Urease Activation Complex Derived from Ion Mobility-Mass Spectrometry and Integrative Modeling

(2018) Joseph D. Eschweiler et al.   STRUCTURE

Molecular Dynamics Simulations on Gas-Phase Proteins with Mobile Protons: Inclusion of All-Atom Charge Solvation

(2017) Lars Konermann   JOURNAL OF PHYSICAL CHEMISTRY B

Investigating the Structural Compaction of Biomolecules Upon Transition to the Gas-Phase Using ESI-TWIMS-MS

(2017) Paul W. A. Devine et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Mechanistic insight into the assembly of the HerA–NurA helicase–nuclease DNA end resection complex

(2017) Zainab Ahdash et al.   NUCLEIC ACIDS RESEARCH

Compaction of Duplex Nucleic Acids upon Native Electrospray Mass Spectrometry

(2017) Massimiliano Porrini et al.   ACS Central Science

Antibody-drug conjugates—an emerging class of cancer treatment

(2016) Nikolaos Diamantis et al.   BRITISH JOURNAL OF CANCER

Collision-Induced Dissociation of Electrosprayed Protein Complexes: An All-Atom Molecular Dynamics Model with Mobile Protons

(2016) Vlad Popa et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Hybrid Mass Spectrometry: Towards Characterization of Protein Conformational States

(2016) Zainab Ahdash et al.   TRENDS IN BIOCHEMICAL SCIENCES

Human IgG4: a structural perspective

(2015) Anna M. Davies et al.   IMMUNOLOGICAL REVIEWS

The Solution Structures of Two Human IgG1 Antibodies Show Conformational Stability and Accommodate Their C1q and FcγR Ligands

(2015) Lucy E. Rayner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Release of Native-like Gaseous Proteins from Electrospray Droplets via the Charged Residue Mechanism: Insights from Molecular Dynamics Simulations

(2015) Robert G. McAllister et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases

(2015) Vashti Irani et al.   MOLECULAR IMMUNOLOGY

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

(2015) Giovanna Scapin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5

(2015) Daniel Scott et al.   PROTEOMICS

Collision Cross Sections for Structural Proteomics

(2015) Erik G. Marklund et al.   STRUCTURE

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

(2015) Giovanna Scapin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In-depth analysis of subclass-specific conformational preferences of IgG antibodies

(2015) Xinsheng Tian et al.   IUCrJ

Dynamics of Intact Immunoglobulin G Explored by Drift-Tube Ion-Mobility Mass Spectrometry and Molecular Modeling

(2014) Kamila J. Pacholarz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Fab Conformations in the Solution Structure of Human Immunoglobulin G4 (IgG4) Restrict Access to Its Fc Region

(2014) Lucy E. Rayner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IgG Subclasses and Allotypes: From Structure to Effector Functions

(2014) Gestur Vidarsson et al.   Frontiers in Immunology

Antibody–drug conjugates: current status and future directions

(2013) Heidi L. Perez et al.   DRUG DISCOVERY TODAY

Native ion mobility-mass spectrometry and related methods in structural biology

(2012) A. Konijnenberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structural Modeling of Heteromeric Protein Complexes from Disassembly Pathways and Ion Mobility-Mass Spectrometry

(2012) Zoe Hall et al.   STRUCTURE

Tandem Differential Mobility Analysis-Mass Spectrometry Reveals Partial Gas-Phase Collapse of the GroEL Complex

(2011) Christopher J. Hogan et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Principles of Electrospray Ionization

(2011) Matthias Wilm   MOLECULAR & CELLULAR PROTEOMICS

How useful is ion mobility mass spectrometry for structural biology? The relationship between protein crystal structures and their collision cross sections in the gas phase

(2010) Ewa Jurneczko et al.   ANALYST

Structure and function of immunoglobulins

(2010) Harry W. Schroeder et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Therapeutic antibodies: successes, limitations and hopes for the future

(2009) Patrick Chames et al.   BRITISH JOURNAL OF PHARMACOLOGY

Electrospray: From ions in solution to ions in the gas phase, what we know now

(2009) Paul Kebarle et al.   MASS SPECTROMETRY REVIEWS

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

Ion mobility–mass spectrometry analysis of large protein complexes

(2008) Brandon T Ruotolo et al.   Nature Protocols

Travelling wave ion mobility mass spectrometry studies of protein structure: biological significance and comparison with X-ray crystallography and nuclear magnetic resonance spectroscopy measurements

(2008) Charlotte A. Scarff et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY