More than meets the islet: aligning nutrient and paracrine inputs with hormone secretion in health and disease

Combined deletion of free fatty-acid receptors 1 and 4 minimally impacts glucose homeostasis in mice

(2021) Marine L Croze et al.   ENDOCRINOLOGY

Free fatty-acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice

(2021) Marine L. Croze et al.   Molecular Metabolism

The Human Islet: Mini-organ with Mega-impact

(2021) John T Walker et al.   ENDOCRINE REVIEWS

Mitochondrial Efflux of Citrate and Isocitrate Is Fully Dispensable for Glucose-Stimulated Insulin Secretion and Pancreatic Islet β-Cell Function

(2021) Casey J. Bauchle et al.   DIABETES

Glucose-induced insulin secretion in isolated human islets: Does it truly reflect β-cell function in vivo?

(2021) Jean-Claude Henquin   Molecular Metabolism

What Regulates Basal Insulin Secretion and Causes Hyperinsulinemia?

(2021) Barbara E. Corkey et al.   DIABETES

The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition

(2020) Megan E. Capozzi et al.   DIABETES

Nutrient-Induced Metabolic Stress, Adaptation, Detoxification, and Toxicity in the Pancreatic β-Cell

(2020) Marc Prentki et al.   DIABETES

The Role of α-Cells in Islet Function and Glucose Homeostasis in Health and Type 2 Diabetes

(2020) Patrick Gilon   JOURNAL OF MOLECULAR BIOLOGY

In the rat pancreas, somatostatin tonically inhibits glucagon secretion and is required for glucose‐induced inhibition of glucagon secretion

(2020) Stella F.S. Xu et al.   Acta Physiologica

Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells

(2020) Sarah M Gray et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion

(2020) Guo-Fang Zhang et al.   Cell Metabolism

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes

(2020) Lorella Marselli et al.   Cell Reports

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

(2019) Elisa Vergari et al.   Nature Communications

The Central Role of Glucokinase in Glucose Homeostasis: A Perspective 50 Years After Demonstrating the Presence of the Enzyme in Islets of Langerhans

(2019) Franz M. Matschinsky et al.   Frontiers in Physiology

Postprandial Aminogenic Insulin and Glucagon Secretion can Stimulate Glucose Flux in Humans

(2019) Teddy Ang et al.   DIABETES

Metabolomics Analysis of Nutrient Metabolism in β-Cells

(2019) Peter Spégel et al.   JOURNAL OF MOLECULAR BIOLOGY

Glucolipotoxicity, β-Cells, and Diabetes: The Emperor Has No Clothes

(2019) Gordon C. Weir   DIABETES

Lipid-associated metabolic signalling networks in pancreatic beta cell function

(2019) Marc Prentki et al.   DIABETOLOGIA

A Primary Role for Alpha Cells as Amino Acid Sensors

(2019) E. Danielle Dean   DIABETES

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

(2019) Maria Lytrivi et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis for delta cell paracrine regulation in pancreatic islets

(2019) Rafael Arrojo e Drigo et al.   Nature Communications

Concentration-Dependency and Time Profile of Insulin Secretion: Dynamic Perifusion Studies With Human and Murine Islets

(2019) Oscar Alcazar et al.   Frontiers in Endocrinology

Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss

(2019) Ahmad Al-Mrabeh et al.   Cell Metabolism

Cell culture models of fatty acid overload: Problems and solutions

(2018) Nour Alsabeeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point

(2018) Rayner Rodriguez-Diaz et al.   Cell Metabolism

Endogenous Fatty Acids are Essential Signaling Factors of Pancreaticβ-Cells and Insulin Secretion

(2018) Sebastian Hauke et al.   DIABETES

GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia

(2018) Nina Xiaoyan Li et al.   DIABETES

Evidence of a liver–alpha cell axis in humans: hepatic insulin resistance attenuates relationship between fasting plasma glucagon and glucagonotropic amino acids

(2018) Nicolai J. Wewer Albrechtsen et al.   DIABETOLOGIA

The somatostatin-secreting pancreatic δ-cell in health and disease

(2018) Patrik Rorsman et al.   Nature Reviews Endocrinology

Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation

(2018) Atsushi Miki et al.   PLoS One

20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1

(2018) Sorin Tunaru et al.   Nature Communications

CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets

(2018) Linford J.B. Briant et al.   Cell Reports

Sex differences underlying pancreatic islet biology and its dysfunction

(2018) Maureen Gannon et al.   Molecular Metabolism

Fatty Acids and Insulin Secretion: From FFAR and Near?

(2018) Vincent Poitout   DIABETES

A Model for Human Islet Transplantation to Immunodeficient Streptozotocin-Induced Diabetic Mice

(2018) Elisabet Estil·les et al.   CELL TRANSPLANTATION

Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function

(2018) Matthew Wortham et al.   Cell Reports

Insulin Secretion Depends on Intra-islet Glucagon Signaling

(2018) Berit Svendsen et al.   Cell Reports

Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells

(2017) Yves Mugabo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of the amplifying pathway of insulin secretion in the β cell

(2017) Michael A. Kalwat et al.   PHARMACOLOGY & THERAPEUTICS

The triggering pathway to insulin secretion: Functional similarities and differences between the human and the mouse β cells and their translational relevance

(2017) Maša Skelin Klemen et al.   Islets

NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells

(2017) Laila R.B. Santos et al.   Molecular Metabolism

Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism

(2017) Kirsten Roomp et al.   PLoS One

Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion

(2017) H. Kristinsson et al.   Scientific Reports

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

(2016) Alice E. Adriaenssens et al.   DIABETOLOGIA

Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCore

(2016) James Lyon et al.   ENDOCRINOLOGY

Fatty acids stimulate insulin secretion from human pancreatic islets at fasting glucose concentrations via mitochondria-dependent and -independent mechanisms

(2016) Jing Cen et al.   Nutrition & Metabolism

The role of lipid droplet formation in the protection of unsaturated fatty acids against palmitic acid induced lipotoxicity to rat insulin-producing cells

(2016) Thomas Plötz et al.   Nutrition & Metabolism

The Pancreatic β-Cell: A Bioenergetic Perspective

(2016) David G. Nicholls   PHYSIOLOGICAL REVIEWS

Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes

(2016) Yves Mugabo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

(2016) Michael R. DiGruccio et al.   Molecular Metabolism

Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas

(2016) Garima Singhal et al.   PLoS One

Control of Insulin Secretion by Production of Reactive Oxygen Species: Study Performed in Pancreatic Islets from Fed and 48-Hour Fasted Wistar Rats

(2016) Ana Cláudia Munhoz et al.   PLoS One

Enumerating β-Cells in Whole Human Islets: Sex Differences and Associations With Clinical Outcomes After Islet Transplantation

(2015) Enza Marchese et al.   DIABETES CARE

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells

(2015) Mourad Ferdaoussi et al.   JOURNAL OF CLINICAL INVESTIGATION

Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion

(2015) Talitha van der Meulen et al.   NATURE MEDICINE

α/β-Hydrolase Domain-6-Accessible Monoacylglycerol Controls Glucose-Stimulated Insulin Secretion

(2014) Shangang Zhao et al.   Cell Metabolism

Perilipin 5 Regulates Islet Lipid Metabolism and Insulin Secretion in a cAMP-Dependent Manner: Implication of Its Role in the Postprandial Insulin Secretion

(2014) Michelle B. Trevino et al.   DIABETES

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans

(2014) Virginia M. Stone et al.   DIABETOLOGIA

Using pancreas tissue slices for in situ studies of islet of Langerhans and acinar cell biology

(2014) Anja Marciniak et al.   Nature Protocols

Roles of Sphingolipid Metabolism in Pancreatic β Cell Dysfunction Induced by Lipotoxicity

(2014) Julien Véret et al.   Journal of Clinical Medicine

Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release

(2013) Peter Spégel et al.   BIOCHEMICAL JOURNAL

Metabolic Signaling in Fuel-Induced Insulin Secretion

(2013) Marc Prentki et al.   Cell Metabolism

UCP2 Regulates the Glucagon Response to Fasting and Starvation

(2013) E. M. Allister et al.   DIABETES

Coordinate Changes in Histone Modifications, mRNA Levels, and Metabolite Profiles in Clonal INS-1 832/13 β-Cells Accompany Functional Adaptations to Lipotoxicity

(2013) Siri Malmgren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic β-Cells

(2013) Ebru Boslem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fasting of mice: a review

(2013) TL Jensen et al.   LABORATORY ANIMALS

Mathematical Model of Metabolism and Electrophysiology of Amino Acid and Glucose Stimulated Insulin Secretion: In Vitro Validation Using a β-Cell Line

(2013) Manuela Salvucci et al.   PLoS One

Regulation of Glucagon Secretion in Normal and Diabetic Human Islets by γ-Hydroxybutyrate and Glycine

(2012) Changhong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The G Protein-Coupled Taste Receptor T1R1/T1R3 Regulates mTORC1 and Autophagy

(2012) Eric M. Wauson et al.   MOLECULAR CELL

Fasting insulin reflects heterogeneous physiological processes: role of insulin clearance

(2011) Mark O. Goodarzi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

β-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

(2011) Christine A. Robson-Doucette et al.   DIABETES

Amino acid taste receptor regulates insulin secretion in pancreatic β-cell line MIN6 cells

(2011) Manami Oya et al.   GENES TO CELLS

Acute stimulation of glucagon secretion by linoleic acid results from GPR40 activation and [Ca2+]i increase in pancreatic islet α-cells

(2011) Li Wang et al.   JOURNAL OF ENDOCRINOLOGY

Ghrelin Directly Stimulates Glucagon Secretion from Pancreatic α-Cells

(2011) Jen-Chieh Chuang et al.   MOLECULAR ENDOCRINOLOGY

The Mitochondrial 2-Oxoglutarate Carrier Is Part of a Metabolic Pathway That Mediates Glucose- and Glutamine-stimulated Insulin Secretion

(2010) Matthew L. Odegaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipidomics reveals a remarkable diversity of lipids in human plasma,

(2010) Oswald Quehenberger et al.   JOURNAL OF LIPID RESEARCH

Pancreatic islet plasticity: Interspecies comparison of islet architecture and composition

(2010) Donald J. Steiner et al.   Islets

Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca2+ Channels from Secretory Granules

(2009) Michael B. Hoppa et al.   Cell Metabolism

Insulin Signaling in α Cells Modulates Glucagon Secretion In Vivo

(2009) Dan Kawamori et al.   Cell Metabolism

Towards better understanding of the contributions of overwork and glucotoxicity to the β-cell inadequacy of type 2 diabetes

(2009) G. C. Weir et al.   DIABETES OBESITY & METABOLISM

Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis

(2009) Michael K. Badman et al.   ENDOCRINOLOGY

Molecular Physiology of Mammalian Glucokinase

(2008) P. B. Iynedjian   CELLULAR AND MOLECULAR LIFE SCIENCES

Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet-Induced Metabolic Disease

(2008) H. Lan et al.   DIABETES

Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon

(2008) S. C. Collins et al.   DIABETOLOGIA

Glucolipotoxicity: Fuel Excess and β-Cell Dysfunction

(2008) Vincent Poitout et al.   ENDOCRINE REVIEWS

Silencing of Cytosolic or Mitochondrial Isoforms of Malic Enzyme Has No Effect on Glucose-stimulated Insulin Secretion from Rodent Islets

(2008) Sarah M. Ronnebaum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetoacetate and β-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion

(2007) Michael J. MacDonald et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY