Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions

Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies

(2012) Aleksandr E. Miklos et al.   CHEMISTRY & BIOLOGY

Engineering Aggregation-Resistant Antibodies

(2012) Joseph M. Perchiacca et al.   Annual Review of Chemical and Biomolecular Engineering

Structure-based design of conformation- and sequence-specific antibodies against amyloid  

(2011) J. M. Perchiacca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions

(2011) Joseph M. Perchiacca et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

(2010) Sebastian Maurer-Stroh et al.   NATURE METHODS

Structure-based engineering of a monoclonal antibody for improved solubility

(2010) S.-J. Wu et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Formulation and manufacturability of biologics

(2009) Steven J Shire   CURRENT OPINION IN BIOTECHNOLOGY

Thermodynamically Stable Aggregation-Resistant Antibody Domains through Directed Evolution

(2008) Kristoffer Famm et al.   JOURNAL OF MOLECULAR BIOLOGY

Aggregation-resistant VHs selected by in vitro evolution tend to have disulfide-bonded loops and acidic isoelectric points

(2008) M. Arbabi-Ghahroudi et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Sequence determinants of protein aggregation in human VH domains

(2008) K. Dudgeon et al.   PROTEIN ENGINEERING DESIGN & SELECTION