Journal
MOLECULAR METABOLISM
Volume 15, Issue -, Pages 82-91Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molmet.2018.05.017
Keywords
Sex differences; Gender differences; Islet; beta-cell; alpha-cell; Diabetes; Immune cells
Categories
Funding
- National Institutes of Health (NIH) [R01 DK105689, 2R24 DK090964-06]
- Department of Veterans Affairs Merit Review Award [BX003744, BX003725]
- NIH [R01 DK67536, R01 DK103215, R01 DK099550, R01 DK074970, R01 DK107444]
- JDRF [2-SRA-2016-270-S-B, 2-PNF-2016-322-S-B]
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Background: The sex of an individual affects glucose homeostasis and the pathophysiology, incidence, and prevalence of diabetes as well as the response to therapy. Scope of the review: This review focuses on clinical and experimental sex differences in islet cell biology and dysfunction during development and in adulthood in human and animal models. We discuss sex differences in beta-cell and alpha-cell function, heterogeneity, and dysfunction. We cover sex differences in communication between gonads and islets and islet-cell immune interactions. Finally, we discuss sex differences in beta-cell programming by nutrition and other environmental factors during pregnancy. Major conclusions: Important sex differences exist in islet cell function and susceptibility to failure. These differences represent sex-related biological factors that can be harnessed for gender-based prevention of and therapy for diabetes. Published by Elsevier GmbH.
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